LOCUS       NP_055974                235 aa            linear   PRI 29-APR-2025
DEFINITION  protein FAM168A isoform 2 [Homo sapiens].
ACCESSION   NP_055974
VERSION     NP_055974.1
DBSOURCE    REFSEQ: accession NM_015159.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 235)
  AUTHORS   Zhao,S., Li,X., Yin,L., Hou,L., Lan,J. and Zhu,X.
  TITLE     TCRP1 induces tamoxifen resistance by promoting the activation of
            SGK1 in MCF-7 cells
  JOURNAL   Oncol Rep 43 (6), 2017-2027 (2020)
   PUBMED   32323833
  REMARK    GeneRIF: TCRP1 induces tamoxifen resistance by promoting the
            activation of SGK1 in MCF7 cells.
REFERENCE   2  (residues 1 to 235)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (residues 1 to 235)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 235)
  AUTHORS   Liu,X., Mai,H., Jiang,H., Xing,Z., Peng,D., Kong,Y., Zhu,C. and
            Chen,Y.
  TITLE     FAM168A participates in the development of chronic myeloid leukemia
            via BCR-ABL1/AKT1/NFkappaB pathway
  JOURNAL   BMC Cancer 19 (1), 679 (2019)
   PUBMED   31291942
  REMARK    GeneRIF: FAM168A involved in the regulation of AKT1/NFkappaB
            signaling pathway and cell cycle in chronic myeloid leukemia.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 235)
  AUTHORS   Gu,Y., Zhang,Z., Yin,J., Ye,J., Song,Y., Liu,H., Xiong,Y., Lu,M.,
            Zheng,G. and He,Z.
  TITLE     Epigenetic silencing of miR-493 increases the resistance to
            cisplatin in lung cancer by targeting tongue cancer
            resistance-related protein 1(TCRP1)
  JOURNAL   J Exp Clin Cancer Res 36 (1), 114 (2017)
   PUBMED   28859669
  REMARK    GeneRIF: Our results highlight that hyper-methylation of miR-493CpG
            island might play important roles in the development of lung cancer
            chemo-resistance by targeting TCRP1, which might be used as a
            potential therapeutic target in preventing the chemo-resistance of
            lung cancer.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 235)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 235)
  AUTHORS   Peng,B., Yi,S., Gu,Y., Zheng,G. and He,Z.
  TITLE     Purification and biochemical characterization of a novel
            protein-tongue cancer chemotherapy resistance-associated protein1
            (TCRP1)
  JOURNAL   Protein Expr Purif 82 (2), 360-367 (2012)
   PUBMED   22365988
REFERENCE   8  (residues 1 to 235)
  AUTHORS   Peng,B., Gu,Y., Xiong,Y., Zheng,G. and He,Z.
  TITLE     Microarray-assisted pathway analysis identifies MT1X & NFkappaB as
            mediators of TCRP1-associated resistance to cisplatin in oral
            squamous cell carcinoma
  JOURNAL   PLoS One 7 (12), e51413 (2012)
   PUBMED   23251525
  REMARK    GeneRIF: siRNA-mediated knockdown of TCRP1 and MT1X was found to
            sensitize cells to cisplatin, leading to increased apoptosis and
            inhibition of cell proliferation
REFERENCE   9  (residues 1 to 235)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   10 (residues 1 to 235)
  AUTHORS   Gu,Y., Fan,S., Xiong,Y., Peng,B., Zheng,G., Yu,Y., Ouyang,Y. and
            He,Z.
  TITLE     Cloning and functional characterization of TCRP1, a novel gene
            mediating resistance to cisplatin in an oral squamous cell
            carcinoma cell line
  JOURNAL   FEBS Lett 585 (6), 881-887 (2011)
   PUBMED   21334329
  REMARK    GeneRIF: Data suggest that TCRP1 (EF363480) might be a novel
            molecular target to develop agents to reverse cisplatin-induced
            chemoresistance.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC052341.1 and AP000763.5.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon, compared to variant 1. The encoded isoform (2) is shorter
            than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.2305072.1,
                                           SRR14372080.2725372.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356467.5/ ENSP00000348852.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..235
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     Protein         1..235
                     /product="protein FAM168A isoform 2"
                     /note="tongue cancer chemotherapy resistance-associated
                     protein 1; protein FAM168A"
                     /calculated_mol_wt=24930
     Region          1..235
                     /region_name="TCRP1"
                     /note="Tongue Cancer Chemotherapy Resistant Protein 1;
                     pfam14944"
                     /db_xref="CDD:434335"
     CDS             1..235
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /coded_by="NM_015159.3:209..916"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS41689.1"
                     /db_xref="GeneID:23201"
                     /db_xref="HGNC:HGNC:28999"
                     /db_xref="MIM:616316"
ORIGIN      
        1 mnpvyspvqp gapygnpknm aytgyptayp aaapaynpsl yptnspsyap atllmkqawp
       61 qnssscgteg tfhlpvdtgt enrtyqassa afrytagtpy kvpptqsnta pppyspspnp
      121 yqtamypirs aypqqnlyaq gayytqpvya aqphvihhtt vvqpnsipsa iypapvaapr
      181 tngvamgmva gttmamsagt llttpqhtai gahpvsmpty raqgtpaysy vpphw
//
