LOCUS       NM_207446               2604 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 174 member B
            (FAM174B), mRNA.
ACCESSION   NM_207446
VERSION     NM_207446.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2604)
  AUTHORS   Serebrenik,Y.V., Hellerschmied,D., Toure,M., Lopez-Giraldez,F.,
            Brookner,D. and Crews,C.M.
  TITLE     Targeted protein unfolding uncovers a Golgi-specific
            transcriptional stress response
  JOURNAL   Mol Biol Cell 29 (11), 1284-1298 (2018)
   PUBMED   29851555
REFERENCE   2  (bases 1 to 2604)
  AUTHORS   Petrovski,S., Fellay,J., Shianna,K.V., Carpenetti,N., Kumwenda,J.,
            Kamanga,G., Kamwendo,D.D., Letvin,N.L., McMichael,A.J.,
            Haynes,B.F., Cohen,M.S. and Goldstein,D.B.
  CONSRTM   Center for HIV/AIDS Vaccine Immunology
  TITLE     Common human genetic variants and HIV-1 susceptibility: a
            genome-wide survey in a homogeneous African population
  JOURNAL   AIDS 25 (4), 513-518 (2011)
   PUBMED   21160409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091544.11 and BC060873.1.
            
            On Nov 23, 2018 this sequence version replaced NM_207446.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.710304.1, AK075564.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327355.6/ ENSP00000329040.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-335               AC091544.11        102386-102720
            336-1211            BC060873.1         253-1128
            1212-2604           AC091544.11        139321-140713
FEATURES             Location/Qualifiers
     source          1..2604
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..2604
                     /gene="FAM174B"
                     /note="family with sequence similarity 174 member B"
                     /db_xref="GeneID:400451"
                     /db_xref="HGNC:HGNC:34339"
     exon            1..460
                     /gene="FAM174B"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..596
                     /gene="FAM174B"
                     /note="membrane protein FAM174B"
                     /codon_start=1
                     /product="membrane protein FAM174B precursor"
                     /protein_id="NP_997329.2"
                     /db_xref="CCDS:CCDS45355.1"
                     /db_xref="GeneID:400451"
                     /db_xref="HGNC:HGNC:34339"
                     /translation="MRAVPLPAPLLPLLLLALLAAPAARASRAESVSAPWPEPERESR
                     PPPGPGPGNTTRFGSGAAGGSGSSSSNSSGDALVTRISILLRDLPTLKAAVIVAFAFT
                     TLLIACLLLRVFRSGKRLKKTRKYDIITTPAERVEMAPLNEEDDEDEDSTVFDIKYR"
     exon            461..592
                     /gene="FAM174B"
                     /inference="alignment:Splign:2.1.0"
     exon            593..2604
                     /gene="FAM174B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2582..2587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM174B"
                     /note="hexamer: AATAAA"
     polyA_site      2604
                     /gene="FAM174B"
                     /note="major polyA site"
ORIGIN      
        1 aagcaccgcg cagccgcctc cgccgcagga tcccccggtg caggcctccg tgctggtgcg
       61 gatcctggag ctcagccgcg cgcgccctgc ccgatcctgt gccgacccac cgcactatgc
      121 gcgccgtgcc gctgcccgcc ccgctcctgc cgctgctgct gctcgcgctc ctggccgctc
      181 ccgccgcccg cgccagcaga gccgagtccg tctccgcgcc gtggcccgaa cccgagcgcg
      241 agtcgcggcc accgcccggc ccggggcccg ggaacaccac ccggtttggg tctggggcgg
      301 cgggcggcag cggcagctcc agctccaaca gcagtggcga cgccttggtg acccgcattt
      361 ccatcctcct ccgcgaccta cccaccctca aggcagccgt gatcgtggcg ttcgccttta
      421 ccaccctcct catcgcctgc ctgctgctgc gcgtcttcag gtcgggaaag aggttaaaga
      481 agacacgcaa gtatgatatc atcaccactc cagcagagcg agtggaaatg gcgccactaa
      541 atgaagagga tgatgaagat gaggactcca cagtattcga catcaaatac aggtaaaacc
      601 tgtttcccag cctggtggca tcctgtggaa agttggtcag ctgcaacctg gggtgtgaag
      661 gactggacct ggaagccctc ttgcgtcgga ggtgttgaaa ccaaaacgaa cgttatgtat
      721 aaaaccccag ctccatcgtg cgtgtcaggc atctgctcag actgtcactg gcaagctcgt
      781 ttccacgtca ccacaatgga gttgcttctg ccaccctttg ggcatccctt taaagtgccc
      841 cctacttcta ctccccatgt aagaggcttt gtgccttgct aaggagcaaa gggtagaaac
      901 atgttgattt taaagaagtt tttttaagac aattgttgac aatagtaaaa gagatcagga
      961 ggatcaagaa tctaaaacaa gcctgaagga tgtccaactg tgtatttaga atttccgaca
     1021 ttcttctcta ctggatctac acattggacc ccatctgatc ctttgctgct tttttggctt
     1081 ggtcaggtcc tggcctcatt ttggcgttac ctgtgtcaga gttcaaggtg gatgtgctta
     1141 gagctggtca gccccttcca gacctggaca cgtctgtggc tccttttctt tcttcctttt
     1201 tttttttttt taaaaaaaaa aaaggttcag cagaaatcag cgtggctagt tcacaaagaa
     1261 tttccagtat cagggaaaaa ctgtgcgtgt gtgtgtgtgt gtgtgtgcac gtgtgtgcgt
     1321 gtgcacgtgt gtgataccta taaaacagtt tctccttctc tgaagggaaa ggaaagtgct
     1381 aggcagcctg tgattagcaa cattctttgt gcttttttgt tgttcctctg ctctgtcaca
     1441 gttctacgtt gtttgcctta gaaatgtaat ttttaaaaac cattttaaaa atgaacggtg
     1501 atttggctgg ctggaaaaaa tcacactgtc aggggactat atttgaagtc agtctagacg
     1561 gggctggact aggaacccac ctggacccag gagaccccac aggacccagg aggtccctgc
     1621 cggaaggcag aggttcaggt gagagtggct cacctctgag ctggtgaagt gaggacttgc
     1681 ctgtgacatg acccagggat ctgctgctgg cttctggaga cagggccttg ggctgacttc
     1741 tcaggttgat tgaggcctcc tgactagcgg tgttcccagg ctagaggtga ttggctgcaa
     1801 caaagatgct tctattagtc tattagcagt gccttcggga ccctgggatt ttgctctctc
     1861 tagaaaggtg ttttttattt ttttattttt tatctccccc ttttttcctg gctttgctcc
     1921 agggtttgtg tatttgcctg tttattgtcc tgctcttttt ttttttggat gaaaactcca
     1981 gcctttcctg actcacctcc atcttcggtt cttcagtttt ctgagaagag ttgggatatg
     2041 tgggaagggg catgggagct cggcagcctc cgcctgccag gaaggcagtt tcgcctctgc
     2101 aggaaagagc agagcccgtg ggaagccctg ggtgagggtg gcgcagccgg cccagcacgc
     2161 atggtattgc cagccacggg gggcctgcgt gtagtctctg ctccctgcat ttcaccttct
     2221 ttgttgactt tccttctctg ttttccccca tctgtttgcc agaggggtgg gactggcaac
     2281 agaacagccg tggctgcttt atctctcctc tccacggtgt actcaggcct gagtggtgac
     2341 tcacgggagc ctggccacct cgcagctgtt cgccccctca acctttgaac tggaactgct
     2401 ggctcacaca gggttttcga caactgcagc tgaatctcat ggaaaagctg gattcctctg
     2461 ccttacgcag aaacacccgg gctccatctg ccaggtgctt gccactggtc ctggcagaaa
     2521 tggcggctgc tgaaagtgac cttccaaatc cttggtggca cttcagcgcc acaggctctc
     2581 caataaaaac cctttacaca caaa
//
