LOCUS       NM_001080515            2778 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens family with sequence similarity 163 member B
            (FAM163B), transcript variant 1, mRNA.
ACCESSION   NM_001080515 XM_005272203 XM_926352
VERSION     NM_001080515.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2778)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2778)
  AUTHORS   Miwa,H. and Itoh,N.
  TITLE     Unknown genes, Cebelin and Cebelin-like, predominantly expressed in
            mouse brain
  JOURNAL   Heliyon 4 (9), e00773 (2018)
   PUBMED   30294689
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2778)
  AUTHORS   Sundell,G.N., Arnold,R., Ali,M., Naksukpaiboon,P., Orts,J.,
            Guntert,P., Chi,C.N. and Ivarsson,Y.
  TITLE     Proteome-wide analysis of phospho-regulated PDZ domain interactions
  JOURNAL   Mol Syst Biol 14 (8), e8129 (2018)
   PUBMED   30126976
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2778)
  AUTHORS   Ivarsson,Y., Arnold,R., McLaughlin,M., Nim,S., Joshi,R., Ray,D.,
            Liu,B., Teyra,J., Pawson,T., Moffat,J., Li,S.S., Sidhu,S.S. and
            Kim,P.M.
  TITLE     Large-scale interaction profiling of PDZ domains through proteomic
            peptide-phage display using human and viral phage peptidomes
  JOURNAL   Proc Natl Acad Sci U S A 111 (7), 2542-2547 (2014)
   PUBMED   24550280
REFERENCE   5  (bases 1 to 2778)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002101.1 and BX629352.5.
            
            On or before Jul 16, 2019 this sequence version replaced
            XM_005272203.5, NM_001080515.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.1453635.1,
                                           SRR14038197.1334119.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000673969.1/ ENSP00000501259.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-313               AC002101.1         20695-21007         c
            314-429             BX629352.5         13653-13768         c
            430-2778            BX629352.5         10603-12951         c
FEATURES             Location/Qualifiers
     source          1..2778
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.2"
     gene            1..2778
                     /gene="FAM163B"
                     /gene_synonym="C9orf166"
                     /note="family with sequence similarity 163 member B"
                     /db_xref="GeneID:642968"
                     /db_xref="HGNC:HGNC:33277"
     exon            1..313
                     /gene="FAM163B"
                     /gene_synonym="C9orf166"
                     /inference="alignment:Splign:2.1.0"
     exon            314..429
                     /gene="FAM163B"
                     /gene_synonym="C9orf166"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..837
                     /gene="FAM163B"
                     /gene_synonym="C9orf166"
                     /note="cebelin-like"
                     /codon_start=1
                     /product="protein FAM163B"
                     /protein_id="NP_001073984.1"
                     /db_xref="CCDS:CCDS35171.1"
                     /db_xref="GeneID:642968"
                     /db_xref="HGNC:HGNC:33277"
                     /translation="MTAGTVVITGGILATVILLCIIAVLCYCRLQYYCCKKDESEEDE
                     EEPDFAVHSHLPPLHSNRNLVLTNGPALYPTASTSFSQKSPQARALCRSCSHCEPPTF
                     FLQEPPEEEEDVLNGGERVLYKSVSQEDVELPPGGFGGLQALNPNRLSAMREAFARSR
                     SISTDV"
     exon            430..2778
                     /gene="FAM163B"
                     /gene_synonym="C9orf166"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2761..2766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM163B"
                     /gene_synonym="C9orf166"
                     /note="hexamer: AATAAA"
     polyA_site      2778
                     /gene="FAM163B"
                     /gene_synonym="C9orf166"
                     /note="major polyA site"
ORIGIN      
        1 agcgcgcgcc ctgcgctcgg gaccaggctg gagccgcgcg tgcagctcgc agggagccag
       61 ccggggcgtc cggagtcgcg gccgcagcgc ggagctggca ggggtgcccg cctgggcacg
      121 cagtcgcctc cccgggggcc tcccgggctt ctcagcgccc gcctcgcccg cccagccaca
      181 ccaggcgcca ccgccgtggc ctgggcatga gcggccgccg ctagctgcgc cctgcccggg
      241 tcggacgccc gcccgccccg tcacgtgcgc ccaagtcctc gcggccgggg cagcgcggtt
      301 cccatgcttc aaggctgttg atggagaagg gggcggatga cagccgggac cgtggtcatc
      361 accgggggca tcttggcgac tgtgattttg ctctgcatca tcgctgttct gtgctactgc
      421 cggctccagt actactgctg caagaaggac gagtcggagg aggacgagga ggaaccagac
      481 ttcgccgttc actcgcacct gcccccgctg cactccaacc gcaacctggt gctgaccaac
      541 gggccggcgc tctaccccac cgcctccacc tccttcagcc agaagtcccc gcaggcccgc
      601 gccctctgcc gcagctgctc ccactgcgag ccccccacct tcttcctgca ggagccgccg
      661 gaggaggaag aggacgtgct gaacggcggg gagcgcgtgc tctacaagag cgtgagccag
      721 gaggacgtgg agctgccccc ggggggcttc gggggcctgc aggcgctcaa ccccaaccgc
      781 ctctcagcca tgcgggaggc cttcgccagg agccgcagca tcagcaccga cgtgtgacct
      841 gggcccgccc ccgggatcct ggccttgaag gtcctgagac aatgggggga ttcctttggc
      901 acacccacct ggccccaggc cccaagtggg gcttggctga gccctcctgg aatccctgtc
      961 ctcaggggag gcccaggctt ggggagcccc caggctcgtg gcagggataa ggctcattga
     1021 acacaaatgt gtcctggggg gaggcacagc tggggcctgg ggctagaagg accaggtgac
     1081 catacagccg gctgggcatg caccagggct ctcaggcaca gaggccaccg ttactcctga
     1141 tgattctgtc tcagacccaa caacctggcc ttcccaggag gtctccatgt gtcaccccct
     1201 ccctgggtct cacccttctc acctgctcaa ggaagggatg acctcagtga ggcccagggc
     1261 cctgcagcaa ggccctccct ggcaattgca gaccaaggat tctgctcctc caccttgaac
     1321 tccagcctct ttctctccat ttttccctct ctctccccta cccgtctctc cctctctctc
     1381 acacacacac tcttccgggt tcaagggcca agtgtctgcc taggctgaga cacgtgctga
     1441 gctccctgaa gatggaccag ctgcccccta gaagggagac tttcaggggc atcagggccc
     1501 ttgggatgct ccgccctgac cagctttttg gtggcagagg gaggcacggg gagagggaga
     1561 ggccatgtcg cagtccccct gccgtgggag aggcaacgtg gaaatgtata gacccagtgc
     1621 tcagccagaa acagggccag caagcggcag tgaacggagg cagcccgggg ctcgtcaggg
     1681 gcagagccat ggcccagggg ttgaaaaccc ccgagttccc cgtgagactt ggctggccct
     1741 tcccacccct gggcctcagt ctccccatct tgtgtgatga ggagagaccc tgaggacaga
     1801 ggtcttcagg ctgtgggtct caacaggaac tgagatcccc aagggagaca gagttgcagg
     1861 tcacctcccc tacctgcttc tcagcaggac ctaggaggcc tggcccagct cctggtggac
     1921 cccaagcagc cagagcctac tgctgccatc tgaagacctc atctgagccc actttccacc
     1981 aagcgcccac ccaggctgag gtctcctggg aattctcacc cgctctcctg ctgctaagga
     2041 aatgacgtca atggctaccc cagagaaatg ccccacatcc caggacacca gccatcagga
     2101 aggcagctct tcctcaccca gaaagaggca attatttcct ctcagcagcc tggccccagg
     2161 agcccccttc cctctctggg gctctgcctc tccttttgtg ccctgccatg gagccccagg
     2221 gccggggcag cccctctctg cccagggaag gcaccgccct caaagacaag gcttggccgg
     2281 gcagtgacct tccctgagcg gaggggtggc ttgagcagga cacttcttgc ccttactcaa
     2341 aaacgaaatg gccagtttcc agaggcgtcg ggggaacggc tgacgaagtc acaatcgtta
     2401 tgttctcaat tgttttcctc ctcttacttt ctctcctgcc tcgtttggac aggccagtgg
     2461 cattcgccct tgaggtccct cgcagccccg gccccccggg cccgcccaca cctctggctt
     2521 cctctgtgca tcctgtgaag tctgtttctg atgcgttggc gtggggggtg ggctgggtgg
     2581 ggtggggatg agggcccagc cctcatgatt ccatttccca attcctttct ggtctccatc
     2641 ctctctgtag atatgtagat ctctttgaaa cgaagtaagc acccatccct cccagctcac
     2701 tcggctccac cgtggggacc tgctggggga gccgctggct ccctgaggaa agtgaaagcc
     2761 aataaaacat ctcccaca
//
