LOCUS       NM_015159               7192 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens family with sequence similarity 168 member A
            (FAM168A), transcript variant 2, mRNA.
ACCESSION   NM_015159
VERSION     NM_015159.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7192)
  AUTHORS   Zhao,S., Li,X., Yin,L., Hou,L., Lan,J. and Zhu,X.
  TITLE     TCRP1 induces tamoxifen resistance by promoting the activation of
            SGK1 in MCF-7 cells
  JOURNAL   Oncol Rep 43 (6), 2017-2027 (2020)
   PUBMED   32323833
  REMARK    GeneRIF: TCRP1 induces tamoxifen resistance by promoting the
            activation of SGK1 in MCF7 cells.
REFERENCE   2  (bases 1 to 7192)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 7192)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7192)
  AUTHORS   Liu,X., Mai,H., Jiang,H., Xing,Z., Peng,D., Kong,Y., Zhu,C. and
            Chen,Y.
  TITLE     FAM168A participates in the development of chronic myeloid leukemia
            via BCR-ABL1/AKT1/NFkappaB pathway
  JOURNAL   BMC Cancer 19 (1), 679 (2019)
   PUBMED   31291942
  REMARK    GeneRIF: FAM168A involved in the regulation of AKT1/NFkappaB
            signaling pathway and cell cycle in chronic myeloid leukemia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7192)
  AUTHORS   Gu,Y., Zhang,Z., Yin,J., Ye,J., Song,Y., Liu,H., Xiong,Y., Lu,M.,
            Zheng,G. and He,Z.
  TITLE     Epigenetic silencing of miR-493 increases the resistance to
            cisplatin in lung cancer by targeting tongue cancer
            resistance-related protein 1(TCRP1)
  JOURNAL   J Exp Clin Cancer Res 36 (1), 114 (2017)
   PUBMED   28859669
  REMARK    GeneRIF: Our results highlight that hyper-methylation of miR-493CpG
            island might play important roles in the development of lung cancer
            chemo-resistance by targeting TCRP1, which might be used as a
            potential therapeutic target in preventing the chemo-resistance of
            lung cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7192)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7192)
  AUTHORS   Peng,B., Yi,S., Gu,Y., Zheng,G. and He,Z.
  TITLE     Purification and biochemical characterization of a novel
            protein-tongue cancer chemotherapy resistance-associated protein1
            (TCRP1)
  JOURNAL   Protein Expr Purif 82 (2), 360-367 (2012)
   PUBMED   22365988
REFERENCE   8  (bases 1 to 7192)
  AUTHORS   Peng,B., Gu,Y., Xiong,Y., Zheng,G. and He,Z.
  TITLE     Microarray-assisted pathway analysis identifies MT1X & NFkappaB as
            mediators of TCRP1-associated resistance to cisplatin in oral
            squamous cell carcinoma
  JOURNAL   PLoS One 7 (12), e51413 (2012)
   PUBMED   23251525
  REMARK    GeneRIF: siRNA-mediated knockdown of TCRP1 and MT1X was found to
            sensitize cells to cisplatin, leading to increased apoptosis and
            inhibition of cell proliferation
REFERENCE   9  (bases 1 to 7192)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   10 (bases 1 to 7192)
  AUTHORS   Gu,Y., Fan,S., Xiong,Y., Peng,B., Zheng,G., Yu,Y., Ouyang,Y. and
            He,Z.
  TITLE     Cloning and functional characterization of TCRP1, a novel gene
            mediating resistance to cisplatin in an oral squamous cell
            carcinoma cell line
  JOURNAL   FEBS Lett 585 (6), 881-887 (2011)
   PUBMED   21334329
  REMARK    GeneRIF: Data suggest that TCRP1 (EF363480) might be a novel
            molecular target to develop agents to reverse cisplatin-induced
            chemoresistance.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC052341.1 and AP000763.5.
            
            On Jun 2, 2019 this sequence version replaced NM_015159.2.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon, compared to variant 1. The encoded isoform (2) is shorter
            than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.2305072.1,
                                           SRR14372080.2725372.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356467.5/ ENSP00000348852.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1696              BC052341.1         72-1767
            1697-7192           AP000763.5         21969-27464         c
FEATURES             Location/Qualifiers
     source          1..7192
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..7192
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /note="family with sequence similarity 168 member A"
                     /db_xref="GeneID:23201"
                     /db_xref="HGNC:HGNC:28999"
                     /db_xref="MIM:616316"
     exon            1..190
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            191..278
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..916
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     tongue cancer chemotherapy resistance-associated protein
                     1; protein FAM168A"
                     /codon_start=1
                     /product="protein FAM168A isoform 2"
                     /protein_id="NP_055974.1"
                     /db_xref="CCDS:CCDS41689.1"
                     /db_xref="GeneID:23201"
                     /db_xref="HGNC:HGNC:28999"
                     /db_xref="MIM:616316"
                     /translation="MNPVYSPVQPGAPYGNPKNMAYTGYPTAYPAAAPAYNPSLYPTN
                     SPSYAPATLLMKQAWPQNSSSCGTEGTFHLPVDTGTENRTYQASSAAFRYTAGTPYKV
                     PPTQSNTAPPPYSPSPNPYQTAMYPIRSAYPQQNLYAQGAYYTQPVYAAQPHVIHHTT
                     VVQPNSIPSAIYPAPVAAPRTNGVAMGMVAGTTMAMSAGTLLTTPQHTAIGAHPVSMP
                     TYRAQGTPAYSYVPPHW"
     exon            279..359
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            360..485
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            486..628
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..803
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            804..934
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            935..7192
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6594..6599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /note="hexamer: AATAAA"
     polyA_site      6620
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
     regulatory      7169..7174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /note="hexamer: AATAAA"
     polyA_site      7192
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /note="major polyA site"
ORIGIN      
        1 gtcgggctcc tcggcggcta ctgcagagga ttcagagccg agtcgctgag gaggaggctc
       61 cggtccccgc gcgccatccg ccaccctact ggacacgggc gagagcgtcg ccgccgtagc
      121 ctccggagaa gacaagggca tcgccgcctc agccgccgcc gccgccgttt tcgcctgcag
      181 ctgctcaccg gatcctcagt cttccacaat gaaccctgtt tacagccccg tgcagcctgg
      241 ggctccttat ggcaacccta agaacatggc ctacacgggt taccccacag cctatccagc
      301 agctgcccct gcctacaatc ccagcctgta ccccaccaat agtcccagtt atgctccagc
      361 aactctgctg atgaaacagg cctggccaca gaactcgtct tcctgtggca ctgaaggcac
      421 cttccacctc ccagtggaca ccgggaccga gaaccgaact taccaagcat cctctgcggc
      481 tttcagatat actgcgggga caccatacaa ggtcccaccg acccagagta acactgctcc
      541 acccccctac tccccatcac ccaaccccta tcagacggcc atgtatccaa tcagaagtgc
      601 ctacccccag cagaatctgt atgcccaggg agcctactac acacagccgg tgtatgctgc
      661 ccagcctcat gtcatccacc ataccacggt cgtccagccc aacagcattc cctctgctat
      721 ctacccagca cctgttgccg ccccgaggac caacggtgtg gccatgggca tggtggcagg
      781 caccaccatg gcaatgtcag caggtaccct gctgactaca ccccagcaca cggcgattgg
      841 ggcacaccct gtctccatgc caacatatag ggcccaagga acccctgcgt acagctacgt
      901 gcccccacac tggtaaagcc tgcagcccat ccaaatctgg agtcacacat tgtatgcaac
      961 tactcaagtc ttacaccggt gctggagcag ttccctagca gcaccacctc tatttgcaag
     1021 aagagacaac ggaagtgcaa gggtcacttt atgcatcttt aatggttttg atttttattt
     1081 ttggtttttg taaaagctgc tttttctaat ctcctgcctc tccccaactg tccccctctt
     1141 agcccctgcc cttccagctc tatccccttc ctcctacctg accaggccat gtcctctctg
     1201 ctcttcccta agtgtcctgt ccctggggat cccagtctag aggcaagcag agagtagggt
     1261 ttattgcagt ggttcatctg aaggctggat tccatttgaa gagcataaac agatgtggtc
     1321 cagggtagga actcagagct gttgagcagg ctacatctct aggggagtgt tctggttgtt
     1381 ttttcttaag caagattagt tcaggacatt cccatgtccc agacacaaat gaaatgtctc
     1441 ctgagaacca ttgcaacaga ccaagaacaa aaccacctga gtatgtaggc gtgttattag
     1501 cagcttaata ccccaggctg agaacctggg gaaaaaagtc tttagaattt gggggagggt
     1561 ggggggaggg agggcattgt ggggaaggag agggaagaag ggaggagcgg tgcttgcctc
     1621 atggctttgg tttgaaaggt ctctggccaa agcatctggc cctggacctt ctgatttgca
     1681 cagtgatgtt aactgacctg gcacttcctc aaaaggtgat tttgtcctta gacctgccaa
     1741 gcggctgcag ggtggtagga tcccagcatc ccgaggcctt ggaaggccgg atgccctgtg
     1801 tcatccagac ttcagcctct gagctgtcat ggacccactc tgatgaggag cttcctcctg
     1861 attggagtgg gaacctaggg catttctctc ccttttcttt tgcccttccc agtgccagga
     1921 ctcacctgtc tgaccataga gcttgcaggc aggccaagct cttggttacc tgtgccattc
     1981 atggcccaag tgaaggaacc acattccagg tgggtgctgg cagctctgaa ggtgaggata
     2041 gtgaaggaaa agcaatagca ataaacattt catagactca tggaactgaa gggaccttag
     2101 caatcatctc atccatttcc ctatttggca gatgaggaaa ctgaggccca gagaagcgga
     2161 aaggacttcc ctagacctta cagtaaatta gcattaaatg cagccttcct acctagtggg
     2221 caccttgctt acaaaaattt acctagggac ggattggctt ggttttgtaa aaattaagtc
     2281 ggcagcgccc atacctggtg agtctggaat ggtctctggg ctcctgtttc tgctcttttc
     2341 ctccacggac tccaaaggcg ggggttgaag actgggcaga ggctacatgg gggcggatgg
     2401 caggaacaga aattgcaaat gaagaaatag catttggaaa ttctgtgaag acatctggaa
     2461 cttccgtcct gtacctgact ccacctccag gagaaggagc aggtggactg gccgaaaagg
     2521 agaggccatg cttttaggac agtagcccct catcccgaga ggagaggaag aggaggaaga
     2581 cagtgggagt catcaggaga ggagaatgag gatgaggccc aggagacagg ctcatctggg
     2641 agaagaggga cccctgggac gaggaggtcc ctgctagtct cagccaggag cctggattgc
     2701 ccagcagcag cctccggcac ccagcgcttg gctgggccag cagcccctct gggggtgggg
     2761 cacgaacatt ttattgtaaa aaatgggatc attgacaaca tttgggactt taaaaaactg
     2821 ctttcattta aaattcatgc aaacttggac atatccttac cccaacctcc catgtctccc
     2881 taagggaggg aaaaatcagg aaacccttgg gttggaagga gctcagaagc tgtctagcca
     2941 ttcccaggag ggtaaagccc atcagcctcc ttggcctaga gccaggagtt tgggggccca
     3001 ccttcctggg cttccaagga actttaggac cagtaagaaa aaattcagct gttctaaatt
     3061 atctgttctg ggtgctgatg aggtttcact ttaaaacaat agaaagtttt ccagtgttaa
     3121 ttcacttttt gcaaatacct ccttccaccc tctttggttt tgtaaaggtg ggtgaaggtt
     3181 gttctagatt atgtcatacg tgtttgaaaa atgccaaaat aataataatg ataataataa
     3241 tagaaacctt tggatttgtc aggtgcatca cagaggtcaa agcacttcac ggcctttcat
     3301 gtactcgccc tgagagggac agggttagag ttattacagt caattgacaa atgaggaaac
     3361 aggttatgga agggaacagg cccacagtga gcagcatgct ggtatccgct aggcttccca
     3421 gaaccctgct gcctccatgt gggctggggt ggaaccacag agaggagaaa ggaagaagag
     3481 gagacctagg aatgaccttg taacttttgt tctttcaaca ccagtaagta aaactaacag
     3541 ctggacctca cagttcacag aacagttgaa cataaattat ctggtttaac ccgatgaaat
     3601 agaggttatt tctcctattt gatccataag gaaatcaagg cttggaaaag tcaagtgact
     3661 tgctaataag tgacagagcc actcgaatcc caggctgtct gctgtctcgt tcccctccat
     3721 ctgatcccca cacaggctca cgtactgaag catctgtgct ctgtgcccta tcttagcacc
     3781 tactatgtaa ttcaagagca aaggggggcc ccaaggtgaa aataaggcac tgaaaggctg
     3841 tggtctggaa gagcccaggt ccagcacccc tttttcagta tgagccccag ttcagccggc
     3901 ctcagcctct tgctgtgatg gagatccaca agcctagcca agcttgggga gtcactgcaa
     3961 aaggactgag cccaggagag cggggacagt catgtgcctc tggtaggatg ggcacagtta
     4021 ctggtaaggt cacagagatc tagtgggagg taccataggt agatacctcc aaagattcta
     4081 gatggcacgg tggtcaagct agacaaaaag tcagagctgg aagggccgtc tcattgaagg
     4141 caggcaagca agagaggaca agggatgtag ccgcctgaca gtgagctaca gcactggccc
     4201 caggatgcaa acccctctct cctcctcatg ccactgcctc tccccaagtg caacacctat
     4261 ggccaggatc aggggtacag atggctcgtt accagccaac ccttttgaat tcttctactt
     4321 ctacctgacc ccctctcctc actggcctgg ggtcaagaag tttgagtctg ggagctggat
     4381 tgcctgcaaa tagtgaaagc ctgaaacata atggtttgcc atgttttgaa aaaaaatgca
     4441 tatttaattt cttcctcatg agataggaca gttgctgttc tttcttacct ggcaatgacc
     4501 ctaaaatgta tatcctcttt cctgaatatt tagcagagac acacacacct gtccagagcg
     4561 tttttggtat gcaaagtact ttgacattgg ttgccaaagt cctccatttt atagatgaaa
     4621 aaactaaggc tcaggaggct tgagacttgc taaaaggtca cacagcttgg aagtgattct
     4681 tcaaatcctc tgctctttct gctgccacct gctgggtctc ttggcaagca tggagggagg
     4741 ggctaactgt actttataga gctgggaagc ccagtctctg agctgagcag atttgtatga
     4801 actgctttgg gccaggacct gtaatgagcc ctggggaggg acccagaggc acatctaact
     4861 ggcagcacaa ggaggatgag aatttgcaac taaaggcctc acttggacaa aacactttgg
     4921 ggtcacaatg cccaggaccg aagacatgtt caaggacagc acgaggcatc tttctattgg
     4981 gagacccatg tccttggtaa gcctgcacac ctggcttcct aatccctgag agcctgccca
     5041 ctgtccagat ccagtgagtt ggtacaaaac gtacagactg aagtccctgg gcttgctttt
     5101 cccatgggtg aggaccagaa ccagactctg agcatcctta cccctggcca cccgaattgt
     5161 tccaagtttg aggtaccccg ttcccagaga tctgggggtc cttctttgga gggcttgctt
     5221 tgttctgatg gccttcagaa aggaatcaca tgaagtataa aaggacaggc cccttggtca
     5281 ccaagttttg gctcctcata cagataggac tcatccaggt tcccagcgag gcactgacta
     5341 agcgaggctc agagcttcca tatcaaattc ctcagctttg ttctgtgccc agagggggtg
     5401 ggccccattc tgggccctgt gaactttgtc ttatatatca ccatctgtat cagaattcct
     5461 cctcaattgc agttaagtga aaatacgtgg aagtctgctt ttccatcctg tattctccca
     5521 catcactact ggctgtgcgg cccccgctgc ttgccaagct tgggaatcca gagaggggca
     5581 gtagtagagt gggccagttg ggacccaccc gcagagctga agaaacacgc cagactaact
     5641 gatgggattc cacaccggag cctctgagcg cacaggcagg catgccaagg gggctgcagg
     5701 gtttgtcctt tacttatctg cccctttcct agaaaactcc tcgtttctga aattaggcat
     5761 tatatggttc caggacccag ccttcaaaat tcctggcagg ccagcttcaa cattccatgg
     5821 ccagccctgc ctaagccaga cttgggtccc agtccctcag tctctccagt ggatatcttc
     5881 tgtggtgcat gctgttgagt ccaacccaaa ggccaaccga ggcacacagg agttgggact
     5941 ggctgccaca aagctagaaa gggacaaaac agcacttgct tccctatggc cacatggata
     6001 gtccctggat atccttgctg tggtagaggt cctctaccca ttccagccac tgatagcagg
     6061 gggattttcc ttcctaagga gaacagatgt aacagctttg caaagtaccg gcccatagga
     6121 atcaaatggg tgagatcagc tttgggcctg accccagcaa gaccagcatc tccagacccc
     6181 agcctttctc ctcaggccta agagagtcag ggaaagagag gagactgtcc cagagacctt
     6241 ctcctcgggt cagccagata gtctggatct atggtgtgac tcaagctcct ccttacccag
     6301 ggggggtaag gccaggcctc tagctacttg gagttgtctg taataatctt gaaaggccca
     6361 agggcctgtc cccatcctga cttaaaggca tctgcttccc tgtttcatat cacatgacag
     6421 agaaacctgt tctcatggca tgtaacatcc ctgtgaagag agcgttgtat atgattttgt
     6481 attttttaat tcattttaat ctacaggttg gaatctaatt tttaaatttt attggaactc
     6541 acattttaaa aagaaataaa atttaaaata ataataataa taataataat aataataaac
     6601 ctttgaccag tgtcttccaa gtagtttgat caaagaattt ataggtgttt tcaaaacaca
     6661 gtccggagtg taaagattgg aaagccccat ggccttgcct gtgtgtatga agtgtaaatc
     6721 tggttttgtt ttgttgtttt ggattctttt gggtttttgt tttgttttga agatcagaca
     6781 gtgatcactc tgaaagattg aagccaagaa tttgtaacta tggtatttac tgtaagctgt
     6841 agaacactca ataactatta aaaaaaaaaa ttccccccca aaaaaaagtc ttaggtgact
     6901 agactgagtg gttcttgggg agggaggcac agaggactgt cctgggccag tgagtccctt
     6961 gggcgtctcc ccaagttgat gctaaatttg ttctcagtag tcaagaaaaa cctatggtac
     7021 atcttacagc tgatctgaca ggggtctgcc ctaagggtct cacagctgct ggggagcttt
     7081 aagtggcaac ttcagcaccc accctaagtg tgtgatgtgg gagcacagtg aggccattca
     7141 gagttgaaat ccattgagcc atccgcgcaa taaagctgac atctattgtg tg
//
