LOCUS       NM_001367956            1379 bp    mRNA    linear   PRI 05-FEB-2025
DEFINITION  Homo sapiens family with sequence similarity 170 member A
            (FAM170A), transcript variant 3, mRNA.
ACCESSION   NM_001367956
VERSION     NM_001367956.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1379)
  AUTHORS   Cheng,J., Gu,Y., Wang,Y., Xun,J., Wang,G., Wang,Y., Wang,J., Li,Y.
            and Sun,F.
  TITLE     Fam170a deficiency causes male infertility by impairing
            histone-to-protamine exchange during mouse spermiogenesis
  JOURNAL   Nucleic Acids Res 53 (3) (2025)
   PUBMED   39868537
REFERENCE   2  (bases 1 to 1379)
  AUTHORS   Xu,F., Wang,W., Lei,C., Liu,Q., Qiu,H., Muraleedharan,V., Zhou,B.,
            Cheng,H., Huang,Z., Xu,W., Li,B. and Wang,M.
  TITLE     Activation of transcriptional activity of HSE by a novel mouse zinc
            finger protein ZNFD specifically expressed in testis
  JOURNAL   Mol Cell Biochem 363 (1-2), 409-417 (2012)
   PUBMED   22231842
REFERENCE   3  (bases 1 to 1379)
  AUTHORS   Lei,C., Liu,Q., Wang,W., Li,J., Xu,F., Liu,Y., Liu,J., Wu,S. and
            Wang,M.
  TITLE     Isolation and characterization of a novel zinc finger gene, ZNFD,
            activating AP1(PMA) transcriptional activities
  JOURNAL   Mol Cell Biochem 340 (1-2), 63-71 (2010)
   PUBMED   20162441
  REMARK    GeneRIF: Data indicate that ZNFD is probably a new type of C(2)H(2)
            zinc finger protein that may activate AP1 transcriptional
            activities.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010409.6 and BC128243.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.202682.1,
                                           SRR5189667.91266.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000695508.1/ ENSP00000511971.1
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AC010409.6         84134-84261
            129-1252            BC128243.1         1-1124
            1253-1256           AC010409.6         89659-89662
            1257-1379           AC010409.6         90276-90398
FEATURES             Location/Qualifiers
     source          1..1379
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.1"
     gene            1..1379
                     /gene="FAM170A"
                     /gene_synonym="ZNFD"
                     /note="family with sequence similarity 170 member A"
                     /db_xref="GeneID:340069"
                     /db_xref="HGNC:HGNC:27963"
                     /db_xref="MIM:618401"
     exon            1..281
                     /gene="FAM170A"
                     /gene_synonym="ZNFD"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..1204
                     /gene="FAM170A"
                     /gene_synonym="ZNFD"
                     /note="isoform 3 is encoded by transcript variant 3; Znf
                     domain containing protein; zinc finger protein ZNFD; zinc
                     finger domain-containing protein; protein FAM170A"
                     /codon_start=1
                     /product="protein FAM170A isoform 3"
                     /protein_id="NP_001354885.1"
                     /db_xref="CCDS:CCDS93765.1"
                     /db_xref="GeneID:340069"
                     /db_xref="HGNC:HGNC:27963"
                     /db_xref="MIM:618401"
                     /translation="MKRRQKRKHLENEESQETAEKGGGMSKSQEDALQPGSTRVAKGW
                     SQGVGEVTSTSEYCSCVSSSRKLIHSGIQRIHRDSPQPQSPLAQVQERGETPPRSQHV
                     SLSSYSSYKTCVSSLCVNKEERGMKIYYMQVQMNKGVAVSWETEETLESLEKQPRMEE
                     VTLSEVVRVGTPPSDVSTRNLLSDSEPSGEEKEHEERTESDSLPGSPTVEDTPRAKTP
                     DWLVTMENGFRCMACCRVFTTMEALQEHVQFGIREGFSCHVFHLTMAQLTGNMESEST
                     QDEQEEENGNEKEEEEKPEAKEEEGQPTEEDLGLRRSWSQCPGCVFHSPKDRNS"
     exon            282..422
                     /gene="FAM170A"
                     /gene_synonym="ZNFD"
                     /inference="alignment:Splign:2.1.0"
     exon            423..1197
                     /gene="FAM170A"
                     /gene_synonym="ZNFD"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1256
                     /gene="FAM170A"
                     /gene_synonym="ZNFD"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1379
                     /gene="FAM170A"
                     /gene_synonym="ZNFD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1355..1360
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM170A"
                     /gene_synonym="ZNFD"
                     /note="hexamer: AATAAA"
     polyA_site      1379
                     /gene="FAM170A"
                     /gene_synonym="ZNFD"
                     /note="major polyA site"
ORIGIN      
        1 gaaccttaac agccctgcag tgtagtgggc actgggcagt gctgctcctt cactaagcgg
       61 tctgagttct ttagctatct cggagattca actacgttta ctcgtactga atctttttaa
      121 tgaatttcct gagagccaag aagggccaat ctacaggaaa aagtgggagg tggacattaa
      181 gcatcttcta gaaactcttc tagctgatat catgaaacga cgacaaaaga ggaaacattt
      241 ggaaaatgaa gagtcccagg aaaccgctga gaagggagga ggaatgtcaa agtcccaaga
      301 ggatgccctg cagcctggat ccactagagt ggccaaaggc tggagccaag gggtgggaga
      361 agttacttct acctccgaat actgctcctg cgtttcttct tcacgcaagc tcatccacag
      421 tggaatccag agaatacatc gagacagccc ccagcctcaa tcacccctgg cccaggttca
      481 ggaacgagga gagactcctc cccgctcaca acatgtctcc ttgtcgtcct attcatccta
      541 taagacttgt gtgtcctctc tgtgtgtaaa caaagaggaa aggggcatga aaatatacta
      601 catgcaggta caaatgaaca aaggtgtggc tgtctcctgg gagacagagg aaactttgga
      661 gtccttagaa aagcagccaa ggatggaaga agtgaccctt tctgaggttg tgagggtagg
      721 tactcccccc tctgatgtgt ccaccagaaa cctcctgtct gacagtgagc ccagtgggga
      781 ggagaaagag catgaggaaa ggacagaatc agacagcctg ccaggctcac ccaccgttga
      841 ggacacaccc agagccaaga ctcctgactg gctggtgacc atggagaacg gcttcaggtg
      901 catggcctgc tgccgggtgt tcaccaccat ggaagccctc caggagcatg tgcagtttgg
      961 gatcagagag ggcttcagct gccacgtctt tcatctcacc atggctcagc tgacaggcaa
     1021 catggaatca gagagcaccc aagatgagca ggaggaggaa aatggaaatg agaaggagga
     1081 ggaagagaaa ccagaagcaa aggaggagga ggggcagccc acagaagaag accttggcct
     1141 gaggagatcc tggagccaat gtccaggctg tgtgtttcat tctccaaagg acaggaacag
     1201 ctgagactta tgggccagaa gatactggaa gatggtgtgg ccttctcttg caagagggag
     1261 aagaaagagc catggagata gtagcagaca ggctgcccaa ggtatgaagc agatgaggga
     1321 ccagcactca gtctaacatg taaacatcat acgtaataaa ggttgtgttt caaacctta
//
