LOCUS       NM_032648                947 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 167 member B
            (FAM167B), mRNA.
ACCESSION   NM_032648
VERSION     NM_032648.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 947)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (bases 1 to 947)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG282224.1 and BC004269.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032648.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004269.1, BU741530.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373582.4/ ENSP00000362684.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BG282224.1         7-17
            12-947              BC004269.1         1-936
FEATURES             Location/Qualifiers
     source          1..947
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2"
     gene            1..947
                     /gene="FAM167B"
                     /gene_synonym="C1orf90; DIORA-2"
                     /note="family with sequence similarity 167 member B"
                     /db_xref="GeneID:84734"
                     /db_xref="HGNC:HGNC:28133"
     exon            1..461
                     /gene="FAM167B"
                     /gene_synonym="C1orf90; DIORA-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..692
                     /gene="FAM167B"
                     /gene_synonym="C1orf90; DIORA-2"
                     /note="disordered autoimmunity 2"
                     /codon_start=1
                     /product="protein FAM167B"
                     /protein_id="NP_116037.2"
                     /db_xref="CCDS:CCDS358.2"
                     /db_xref="GeneID:84734"
                     /db_xref="HGNC:HGNC:28133"
                     /translation="MSLGLLKFQAVGEEDEEDEEGESLDSVKALTAKLQLQTRRPSYL
                     EWTAQVQSQAWRRAQAKPGPGGPGDICGFDSMDSALEWLRRELREMQAQDRQLAGQLL
                     RLRAQLHRLKMDQACHLHQELLDEAELELELEPGAGLALAPLLRHLGLTRMNISARRF
                     TLC"
     exon            462..947
                     /gene="FAM167B"
                     /gene_synonym="C1orf90; DIORA-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      924..929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM167B"
                     /gene_synonym="C1orf90; DIORA-2"
                     /note="hexamer: AATAAA"
     polyA_site      947
                     /gene="FAM167B"
                     /gene_synonym="C1orf90; DIORA-2"
                     /note="major polyA site"
ORIGIN      
        1 atacttggcc tcacacaccc atctgctcac tcaccctggc acattcagcc cccctaaccc
       61 accttgaaca ttgaccacca cacactccct ggcacgctct tctcaccctc aacttctgcc
      121 acctctccct gggcaatact gccagccttt ccctaatctc agagctgcag ccctgccctg
      181 tcactcacct caaacctgcc atgtccctgg ggctactgaa attccaggca gtgggtgaag
      241 aggacgagga ggatgaggag ggggagagcc tggactctgt gaaggcactg acagccaagc
      301 tgcagctgca gactcggcgg ccctcatatc tggagtggac agcccaggtc cagagccagg
      361 cctggcgcag ggcccaagcc aaacctggac cagggggacc tggggacatc tgtggtttcg
      421 actcaatgga ctccgccctt gagtggctcc gacgggagct gcgggagatg caggcgcagg
      481 acaggcagct ggcagggcag ctgctgcggc tgcgggccca gctgcaccga ctgaagatgg
      541 accaagcctg tcacctgcac caggagctgc tggatgaggc cgagctggag ctggagctgg
      601 agcccggggc cggcctagcc ctggccccgc tgctgcggca cctgggcctc acgcgcatga
      661 acatcagcgc ccggcgcttc accctctgct gaggaacacc tgtgcccccc gactccccgc
      721 cccctctccc aatgccgctt cccctgcctg cctgggaaga ggaaagggag gggtgcccca
      781 gaggcaccag ctcctggcgg gggaggagga acattcaggt ttctgagagc tgaattccaa
      841 gagtgcaaaa ccccagcatc ctgtttcctc tgctgaccca gctgggaggg ggaggaggag
      901 gagctcacac cctcaaactc ctcaataaac gctttctctg gttccca
//
