LOCUS       NM_198507               1287 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 174 member A
            (FAM174A), mRNA.
ACCESSION   NM_198507 XM_293959
VERSION     NM_198507.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1287)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1287)
  AUTHORS   Li,Z., Feng,S., Zhou,L., Liu,S. and Cheng,J.
  TITLE     NS5ATP6 modulates intracellular triglyceride content through FGF21
            and independently of SIRT1 and SREBP1
  JOURNAL   Biochem Biophys Res Commun 475 (1), 133-139 (2016)
   PUBMED   27179781
  REMARK    GeneRIF: NS5ATP6 regulates the intracellular triglyceride level via
            FGF21, and independently of SIRT1 and SREBP1.
REFERENCE   3  (bases 1 to 1287)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI462478.1, BC027332.1 and AY359108.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198507.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY359108.1, SRR5189667.251870.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312637.5/ ENSP00000307954.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                BI462478.1         75-120
            47-1282             BC027332.1         10-1245
            1283-1287           AY359108.1         1317-1321
FEATURES             Location/Qualifiers
     source          1..1287
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q21.1"
     gene            1..1287
                     /gene="FAM174A"
                     /gene_synonym="HGS_RE408; NS5ATP6; TMEM157; UNQ1912"
                     /note="family with sequence similarity 174 member A"
                     /db_xref="GeneID:345757"
                     /db_xref="HGNC:HGNC:24943"
     exon            1..591
                     /gene="FAM174A"
                     /gene_synonym="HGS_RE408; NS5ATP6; TMEM157; UNQ1912"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..730
                     /gene="FAM174A"
                     /gene_synonym="HGS_RE408; NS5ATP6; TMEM157; UNQ1912"
                     /note="transmembrane protein 157; membrane protein
                     FAM174A; HCV NS5A-transactivated protein 6; hepatitis C
                     virus NS5A-transactivated protein 6; hepatitis C virus
                     nonstructural protein 5A trans-activated protein 6"
                     /codon_start=1
                     /product="membrane protein FAM174A precursor"
                     /protein_id="NP_940909.1"
                     /db_xref="CCDS:CCDS4090.1"
                     /db_xref="GeneID:345757"
                     /db_xref="HGNC:HGNC:24943"
                     /translation="MKASQCCCCLSHLLASVLLLLLLPELSGPLAVLLQAAEAAPGLG
                     PPDPRPRTLPPLPPGPTPAQQPGRGLAEAAGPRGSEGGNGSNPVAGLETDDHGGKAGE
                     GSVGGGLAVSPNPGDKPMTQRALTVLMVVSGAVLVYFVVRTVRMRRRNRKTRRYGVLD
                     TNIENMELTPLEQDDEDDDNTLFDANHPRR"
     exon            592..726
                     /gene="FAM174A"
                     /gene_synonym="HGS_RE408; NS5ATP6; TMEM157; UNQ1912"
                     /inference="alignment:Splign:2.1.0"
     exon            727..1287
                     /gene="FAM174A"
                     /gene_synonym="HGS_RE408; NS5ATP6; TMEM157; UNQ1912"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1260..1265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM174A"
                     /gene_synonym="HGS_RE408; NS5ATP6; TMEM157; UNQ1912"
                     /note="hexamer: AATAAA"
     polyA_site      1287
                     /gene="FAM174A"
                     /gene_synonym="HGS_RE408; NS5ATP6; TMEM157; UNQ1912"
                     /note="major polyA site"
ORIGIN      
        1 agctgccact gctgtagctt ctgccacctg ccacgaccgg gcctctccct ggcgtttggt
       61 cacctctgct tcattctcca ccgcgcctat ggtccctctt ggagccagcg tggcgggcct
      121 ggcggctccc gggtggtgag agagcggtcc gggaacgatg aaggcctcgc agtgctgctg
      181 ctgtctcagc cacctcttgg cttccgtcct cctcctgctg ttgctgcctg aactaagcgg
      241 gcccctggca gtcctgctgc aggcagccga ggccgcgcca ggtcttgggc ctcctgaccc
      301 tagaccacgg acattaccgc cgctgccacc gggccctacc cctgcccagc agccgggccg
      361 tggtctggct gaagctgcgg ggccgcgggg ctccgaggga ggcaatggca gcaaccctgt
      421 ggccgggctt gagacggacg atcacggagg gaaggccggg gaaggctcgg tgggtggcgg
      481 ccttgctgtg agccccaacc ctggcgacaa gcccatgacc cagcgggccc tgaccgtgtt
      541 gatggtggtg agcggcgcgg tgctggtgta cttcgtggtc aggacggtca ggatgagaag
      601 aagaaaccga aagactagga gatatggagt tttggacact aacatagaaa atatggaatt
      661 gacaccttta gaacaggatg atgaggatga tgacaacacg ttgtttgatg ccaatcatcc
      721 tcgaagataa gaatgtgcct tttgatgaaa gaactttatc tttctacaat gaagagtgga
      781 atttctatgt ttaaggaata agaagccact atatcaatgt tgggggggta tttaagttac
      841 atatatttta acaaccttta atttgctgtt gcaataaata ccgtatcctt ttattatatc
      901 tttatatgta tagaagtact ctgttaatgg gctcagagat gttggggata aagtatactg
      961 taataattta tctgtttgaa aattactata aaacggtgtt ttctgatcgg tttttgtttc
     1021 ctgcttacca tatgattgta aattgtttta tgtattaatc agttaatgct aattattttt
     1081 gctgatgtca tatgttaaag agctataaat tccaacaacc aactggtgtg taaaaataat
     1141 ttaaaatttc ctttactgaa aggtatttcc catttttgtg gggaaaagaa gccaaattta
     1201 ttactttgtg ttggggtttt taaaatatta agaaatgtct aagttattgt ttgcaaaaca
     1261 ataaatatga ttttaaattc tcttaaa
//
