LOCUS       NM_001329713            2976 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 163 member A
            (FAM163A), transcript variant 3, mRNA.
ACCESSION   NM_001329713
VERSION     NM_001329713.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2976)
  AUTHORS   Han,X., Pan,S., Liu,J., Ding,X., Lin,X., Wang,D., Xie,Z., Zeng,C.,
            Liu,F., He,M., Zhou,X., Liu,T., Luo,L. and Liu,Y.
  TITLE     Novel loci for ocular axial length identified through
            extreme-phenotype genome-wide association study in Chinese
            populations
  JOURNAL   Br J Ophthalmol 108 (6), 865-872 (2024)
   PUBMED   37524447
  REMARK    GeneRIF: Novel loci for ocular axial length identified through
            extreme-phenotype genome-wide association study in Chinese
            populations.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2976)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2976)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2976)
  AUTHORS   Miwa,H. and Itoh,N.
  TITLE     Unknown genes, Cebelin and Cebelin-like, predominantly expressed in
            mouse brain
  JOURNAL   Heliyon 4 (9), e00773 (2018)
   PUBMED   30294689
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2976)
  AUTHORS   Vasudevan,S.A., Shang,X., Chang,S., Ge,N., Diaz-Miron,J.L.,
            Russell,H.V., Hicks,M.J., Ludwig,A.D., Wesson,C.L.,
            Burlingame,S.M., Kim,E.S., Khan,J., Yang,J. and Nuchtern,J.G.
  TITLE     Neuroblastoma-derived secretory protein is a novel secreted factor
            overexpressed in neuroblastoma
  JOURNAL   Mol Cancer Ther 8 (8), 2478-2489 (2009)
   PUBMED   19671756
  REMARK    GeneRIF: NDSP is specifically overexpressed in neuroblastoma and
            actively secreted from tumor cells. Furthermore, NDSP serves as a
            growth factor for neuroblastoma tumor cells through activation of
            the ERK-mediated proliferation pathway.
            Erratum:[Mol Cancer Ther. 2009 Sep;8(9):2771. Shang, Xiaoyi
            [corrected to Shang, Xiaoying]]
REFERENCE   6  (bases 1 to 2976)
  AUTHORS   Vasudevan,S.A., Russell,H.V., Okcu,M.F., Burlingame,S.M., Liu,Z.J.,
            Yang,J. and Nuchtern,J.G.
  TITLE     Neuroblastoma-derived secretory protein messenger RNA levels
            correlate with high-risk neuroblastoma
  JOURNAL   J Pediatr Surg 42 (1), 148-152 (2007)
   PUBMED   17208556
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB066264.1, AK292432.1, AL359853.18 and BC009382.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001329713.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292432.1, DB067001.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 128071543
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DB066264.1         14-17
            5-220               AK292432.1         2-217
            221-221             AL359853.18        35811-35811
            222-1327            AK292432.1         219-1324
            1328-2976           BC009382.2         1261-2909
FEATURES             Location/Qualifiers
     source          1..2976
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.2"
     gene            1..2976
                     /gene="FAM163A"
                     /gene_synonym="C1orf76; NDSP"
                     /note="family with sequence similarity 163 member A"
                     /db_xref="GeneID:148753"
                     /db_xref="HGNC:HGNC:28274"
                     /db_xref="MIM:611727"
     exon            1..70
                     /gene="FAM163A"
                     /gene_synonym="C1orf76; NDSP"
                     /inference="alignment:Splign:2.1.0"
     exon            71..228
                     /gene="FAM163A"
                     /gene_synonym="C1orf76; NDSP"
                     /inference="alignment:Splign:2.1.0"
     exon            229..319
                     /gene="FAM163A"
                     /gene_synonym="C1orf76; NDSP"
                     /inference="alignment:Splign:2.1.0"
     exon            320..441
                     /gene="FAM163A"
                     /gene_synonym="C1orf76; NDSP"
                     /inference="alignment:Splign:2.1.0"
     exon            442..556
                     /gene="FAM163A"
                     /gene_synonym="C1orf76; NDSP"
                     /inference="alignment:Splign:2.1.0"
     CDS             464..967
                     /gene="FAM163A"
                     /gene_synonym="C1orf76; NDSP"
                     /note="cebelin; neuroblastoma derived secretory protein"
                     /codon_start=1
                     /product="protein FAM163A"
                     /protein_id="NP_001316642.1"
                     /db_xref="CCDS:CCDS1333.1"
                     /db_xref="GeneID:148753"
                     /db_xref="HGNC:HGNC:28274"
                     /db_xref="MIM:611727"
                     /translation="MTAGTVVITGGILATVILLCIIAVLCYCRLQYYCCKKSGTEVAD
                     EEEEREHDLPTHPRGPTCNACSSQALDGRGSLAPLTSEPCSQPCGVAASHCTTCSPYS
                     SPFYIRTADMVPNGGGGERLSFAPTYYKEGGPPSLKLAAPQSYPVTWPGSGREAFTNP
                     RAISTDV"
     exon            557..2976
                     /gene="FAM163A"
                     /gene_synonym="C1orf76; NDSP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2955..2960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM163A"
                     /gene_synonym="C1orf76; NDSP"
                     /note="hexamer: AACAAG"
     polyA_site      2976
                     /gene="FAM163A"
                     /gene_synonym="C1orf76; NDSP"
                     /note="major polyA site"
ORIGIN      
        1 tgacataatc ttgaactaac tgtgtggtgt tttggaagca tagagaagag aagctcccaa
       61 gaaaaacaca aactaacctg cctaagaaga gaggaaaact gttgatgtag tgggaacgct
      121 ccctcctcga gcattaaccg ggttgacccc acccctctgt cctcgctgtc ttcagtccaa
      181 tcaagatcgg aaagcaggat caagagaaag atgatcagac cggaacaggg actgatgccc
      241 ttggccagac gcacccccaa ctgctgtctg ctcaggtgta gcccgcgtga ctgagtcacc
      301 gctgctccag ctgtttcact cacacttgag aattcagagg aagagaggca agccttggtt
      361 acgattcctc gcaatcctac tggcaaggga gacgtgagag gaatgtgaga gctgagcgtt
      421 ttgttcatct ttgctttaca aagtttgatg gggcgccggg cggatgacag cgggaacggt
      481 tgtgatcact ggcggaatcc tagctacggt gatcctcctc tgcatcattg ccgtcctgtg
      541 ctactgcagg ctccagtatt actgctgcaa gaagagcgga accgaggttg cagacgagga
      601 ggaggagcgg gagcacgacc ttcccacgca tcccagaggc cccacctgca atgcctgcag
      661 ctcccaagcc ctggacggca gaggcagcct ggcgcctctc accagcgagc cctgcagcca
      721 gccctgtggg gtggccgcga gccactgcac tacctgctcc ccatacagct ccccctttta
      781 catacggacg gctgacatgg tgcccaatgg gggtggaggc gagaggctct cctttgctcc
      841 cacatactac aaagaggggg gacccccatc cctcaaattg gcagcacccc agagttaccc
      901 ggtgacctgg ccaggctctg ggcgtgaggc cttcaccaat ccaagggcta ttagtacaga
      961 cgtgtaaatc cttccacccc gacccgcaca cacacccaca ctgctgccct ggcgggggcc
     1021 atgggggtga tgaatgaccc tccaacagcc ccacatgggt tgtttctgtt tctttggctt
     1081 ttctcgctcc gcagtggagg gtttactagg atttaagctt ttgagtgcat tgagaaccaa
     1141 gacagggcct ggctccaact ctgtgggcca gaggtggggg actgctaggt cgagtctgca
     1201 gcttcgccag tttcttggtt gggacactcc tctggcagcc ccagcaccac cacaacccct
     1261 tgcagtgtgc cccagtcccc tggattcgct ggactgcaaa aaggagcacc agggaaagct
     1321 cagcaaaggc tcaggaggcc tcccgggtcc tcgggagatg aagcatccgt gcctaggaaa
     1381 aggggacaga gggcaaggag agaagtgaga gctacaattc cagcattgga gaagcgaggg
     1441 gcggggcgtc aacggcactg cttcaggacg cgcttgctga aacgactcca acagctagtt
     1501 cacagcccag ctttgtacgt tggttaccat agctactgct gtcactgtag ctgctcccgt
     1561 agggtcgttg attcctgaac gtatcacatc tcacctgccc ccttcctcgt gggacgtgtc
     1621 aagttgactt taaagcctaa ggtggcttgt ggggactgca ccagaaagtg tctaaccttg
     1681 tgttccccga aatcctttct ctgacttagg aaccagcgcc ccctgctgga gaagtttttt
     1741 cattttgtta gccgacttct ggtagcttag caaagagacc agctgactgt ctctcggccc
     1801 agcccaccac gccgagtagc ttgtgtggat gcagtcctgt gagggtgtgc ataaccgttc
     1861 ccaggtgtac gcacgcgcgc gcgcgcgcac agacacacac acacacacac acacacacac
     1921 acacacacag taaccacggg taggcaccag gggctttgta cattcaggag ctgcagagag
     1981 gaaaggtctc ccatgtacca gagaaggaaa agtctgatcc cgaaacagct tgaacgaaag
     2041 gtggttaaca cgtgaccaat ccccatggca gacagcgggc tggtgaacag gaagagcaca
     2101 gaatctctgt ggggcgatgc tgcagcggct gaaaccacgt caagtccccc agagcccggc
     2161 attctatgta agcatccacc tgtgacgccg tggagcagga tcttcattca tctcaccaga
     2221 gcaacagccc agtcctgagg atgggaggga cgtgacttag ccttgggatt ccacgctcgc
     2281 cgccctccct tggccgccct actccccagt ttcctggcga tgagccattt attgtgtctc
     2341 acaccagcct catttccaac tccgacttcc tacttagaat gtggcagtgg ctttgtgagt
     2401 gagaatcctg atgagttttc cagtggcctc tgcagaagct ggcccccttc taagggcata
     2461 gctaaccccc ttcccactcc tgagtcactg aattcgagga gggtggggca gggaaagggc
     2521 tggcccccct gctgaaatct tgattctgca tttgaggaag gtcagggtgc cgctggggga
     2581 gcagggagcg gggagggagg aagaggggaa tgcacatctt ttgcgccact attaaggcac
     2641 ctgtcacctt acatctcaat ctggaatcaa agtgccctgg gttgagaagc agacctgggc
     2701 tctggtcaca ctttggtcac tcattagctc taggaccagt cactaatctc tgagactcca
     2761 ttttctccag ggaaacgagg cttgcccaga tagactaaca accctttagt gctccaagaa
     2821 gtgagaattt ccgaaaaaga tctgccggcc cagagcactc cctcttgccc taatcctggc
     2881 agggtctgga tgtatttacc caactctgat cttgcgtgca gggatgcttg ctgatggatg
     2941 aaagaccaca ataaaacaag attagcagca aaacaa
//
