LOCUS       NM_001286050            7219 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens family with sequence similarity 168 member A
            (FAM168A), transcript variant 1, mRNA.
ACCESSION   NM_001286050
VERSION     NM_001286050.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7219)
  AUTHORS   Zhao,S., Li,X., Yin,L., Hou,L., Lan,J. and Zhu,X.
  TITLE     TCRP1 induces tamoxifen resistance by promoting the activation of
            SGK1 in MCF-7 cells
  JOURNAL   Oncol Rep 43 (6), 2017-2027 (2020)
   PUBMED   32323833
  REMARK    GeneRIF: TCRP1 induces tamoxifen resistance by promoting the
            activation of SGK1 in MCF7 cells.
REFERENCE   2  (bases 1 to 7219)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 7219)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7219)
  AUTHORS   Liu,X., Mai,H., Jiang,H., Xing,Z., Peng,D., Kong,Y., Zhu,C. and
            Chen,Y.
  TITLE     FAM168A participates in the development of chronic myeloid leukemia
            via BCR-ABL1/AKT1/NFkappaB pathway
  JOURNAL   BMC Cancer 19 (1), 679 (2019)
   PUBMED   31291942
  REMARK    GeneRIF: FAM168A involved in the regulation of AKT1/NFkappaB
            signaling pathway and cell cycle in chronic myeloid leukemia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7219)
  AUTHORS   Gu,Y., Zhang,Z., Yin,J., Ye,J., Song,Y., Liu,H., Xiong,Y., Lu,M.,
            Zheng,G. and He,Z.
  TITLE     Epigenetic silencing of miR-493 increases the resistance to
            cisplatin in lung cancer by targeting tongue cancer
            resistance-related protein 1(TCRP1)
  JOURNAL   J Exp Clin Cancer Res 36 (1), 114 (2017)
   PUBMED   28859669
  REMARK    GeneRIF: Our results highlight that hyper-methylation of miR-493CpG
            island might play important roles in the development of lung cancer
            chemo-resistance by targeting TCRP1, which might be used as a
            potential therapeutic target in preventing the chemo-resistance of
            lung cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7219)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7219)
  AUTHORS   Peng,B., Yi,S., Gu,Y., Zheng,G. and He,Z.
  TITLE     Purification and biochemical characterization of a novel
            protein-tongue cancer chemotherapy resistance-associated protein1
            (TCRP1)
  JOURNAL   Protein Expr Purif 82 (2), 360-367 (2012)
   PUBMED   22365988
REFERENCE   8  (bases 1 to 7219)
  AUTHORS   Peng,B., Gu,Y., Xiong,Y., Zheng,G. and He,Z.
  TITLE     Microarray-assisted pathway analysis identifies MT1X & NFkappaB as
            mediators of TCRP1-associated resistance to cisplatin in oral
            squamous cell carcinoma
  JOURNAL   PLoS One 7 (12), e51413 (2012)
   PUBMED   23251525
  REMARK    GeneRIF: siRNA-mediated knockdown of TCRP1 and MT1X was found to
            sensitize cells to cisplatin, leading to increased apoptosis and
            inhibition of cell proliferation
REFERENCE   9  (bases 1 to 7219)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   10 (bases 1 to 7219)
  AUTHORS   Gu,Y., Fan,S., Xiong,Y., Peng,B., Zheng,G., Yu,Y., Ouyang,Y. and
            He,Z.
  TITLE     Cloning and functional characterization of TCRP1, a novel gene
            mediating resistance to cisplatin in an oral squamous cell
            carcinoma cell line
  JOURNAL   FEBS Lett 585 (6), 881-887 (2011)
   PUBMED   21334329
  REMARK    GeneRIF: Data suggest that TCRP1 (EF363480) might be a novel
            molecular target to develop agents to reverse cisplatin-induced
            chemoresistance.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB074440.1, D87470.1, BC052341.1 and AP000763.5.
            
            On Jun 2, 2019 this sequence version replaced NM_001286050.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D87470.1, SRR14372079.1013366.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                DB074440.1         79-144
            67-708              D87470.1           1-642
            709-1723            BC052341.1         753-1767
            1724-7219           AP000763.5         21969-27464         c
FEATURES             Location/Qualifiers
     source          1..7219
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..7219
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /note="family with sequence similarity 168 member A"
                     /db_xref="GeneID:23201"
                     /db_xref="HGNC:HGNC:28999"
                     /db_xref="MIM:616316"
     exon            1..190
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            191..278
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..943
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tongue cancer chemotherapy resistance-associated protein
                     1; protein FAM168A"
                     /codon_start=1
                     /product="protein FAM168A isoform 1"
                     /protein_id="NP_001272979.1"
                     /db_xref="CCDS:CCDS73346.1"
                     /db_xref="GeneID:23201"
                     /db_xref="HGNC:HGNC:28999"
                     /db_xref="MIM:616316"
                     /translation="MNPVYSPVQPGAPYGNPKNMAYTGYPTAYPAAAPAYNPSLYPTN
                     SPSYAPEFQFLHSAYATLLMKQAWPQNSSSCGTEGTFHLPVDTGTENRTYQASSAAFR
                     YTAGTPYKVPPTQSNTAPPPYSPSPNPYQTAMYPIRSAYPQQNLYAQGAYYTQPVYAA
                     QPHVIHHTTVVQPNSIPSAIYPAPVAAPRTNGVAMGMVAGTTMAMSAGTLLTTPQHTA
                     IGAHPVSMPTYRAQGTPAYSYVPPHW"
     exon            279..359
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            360..386
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..512
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..655
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            656..830
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..961
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            962..7219
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6621..6626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /note="hexamer: AATAAA"
     polyA_site      6647
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
     regulatory      7196..7201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /note="hexamer: AATAAA"
     polyA_site      7219
                     /gene="FAM168A"
                     /gene_synonym="KIAA0280; TCRP1"
                     /note="major polyA site"
ORIGIN      
        1 gtcgggctcc tcggcggcta ctgcagagga ttcagagccg agtcgctgag gaggaggctc
       61 cggtccccgc gcgccatccg ccaccctact ggacacgggc gagagcgtcg ccgccgtagc
      121 ctccggagaa gacaagggca tcgccgcctc agccgccgcc gccgccgttt tcgcctgcag
      181 ctgctcaccg gatcctcagt cttccacaat gaaccctgtt tacagccccg tgcagcctgg
      241 ggctccttat ggcaacccta agaacatggc ctacacgggt taccccacag cctatccagc
      301 agctgcccct gcctacaatc ccagcctgta ccccaccaat agtcccagtt atgctccaga
      361 gtttcagttc ctgcattcag cttatgcaac tctgctgatg aaacaggcct ggccacagaa
      421 ctcgtcttcc tgtggcactg aaggcacctt ccacctccca gtggacaccg ggaccgagaa
      481 ccgaacttac caagcatcct ctgcggcttt cagatatact gcggggacac catacaaggt
      541 cccaccgacc cagagtaaca ctgctccacc cccctactcc ccatcaccca acccctatca
      601 gacggccatg tatccaatca gaagtgccta cccccagcag aatctgtatg cccagggagc
      661 ctactacaca cagccggtgt atgctgccca gcctcatgtc atccaccata ccacggtcgt
      721 ccagcccaac agcattccct ctgctatcta cccagcacct gttgccgccc cgaggaccaa
      781 cggtgtggcc atgggcatgg tggcaggcac caccatggca atgtcagcag gtaccctgct
      841 gactacaccc cagcacacgg cgattggggc acaccctgtc tccatgccaa catatagggc
      901 ccaaggaacc cctgcgtaca gctacgtgcc cccacactgg taaagcctgc agcccatcca
      961 aatctggagt cacacattgt atgcaactac tcaagtctta caccggtgct ggagcagttc
     1021 cctagcagca ccacctctat ttgcaagaag agacaacgga agtgcaaggg tcactttatg
     1081 catctttaat ggttttgatt tttatttttg gtttttgtaa aagctgcttt ttctaatctc
     1141 ctgcctctcc ccaactgtcc ccctcttagc ccctgccctt ccagctctat ccccttcctc
     1201 ctacctgacc aggccatgtc ctctctgctc ttccctaagt gtcctgtccc tggggatccc
     1261 agtctagagg caagcagaga gtagggttta ttgcagtggt tcatctgaag gctggattcc
     1321 atttgaagag cataaacaga tgtggtccag ggtaggaact cagagctgtt gagcaggcta
     1381 catctctagg ggagtgttct ggttgttttt tcttaagcaa gattagttca ggacattccc
     1441 atgtcccaga cacaaatgaa atgtctcctg agaaccattg caacagacca agaacaaaac
     1501 cacctgagta tgtaggcgtg ttattagcag cttaataccc caggctgaga acctggggaa
     1561 aaaagtcttt agaatttggg ggagggtggg gggagggagg gcattgtggg gaaggagagg
     1621 gaagaaggga ggagcggtgc ttgcctcatg gctttggttt gaaaggtctc tggccaaagc
     1681 atctggccct ggaccttctg atttgcacag tgatgttaac tgacctggca cttcctcaaa
     1741 aggtgatttt gtccttagac ctgccaagcg gctgcagggt ggtaggatcc cagcatcccg
     1801 aggccttgga aggccggatg ccctgtgtca tccagacttc agcctctgag ctgtcatgga
     1861 cccactctga tgaggagctt cctcctgatt ggagtgggaa cctagggcat ttctctccct
     1921 tttcttttgc ccttcccagt gccaggactc acctgtctga ccatagagct tgcaggcagg
     1981 ccaagctctt ggttacctgt gccattcatg gcccaagtga aggaaccaca ttccaggtgg
     2041 gtgctggcag ctctgaaggt gaggatagtg aaggaaaagc aatagcaata aacatttcat
     2101 agactcatgg aactgaaggg accttagcaa tcatctcatc catttcccta tttggcagat
     2161 gaggaaactg aggcccagag aagcggaaag gacttcccta gaccttacag taaattagca
     2221 ttaaatgcag ccttcctacc tagtgggcac cttgcttaca aaaatttacc tagggacgga
     2281 ttggcttggt tttgtaaaaa ttaagtcggc agcgcccata cctggtgagt ctggaatggt
     2341 ctctgggctc ctgtttctgc tcttttcctc cacggactcc aaaggcgggg gttgaagact
     2401 gggcagaggc tacatggggg cggatggcag gaacagaaat tgcaaatgaa gaaatagcat
     2461 ttggaaattc tgtgaagaca tctggaactt ccgtcctgta cctgactcca cctccaggag
     2521 aaggagcagg tggactggcc gaaaaggaga ggccatgctt ttaggacagt agcccctcat
     2581 cccgagagga gaggaagagg aggaagacag tgggagtcat caggagagga gaatgaggat
     2641 gaggcccagg agacaggctc atctgggaga agagggaccc ctgggacgag gaggtccctg
     2701 ctagtctcag ccaggagcct ggattgccca gcagcagcct ccggcaccca gcgcttggct
     2761 gggccagcag cccctctggg ggtggggcac gaacatttta ttgtaaaaaa tgggatcatt
     2821 gacaacattt gggactttaa aaaactgctt tcatttaaaa ttcatgcaaa cttggacata
     2881 tccttacccc aacctcccat gtctccctaa gggagggaaa aatcaggaaa cccttgggtt
     2941 ggaaggagct cagaagctgt ctagccattc ccaggagggt aaagcccatc agcctccttg
     3001 gcctagagcc aggagtttgg gggcccacct tcctgggctt ccaaggaact ttaggaccag
     3061 taagaaaaaa ttcagctgtt ctaaattatc tgttctgggt gctgatgagg tttcacttta
     3121 aaacaataga aagttttcca gtgttaattc actttttgca aatacctcct tccaccctct
     3181 ttggttttgt aaaggtgggt gaaggttgtt ctagattatg tcatacgtgt ttgaaaaatg
     3241 ccaaaataat aataatgata ataataatag aaacctttgg atttgtcagg tgcatcacag
     3301 aggtcaaagc acttcacggc ctttcatgta ctcgccctga gagggacagg gttagagtta
     3361 ttacagtcaa ttgacaaatg aggaaacagg ttatggaagg gaacaggccc acagtgagca
     3421 gcatgctggt atccgctagg cttcccagaa ccctgctgcc tccatgtggg ctggggtgga
     3481 accacagaga ggagaaagga agaagaggag acctaggaat gaccttgtaa cttttgttct
     3541 ttcaacacca gtaagtaaaa ctaacagctg gacctcacag ttcacagaac agttgaacat
     3601 aaattatctg gtttaacccg atgaaataga ggttatttct cctatttgat ccataaggaa
     3661 atcaaggctt ggaaaagtca agtgacttgc taataagtga cagagccact cgaatcccag
     3721 gctgtctgct gtctcgttcc cctccatctg atccccacac aggctcacgt actgaagcat
     3781 ctgtgctctg tgccctatct tagcacctac tatgtaattc aagagcaaag gggggcccca
     3841 aggtgaaaat aaggcactga aaggctgtgg tctggaagag cccaggtcca gcaccccttt
     3901 ttcagtatga gccccagttc agccggcctc agcctcttgc tgtgatggag atccacaagc
     3961 ctagccaagc ttggggagtc actgcaaaag gactgagccc aggagagcgg ggacagtcat
     4021 gtgcctctgg taggatgggc acagttactg gtaaggtcac agagatctag tgggaggtac
     4081 cataggtaga tacctccaaa gattctagat ggcacggtgg tcaagctaga caaaaagtca
     4141 gagctggaag ggccgtctca ttgaaggcag gcaagcaaga gaggacaagg gatgtagccg
     4201 cctgacagtg agctacagca ctggccccag gatgcaaacc cctctctcct cctcatgcca
     4261 ctgcctctcc ccaagtgcaa cacctatggc caggatcagg ggtacagatg gctcgttacc
     4321 agccaaccct tttgaattct tctacttcta cctgaccccc tctcctcact ggcctggggt
     4381 caagaagttt gagtctggga gctggattgc ctgcaaatag tgaaagcctg aaacataatg
     4441 gtttgccatg ttttgaaaaa aaatgcatat ttaatttctt cctcatgaga taggacagtt
     4501 gctgttcttt cttacctggc aatgacccta aaatgtatat cctctttcct gaatatttag
     4561 cagagacaca cacacctgtc cagagcgttt ttggtatgca aagtactttg acattggttg
     4621 ccaaagtcct ccattttata gatgaaaaaa ctaaggctca ggaggcttga gacttgctaa
     4681 aaggtcacac agcttggaag tgattcttca aatcctctgc tctttctgct gccacctgct
     4741 gggtctcttg gcaagcatgg agggaggggc taactgtact ttatagagct gggaagccca
     4801 gtctctgagc tgagcagatt tgtatgaact gctttgggcc aggacctgta atgagccctg
     4861 gggagggacc cagaggcaca tctaactggc agcacaagga ggatgagaat ttgcaactaa
     4921 aggcctcact tggacaaaac actttggggt cacaatgccc aggaccgaag acatgttcaa
     4981 ggacagcacg aggcatcttt ctattgggag acccatgtcc ttggtaagcc tgcacacctg
     5041 gcttcctaat ccctgagagc ctgcccactg tccagatcca gtgagttggt acaaaacgta
     5101 cagactgaag tccctgggct tgcttttccc atgggtgagg accagaacca gactctgagc
     5161 atccttaccc ctggccaccc gaattgttcc aagtttgagg taccccgttc ccagagatct
     5221 gggggtcctt ctttggaggg cttgctttgt tctgatggcc ttcagaaagg aatcacatga
     5281 agtataaaag gacaggcccc ttggtcacca agttttggct cctcatacag ataggactca
     5341 tccaggttcc cagcgaggca ctgactaagc gaggctcaga gcttccatat caaattcctc
     5401 agctttgttc tgtgcccaga gggggtgggc cccattctgg gccctgtgaa ctttgtctta
     5461 tatatcacca tctgtatcag aattcctcct caattgcagt taagtgaaaa tacgtggaag
     5521 tctgcttttc catcctgtat tctcccacat cactactggc tgtgcggccc ccgctgcttg
     5581 ccaagcttgg gaatccagag aggggcagta gtagagtggg ccagttggga cccacccgca
     5641 gagctgaaga aacacgccag actaactgat gggattccac accggagcct ctgagcgcac
     5701 aggcaggcat gccaaggggg ctgcagggtt tgtcctttac ttatctgccc ctttcctaga
     5761 aaactcctcg tttctgaaat taggcattat atggttccag gacccagcct tcaaaattcc
     5821 tggcaggcca gcttcaacat tccatggcca gccctgccta agccagactt gggtcccagt
     5881 ccctcagtct ctccagtgga tatcttctgt ggtgcatgct gttgagtcca acccaaaggc
     5941 caaccgaggc acacaggagt tgggactggc tgccacaaag ctagaaaggg acaaaacagc
     6001 acttgcttcc ctatggccac atggatagtc cctggatatc cttgctgtgg tagaggtcct
     6061 ctacccattc cagccactga tagcaggggg attttccttc ctaaggagaa cagatgtaac
     6121 agctttgcaa agtaccggcc cataggaatc aaatgggtga gatcagcttt gggcctgacc
     6181 ccagcaagac cagcatctcc agaccccagc ctttctcctc aggcctaaga gagtcaggga
     6241 aagagaggag actgtcccag agaccttctc ctcgggtcag ccagatagtc tggatctatg
     6301 gtgtgactca agctcctcct tacccagggg gggtaaggcc aggcctctag ctacttggag
     6361 ttgtctgtaa taatcttgaa aggcccaagg gcctgtcccc atcctgactt aaaggcatct
     6421 gcttccctgt ttcatatcac atgacagaga aacctgttct catggcatgt aacatccctg
     6481 tgaagagagc gttgtatatg attttgtatt ttttaattca ttttaatcta caggttggaa
     6541 tctaattttt aaattttatt ggaactcaca ttttaaaaag aaataaaatt taaaataata
     6601 ataataataa taataataat aataaacctt tgaccagtgt cttccaagta gtttgatcaa
     6661 agaatttata ggtgttttca aaacacagtc cggagtgtaa agattggaaa gccccatggc
     6721 cttgcctgtg tgtatgaagt gtaaatctgg ttttgttttg ttgttttgga ttcttttggg
     6781 tttttgtttt gttttgaaga tcagacagtg atcactctga aagattgaag ccaagaattt
     6841 gtaactatgg tatttactgt aagctgtaga acactcaata actattaaaa aaaaaaattc
     6901 ccccccaaaa aaaagtctta ggtgactaga ctgagtggtt cttggggagg gaggcacaga
     6961 ggactgtcct gggccagtga gtcccttggg cgtctcccca agttgatgct aaatttgttc
     7021 tcagtagtca agaaaaacct atggtacatc ttacagctga tctgacaggg gtctgcccta
     7081 agggtctcac agctgctggg gagctttaag tggcaacttc agcacccacc ctaagtgtgt
     7141 gatgtgggag cacagtgagg ccattcagag ttgaaatcca ttgagccatc cgcgcaataa
     7201 agctgacatc tattgtgtg
//
