LOCUS       NM_152445               3992 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens FAM161 centrosomal protein B (FAM161B), mRNA.
ACCESSION   NM_152445
VERSION     NM_152445.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3992)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3992)
  AUTHORS   Zach,F., Grassmann,F., Langmann,T., Sorusch,N., Wolfrum,U. and
            Stohr,H.
  TITLE     The retinitis pigmentosa 28 protein FAM161A is a novel ciliary
            protein involved in intermolecular protein interaction and
            microtubule association
  JOURNAL   Hum Mol Genet 21 (21), 4573-4586 (2012)
   PUBMED   22791751
REFERENCE   3  (bases 1 to 3992)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK302982.1, BC053909.1, BI253737.1, AW274700.1, AI082216.1 and
            AC005480.3.
            
            On Oct 26, 2018 this sequence version replaced NM_152445.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3963512.1,
                                           SRR14038195.501370.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000286544.5/ ENSP00000286544.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-354               AK302982.1         321-674
            355-2271            BC053909.1         347-2263
            2272-2767           BI253737.1         149-644
            2768-3202           AW274700.1         3-437               c
            3203-3276           AI082216.1         7-80                c
            3277-3992           AC005480.3         76356-77071
FEATURES             Location/Qualifiers
     source          1..3992
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..3992
                     /gene="FAM161B"
                     /gene_synonym="C14orf44; c14_5547"
                     /note="FAM161 centrosomal protein B"
                     /db_xref="GeneID:145483"
                     /db_xref="HGNC:HGNC:19854"
     exon            1..122
                     /gene="FAM161B"
                     /gene_synonym="C14orf44; c14_5547"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..2012
                     /gene="FAM161B"
                     /gene_synonym="C14orf44; c14_5547"
                     /note="family with sequence similarity 161 member B;
                     FAM161B, centrosomal protein"
                     /codon_start=1
                     /product="protein FAM161B"
                     /protein_id="NP_689658.3"
                     /db_xref="CCDS:CCDS9822.3"
                     /db_xref="GeneID:145483"
                     /db_xref="HGNC:HGNC:19854"
                     /translation="MTVGRPEGAPGGAEGSRQIFPPESFADTEAGEELSGDGLVLPRA
                     SKLDEFLSPEEEIDSTSDSTGSIYQNLQELKQKGRWCLLESLFQSDPESDENLSEDEE
                     DLESFFQDKDRGMVQVQCPQALRCGSTRRCSSLNNLPSNIPRPQTQPPSGSRPPSQHR
                     SVSSWASSITVPRPFRMTLREARKKAEWLGSPASFEQERQRAQRQGEEEAECHRQFRA
                     QPVPAHVYLPLYQEIMERSEARRQAGIQKRKELLLSSLKPFSFLEKEEQLKEAARQRD
                     LAATAEAKISKQKATRRIPKSILEPALGDKLQEAELFRKIRIQMRALDMLQMASSPIA
                     SSSNRANPQPRTATRTQQEKLGFLHTNFRFQPRVNPVVPDYEGLYKAFQRRAAKRRET
                     QEATRNKPFLLRTANLRHPQRPCDAATTGRRQDSPQPPATPLPRSRSLSGLASLSANT
                     LPVHITDATRKRESAVRSALEKKNKADESIQWLEIHKKKSQAMSKSVTLRAKAMDPHK
                     SLEEVFKAKLKENRNNDRKRAKEYKKELEEMKQRIQTRPYLFEQVAKDLAKKEAEQWY
                     LDTLKQAGLEEDFVRNKGQGTRAVQEKETKIKDFPRFQETTKLSIRDPEQGLEGSLEQ
                     PASPRKVLEELSHQSPENLVSLA"
     exon            123..442
                     /gene="FAM161B"
                     /gene_synonym="C14orf44; c14_5547"
                     /inference="alignment:Splign:2.1.0"
     exon            443..993
                     /gene="FAM161B"
                     /gene_synonym="C14orf44; c14_5547"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1340
                     /gene="FAM161B"
                     /gene_synonym="C14orf44; c14_5547"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1468
                     /gene="FAM161B"
                     /gene_synonym="C14orf44; c14_5547"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1633
                     /gene="FAM161B"
                     /gene_synonym="C14orf44; c14_5547"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1733
                     /gene="FAM161B"
                     /gene_synonym="C14orf44; c14_5547"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1873
                     /gene="FAM161B"
                     /gene_synonym="C14orf44; c14_5547"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..3992
                     /gene="FAM161B"
                     /gene_synonym="C14orf44; c14_5547"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3167..3172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM161B"
                     /gene_synonym="C14orf44; c14_5547"
                     /note="hexamer: AACAAA"
     polyA_site      3189
                     /gene="FAM161B"
                     /gene_synonym="C14orf44; c14_5547"
     polyA_site      3754
                     /gene="FAM161B"
                     /gene_synonym="C14orf44; c14_5547"
                     /note="major polyA site"
     regulatory      3968..3973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM161B"
                     /gene_synonym="C14orf44; c14_5547"
                     /note="hexamer: TATAAA"
     polyA_site      3992
                     /gene="FAM161B"
                     /gene_synonym="C14orf44; c14_5547"
ORIGIN      
        1 atagctctcg ctgccaccgc tgctgccact atcgctgtca ctgtcgctgc tgcctctgtc
       61 cagctgaaat gaccgtgggg aggcctgagg gagcccccgg aggcgcggag gggagccgtc
      121 agatatttcc ccccgagtcc ttcgcagaca cagaggcagg agaggagctg tccggggatg
      181 ggctggtttt gcccagggcc agcaaacttg acgagttcct cagcccagag gaggagatag
      241 attctacttc tgactcaact gggagcattt accagaactt acaggaactg aagcagaaag
      301 ggagatggtg tctgttggag tctctctttc agtctgaccc agagagtgat gaaaacctct
      361 ctgaagatga ggaggacctg gagagtttct tccaagacaa ggacaggggg atggtgcagg
      421 tccagtgccc gcaggctctg aggtgtggct ccacaaggcg ctgcagctcc ctgaacaacc
      481 ttccctccaa cattcccagg cctcagaccc agccaccctc aggctcccgg cctccctccc
      541 agcacagaag cgtcagctcc tgggcatcat ccattactgt ccctcggcca ttccgcatga
      601 cgctgcgcga ggcccggaag aaggccgagt ggctgggctc acctgcctcc tttgagcagg
      661 agaggcagcg ggcccagagg cagggtgagg aagaggccga gtgccacagg cagttccggg
      721 cacagcctgt gcctgcacat gtctacctgc ccctctacca agagatcatg gagcgcagcg
      781 aggcccgaag gcaggcaggg atccagaaga ggaaggaact gctcctctct tctttgaagc
      841 ccttcagctt cctggagaag gaggagcagc taaaggaagc tgctcgacag agagacttgg
      901 cagccacagc tgaagccaag atctccaagc agaaggccac cagaaggatt cccaagtcca
      961 ttctggagcc agcccttggg gataaactcc aggaagctga gctcttcagg aaaattcgca
     1021 tccaaatgag agccctggac atgctccaga tggcctcttc ccctatcgcc tcctctagta
     1081 accgggctaa cccacagccc cgcacagcca cccgaaccca gcaggaaaag cttgggtttc
     1141 tgcacactaa cttcagattc cagcctcggg tgaatcctgt ggtccctgac tatgagggcc
     1201 tttacaaggc cttccagaga agagcagcca aaagaagaga aacccaagag gccactcgca
     1261 acaagccctt cttgctgagg accgccaacc tgcgccaccc tcagcggccc tgtgatgctg
     1321 ccaccaccgg aaggaggcag gattccccac agccaccagc tacacccctg ccaaggagtc
     1381 gttctctgag cggccttgct tccctctctg ccaacactct ccctgtgcac atcacagatg
     1441 ccaccaggaa gagggaatct gcagtcagaa gtgcacttga aaaaaagaac aaagcagatg
     1501 agagtattca gtggctggag atacacaaaa agaagtctca agcaatgtcc aaatctgtga
     1561 ccttgcgtgc aaaagccatg gatccccata aaagcctgga ggaagtgttc aaagcaaagc
     1621 tgaaagagaa ccggaacaat gaccgtaaaa gagcgaaaga atataagaaa gaactggagg
     1681 aaatgaagca gcgaatacaa acaaggccct atctctttga acaagttgcc aaggatctag
     1741 ccaagaaaga agcagaacag tggtatctag acaccctgaa gcaggctggg ctggaggaag
     1801 actttgtgag aaacaagggt caaggcaccc gggctgttca agagaaagag accaaaatca
     1861 aggattttcc caggttccaa gaaactacaa aactcagcat cagagatcca gagcagggtt
     1921 tagaaggatc tctagaacag cctgcaagcc ccaggaaagt actggaggag ctgtctcatc
     1981 agtcaccaga aaatctcgta tcacttgctt aatcactaca cttaaaatta ctgcttttga
     2041 aaaatattaa gcagctaact tgggtttgag tcaaggcagg gaaaacttgg gttttgagtc
     2101 atggctactg ttagaggatg gacaaatgaa gagtagcaga ttaacaggcc aggcgcagtg
     2161 gctcacgcct gtaatcccaa cactttggga ggctgaggca ggcagatcat ctgaggtcag
     2221 gagtttgaga ccagtccagc caacacggca aaactccacc tctactaaaa atacaaaaat
     2281 tagctgggcg tgatgacacg tgcctgtaat cctagctact tgggaagctg aggcaggaga
     2341 atcacttgaa cccaagaggc agaggttgta atgagctgag atcactccac agcactccag
     2401 cctgggcagc agagcaaaac tctgtctgag aaaaaaaaag agcagcagat aacagagaat
     2461 agttcaagga aatcaaagtg gggaggctca ggtggaggga tggtagccta aagttaaggg
     2521 ttcctgcttt gtgcctcaca cttagagaat taggtacaga aaagagagca caggcccaaa
     2581 tgcctataag gggctagtgc agaaacataa atgcgtccat ggagtgggtg tagacagtag
     2641 gagatagtag acactggaaa gtatcaaatc ctgctggaat ataggctcag agttactaca
     2701 tcaactacat tttcatcaag ccagaaattt gtatgctatc aactaattta aaaattactt
     2761 agaaatattg tatgggcaaa ataaaataca tctgcatatc agatctagcc catgggggat
     2821 gaaaaactta caacttctag tacaggattt cttatcctca gtgctattaa tattttgggc
     2881 cacctaattc tttgttgagg gttggggaag ggaactgtcc tgtacattgt agaatgttta
     2941 gtagcatccc tggccactac ctgctagatg ccagtagtac ccctctcccc agctgtgaca
     3001 accaaaaatg tctccagata ttgcatatcc ccagggggca aaaatgtgcc tggctgagaa
     3061 ccactgctct aatataaatg gctgcatgaa gcaaaaactg gcattctaag aatacaagta
     3121 attgccatga acacagtcta tgtactatgt gattatgcat gtcattaaca aattaagaat
     3181 ttaaaacaat tctctcccgt tatctgttta gaatgtgcct gtgtgtttat gtgagcatga
     3241 ggttcatttt aagtaaactt aaaatttccc agacaaccaa gattttctac tagtaggtga
     3301 actttggaat aattttcttc tcaccaataa taattggata ttctggctcg gtgcagtggt
     3361 tcatgcttgt aatcccagca ctttgagggg ccaaggcagg aggatcgctt gaagccaggc
     3421 gttcaagacc agcctgggca acacagacct catttctacc aaaaaaacca caaaaagtta
     3481 gctggactgg tggtacatgc ctatagtcct agctattcag gaggctgagg tgggaggatg
     3541 ccttgagcgt aggagttcaa ggttacattg agctatgatt acactactgc actccagcct
     3601 gggtgacaga gcaagacccc atctcaaatc ataatgatga tgagtggata ttttctcagt
     3661 agctgtggag acaggatgac tgatagcaag agtgcctgct ctaactaaag cacctttctc
     3721 aagctttttt aaaaaaacta tctttgtgga aaaattcaga agtatctgtt tttattgcca
     3781 ttttctcaga tgcgtctttt ttggtggtga cagagtaact atcacctggg cttaagaaat
     3841 gaagatgttc ttgttgtttc ctaagactcc tcggttcagt tttactggta tggaatccta
     3901 agggtaaatc aatacactat tttaaaggga aagattaaat tcttaatctc taagaaaaca
     3961 aattttgtat aaaacaagag ccaaagaact ga
//
