LOCUS       NM_001164484            1414 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 170 member B
            (FAM170B), mRNA.
ACCESSION   NM_001164484 XM_001715115 XM_096317 XM_937528
VERSION     NM_001164484.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1414)
  AUTHORS   Devlin,D.J., Nozawa,K., Ikawa,M. and Matzuk,M.M.
  TITLE     Knockout of family with sequence similarity 170 member A (Fam170a)
            causes male subfertility, while Fam170b is dispensable in
            micedagger
  JOURNAL   Biol Reprod 103 (2), 205-222 (2020)
   PUBMED   32588889
  REMARK    GeneRIF: Knockout of family with sequence similarity 170 member A
            (Fam170a) causes male subfertility, while Fam170b is dispensable in
            micedagger.
REFERENCE   2  (bases 1 to 1414)
  AUTHORS   Li,Y., Lin,S., Luo,M., Guo,H., Chen,J., Ma,Q., Gu,Y., Jiang,Z. and
            Gui,Y.
  TITLE     FAM170B, a novel acrosomal protein involved in fertilization in
            mice
  JOURNAL   Mol Reprod Dev 82 (10), 787-796 (2015)
   PUBMED   26179146
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084727.14.
            
            On Nov 27, 2019 this sequence version replaced NM_001164484.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047597.1, BI827656.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311787.6/ ENSP00000308292.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               AC084727.14        150329-150543       c
            216-1414            AC084727.14        147676-148874       c
FEATURES             Location/Qualifiers
     source          1..1414
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.23"
     gene            1..1414
                     /gene="FAM170B"
                     /gene_synonym="C10orf73"
                     /note="family with sequence similarity 170 member B"
                     /db_xref="GeneID:170370"
                     /db_xref="HGNC:HGNC:19736"
     exon            1..215
                     /gene="FAM170B"
                     /gene_synonym="C10orf73"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..955
                     /gene="FAM170B"
                     /gene_synonym="C10orf73"
                     /note="putative protein FAM170B; acrosome-related protein"
                     /codon_start=1
                     /product="protein FAM170B"
                     /protein_id="NP_001157956.1"
                     /db_xref="CCDS:CCDS53536.1"
                     /db_xref="GeneID:170370"
                     /db_xref="HGNC:HGNC:19736"
                     /translation="MKCYFTDHRGEQSPTDGTTLSLTSPESTEESVEVFWPGTIQREG
                     SSPRPGPAIPREEGLYFAARDRGMRDWSSSPSSESSEYQSYSQYQSCCSCMCDEDNAA
                     PQSVCAFYTHVQTVRGVAVAWETEAGFEPVTRKPRIHEAQFIKRQRWNGSSFEMASNT
                     DMRWDLEACKSNCSPEPEDIDLLECCLQELREPPDWLVTTNYGVRCVACCRVLPSLDA
                     LLEHAQHGIREGFSCQIFFEEMLERRRAQGQAHDQQLEEEQSPSDNSECSRPQGEVLS
                     AQQQEKQ"
     exon            216..1414
                     /gene="FAM170B"
                     /gene_synonym="C10orf73"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1393..1398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM170B"
                     /gene_synonym="C10orf73"
                     /note="hexamer: ATTAAA"
     polyA_site      1414
                     /gene="FAM170B"
                     /gene_synonym="C10orf73"
                     /note="major polyA site"
ORIGIN      
        1 agtgtccact ctggctgggg ccagctggag gccttcagta cagccccagc caactctcac
       61 tgaacagctg gagcaccgac accctgggca ctcatttcaa atcatgaaat gctacttcac
      121 agatcacagg ggagaacagt cacccaccga tgggaccacc ctcagcttga ccagccctga
      181 gtccactgag gagagtgtgg aagtgttctg gccagggact atacagagag aagggtcgtc
      241 cccacggccg gggcctgcca ttccccggga ggagggcctc tacttcgctg ccagggaccg
      301 ggggatgcgg gactggagca gctccccatc ctcagagtcc tccgagtacc agtcctactc
      361 ccagtaccag tcgtgctgct cctgcatgtg cgatgaggac aatgctgctc cgcagagtgt
      421 gtgtgccttc tacacgcacg tgcagactgt gcggggtgtg gctgtggcct gggagacgga
      481 ggccggcttc gagccggtca ccaggaagcc ccgcatccat gaagcccagt tcatcaagag
      541 gcagaggtgg aacggctcct ccttcgaaat ggcttccaac accgatatgc gctgggacct
      601 ggaagcctgc aagagcaact gcagccccga gcccgaggac atagacctgc tggagtgctg
      661 cctgcaggag ctgcgggagc cgccggactg gctggtcacc accaactacg gggtgcgctg
      721 cgtggcctgc tgcagggtct tgccctccct ggacgctctg ctggagcacg cccagcatgg
      781 catccgggag ggcttcagct gtcagatctt ttttgaggag atgctggaga gaaggcgggc
      841 tcagggccaa gcacatgacc aacagctgga ggaggagcag agtccttcag acaacagcga
      901 atgttcccgg ccccagggtg aggtgctctc agcacagcag caggagaagc agtgagccag
      961 aggggagata cccaaccctg ccctcacctc cagggcctgg gactgctcct tccccagcca
     1021 gcagtatcag agccactagg gcagggagag aggaccaggg tcagggggaa ggaaaggcat
     1081 ggagtgtaga gcaaggaggg ccaggagact ggaaggaacc cccttcctgc cctaggcaca
     1141 gcatctccac cagagtccat ttcaaaaccc aaacgagagg gctttgagtg tttctgatgg
     1201 caggcacaac atctgaaacc cacaaacgca tggccagagg gatttctatt tttgccggtg
     1261 gatcaggcag gtccacactt gctaagtata tgtgggtcac aggacagcca actgcaaatt
     1321 actctccagc cctatttttt tcactattac aaatctgtca tatgccctag ttctatgtct
     1381 tatgttattg ggattaaact tgaataacac aaaa
//
