LOCUS       NM_173509               2781 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 163 member A
            (FAM163A), transcript variant 2, mRNA.
ACCESSION   NM_173509
VERSION     NM_173509.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2781)
  AUTHORS   Han,X., Pan,S., Liu,J., Ding,X., Lin,X., Wang,D., Xie,Z., Zeng,C.,
            Liu,F., He,M., Zhou,X., Liu,T., Luo,L. and Liu,Y.
  TITLE     Novel loci for ocular axial length identified through
            extreme-phenotype genome-wide association study in Chinese
            populations
  JOURNAL   Br J Ophthalmol 108 (6), 865-872 (2024)
   PUBMED   37524447
  REMARK    GeneRIF: Novel loci for ocular axial length identified through
            extreme-phenotype genome-wide association study in Chinese
            populations.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2781)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2781)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2781)
  AUTHORS   Miwa,H. and Itoh,N.
  TITLE     Unknown genes, Cebelin and Cebelin-like, predominantly expressed in
            mouse brain
  JOURNAL   Heliyon 4 (9), e00773 (2018)
   PUBMED   30294689
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2781)
  AUTHORS   Vasudevan,S.A., Shang,X., Chang,S., Ge,N., Diaz-Miron,J.L.,
            Russell,H.V., Hicks,M.J., Ludwig,A.D., Wesson,C.L.,
            Burlingame,S.M., Kim,E.S., Khan,J., Yang,J. and Nuchtern,J.G.
  TITLE     Neuroblastoma-derived secretory protein is a novel secreted factor
            overexpressed in neuroblastoma
  JOURNAL   Mol Cancer Ther 8 (8), 2478-2489 (2009)
   PUBMED   19671756
  REMARK    GeneRIF: NDSP is specifically overexpressed in neuroblastoma and
            actively secreted from tumor cells. Furthermore, NDSP serves as a
            growth factor for neuroblastoma tumor cells through activation of
            the ERK-mediated proliferation pathway.
            Erratum:[Mol Cancer Ther. 2009 Sep;8(9):2771. Shang, Xiaoyi
            [corrected to Shang, Xiaoying]]
REFERENCE   6  (bases 1 to 2781)
  AUTHORS   Vasudevan,S.A., Russell,H.V., Okcu,M.F., Burlingame,S.M., Liu,Z.J.,
            Yang,J. and Nuchtern,J.G.
  TITLE     Neuroblastoma-derived secretory protein messenger RNA levels
            correlate with high-risk neuroblastoma
  JOURNAL   J Pediatr Surg 42 (1), 148-152 (2007)
   PUBMED   17208556
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC009382.2.
            
            On Jun 2, 2019 this sequence version replaced NM_173509.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY902195.1, BC009382.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2159764
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341785.5/ ENSP00000354891.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2781              BC009382.2         129-2909
FEATURES             Location/Qualifiers
     source          1..2781
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.2"
     gene            1..2781
                     /gene="FAM163A"
                     /gene_synonym="C1orf76; NDSP"
                     /note="family with sequence similarity 163 member A"
                     /db_xref="GeneID:148753"
                     /db_xref="HGNC:HGNC:28274"
                     /db_xref="MIM:611727"
     exon            1..133
                     /gene="FAM163A"
                     /gene_synonym="C1orf76; NDSP"
                     /inference="alignment:Splign:2.1.0"
     exon            134..224
                     /gene="FAM163A"
                     /gene_synonym="C1orf76; NDSP"
                     /inference="alignment:Splign:2.1.0"
     exon            225..246
                     /gene="FAM163A"
                     /gene_synonym="C1orf76; NDSP"
                     /inference="alignment:Splign:2.1.0"
     exon            247..361
                     /gene="FAM163A"
                     /gene_synonym="C1orf76; NDSP"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..772
                     /gene="FAM163A"
                     /gene_synonym="C1orf76; NDSP"
                     /note="cebelin; neuroblastoma derived secretory protein"
                     /codon_start=1
                     /product="protein FAM163A"
                     /protein_id="NP_775780.1"
                     /db_xref="CCDS:CCDS1333.1"
                     /db_xref="GeneID:148753"
                     /db_xref="HGNC:HGNC:28274"
                     /db_xref="MIM:611727"
                     /translation="MTAGTVVITGGILATVILLCIIAVLCYCRLQYYCCKKSGTEVAD
                     EEEEREHDLPTHPRGPTCNACSSQALDGRGSLAPLTSEPCSQPCGVAASHCTTCSPYS
                     SPFYIRTADMVPNGGGGERLSFAPTYYKEGGPPSLKLAAPQSYPVTWPGSGREAFTNP
                     RAISTDV"
     exon            362..2781
                     /gene="FAM163A"
                     /gene_synonym="C1orf76; NDSP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2760..2765
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM163A"
                     /gene_synonym="C1orf76; NDSP"
                     /note="hexamer: AACAAG"
     polyA_site      2781
                     /gene="FAM163A"
                     /gene_synonym="C1orf76; NDSP"
                     /note="major polyA site"
ORIGIN      
        1 agtcctcgga gcgccgggga ggccgcggag cctcacgtgt gccgccccag ccgctggcgc
       61 ccggaaggac gcgctgcgac cccgtgggag ccgaacgcgg gagtcgctgc ccgagcggag
      121 ctgctcagcc gcgggactga tgcccttggc cagacgcacc cccaactgct gtctgctcag
      181 gtgtagcccg cgtgactgag tcaccgctgc tccagctgtt tcacgtcgcc gttcccttta
      241 ctgaatagtt tgatggggcg ccgggcggat gacagcggga acggttgtga tcactggcgg
      301 aatcctagct acggtgatcc tcctctgcat cattgccgtc ctgtgctact gcaggctcca
      361 gtattactgc tgcaagaaga gcggaaccga ggttgcagac gaggaggagg agcgggagca
      421 cgaccttccc acgcatccca gaggccccac ctgcaatgcc tgcagctccc aagccctgga
      481 cggcagaggc agcctggcgc ctctcaccag cgagccctgc agccagccct gtggggtggc
      541 cgcgagccac tgcactacct gctccccata cagctccccc ttttacatac ggacggctga
      601 catggtgccc aatgggggtg gaggcgagag gctctccttt gctcccacat actacaaaga
      661 ggggggaccc ccatccctca aattggcagc accccagagt tacccggtga cctggccagg
      721 ctctgggcgt gaggccttca ccaatccaag ggctattagt acagacgtgt aaatccttcc
      781 accccgaccc gcacacacac ccacactgct gccctggcgg gggccatggg ggtgatgaat
      841 gaccctccaa cagccccaca tgggttgttt ctgtttcttt ggcttttctc gctccgcagt
      901 ggagggttta ctaggattta agcttttgag tgcattgaga accaagacag ggcctggctc
      961 caactctgtg ggccagaggt gggggactgc taggtcgagt ctgcagcttc gccagtttct
     1021 tggttgggac actcctctgg cagccccagc accaccacaa ccccttgcag tgtgccccag
     1081 tcccctggat tcgctggact gcaaaaagga gcaccaggga aagctcagca aaggctcagg
     1141 aggcctcccg ggtcctcggg agatgaagca tccgtgccta ggaaaagggg acagagggca
     1201 aggagagaag tgagagctac aattccagca ttggagaagc gaggggcggg gcgtcaacgg
     1261 cactgcttca ggacgcgctt gctgaaacga ctccaacagc tagttcacag cccagctttg
     1321 tacgttggtt accatagcta ctgctgtcac tgtagctgct cccgtagggt cgttgattcc
     1381 tgaacgtatc acatctcacc tgcccccttc ctcgtgggac gtgtcaagtt gactttaaag
     1441 cctaaggtgg cttgtgggga ctgcaccaga aagtgtctaa ccttgtgttc cccgaaatcc
     1501 tttctctgac ttaggaacca gcgccccctg ctggagaagt tttttcattt tgttagccga
     1561 cttctggtag cttagcaaag agaccagctg actgtctctc ggcccagccc accacgccga
     1621 gtagcttgtg tggatgcagt cctgtgaggg tgtgcataac cgttcccagg tgtacgcacg
     1681 cgcgcgcgcg cgcacagaca cacacacaca cacacacaca cacacacaca cacagtaacc
     1741 acgggtaggc accaggggct ttgtacattc aggagctgca gagaggaaag gtctcccatg
     1801 taccagagaa ggaaaagtct gatcccgaaa cagcttgaac gaaaggtggt taacacgtga
     1861 ccaatcccca tggcagacag cgggctggtg aacaggaaga gcacagaatc tctgtggggc
     1921 gatgctgcag cggctgaaac cacgtcaagt cccccagagc ccggcattct atgtaagcat
     1981 ccacctgtga cgccgtggag caggatcttc attcatctca ccagagcaac agcccagtcc
     2041 tgaggatggg agggacgtga cttagccttg ggattccacg ctcgccgccc tcccttggcc
     2101 gccctactcc ccagtttcct ggcgatgagc catttattgt gtctcacacc agcctcattt
     2161 ccaactccga cttcctactt agaatgtggc agtggctttg tgagtgagaa tcctgatgag
     2221 ttttccagtg gcctctgcag aagctggccc ccttctaagg gcatagctaa cccccttccc
     2281 actcctgagt cactgaattc gaggagggtg gggcagggaa agggctggcc cccctgctga
     2341 aatcttgatt ctgcatttga ggaaggtcag ggtgccgctg ggggagcagg gagcggggag
     2401 ggaggaagag gggaatgcac atcttttgcg ccactattaa ggcacctgtc accttacatc
     2461 tcaatctgga atcaaagtgc cctgggttga gaagcagacc tgggctctgg tcacactttg
     2521 gtcactcatt agctctagga ccagtcacta atctctgaga ctccattttc tccagggaaa
     2581 cgaggcttgc ccagatagac taacaaccct ttagtgctcc aagaagtgag aatttccgaa
     2641 aaagatctgc cggcccagag cactccctct tgccctaatc ctggcagggt ctggatgtat
     2701 ttacccaact ctgatcttgc gtgcagggat gcttgctgat ggatgaaaga ccacaataaa
     2761 acaagattag cagcaaaaca a
//
