LOCUS       NM_177454               5731 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens family with sequence similarity 171 member B
            (FAM171B), mRNA.
ACCESSION   NM_177454
VERSION     NM_177454.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5731)
  AUTHORS   Hu,W.M., Li,M., Ning,J.Z., Tang,Y.Q., Song,T.B., Li,L.Z., Zou,F.,
            Cheng,F. and Yu,W.M.
  TITLE     FAM171B stabilizes vimentin and enhances CCL2-mediated TAM
            infiltration to promote bladder cancer progression
  JOURNAL   J Exp Clin Cancer Res 42 (1), 290 (2023)
   PUBMED   37915048
  REMARK    GeneRIF: FAM171B stabilizes vimentin and enhances CCL2-mediated TAM
            infiltration to promote bladder cancer progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5731)
  AUTHORS   Tran,Q., Sudasinghe,A., Jones,B., Xiong,K., Cohen,R.E.,
            Sharlin,D.S., Hartert,K.T. and Goellner,G.M.
  TITLE     FAM171B is a novel polyglutamine protein widely expressed in the
            mammalian brain
  JOURNAL   Brain Res 1766, 147540 (2021)
   PUBMED   34052262
  REMARK    GeneRIF: FAM171B is a novel polyglutamine protein widely expressed
            in the mammalian brain.
REFERENCE   3  (bases 1 to 5731)
  AUTHORS   Liang,H., Xu,Y., Zhang,Q., Yang,Y., Mou,Y., Gao,Y., Chen,R.,
            Chen,C. and Dai,P.
  TITLE     MiR-483-3p regulates oxaliplatin resistance by targeting FAM171B in
            human colorectal cancer cells
  JOURNAL   Artif Cells Nanomed Biotechnol 47 (1), 725-736 (2019)
   PUBMED   30861353
  REMARK    GeneRIF: FAM171B expression is up-regulated in
            oxaliplatin-resistant colorectal cancer cell line. Transfection of
            miR-483-3p mimics markedly decreases the levels of FAM171B and
            restores oxaliplatin responsiveness, and this alteration enhances
            cell apoptosis and weakens cell migration. Knockdown of FAM171B in
            oxaliplatin-resistant colorectal cancer cell line sensitizes its
            reaction of the treatment with oxaliplatin.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC017101.10, BC060872.1 and AB075826.1.
            
            On Nov 22, 2018 this sequence version replaced NM_177454.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.80452.1,
                                           SRR1660809.225950.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304698.10/ ENSP00000304108.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC017101.10        113038-113039
            3-263               BC060872.1         1-261
            264-1017            BC060872.1         268-1021
            1018-3559           AB075826.1         465-3006
            3560-5731           AC017101.10        182766-184937
FEATURES             Location/Qualifiers
     source          1..5731
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.1"
     gene            1..5731
                     /gene="FAM171B"
                     /gene_synonym="KIAA1946"
                     /note="family with sequence similarity 171 member B"
                     /db_xref="GeneID:165215"
                     /db_xref="HGNC:HGNC:29412"
                     /db_xref="MIM:620309"
     exon            1..352
                     /gene="FAM171B"
                     /gene_synonym="KIAA1946"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..2595
                     /gene="FAM171B"
                     /gene_synonym="KIAA1946"
                     /note="protein FAM171B"
                     /codon_start=1
                     /product="protein FAM171B precursor"
                     /protein_id="NP_803237.3"
                     /db_xref="CCDS:CCDS33347.1"
                     /db_xref="GeneID:165215"
                     /db_xref="HGNC:HGNC:29412"
                     /db_xref="MIM:620309"
                     /translation="MARLCRRVPCTLLLGLAVVLLKARLVPAAARAELSRSDLSLIQQ
                     QQQQQQQQQQQQKQLEEAEEERTEVPGATSTLTVPVSVFMLKVQVNDIISRQYLSQAV
                     VEVFVNYTKTNSTVTKSNGAVLIKVPYKLGLSLTIIAYKDGYVLTPLPWKTRRMPIYS
                     SVTLSLFPQSQANIWLFEDTVLITGKLADAKSQPSVQFSKALIKLPDNHHISNVTGYL
                     TVLQQFLKVDNFLHTTGITLNKPGFENIELTPLAAICVKIYSGGKELKVNGSIQVSLP
                     LLRLNDISAGDRIPAWTFDMNTGAWVNHGRGMVKEHNNHLIWTYDAPHLGYWIAAPLP
                     GTRGSGINEDSKDITAYHTVFLTAILGGTIVIVIGFFAVLLCYCRDKCGTPQKRERNI
                     TKLEVLKRDQTTSTTHINHISTVKVALKAEDKSQLFNAKNSSYSPQKKEPSKAETEER
                     VSMVKTRDDFKIYNEDVSFLSVNQNNYSRNPTQSLEPNVGSKQPKHINNNLSSSLGDA
                     QDEKRYLTGNEEAYGRSHIPEQLMHIYSQPIAILQTSDLFSTPEQLHTAKSATLPRKG
                     QLVYGQLMEPVNRENFTQTLPKMPIHSHAQPPDAREEDIILEGQQSLPSQASDWSRYS
                     SSLLESVSVPGTLNEAVVMTPFSSELQGISEQTLLELSKGKPSPHPRAWFVSLDGKPV
                     AQVRHSFIDLKKGKRTQSNDTSLDSGVDMNELHSSRKLEREKTFIKSMHQPKILYLED
                     LDLSSSESGTTVCSPEDPALRHILDGGSGVIMEHPGEESPGRKSTVEDFEANTSPTKR
                     RGRPPLAKRDSKTNIWKKREERPLIPIN"
     exon            353..586
                     /gene="FAM171B"
                     /gene_synonym="KIAA1946"
                     /inference="alignment:Splign:2.1.0"
     exon            587..679
                     /gene="FAM171B"
                     /gene_synonym="KIAA1946"
                     /inference="alignment:Splign:2.1.0"
     exon            680..838
                     /gene="FAM171B"
                     /gene_synonym="KIAA1946"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1009
                     /gene="FAM171B"
                     /gene_synonym="KIAA1946"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1126
                     /gene="FAM171B"
                     /gene_synonym="KIAA1946"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1250
                     /gene="FAM171B"
                     /gene_synonym="KIAA1946"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..5731
                     /gene="FAM171B"
                     /gene_synonym="KIAA1946"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5710..5715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM171B"
                     /gene_synonym="KIAA1946"
                     /note="hexamer: AATAAA"
     polyA_site      5731
                     /gene="FAM171B"
                     /gene_synonym="KIAA1946"
                     /note="major polyA site"
ORIGIN      
        1 gcagattgcg cgagggggag cgagcgagcg ggcgctgcca ggagcccgca gccctggcgc
       61 ccgccgccgc ccggagcccc gcaatatgcc gccgcggccc tctggctcta ggccatggcg
      121 aggctctgcc ggcgtgtccc ctgcaccctg cttctcggcc tggccgtggt gctgctgaaa
      181 gcgcggctgg tccccgcggc cgccagagcg gaactcagcc gctccgacct cagcctcatc
      241 caacagcagc agcagcagca gcaacaacaa caacaacagc aaaagcagct ggaggaggct
      301 gaggaggaga ggacagaggt gcctggggca acctccacct tgacggttcc agtgtctgta
      361 tttatgttga aagtccaggt gaatgacatc atcagtcgtc agtacctgag ccaagcagtt
      421 gtagaagtgt ttgtaaacta cacgaagaca aattccacag taactaaaag caatggagca
      481 gtgctgataa aagtacccta caaattagga cttagtttaa ctattattgc ttacaaagat
      541 ggctacgtgt tgacccctct gccttggaaa accagaagaa tgccaatata ttcatcagtt
      601 acactttcac tgttcccgca aagccaagca aatatatggc tatttgaaga cactgtttta
      661 attactggaa aattagctga tgccaagtct caaccaagtg ttcagttttc aaaagcctta
      721 attaaacttc ctgacaacca tcatattagc aacgttactg gctatcttac agttctacaa
      781 cagtttttga aagtggacaa ttttctgcat acaactggaa ttactctcaa taaaccaggt
      841 tttgaaaaca ttgaattgac tcctcttgct gcaatatgtg tgaaaatata ttctggagga
      901 aaagaactaa aggtcaatgg ctctattcaa gtttctcttc ctcttctacg tctgaatgat
      961 ataagtgcag gggatcgcat acctgcttgg acatttgata tgaacacagg tgcttgggta
     1021 aatcatggtc ggggaatggt caaggaacat aacaatcatt taatctggac atatgatgca
     1081 ccacatttgg ggtactggat agcagctcca cttccaggaa ctagaggttc aggtataaat
     1141 gaagattcca aggacataac tgcctaccac acagtgtttc ttacagccat attaggagga
     1201 acaatagtca ttgtcattgg attttttgct gtactacttt gttattgcag ggacaagtgt
     1261 ggtactccac agaaaagaga aagaaatatc actaaacttg aggtcctcaa gagagaccag
     1321 acaacttcaa caacacacat aaatcatatc agtacagtta aagttgcatt aaaagctgag
     1381 gacaagtcgc agttattcaa tgccaaaaac tcctcatata gtcctcagaa aaaggaacca
     1441 tcaaaggcag aaacagaaga aagagtttcc atggtaaaaa ctcgggacga ttttaaaatc
     1501 tacaatgaag atgtttcatt tctatcagtc aatcaaaata attactcaag aaacccaaca
     1561 cagtctttgg agcccaatgt agggtccaaa caacctaaac atattaacaa caatctatct
     1621 tcatctctag gtgatgctca agatgaaaag aggtatctca caggtaatga ggaggcgtat
     1681 gggcgttccc atattcctga acagcttatg catatttaca gccaacccat tgccatcctt
     1741 caaacatctg accttttctc cacaccggaa caattacata ctgctaagtc agctactttg
     1801 ccaagaaagg gacagttagt ctatggccaa ttgatggaac cagtaaatcg agagaacttt
     1861 acgcagacct tgcccaaaat gccaattcat tctcatgcac agcccccaga tgccagggaa
     1921 gaggatatca tacttgaagg tcaacagagc ctgccatccc aggcttcaga ttggagccga
     1981 tactcaagca gcttactgga atccgtctct gttcctggaa cactaaatga ggctgttgta
     2041 atgactccat tttcatcgga acttcaagga atttcagaac agaccctcct ggagctgtcc
     2101 aaaggaaagc cctccccgca tcccagagcc tggtttgtgt ctcttgatgg aaagccagtt
     2161 gcacaagtga ggcactcctt tatagacctg aaaaagggca agagaaccca gagcaatgac
     2221 accagtctgg actctggggt ggacatgaat gagcttcact caagtagaaa gctcgagagg
     2281 gagaaaacat tcatcaaaag catgcatcag cccaagatcc tttacttaga agatttagac
     2341 ctaagcagca gtgagagtgg aaccaccgtc tgttcccctg aggacccagc tttaaggcac
     2401 atcctagatg gagggagtgg agtgatcatg gagcaccctg gagaagagtc gccaggaagg
     2461 aaaagcactg ttgaagattt tgaagctaat acatccccca ctaaaagaag gggcagacca
     2521 ccactagcca aaagagatag caagactaac atctggaaga agcgagagga acgcccactg
     2581 attcccataa attaactcca atggggattg tgtgtctgct gtctcgtgct gtttattctt
     2641 gcttcttgtt gtaaattgca gtacgaactt aagaaaatga gactgagcaa tctcatggtt
     2701 cttggacatg tctcaagcag agtaaatggt aattcagtaa tcagagagaa agataccaag
     2761 gaatgctttt tctggcctat tcatttattt ttgggtgatg aatttacagt atctaagttt
     2821 tcaaaatgta aaatagcttc aagatgttag ttatctgaaa atgttgctca gccagccagt
     2881 ttggccttga ctctcttaag aataacagtg aaatatatac tcctcaagtt gcctccaaaa
     2941 atgttgcctc taccatggtg actaccccat ggaacattta gaaacaaaac tgacttcagg
     3001 catcatatta ttttaaatgt tactattacg tcttcttctg cctatactta aaaataactt
     3061 gataaatgac ttggactgat gttactctgg agttatcaca aagaaaatgt tgtttggtct
     3121 ttaaagagca tgtgtattgt atcatcccaa acgtaaatcc tacatttata taagatgggc
     3181 aagaagctac ttggtcatta gagagggaga caccagctct ttggttgttt ttggatataa
     3241 ctttacaaaa taagtaagat gttaatttag aaatttgaga aattaatgct ctaatactga
     3301 gtttttattt aaaaattatt ttttcttccc ctcaacaatg aagcaagctt agctgtcaag
     3361 ggaaactttt tacaaatctg aaaaaaacaa tctatgactt tggtttaagg ctcactgata
     3421 cttttaggct aaattggttt taatatattt cttctattct aaaaacctga actcagtcac
     3481 ttaaaggcta tgaaatttaa aaaaaaagtc gatgtgaaag tttcttttga acactaaaat
     3541 aaaatatgtg cagataaaat atacattgat ttgtttttct taaatgttga tgagaagaaa
     3601 aagagatgcc attttcctga ggctcaaaaa taccttcagg atagttgtat atccagttat
     3661 tgattttctt aaaagatgtg taaggaaaac agtttcaatt tcaggggaaa agtaaaagtt
     3721 tttccctaag tcacttaaag cctttgcaac ttcttttttc agttttgtaa gtaatatatc
     3781 tatgttcttt tcattatagc aagcattcaa tgtgaacaac tttttaatta actctgaatt
     3841 accattcata catcctaaaa ataaaagctc gttattcatt aaaatcaact gatcccattt
     3901 ttcttaaaat ttccctgaag gcaaatgtct gaagcacctt tcccttgtgg gggtaaaaat
     3961 cctaaattgc tttatttttc attccctcct attcaacatg ggagcagcat agagacccaa
     4021 accatgtaaa caagttcagt gaaccaaaac agccacatta gcttcagtaa aattatagct
     4081 agatgtgcaa ttttttcctc caacttctaa cgtgtcaaat aaccttccta ctgttctgtg
     4141 ttaactgaaa gaacataaag accctaggca aatatttgct atatattacc ccaatccata
     4201 gaagaaataa tgttttgggt aatacctagg cttccttttt tttttttttt tttttttttt
     4261 agtgataagg ctcataacaa ttaattagag aaggcttctt attggtctta cacagaaaga
     4321 tacatcaaaa gcagcatgac tcaaaatgat ttggaaaagg ttaaagttag tgctctgctg
     4381 aagtgccttt gatatagact tgcattatta gaaggatata acatcttttt taagtgtgca
     4441 ttttctttca gttaaccaaa ttaaacagat gtgcagtttt attaaaaata tagacctagt
     4501 gtttcatgtt ggaacaataa atattgcatg tgagtagtat ttcttgtttt ttgaatacag
     4561 tatatattga taaattgttt atgttggaat gaagttagaa actatatagc aaaacattat
     4621 attttaagtg tttatttttc ccacctttaa ataaaaatgt ttcatctcag cttggtaatg
     4681 aaatacacat attggtataa gggtatacca ttcaggtatg ccacttattt tattcatttt
     4741 tgtgtaaggg aaatgagatg atgtatccca agggcttttc tagaactact tgtttgcttt
     4801 cagaataaaa ccttattatt ttttacactg cacatgctgt tctcaattgg taattatagg
     4861 caatttatct tttctaatga tcaaaagagt gtgacttctc atttgtgagt agttcacaaa
     4921 tttcctgtta aaaagctgaa accatctact ttttcttaac ccaagtgata ataaacaata
     4981 ttcacaactt tcttaaattt ttaaattgaa aaccaaggtt ttttcaaata taaacctaga
     5041 tgattttggt cacaaattgt taacatttgt cgatcctttg tatatacttt ggatatatat
     5101 taaaggcaaa actatctctt gactaactga tggattcatt tactaaagca cagctgtatg
     5161 tatttttgaa tacatattat gatcttgaga ctttataaat caatttttat gactttatgc
     5221 agttgtatag ggattatgcc ctttcagttc tatagggatt atgccctttt ataatacata
     5281 atataccaca gagattacaa atgttgagga atgaaagcac ttctttgctt tggcaatcat
     5341 tttcagacca ctatgtgttt gaatcctctg gtatcaatac gtattatagg gttttagaga
     5401 tctgtgggtc aaatgatgtc cctcaaaact tcctaaaaag gtgaagctca aagtcacaca
     5461 ttcttataag gcgcatgagt ttctcatttt cccatgtacg agcattgtaa aggaattcag
     5521 ctgtattaat ttctatttca gatctagaat tgacattttg ccttcttgtt tccaggtgtt
     5581 tctatttttt gtattctttc agagaaatct catatttcgg tgtatttatt gctgttacta
     5641 ctatatttac tgctgaaaac tgtaacaacc tgaagatttg taaaatgtta aacatagttc
     5701 attaaaaata ataaaataaa tctaaaatgt a
//
