LOCUS       NM_001010924            4182 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens family with sequence similarity 171 member A1
            (FAM171A1), mRNA.
ACCESSION   NM_001010924 XM_167709
VERSION     NM_001010924.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4182)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4182)
  AUTHORS   Rasila,T., Saavalainen,O., Attalla,H., Lankila,P., Haglund,C.,
            Holtta,E. and Andersson,L.C.
  TITLE     Astroprincin (FAM171A1, C10orf38): A Regulator of Human Cell Shape
            and Invasive Growth
  JOURNAL   Am J Pathol 189 (1), 177-189 (2019)
   PUBMED   30312582
  REMARK    GeneRIF: APCN regulates the dynamics of the actin cytoskeletal and,
            thereby, the cell shape and invasive growth potential of tumor
            cells.
REFERENCE   3  (bases 1 to 4182)
  AUTHORS   Goldstein,J.I., Jarskog,L.F., Hilliard,C., Alfirevic,A., Duncan,L.,
            Fourches,D., Huang,H., Lek,M., Neale,B.M., Ripke,S., Shianna,K.,
            Szatkiewicz,J.P., Tropsha,A., van den Oord,E.J., Cascorbi,I.,
            Dettling,M., Gazit,E., Goff,D.C., Holden,A.L., Kelly,D.L.,
            Malhotra,A.K., Nielsen,J., Pirmohamed,M., Rujescu,D., Werge,T.,
            Levy,D.L., Josiassen,R.C., Kennedy,J.L., Lieberman,J.A., Daly,M.J.
            and Sullivan,P.F.
  TITLE     Clozapine-induced agranulocytosis is associated with rare HLA-DQB1
            and HLA-B alleles
  JOURNAL   Nat Commun 5, 4757 (2014)
   PUBMED   25187353
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4182)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139338.21, AL050367.1, BX496483.1, AK022946.1 and BC034232.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001010924.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY683003.1, SRR1803612.37606.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153307 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378116.9/ ENSP00000367356.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               AL139338.21        24336-24565         c
            231-232             AL050367.1         2-3
            233-336             BX496483.1         6-109
            337-341             BX496483.1         111-115
            342-772             BX496483.1         117-547
            773-1629            AL050367.1         543-1399
            1630-2409           AK022946.1         90-869
            2410-3179           BC034232.1         524-1293
            3180-3393           AL050367.1         2949-3162
            3394-3701           BC034232.1         1508-1815
            3702-4054           AK022946.1         2162-2514
            4055-4182           BC034232.1         2170-2297
FEATURES             Location/Qualifiers
     source          1..4182
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p13"
     gene            1..4182
                     /gene="FAM171A1"
                     /gene_synonym="APCN; C10orf38"
                     /note="family with sequence similarity 171 member A1"
                     /db_xref="GeneID:221061"
                     /db_xref="HGNC:HGNC:23522"
     exon            1..334
                     /gene="FAM171A1"
                     /gene_synonym="APCN; C10orf38"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..2910
                     /gene="FAM171A1"
                     /gene_synonym="APCN; C10orf38"
                     /note="astroprincin; protein FAM171A1"
                     /codon_start=1
                     /product="protein FAM171A1 precursor"
                     /protein_id="NP_001010924.1"
                     /db_xref="CCDS:CCDS31154.1"
                     /db_xref="GeneID:221061"
                     /db_xref="HGNC:HGNC:23522"
                     /translation="MSRSATLLLCLLGCHVWKAVTKTLREPGAGAQEVTLKVHISDAS
                     THQPVADALIEIFTNQASIASGTSGTDGVAFIKFQYKLGSQLIVTASKHAYVPNSAPW
                     KPIRLPVFSSLSLGLLPERSATLMVYEDVVQIVSGFQGARPQPRVHFQRRALRLPENT
                     SYSDLTAFLTAASSPSEVDSFPYLRGLDGNGTGNSTRHDLTPVTAVSVHLLSSNGTPV
                     LVDGPIYVTVPLATQSSLRHNAYVAAWRFDQKLGTWLKSGLGLVHQEGSQLTWTYIAP
                     QLGYWVAAMSPPIPGPVVTQDITTYHTVFLLAILGGMAFILLVLLCLLLYYCRRKCLK
                     PRQHHRKLQLPAGLESSKRDQSTSMSHINLLFSRRASEFPGPLSVTSHGRPEAPGTKE
                     LMSGVHLEMMSPGGEGDLHTPMLKLSYSTSQEFSSREELLSCKEEDKSQISFDNLTPS
                     GTLGKDYHKSVEVFPLKARKSMEREGYESSGNDDYRGSYNTVLSQPLFEKQDREGPAS
                     TGSKLTIQEHLYPAPSSPEKEQLLDRRPTECMMSRSVDHLERPTSFPRPGQLICCSSV
                     DQVNDSVYRKVLPALVIPAHYMKLPGDHSYVSQPLVVPADQQLEIERLQAELSNPHAG
                     IFPHPSSQIQPQPLSSQAISQQHLQDAGTREWSPQNASMSESLSIPASLNDAALAQMN
                     SEVQLLTEKALMELGGGKPLPHPRAWFVSLDGRSNAHVRHSYIDLQRAGRNGSNDASL
                     DSGVDMNEPKSARKGRGDALSLQQNYPPVQEHQQKEPRAPDSTAYTQLVYLDDVEQSG
                     SECGTTVCTPEDSALRCLLEGSSRRSGGQLPSLQEETTRRTADAPSEPAASPHQRRSA
                     HEEEEDDDDDDQGEDKKSPWQKREERPLMAFNIK"
     exon            335..562
                     /gene="FAM171A1"
                     /gene_synonym="APCN; C10orf38"
                     /inference="alignment:Splign:2.1.0"
     exon            563..655
                     /gene="FAM171A1"
                     /gene_synonym="APCN; C10orf38"
                     /inference="alignment:Splign:2.1.0"
     exon            656..814
                     /gene="FAM171A1"
                     /gene_synonym="APCN; C10orf38"
                     /inference="alignment:Splign:2.1.0"
     exon            815..991
                     /gene="FAM171A1"
                     /gene_synonym="APCN; C10orf38"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1108
                     /gene="FAM171A1"
                     /gene_synonym="APCN; C10orf38"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1223
                     /gene="FAM171A1"
                     /gene_synonym="APCN; C10orf38"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..4182
                     /gene="FAM171A1"
                     /gene_synonym="APCN; C10orf38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4159..4164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM171A1"
                     /gene_synonym="APCN; C10orf38"
                     /note="hexamer: AATAAA"
     polyA_site      4182
                     /gene="FAM171A1"
                     /gene_synonym="APCN; C10orf38"
                     /note="major polyA site"
ORIGIN      
        1 aaggagctgg cggagcagca gcagccgccg ccgccgccgc cgccgcggct cttcggggaa
       61 acccggcgcg gggcgcggga gggagcggcc ggggcggcgg ggccgggcca atcgggcggc
      121 gggcccggcg cgcggagcca gcgacatgga ggggggcgcg gcgcccggcc gcccgtgacg
      181 cgccgccgcc cggcccgctc tcggcgagcc cgagccgccg ccggccccgc ggcggagatg
      241 agcaggtccg cgacgctgct gctgtgcctg ctgggctgcc acgtctggaa ggcggtgacc
      301 aagacgctgc gggagcccgg cgccggagcc caagaggtga cgttaaaggt gcacatcagc
      361 gacgccagca cccaccagcc cgtagcagat gcgctcatcg agatcttcac caaccaggcc
      421 tccatagcct ctggcacctc ggggactgat ggcgtcgcct ttatcaagtt ccagtataag
      481 ctgggcagtc agttgattgt caccgcctcg aagcatgcct acgtgccaaa ctctgcccca
      541 tggaagccaa tccggttacc tgtattttcc tctctgagcc ttggcctgct tccagaacgc
      601 tctgccactc taatggtata tgaagatgtc gtccaaatag tatcaggatt ccaaggtgcc
      661 cggccacagc ctcgcgttca tttccagaga agggctctga ggttgcctga gaacaccagc
      721 tacagtgacc tgaccgcgtt tctcacggcc gccagctccc cttcggaggt ggacagtttt
      781 ccttatttgc gaggattaga cggaaatgga acaggaaaca gcaccaggca tgacctgacc
      841 ccagtcacag ccgtcagcgt ccacttgctg agcagtaatg gaacgccggt gctggtggat
      901 ggtcccatct atgtcactgt gcccctggcc acgcagagca gcctgaggca caatgcctat
      961 gtcgcggcgt ggcggtttga ccagaagctg ggaacgtggc tgaagagcgg tctgggtctt
     1021 gtgcaccagg aaggcagcca gctgacgtgg acatacattg ccccccagtt ggggtactgg
     1081 gtggccgcca tgtcccctcc catcccaggt cccgttgtaa cacaggacat taccacgtat
     1141 cacacggtgt ttcttttggc cattttagga ggaatggctt tcatactttt ggttttgctg
     1201 tgtctccttt tatattattg caggaggaag tgcttgaaac ctcgtcagca ccacagaaaa
     1261 ctgcagctcc ctgcaggact ggagagttcc aaaagagacc agtccacgtc catgtcacac
     1321 attaacttgc tgttttcacg ccgagcgtca gaattccctg gcccgctgtc cgtcaccagc
     1381 cacggccgcc ccgaggcccc cggcacgaag gaactgatga gtggagtcca tttggaaatg
     1441 atgtctccgg gcggcgaagg ggacctgcac acccccatgc tcaagctctc ctacagcacc
     1501 tcccaggaat ttagctcccg ggaggagctc ctctcttgca aggaagagga taaaagccag
     1561 atctcctttg ataacctcac tccaagtggg acgctgggga aagactacca taagtcagtg
     1621 gaggtttttc ccttaaaggc aagaaaatct atggaaagag aaggctacga gtcctcgggc
     1681 aatgatgact acaggggtag ttacaacacc gtgctctcac agcctttatt tgaaaagcag
     1741 gacagagaag gtccagcctc cacgggaagc aaactcacca ttcaggaaca tctgtacccc
     1801 gcgccttcat cacctgagaa agaacagctg ctggaccgca gacccactga atgtatgatg
     1861 tcgcgatcag tagatcacct cgagagacct acgtccttcc cacggcccgg ccagttaatc
     1921 tgctgcagtt ctgtcgacca ggtcaatgac agcgtttaca ggaaagtact gcctgccttg
     1981 gtcatcccgg ctcattatat gaaactcccc ggggaccact cctatgtcag ccagcccctc
     2041 gtcgtcccgg ctgatcagca gcttgagata gaaagactac aggctgagct gtccaatccc
     2101 catgccggga tcttcccaca cccgtcctca cagatccagc cccagcccct gtcttcccag
     2161 gccatctctc agcagcacct gcaggatgcg ggcacccggg agtggagccc tcagaacgca
     2221 tccatgtcgg agtctctctc catcccagct tccctgaacg acgcggcttt ggctcagatg
     2281 aacagtgagg tgcagctcct gactgaaaag gccctgatgg agcttggggg tgggaagccg
     2341 cttccgcacc cccgggcgtg gttcgtctcc ttggatggca ggtccaacgc tcacgttaga
     2401 cattcataca ttgatctcca aagagctgga aggaacggaa gtaatgatgc cagtttggac
     2461 tctggcgtag atatgaatga accaaaatca gcccggaagg gaaggggaga tgctttgtct
     2521 ctgcagcaga actacccgcc cgtccaagag caccagcaga aagagcctcg agccccagac
     2581 agcacggcct acacgcagct cgtgtacctg gatgacgtgg aacagagtgg tagcgaatgt
     2641 gggaccacgg tctgtacccc cgaggacagt gccctgcgat gcttgttgga ggggtcgagt
     2701 cggagaagtg gtggccagct gcccagcctg caggaggaga cgaccagacg gactgcggat
     2761 gccccctcgg agccagcagc cagcccccac cagagaagat ctgcccacga ggaagaggaa
     2821 gacgatgatg atgatgacca aggagaagac aagaaaagcc cctggcagaa acgggaggag
     2881 aggcccctga tggcgtttaa cattaaatga gctatcgcag acccacctga ctgtggaata
     2941 taaaattgcc aaatatcctt tctcatggaa gcgcgtaccc gttcgtggag gaaacggaac
     3001 ggcagcccag ccgtgggacg gacgtggacg tttactgcat tcctgtttgc cgtgtaaatg
     3061 ttagaaagga attaaagtta ttactcggaa taaaggatga ctttggcgga tgtcgcccct
     3121 gcaaggaggt ggctgaaagt ggtgtccaga tgtccttccg aggactcggc gtatccgcca
     3181 ccagggacat taagaaaccg cacgtgatgt cgctatgctc taacgatcac ctcagttctc
     3241 cctcggattc tgggaacaga tgaaactttt tgcatcgctt gagtcatttt tatcacaata
     3301 atcctactgt gaagctgtcg ttgagaactt aggttggcac gtagcgtctc aaggtatgcg
     3361 ttctctcaaa ggaaagctat gcatcgctgc ttcgttgtct gattttgctt agattttgct
     3421 ttggttaggt tgcgttttgg ggtttgcctt tttttgttgt cgcttaaatg caatttggtt
     3481 gtaaagattt gattcctttg tgttcatctg ttccgcttct cagcggtcca tctcagcgtc
     3541 tcccttcagg aaccgctgag tgtcctctct taacatccaa gccttttaat gaaatcgtac
     3601 tgaaatctgt atcagctaag agtcctccaa tcctggtccc attaactcca agtgcctttt
     3661 tgacagtgac aacagacagt ccctcgcttt ttgttgttgt tggttttctt aaccccttta
     3721 atggaactgc ctggatttta tacagttatt aaaggatgtc tcttttgctt taaactgcat
     3781 gctgccaagt gccatttggg gtcagcatcc tcgtttcaac acagtgtgct ctctagttat
     3841 catgtgtaac gtgggttctg tttagcgaag atagactaga ggacacgtta gagatgccct
     3901 tccctgctcc atccctgtgg caccattatg gttttttggc tgtttgtata tacggttacg
     3961 tattaactct ggaatcctat gggctcatct tgctcaccca atgtgggagt ctggtttgag
     4021 caagcgagct gaatgtgact attaaaaaaa atttaaaaaa aaaaaagaaa atcttatgta
     4081 ctatccaaaa gtgccagaat gactcttctg tgcattcttc ttaaagagct gcttggttat
     4141 ccaaaaatga aaattcaaaa taaactctga agaaaaggaa aa
//
