LOCUS       NM_001009993            5435 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 168 member B
            (FAM168B), transcript variant 1, mRNA.
ACCESSION   NM_001009993
VERSION     NM_001009993.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5435)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 5435)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5435)
  AUTHORS   Pramanik,S., Kutzner,A. and Heese,K.
  TITLE     Livebearing or egg-laying mammals: 27 decisive nucleotides of
            FAM168
  JOURNAL   Biosci Trends 11 (2), 169-178 (2017)
   PUBMED   28381702
REFERENCE   4  (bases 1 to 5435)
  AUTHORS   Mishra,M., Akatsu,H. and Heese,K.
  TITLE     The novel protein MANI modulates neurogenesis and neurite-cone
            growth
  JOURNAL   J Cell Mol Med 15 (8), 1713-1725 (2011)
   PUBMED   20716133
  REMARK    GeneRIF: novel protein MANI (myelin-associated neurite-outgrowth
            inhibitor)localizes to neural membranes; findings describe the
            novel MANI-Cdc27-APC pathway as an important cascade that prevents
            neurons from extending axons
REFERENCE   5  (bases 1 to 5435)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN418443.1, DB453209.1 and BC110642.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001009993.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.256114.1,
                                           SRR1660807.202620.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389915.4/ ENSP00000374565.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                CN418443.1         1-29
            30-412              DB453209.1         1-383
            413-5435            BC110642.1         263-5285
FEATURES             Location/Qualifiers
     source          1..5435
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q21.1"
     gene            1..5435
                     /gene="FAM168B"
                     /gene_synonym="MANI"
                     /note="family with sequence similarity 168 member B"
                     /db_xref="GeneID:130074"
                     /db_xref="HGNC:HGNC:27016"
                     /db_xref="MIM:620078"
     exon            1..247
                     /gene="FAM168B"
                     /gene_synonym="MANI"
                     /inference="alignment:Splign:2.1.0"
     exon            248..328
                     /gene="FAM168B"
                     /gene_synonym="MANI"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..846
                     /gene="FAM168B"
                     /gene_synonym="MANI"
                     /note="protein FAM168B"
                     /codon_start=1
                     /product="myelin-associated neurite-outgrowth inhibitor"
                     /protein_id="NP_001009993.2"
                     /db_xref="CCDS:CCDS42755.1"
                     /db_xref="GeneID:130074"
                     /db_xref="HGNC:HGNC:27016"
                     /db_xref="MIM:620078"
                     /translation="MNPVYSPGSSGVPYANAKGIGYPAGFPMGYAAAAPAYSPNMYPG
                     ANPTFQTGYTPGTPYKVSCSPTSGAVPPYSSSPNPYQTAVYPVRSAYPQQSPYAQQGT
                     YYTQPLYAAPPHVIHHTTVVQPNGMPATVYPAPIPPPRGNGVTMGMVAGTTMAMSAGT
                     LLTAHSPTPVAPHPVTVPTYRAPGTPTYSYVPPQW"
     exon            329..412
                     /gene="FAM168B"
                     /gene_synonym="MANI"
                     /inference="alignment:Splign:2.1.0"
     exon            413..555
                     /gene="FAM168B"
                     /gene_synonym="MANI"
                     /inference="alignment:Splign:2.1.0"
     exon            556..733
                     /gene="FAM168B"
                     /gene_synonym="MANI"
                     /inference="alignment:Splign:2.1.0"
     exon            734..858
                     /gene="FAM168B"
                     /gene_synonym="MANI"
                     /inference="alignment:Splign:2.1.0"
     exon            859..5435
                     /gene="FAM168B"
                     /gene_synonym="MANI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5413..5418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM168B"
                     /gene_synonym="MANI"
                     /note="hexamer: AATAAA"
     polyA_site      5435
                     /gene="FAM168B"
                     /gene_synonym="MANI"
                     /note="major polyA site"
ORIGIN      
        1 gtcggcggct ccggtggctg cgcagcgtcg gcggggagcg cgggctgcgg agaggcgggc
       61 cgggccaagc ggagccgagc gagcgggagc gcggcgtccg ggaggcggcg gagacgcggg
      121 gctcggaggg tcagcctctt atcgtagcag gtctcctcgg cacgcccccc ttgtttcgcc
      181 ccacggccaa gcccgccgcg ggccggcgtg cgctggtcac tgaggcccag gtcgccgccg
      241 cggcgcgttt ttgaaatcat gaatcctgtt tatagtcctg gatcttctgg ggttccctat
      301 gcaaatgcca aaggaattgg ttatccagct ggttttccca tgggctatgc agcagcagct
      361 cctgcctatt ctcctaacat gtatcctgga gcgaatccta ccttccaaac aggttacact
      421 cctggcacac cttacaaagt gtcctgttcc cccaccagcg gggctgtgcc accgtactcc
      481 tcctccccga acccctacca gactgccgtg taccctgtgc gaagtgccta cccccagcag
      541 agcccgtatg cacagcaagg cacgtactac acacagccgc tgtatgcagc acctcctcac
      601 gtcatccacc acaccacggt ggtgcagccc aacggcatgc ctgcaacggt gtaccctgct
      661 cccatccccc ctcctagagg caacggggtc accatgggca tggtggctgg gaccaccatg
      721 gccatgtcag caggtaccct gctgactgct cactccccaa ctcctgtcgc cccccacccg
      781 gtcactgtgc ccacgtaccg ggccccagga acgcccactt acagctatgt gccccctcag
      841 tggtgatcac ctgcaaatgt ttgaggacgg agctgtgcag tcacattatt ggggattcca
      901 cagctggtgc tgcaggcctt gcgcctccaa ccaggacttt cttcttaatg ctctcgacac
      961 ttagctaaac acgactatat cccggcccag caggccccag cgccgttagt ctccagctga
     1021 ctctgtgggt tggtcttaaa gcaaattctg ttttgtggac tgcctggcaa ttttttagct
     1081 aactgtaatg ataaaaaggg agtattaatc tattctgaat catatctagt tgaatgcatg
     1141 tttaaaaaaa caaacacaaa aagcttgctc aatctacctg cagtgactga tgcaaaacca
     1201 tcatatgcaa aatccaaagg aatggaaacg tattttacaa cttgtatcac taatgcactg
     1261 ttgtaatgta tgcaaagtct tacagttata agtgttaaag tgaatttctt catagagcat
     1321 ctgaaatatc ttagatgatt cttcaacctt ttggggttga tgtgggttgc cagttaggga
     1381 tgtggacatt ttagttttca gcgacctgtt tctttggcac tgactgtcct gggagggagt
     1441 tgcgaggttt gggagagagt agggaagcca cagctgcttg ggtgcagctg gttcatggac
     1501 atccctttga gtttaggctt ggtggagtca gtggaacagg gacatgctta aagctcatca
     1561 tgaaagatta tggtagtgtg gccagtgaaa tttggggcga ggggggtggt ttatgtgtca
     1621 gcaaagcagt ttctctgcta tctaaatttt cattacagtt ctcttagaga gatgatgttt
     1681 ttatatgtct ttattggaaa agtcctatgt aaaactaaat tattttcctg ggatggaaga
     1741 aatgtgaaag agaaacagcc atgcttgcag gaggtattgt cctctgcttt atttagctta
     1801 gaaaatcatt cctttttttt tttttttcct ggagaaatgt ttgaatcagc tgaaaacagg
     1861 taggcattgc tgtttttccc caacaaagaa gggcaaaggt ttcagctgta tgttatgaag
     1921 aaagtggtat atttaagaat gagttaaaag ggaacaaaac tttatttaaa attcctccaa
     1981 tttcttgtag aaaggcaggg ccgtggatat gtctggaaat gtagaaacct gtagctgctt
     2041 ctgggatcac ccacctgatg gtggtgactt gtctgctgag gccggctgga ggggacgctt
     2101 agagatgggg cgagggggag gccagtgtct gttgtctgcg agcctctcct gccatctctt
     2161 ttgcagctga gggcacttgg cacaaagcaa gcacagacag cagagagggc caggcagtgc
     2221 tggagtgcgt ttgctggcag ggtttattgt gggagaggaa tttgagttta ggatctgaat
     2281 cttgtacata agaaatgaaa aggcttccct ccaccccgcc cccaaaatat gcccgtcctg
     2341 tatccatgag agtgcatgtc ggttctcagt gagggtcaga gtgggggtgg gggatgtaag
     2401 gcctgggtcc ctttcagcgg cctctagggc aggagcgtgc gtcttcttcc cagtgcagtg
     2461 gtggtttgag tgctgtgggc tctggtgggg agggggctct gctcctcttc atttgctggt
     2521 agctgggtca gggcactggc gcccagtgag gatgcccact agcattctgc cccagttggt
     2581 tggtgggggg acacctgacc actgagcctt tggtaacctt attttttata gtaagtactt
     2641 cttataattt tctttttcac atcttatttt ataagaagtt taggaatatt tttgcatgga
     2701 tcattgtaaa cagcagattc tttattcctg atgtctatta acatagaatg tttactgata
     2761 agtactttaa attgcttcat gagcacttaa tccatcttag tgtctatgtg tgggggcaga
     2821 catttaccgc aggcacacag tttgtgcccc tttcttcaag tctctgttgg taattccatc
     2881 tgtttagtgg atggttggca ggattagtag gttctaacgg ttccaggggt tcagctgacc
     2941 aagtagcaga gaagtctttt ttcccaattg agtgctaata gattaggata aaatactcac
     3001 aatgttagtg tatgctttta aaaagcccca cacaacaaaa tggaaacata catgtacaac
     3061 tcctgtgagg gctggagtct tggggttcag gaggaggtta gaagttacag gcatctcttc
     3121 aggcttgctt ggtacttggc acacacagga tggtgtttta aagagtgggc tgcacccccc
     3181 acacgccatt tacatcagct tcataaacac ttttcttcct ccctgtaact taaccttttt
     3241 tcccttttat gaagttgaga ggctttatga aataagtttg cattgcacat ccgtgcagaa
     3301 atctttctga ctttgaaatt tttaggacgt cagctgtcag atacgaaagg tagatatcag
     3361 gtaagaatct ggacttagga aatagtcaca aaactgtcat aggttgtaat tttatcaaca
     3421 ttcgcttcta gtaaaattaa agtcaattaa gaaatagaac ttgggtcaaa attctgttac
     3481 aaagcttcat aatttgtccc gaagcatatg gtggagcatt ctgagaaatt tgctttttgt
     3541 gtgtttgaca ttcctaattt gggagtcctt cagctgaatt actattcttt tagaagttga
     3601 gacagcaggt aagcaaagga cctagttcat gtaaacatgg acatcatgat ggctatttaa
     3661 aaaatatttg ttctacacct tctcccctga ggcttgggga gtgtgttcag ccgctgcagt
     3721 ttctctgctc atggaggtct tgtttggatc tgtgctggcg gctgagcatt tagtgtgagc
     3781 cagtgaccca tgaacttgcc gctctgtgag ggccagagtc agggccagtc atggtaatgg
     3841 gcctgaaggc acttccagaa ccttttatgt ctctcgtgag ccatctgtta agaacgttct
     3901 tcttggtgtg gtttgtaggc ctacctgtcg ctattctggg aaaccttctt gagtgctatg
     3961 caaatgtgtt cacaggcaat gggggtggtc ctgagccttg gggtgggcac ctggtcagtg
     4021 agtgtcttgc ccttccccag ctgggcatac agtaccttgc tctttctggt ggcatcatct
     4081 ggctgtgatg aatgaggtct aggaaataat ttgcatgtgt cttgggggac acaacagtaa
     4141 cgagaggaaa tacattatta cagcaacttg cgacgtacta atacctgtca gtgttggccc
     4201 ccgtaaggta tgtaaggcac ctgtgagtgc cagtgagtgc tggtgaaagg ccaacatgta
     4261 ctagttatgt aagtattggt gtctgcttta aaaaaggaga cccagacttc acctgtcctt
     4321 tttaaacatt tgagaacagt gttactctga gcagttgggc caccttcacc ttatccgaca
     4381 gctgactgtt ggatgtgtcc attgtcgcca gtttggctgt tgcccggaca ggacaggacc
     4441 tccattgggc gcagcagcag gtggcagggg tgtggcttga ggtgggtggc agcgtctggt
     4501 cctcctctct ggtgctttct gagagggtct ctaaagcaga gtgtggttgg cctgggggaa
     4561 ggcagagcac gtatttctcc cctctagtac ctctgcattt gtgagtgttc cctctggctt
     4621 tctgaagggc agcagactct tgagtatact gcagaggaca tgctttatca gtaggtcctg
     4681 agggctccag gggctcaact gaccaagtaa cacagaagtt ggggtatgtg gcctatttgg
     4741 gtcggaaact gcatgtttca gaaagtttgt ctctttttcc tactcattat ttgaagaaga
     4801 gagagcctgt ggggatagcc ttatcttggt ccacaggact gaagtgaagt cacttgggaa
     4861 ggggagacag aggatgagcg gcgtctgtgt agggaccccc ccccgggcct gcagaagggt
     4921 ggtgtgctcc caggactggc atgacaggtg tctcctcctc accacaggct gtgcccatga
     4981 gtccctgtgc agaccagtgg gcaaggcagc tgggccagat ctcaggccag ccgtttgtgc
     5041 tcctagcagg gttgctgtgc tggccacacg gagaggccct agagagcctc atggattgta
     5101 actaaagaag aaacggttcc tttttgtttt tttaaaaatg atttttaaat accgtttttt
     5161 acaccgttct ctcggtactt tttttaagct aagtcagcat tgtcttccag tgttaaaggc
     5221 atccctcacc tctgcattga acttacgtat ccatgccaag gaatggaatt tccatcctga
     5281 gccagttcag ttaggtgtca attgatacta ttttaatttt ttatgcaatc tgatgagatg
     5341 agctcagatt taaaaatctc aaaagcacgt ttattgtaac aagaattgtt atgtattaat
     5401 actgcagttt tcaataaaga ttgacttgtg ttgca
//
