LOCUS       NM_001376049            6125 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens family with sequence similarity 169 member A
            (FAM169A), transcript variant 3, mRNA.
ACCESSION   NM_001376049 XM_005248480
VERSION     NM_001376049.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6125)
  AUTHORS   Mestres,I., Atabay,A., Escolano,J.C., Arndt,S., Schmidtke,K.,
            Einsiedel,M., Patsonis,M., Bolanos-Castro,L.A., Yun,M.,
            Bernhardt,N., Taubenberger,A. and Calegari,F.
  TITLE     Manipulation of the nuclear envelope-associated protein SLAP during
            mammalian brain development affects cortical lamination and
            exploratory behavior
  JOURNAL   Biol Open 13 (3) (2024)
   PUBMED   38466184
REFERENCE   2  (bases 1 to 6125)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6125)
  AUTHORS   Roux,K.J., Kim,D.I., Raida,M. and Burke,B.
  TITLE     A promiscuous biotin ligase fusion protein identifies proximal and
            interacting proteins in mammalian cells
  JOURNAL   J Cell Biol 196 (6), 801-810 (2012)
   PUBMED   22412018
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010501.7 and AC093214.2.
            
            On Nov 8, 2019 this sequence version replaced XM_005248480.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.2756167.1,
                                           SRR1660803.237568.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000687041.1/ ENSP00000508577.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               AC010501.7         34229-34451         c
            224-358             AC010501.7         9609-9743           c
            359-458             AC010501.7         8138-8237           c
            459-544             AC010501.7         7029-7114           c
            545-716             AC010501.7         2490-2661           c
            717-896             AC093214.2         129263-129442       c
            897-1025            AC093214.2         120579-120707       c
            1026-1138           AC093214.2         119916-120028       c
            1139-1178           AC093214.2         117013-117052       c
            1179-1329           AC093214.2         116303-116453       c
            1330-1486           AC093214.2         111453-111609       c
            1487-1690           AC093214.2         98354-98557         c
            1691-6125           AC093214.2         92997-97431         c
FEATURES             Location/Qualifiers
     source          1..6125
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.3"
     gene            1..6125
                     /gene="FAM169A"
                     /gene_synonym="SLAP; SLAP75"
                     /note="family with sequence similarity 169 member A"
                     /db_xref="GeneID:26049"
                     /db_xref="HGNC:HGNC:29138"
                     /db_xref="MIM:615769"
     exon            1..223
                     /gene="FAM169A"
                     /gene_synonym="SLAP; SLAP75"
                     /inference="alignment:Splign:2.1.0"
     exon            224..358
                     /gene="FAM169A"
                     /gene_synonym="SLAP; SLAP75"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..2239
                     /gene="FAM169A"
                     /gene_synonym="SLAP; SLAP75"
                     /note="isoform 1 is encoded by transcript variant 3;
                     protein FAM169A; soluble lamina-associated protein of 75
                     kD; soluble lamin-associated protein of 75 kDa;
                     Soluble-Lamin Associated Protein"
                     /codon_start=1
                     /product="soluble lamin-associated protein of 75 kDa
                     isoform 1"
                     /protein_id="NP_001362978.1"
                     /db_xref="CCDS:CCDS43330.1"
                     /db_xref="GeneID:26049"
                     /db_xref="HGNC:HGNC:29138"
                     /db_xref="MIM:615769"
                     /translation="MAFPVDMLENCSHEELENSAEDYMSDLRCGDPENPECFSLLNIT
                     IPISLSNVGFVPLYGGDQTQKILALFAPEDSLTAVALYLADQWWAIDDIVKTSVPSRE
                     GLKQVSTLGERVVLYVLNRIIYRKQEMERNEIPFLCHSSTDYAKILWKKGEAIGFYSV
                     KPTGSICASFLTQSYQLPVLDTMFLRKKYRGKDFGLHMLEDFVDSFTEDALGLRYPLS
                     SLMYTACKQYFEKYPGDHELLWEVEGVGHWYQRIPVTRALQREALKILALSQNEPKRP
                     MSGEYGPASVPEYEARTEDNQSSEMQLTIDSLKDAFASTSEGHDKTSVSTHTRSGNLK
                     RPKIGKRFQDSEFSSSQGEDEKTSQTSLTASINKLESTARPSESSEEFLEEEPEQRGI
                     EFEDESSDRDARPALETQPQQEKQDGEKESELEPMNGEIMDDSLKTSLITEEEDSTSE
                     VLDEELKLQPFNSSEDSTNLVPLVVESSKPPEVDAPDKTPRIPDSEMLMDEGTSDEKG
                     HMEEKLSLLPRKKAHLGSSDNVATMSNEERSDGGFPNSVIAEFSEEPVSENLSPNTTS
                     SLEDQGEEGVSEPQETSTALPQSSLIEVELEDVPFSQNAGQKNQSEEQSEASSEQLDQ
                     FTQSAEKAVDSSSEEIEVEVPVVDRRNLRRKAKGHKGPAKKKAKLT"
     exon            359..458
                     /gene="FAM169A"
                     /gene_synonym="SLAP; SLAP75"
                     /inference="alignment:Splign:2.1.0"
     exon            459..544
                     /gene="FAM169A"
                     /gene_synonym="SLAP; SLAP75"
                     /inference="alignment:Splign:2.1.0"
     exon            545..716
                     /gene="FAM169A"
                     /gene_synonym="SLAP; SLAP75"
                     /inference="alignment:Splign:2.1.0"
     exon            717..896
                     /gene="FAM169A"
                     /gene_synonym="SLAP; SLAP75"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1025
                     /gene="FAM169A"
                     /gene_synonym="SLAP; SLAP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1138
                     /gene="FAM169A"
                     /gene_synonym="SLAP; SLAP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1178
                     /gene="FAM169A"
                     /gene_synonym="SLAP; SLAP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1329
                     /gene="FAM169A"
                     /gene_synonym="SLAP; SLAP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1486
                     /gene="FAM169A"
                     /gene_synonym="SLAP; SLAP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1690
                     /gene="FAM169A"
                     /gene_synonym="SLAP; SLAP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..6125
                     /gene="FAM169A"
                     /gene_synonym="SLAP; SLAP75"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6107..6112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM169A"
                     /gene_synonym="SLAP; SLAP75"
                     /note="hexamer: AATAAA"
     polyA_site      6122
                     /gene="FAM169A"
                     /gene_synonym="SLAP; SLAP75"
     polyA_site      6125
                     /gene="FAM169A"
                     /gene_synonym="SLAP; SLAP75"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgtcac gtcgtcggag ggcacggtgg gccgcggccg acccgcgacg aggagccggg
       61 cgtccggggc gagcgggagg cagccgcact cgccctggca gccgcgagct gtgcggcctg
      121 ggaccggccg gaggtcgcca gcgagcagcc gccggctcca ttcattcgcg cggctccgcc
      181 tcctttcccg ggctcttcca gcggctcccg gggcgcgtct gagaggatgg cattccctgt
      241 ggatatgctg gaaaattgca gccatgagga attggaaaat tctgctgaag attacatgtc
      301 agatttaagg tgtggggacc ctgaaaatcc agagtgtttt tctcttctca atattacgat
      361 tcctattagc ctgtcaaatg taggctttgt acctctttat ggtggagatc agacccagaa
      421 aattcttgct ctctttgcac ctgaagattc actgacagct gtggcacttt accttgctga
      481 tcagtggtgg gctattgatg atattgtgaa aacatctgtt ccttcaagag aggggcttaa
      541 gcaggtgagc actcttgggg agagagtggt tctgtatgtt ctgaatcgaa ttatttatag
      601 aaaacaggaa atggagagaa atgagatccc attcctgtgt catagcagta ctgattatgc
      661 taagattctg tggaagaaag gagaggccat tgggttttat tcagttaagc ctacaggaag
      721 catatgtgcc tcttttctta cccaaagtta ccaattgcca gttcttgata caatgtttct
      781 aagaaagaaa tacagaggta aagattttgg gcttcacatg ctggaggact ttgttgattc
      841 ctttacagaa gatgcgcttg gcttgcggta tccactgtct tctctcatgt atacagcttg
      901 caagcaatac tttgagaagt atccaggaga ccatgaactc ctttgggaag ttgaaggtgt
      961 tggacactgg taccagcgaa taccagtcac cagagcatta caaagagaag cacttaaaat
     1021 tctagcactt tctcaaaatg aacctaaaag acctatgtct ggagaatatg gtcctgcatc
     1081 tgttccagaa tacgaagcaa gaactgaaga caatcagtct agtgagatgc agctaactat
     1141 tgattctcta aaagatgcct ttgcaagcac ttccgaaggt catgataaaa catctgtttc
     1201 cactcatact cgaagtggta atctaaagcg gccaaagatt ggaaagcggt ttcaggattc
     1261 tgaatttagc agttctcaag gtgaagatga aaagacctcc cagacttcac ttacagcttc
     1321 aataaacaaa ttggagtcta ctgcacgccc atcagagagc tcagaagaat tcctggaaga
     1381 agaacctgaa cagagaggga ttgaatttga ggatgaaagc agtgatagag atgcacggcc
     1441 agcactggaa acccagccac agcaagagaa gcaagatggt gaaaaggaat ctgaattaga
     1501 gcctatgaat ggtgagataa tggacgattc tcttaagacc tcacttataa cagaagagga
     1561 agactccact agtgaagttt tagatgaaga attaaaattg cagcctttta attccagtga
     1621 agactctaca aatcttgttc cactggtggt agaatcttca aaaccccctg aggtagatgc
     1681 accagataag accccacgta tacctgactc agaaatgttg atggatgaag gcacatctga
     1741 tgaaaagggg cacatggaag agaaattgtc cctacttcca agaaagaaag cacatcttgg
     1801 gagttcagac aatgttgcta ctatgtcaaa tgaagaacga tctgatggtg gttttccaaa
     1861 ctctgtgata gctgaatttt ccgaagaacc ggtctctgag aatttgtctc ctaatactac
     1921 ttcctcattg gaagaccagg gtgaggaggg ggtatctgag ccccaggaaa catctactgc
     1981 tcttcctcag agttctttga tagaggttga acttgaagac gtgccatttt cacagaatgc
     2041 aggacagaag aatcagtcag aggagcagtc tgaagcatct tccgagcaac tggatcagtt
     2101 tacacaatcg gcagaaaaag ctgtggatag cagctcagag gaaatagaag tggaagtgcc
     2161 tgtggtagac aggcggaatt taagaagaaa ggccaaaggg cataaaggac ctgctaagaa
     2221 gaaagctaag ctgacctgaa ggaagaagaa agtggatgat aaatcctctt ctttgtaaca
     2281 tagttgttgt ttttaaaata tggtaattaa taaacagcat ggggcacagg acaaaaattt
     2341 ccaaaatttc aatttgaact tacttactat gcagtttttt gcttcccttt agaacgtaga
     2401 attcaccatt gtttttaatt ttccaggcta tttttggtaa atgcaatttt ttatttttat
     2461 taaccatgtt tcaattttgg gaaaccagat catattatat tttctttatc aggtggtaca
     2521 tctgaccatt atttcaaaaa tataattaaa aagctgtgaa agtagtagga tttccattac
     2581 ttataaggat cacagaaatc ttttatacta agggttttaa tagtaaaact tggtgagggt
     2641 tctagaagtt ttaaatttca aaactaatca ccaatttttt aaaatgtagg catgcctaaa
     2701 caaaaataag tgtcaataaa ttagaaaaaa tataacttca agtaaatgag agcacaaaaa
     2761 cagaaactta cggtcaaagg ttcatgaaga tattttggtt ttggcctctt aatcctagat
     2821 atagatgcag ttttttcctt tgacttcact atctatggaa aggtacacat aaaatctgtt
     2881 tctgattcat tctatcatct gatgttaaca gtactgtcag ggatttaact gtggcatgtg
     2941 gggactaatt atttaaaatt tcatttgaag tattagtttg ctgtaatttt ttttgtctgc
     3001 atatgtgcag acgcctagaa gtttagactt tcacctttaa tcaggtaaaa atcacaacta
     3061 tactttggag acatggttta atttggactt ctggtcctga tcagatagat aaattaagct
     3121 ggagatttta cttttatccc aacccagtta acatctatat ttcagaagta tgaggctcct
     3181 tcctaaggca tctccttaaa tcttgccacc tccctaattc tacagtctta tttatattcc
     3241 cccacagctt tcatctactt ctgtaactca tggagtgatt ctccaatcaa cagatcttcc
     3301 tgcctgccgg cttatgccct tgatgtccat ttttgggtag gtttggaggt gcaccccaca
     3361 atgttagacc tatatggcag gagtaaaact gcccccagtg ttagacctat atggcagggg
     3421 taaactgcct ttgggggagc tgtggttaca agggcttcaa tcatattgga ggcttcaatc
     3481 atcctttgat ttgtactgag tactggttgc aagctggcct gttaagtata tattgtgttg
     3541 ccataacaaa ggcctaggaa aatttgaaga aaaaaaacac tgaactgtta ttttttgtaa
     3601 tttatttaaa aatggacaaa atggttatta gaatccaaag ataatctaaa aacagttcta
     3661 ctctttggaa atattatgtg tactcaaatt tgcacttaag ttggagaatg ttttgagacc
     3721 atttaaattg ttttaaaaat agcttgatct tgatccttat gcaaaagaaa ctaagacttt
     3781 gtgtcattat ttgaggtagc taaggactga tgttgaaagt gtattcagtc tatagtaagc
     3841 tgatgtcagg tcagtaaatt ttgtttgggg atgttggtat tttcgatcaa gttaaaatct
     3901 taaagcagac aaaaatagta aacgctccta tttgtgttag attttgaaca attgtattac
     3961 cctatatttt ctttaattag tcaaaggtaa gccagattat ttcattctaa atgaaaatta
     4021 aagcactttg gccatttatt ttttcaacaa atgctaatac taagtaaaaa aaaaaaagta
     4081 tgactactat tagtgaatct accaaacatt tatgctgttt tatacatttt atgagaaact
     4141 tctgtcaata tcacaaaggg aaatactctg ttaagattca gtaaattctt aatctttaca
     4201 tgtttcattt cttagatttg aaaacacttg tagatatttt atttttactt ggatttgttt
     4261 aaaatacttt cttttcaaat tattttaaac atggaaacgc ttcatgaatt tgtgtcatcc
     4321 ttgcacaggg gccatgctaa ttttccctgt attgttctaa ttttagtata tgtgctgccg
     4381 aagtgagcac taaaagactt tctttagaca agtgtagttt tttaaagatt gagctcactg
     4441 gctcaactct tgatgtgtga atatagttga gtttacaaaa aatgtttatt aatcatatat
     4501 gaccattggg ggctaacagt ataaacttat tcttgttaaa cttgtttggg ttaaatagta
     4561 agtgaattgt aaacaattta gaagtttttt gttcagcaca caagaacact tctgttacag
     4621 attctctctg acagaaattg ttattttggg gtttatagat tatagaggga aaagttagat
     4681 cacttggaaa aacctaactc tcatgttcag taacttgagt atagaattta taccacaatt
     4741 tatcttcaat aaggaaccta catgaactta atcagttatc tgtagttttt gcaaggcatt
     4801 agaaaaaatt tcacaattac agaggactga aaatgtgatt tcaaccggct agtctagttg
     4861 ttgaatgtcc agtcacatta cacatagtcc tttgtgaact tatttgtgaa gggagttcac
     4921 tttttatgta catacgtgta tatttccttg tgtaatataa agcagatggt tattagtatt
     4981 ttagttcttt caagtttaaa ttattcaatt gctagacatc acagaaatta gtatatttaa
     5041 gaatttatta taaagctcct ctacaacttt taaaggtgag agggtctatt atgatttttt
     5101 tataaaatca aacagcatga tttagaacgt cagtcttcta cttaaaatgt gtctatattc
     5161 atggtatttc cattcagtgt agatggtaag gaaaacatct agtcattaaa gatttactta
     5221 tagcagactc cagaacacta cctacaatgg ggtttcagtg actagaaatc ttgaaggttt
     5281 atgattgcat caaattgagc ctgtactaat atctaaatat ctgctcttat gttctgcttt
     5341 atcccttggg attaccttct aaggtttggt cacaccagca aactgaaaca gatcttaatg
     5401 tacataaaaa atttatacta atattactca tctgtgttac agtattttga aaaatgtttc
     5461 aggtgtcatc tagtcgtctt tcatgggtgt gattagttac aaatgttatg cttatgtttt
     5521 catacttaat atcaagcttt ctttgtacct tacaagatag tatttttggt tctaaaaaaa
     5581 acaagcaaac ttcatttttg tagtatccag aaattacctg gagtcagtat ttttattcgc
     5641 cttctagaac ttgtgatcca cacatcaccc atttatatta gtggtaaaat tatctgctaa
     5701 aatctaattg taagaaaggc ttaccttctg tcatcaagtg attgtatcat cctggatcgt
     5761 catttccaag gaactagcct ttcttttcct aagcgtctgt atgtgttcta aaacttccag
     5821 tatatattta tagaacttag aaaaaatgtt acattattca gagtagcaag tcttactgga
     5881 gtacctatgt ttgttttctt ggtttttatt tttttttaag tttaaaagta gtaattaaac
     5941 ctatattttg tgattgtttc ctggtctgtg tttttaaatt cctttccttc agttttcctc
     6001 atgaagatgt ttcagatact gaatttgttt agacattgaa tgactttgtt aaaggcacaa
     6061 ttaatcacat tggttgtact ctgaagacag acttctttaa aaaaaaaata aacaatttaa
     6121 aacaa
//
