LOCUS       NM_053279               4067 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 167 member A
            (FAM167A), mRNA.
ACCESSION   NM_053279
VERSION     NM_053279.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4067)
  AUTHORS   Yang,T., Sim,K.Y., Ko,G.H., Ahn,J.S., Kim,H.J. and Park,S.G.
  TITLE     FAM167A is a key molecule to induce BCR-ABL-independent TKI
            resistance in CML via noncanonical NF-kappaB signaling activation
  JOURNAL   J Exp Clin Cancer Res 41 (1), 82 (2022)
   PUBMED   35241148
  REMARK    GeneRIF: FAM167A is a key molecule to induce BCR-ABL-independent
            TKI resistance in CML via noncanonical NF-kappaB signaling
            activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4067)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4067)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4067)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4067)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4067)
  AUTHORS   Ito,I., Kawasaki,A., Ito,S., Kondo,Y., Sugihara,M., Horikoshi,M.,
            Hayashi,T., Goto,D., Matsumoto,I., Tsutsumi,A., Takasaki,Y.,
            Hashimoto,H., Matsuta,K., Sumida,T. and Tsuchiya,N.
  TITLE     Replication of association between FAM167A(C8orf13)-BLK region and
            rheumatoid arthritis in a Japanese population
  JOURNAL   Ann Rheum Dis 69 (5), 936-937 (2010)
   PUBMED   19740902
  REMARK    GeneRIF: Results indicate the FAM167A-BLK region may be a shared
            genetic factor for a number of autoimmune diseases in multiple
            populations, but the genetic contribution may be grater in Asian
            populations.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4067)
  AUTHORS   Fung,E.Y., Smyth,D.J., Howson,J.M., Cooper,J.D., Walker,N.M.,
            Stevens,H., Wicker,L.S. and Todd,J.A.
  TITLE     Analysis of 17 autoimmune disease-associated variants in type 1
            diabetes identifies 6q23/TNFAIP3 as a susceptibility locus
  JOURNAL   Genes Immun 10 (2), 188-191 (2009)
   PUBMED   19110536
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4067)
  AUTHORS   Ito,I., Kawasaki,A., Ito,S., Hayashi,T., Goto,D., Matsumoto,I.,
            Tsutsumi,A., Hom,G., Graham,R.R., Takasaki,Y., Hashimoto,H.,
            Ohashi,J., Behrens,T.W., Sumida,T. and Tsuchiya,N.
  TITLE     Replication of the association between the C8orf13-BLK region and
            systemic lupus erythematosus in a Japanese population
  JOURNAL   Arthritis Rheum 60 (2), 553-558 (2009)
   PUBMED   19180478
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 4067)
  AUTHORS   Hom,G., Graham,R.R., Modrek,B., Taylor,K.E., Ortmann,W.,
            Garnier,S., Lee,A.T., Chung,S.A., Ferreira,R.C., Pant,P.V.,
            Ballinger,D.G., Kosoy,R., Demirci,F.Y., Kamboh,M.I., Kao,A.H.,
            Tian,C., Gunnarsson,I., Bengtsson,A.A., Rantapaa-Dahlqvist,S.,
            Petri,M., Manzi,S., Seldin,M.F., Ronnblom,L., Syvanen,A.C.,
            Criswell,L.A., Gregersen,P.K. and Behrens,T.W.
  TITLE     Association of systemic lupus erythematosus with C8orf13-BLK and
            ITGAM-ITGAX
  JOURNAL   N Engl J Med 358 (9), 900-909 (2008)
   PUBMED   18204098
  REMARK    GeneRIF: identified and confirmed through replication two new
            genetic loci for SLE: a promoter-region allele associated with
            reduced expression of BLK and increased expression of C8orf13 and
            variants in the ITGAM-ITGAX region
REFERENCE   10 (bases 1 to 4067)
  AUTHORS   Appel,S., Filter,M., Reis,A., Hennies,H.C., Bergheim,A.,
            Ogilvie,E., Arndt,S., Simmons,A., Lovett,M., Hide,W., Ramsay,M.,
            Reichwald,K., Zimmermann,W. and Rosenthal,A.
  TITLE     Physical and transcriptional map of the critical region for
            keratolytic winter erythema (KWE) on chromosome 8p22-p23 between
            D8S550 and D8S1759
  JOURNAL   Eur J Hum Genet 10 (1), 17-25 (2002)
   PUBMED   11896452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL522457.3 and AJ301564.1.
            
            On Nov 22, 2018 this sequence version replaced NM_053279.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL834122.1, SRR1660809.173229.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284486.9/ ENSP00000284486.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AL522457.3         15-91
            78-4067             AJ301564.1         1-3990
FEATURES             Location/Qualifiers
     source          1..4067
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..4067
                     /gene="FAM167A"
                     /gene_synonym="C8orf13; D8S265; DIORA-1"
                     /note="family with sequence similarity 167 member A"
                     /db_xref="GeneID:83648"
                     /db_xref="HGNC:HGNC:15549"
                     /db_xref="MIM:610085"
     exon            1..128
                     /gene="FAM167A"
                     /gene_synonym="C8orf13; D8S265; DIORA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            129..906
                     /gene="FAM167A"
                     /gene_synonym="C8orf13; D8S265; DIORA-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             526..1170
                     /gene="FAM167A"
                     /gene_synonym="C8orf13; D8S265; DIORA-1"
                     /note="disordered autoimmunity 1"
                     /codon_start=1
                     /product="protein FAM167A"
                     /protein_id="NP_444509.2"
                     /db_xref="CCDS:CCDS5981.1"
                     /db_xref="GeneID:83648"
                     /db_xref="HGNC:HGNC:15549"
                     /db_xref="MIM:610085"
                     /translation="MSVPQIHVEEVGAEEGAGAAAPPDDHLRSLKALTEKLRLETRRP
                     SYLEWQARLEEHTWPFPRPAAEPQASLEEGERGGQEPLLPLREAGQHPPSARSASQGA
                     RPLSTGKLEGFQSIDEAIAWLRKELTEMRLQDQQLARQLMRLRGDINKLKIEHTCRLH
                     RRMLNDATYELEERDELADLFCDSPLASSFSLSTPLKLIGVTKMNINSRRFSLC"
     exon            907..4067
                     /gene="FAM167A"
                     /gene_synonym="C8orf13; D8S265; DIORA-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4026..4031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM167A"
                     /gene_synonym="C8orf13; D8S265; DIORA-1"
                     /note="hexamer: AATAAA"
     polyA_site      4067
                     /gene="FAM167A"
                     /gene_synonym="C8orf13; D8S265; DIORA-1"
                     /note="major polyA site"
ORIGIN      
        1 gagaattcac cggagctcgg ggaggcgagg cgggagccct gagctgaggc cgggcagcgc
       61 ggacccgcgc aggaggaggc ggcggggaca ccggcgagtc cccagcaggg cccctgggct
      121 cccggaaggg tctccagcca cctgcccttc ccgagaagag agagctctgg gccttcttcc
      181 tgccagtctg gtcttcgagt gcgttcagga cagatagacc ttggcacagg ctgccccgag
      241 attcctgcga cgctgtctgt tcctgccttc tgtggagcat ggcacccaca ggcttccagg
      301 acggatcata gacccgagcc tccaggaggg cgccctgtgc ggctcactgc gcggtccctc
      361 tcagctcccc tgccacccag cctctgaggc cggctcctgt cccggaaatg ccctcgggca
      421 cctggatgag gccatcccag agcgggaccc aactgtgcca cccaccaagc ctccccctgc
      481 gccccccgtg ccctcgcatg tccggctgcc agggcagact gtagaatgtc tgtgccccag
      541 atccacgtgg aagaagtggg tgcagaagag ggggcgggag cagccgcacc acccgatgac
      601 cacctccgga gcctgaaggc cctcaccgag aaactgaggc tggagacccg caggccctcc
      661 tacctggaat ggcaggccag gctggaggag catacctggc ccttcccgag gccggctgcg
      721 gagccacagg cgagcttgga ggagggggag cgtggggggc aggagccctt gctccccctg
      781 agagaggctg ggcagcaccc cccttctgcc aggagtgcca gccaaggtgc cagacccctg
      841 tccactggca agctggaagg ctttcagagc atcgatgaag ctatagcctg gctcaggaag
      901 gaactgacgg agatgcggct gcaggaccag caactggcca gacagctcat gcgcctgcgt
      961 ggcgacatca acaagctgaa aatcgaacac acctgccgcc tccacaggag gatgctcaac
     1021 gatgccacct acgagctgga ggagcgggat gagctggccg acctcttctg tgactcccct
     1081 cttgcctcct ccttcagcct ctccacacca ctcaagctta ttggcgtgac caagatgaac
     1141 atcaactctc ggaggttctc tctctgctga ggagccctca gactgggcgg aggggctgga
     1201 gcggagggct tgggctggag gggtgtcaga ggaagctgag gccaagttac tccagtgggt
     1261 ctcccggagg caggggtccc tgggactggc gactcaaggg ccccaggacc tattcagtgg
     1321 tgctctccca cccaggggcc ctgggtgtgg atgccagtgt ctctgtgact ggctcttgct
     1381 tactacccaa agagctctgc agaagggccg ctccaaccaa gatgttaaag gagacctggg
     1441 ttcccaccat aatccatccc tccacggtca cgttcctgtt tcctggaatc actggtgcta
     1501 tgaactggga ttcccaaagg gaggcccccc aacaaagctg tcatttttgc agaaggctgt
     1561 cccgcaaggg ccttggggga aattaggcat gtcagatgtg cctgtctcac gtgctgttgc
     1621 tgtcctctaa gtattgtctc aaattcaccc taagtacatg actcagcaac attgacaggg
     1681 agctactagg aagggaaaat cgaaaggcat gacaaatggg cacttgggga cgcagcccca
     1741 gtggctggca gccagtgtct ctggtgagcc tgacactata aggctgtgta aattgtaaat
     1801 tctggcgtgt gctgggacat gtgatggggg cactagcgta gcttgggtgc aacaagcaca
     1861 gatgtcccca ttgtctcccc tggccacatg catctccaaa gagcctcttc actgccaccc
     1921 acaccccagg gtgacagcct gggagaccac tggtgactga accaggcagg tcctgaaagc
     1981 attttccata actgaattct cctgcagggg cgtgaccggg gcctcctggt ggattctggt
     2041 ggtgtcacct tactgccctc tctggaaaga caatctaggg agcccagagg cccatcctga
     2101 gcctcctctg agattttgtg cctgacctaa acaactagtt ttaataagac tgttactgat
     2161 gtgttgttca cttgttagta actgattttt gtccaaatgc ggaagccact tgtgtaggtc
     2221 aactacagtg cgtaggattt gattttaaga gtttctccct cccaacaggc ttgaggatca
     2281 gcaagttaag accccagcag gttagggagg tcagtctggg gtcatacggc atggcagggg
     2341 tccctcggcc agacccgtag aatcctgaga taaggagtgt ttctgacctt tggtgtcatc
     2401 tagtcgagtc ctctcattag taaaggagca aagtgaaacc tgggggagga gaaggacttc
     2461 cctcaggttg cacagctgtt taggctatag aatattgatg tgtgaaacca ttattgataa
     2521 tgcctagtag atcacatgtc aatgaacttg aaccccaaag atggtcgtga tgctttgcca
     2581 aacccgcaca ctgccaaccc ctctactctc cacctcagcc cccacccaca tctcccagag
     2641 tattgcaatt cagaacattt gggtcaaggt ggagcaaggc actgacagtg gccccacagg
     2701 gcatgtgtca ctaatcactg tcccatggtc tacgcacggc atctggctgc tctgtctact
     2761 gtgacttctt cctgtgtaat ctcagtgggg cccgtgtcca cccacacatc gtgacccaca
     2821 taggggagag gttgcttttc ttttgtgggc tgagagtagg acaatgcaaa tgaatgatct
     2881 ctagtagaca gaaaagaact tggtctcttt tttaaaattt caaagagcca gaagttctat
     2941 gcctccttca aagtaggcag aacaacgcag ccaagatcta ctgtctgcca tgctctgtgc
     3001 aatgaagtct gcaggcctga ggaccatgta ctgctgtcct tcctcagagc tctgcacaaa
     3061 cactgccaag tcctgaagac gcattccttt cctgccaacc tctttccaga taagcccttg
     3121 aggtctcggg ctgacctaca cacacacaca cacacacaca cacacacacc cccacacaca
     3181 cacacacgac agagaacatg ccataaacat ccttgaaccc atgcaggaaa gcccatccca
     3241 tattctgaaa aaatgccaaa ttaggttttt ctttcttttt ggaaatcagt cattacagta
     3301 accgaaacca ttgggttcag cgaaaatgga aagatttagc tgaatgtagt cagtccaatt
     3361 aagttggatg caactgagtg atttagttgc ttgggtaacc cagtgcttgc ttgctttctt
     3421 cattctctgg gtggaaacta agatcaagac acatgtttgg ggataagtta aatgtctgag
     3481 ctattttgct cggtttatcc taagagaact ttattatggg atgaggaggt gacccaagat
     3541 gagaagtgga gggggacagc gatgttttct aaacatcgtc cagtgttgac tggcttcctt
     3601 actttgcaca gtgaacacaa ctaaccacat taattcagct ttgtgaagtc cctgctctct
     3661 gtgggtctat gagtcagcag caacattggc ctaacctccg tcccagcctc ctggctcacc
     3721 acatgtgtac agtgctgttt gcagttgtac tcattatcca tccatctctc tgccatcccc
     3781 aagcatcgct gggtgtaaaa cgcaaactct ccaccgacac tgccatgcgt ggtcatgtct
     3841 tgatgccttc aggggctcag tagctatcaa agaggcctgg agggcctggg caggcttgac
     3901 gatgcctgac cgagttcaag acccacaccc tgtagcaata ccaagtgcta ttacataatc
     3961 aatggacgat ttatactttt attttttatg attatttgtt tctatattgc tgttagaaaa
     4021 agtgaaataa aaatacttca aaagaagata tccatataaa aataaaa
//
