LOCUS       NM_001201543            3777 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens FAM161 centrosomal protein A (FAM161A), transcript
            variant 1, mRNA.
ACCESSION   NM_001201543
VERSION     NM_001201543.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3777)
  AUTHORS   Arslanhan,M.D., Cengiz-Emek,S., Odabasi,E., Steib,E., Hamel,V.,
            Guichard,P. and Firat-Karalar,E.N.
  TITLE     CCDC15 localizes to the centriole inner scaffold and controls
            centriole length and integrity
  JOURNAL   J Cell Biol 222 (12) (2023)
   PUBMED   37934472
REFERENCE   2  (bases 1 to 3777)
  AUTHORS   Liu,Y., Chen,J., Sager,R., Sasaki,E. and Hu,H.
  TITLE     Interactions between C8orf37 and FAM161A, Two Ciliary Proteins
            Essential for Photoreceptor Survival
  JOURNAL   Int J Mol Sci 23 (19), 12033 (2022)
   PUBMED   36233334
  REMARK    GeneRIF: Interactions between C8orf37 and FAM161A, Two Ciliary
            Proteins Essential for Photoreceptor Survival.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3777)
  AUTHORS   Mercey,O., Kostic,C., Bertiaux,E., Giroud,A., Sadian,Y.,
            Gaboriau,D.C.A., Morrison,C.G., Chang,N., Arsenijevic,Y.,
            Guichard,P. and Hamel,V.
  TITLE     The connecting cilium inner scaffold provides a structural
            foundation that protects against retinal degeneration
  JOURNAL   PLoS Biol 20 (6), e3001649 (2022)
   PUBMED   35709082
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3777)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3777)
  AUTHORS   Zach,F., Grassmann,F., Langmann,T., Sorusch,N., Wolfrum,U. and
            Stohr,H.
  TITLE     The retinitis pigmentosa 28 protein FAM161A is a novel ciliary
            protein involved in intermolecular protein interaction and
            microtubule association
  JOURNAL   Hum Mol Genet 21 (21), 4573-4586 (2012)
   PUBMED   22791751
  REMARK    GeneRIF: FAM161A is a microtubule-associated ciliary protein
            presumably involved in microtubule stabilization to maintain the
            microtubule tracks and/or in transport processes along microtubules
            in photoreceptors and other retinal cell types.
REFERENCE   6  (bases 1 to 3777)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   7  (bases 1 to 3777)
  AUTHORS   Bandah-Rozenfeld,D., Mizrahi-Meissonnier,L., Farhy,C.,
            Obolensky,A., Chowers,I., Pe'er,J., Merin,S., Ben-Yosef,T.,
            Ashery-Padan,R., Banin,E. and Sharon,D.
  TITLE     Homozygosity mapping reveals null mutations in FAM161A as a cause
            of autosomal-recessive retinitis pigmentosa
  JOURNAL   Am J Hum Genet 87 (3), 382-391 (2010)
   PUBMED   20705279
  REMARK    GeneRIF: These data suggest a pivotal role for FAM161A in
            photoreceptors and reveal that FAM161A loss-of-function mutations
            are a major cause of autosomal-recessive Retinitis pigmentosa.
REFERENCE   8  (bases 1 to 3777)
  AUTHORS   Langmann,T., Di Gioia,S.A., Rau,I., Stohr,H., Maksimovic,N.S.,
            Corbo,J.C., Renner,A.B., Zrenner,E., Kumaramanickavel,G.,
            Karlstetter,M., Arsenijevic,Y., Weber,B.H., Gal,A. and Rivolta,C.
  TITLE     Nonsense mutations in FAM161A cause RP28-associated recessive
            retinitis pigmentosa
  JOURNAL   Am J Hum Genet 87 (3), 376-381 (2010)
   PUBMED   20705278
  REMARK    GeneRIF: Null mutations in FAM161A are responsible for the
            RP28-associated autosomal-recessive retinitis pigmentosa.
REFERENCE   9  (bases 1 to 3777)
  AUTHORS   Gu,S., Kumaramanickavel,G., Srikumari,C.R., Denton,M.J. and Gal,A.
  TITLE     Autosomal recessive retinitis pigmentosa locus RP28 maps between
            D2S1337 and D2S286 on chromosome 2p11-p15 in an Indian family
  JOURNAL   J Med Genet 36 (9), 705-707 (1999)
   PUBMED   10507729
REFERENCE   10 (bases 1 to 3777)
  AUTHORS   Fahim,A.T., Daiger,S.P. and Weleber,R.G.
  TITLE     Nonsyndromic Retinitis Pigmentosa Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301590
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC107081.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001201543.1.
            
            Summary: This gene belongs to the FAM161 family. It is expressed
            mainly in the retina. Mouse studies suggested that this gene is
            involved in development of retinal progenitors during
            embryogenesis, and that its activity is restricted to mature
            photoreceptors after birth. Mutations in this gene cause autosomal
            recessive retinitis pigmentosa-28. Alternatively spliced transcript
            variants have been identified.[provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.88349.1, BX648834.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000404929.6/ ENSP00000385158.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               AC107081.5         31979-32180         c
            203-441             AC107081.5         20242-20480         c
            442-1602            AC107081.5         17541-18701         c
            1603-1770           AC107081.5         16658-16825         c
            1771-1870           AC107081.5         14130-14229         c
            1871-2025           AC107081.5         5224-5378           c
            2026-3777           AC107081.5         2968-4719           c
FEATURES             Location/Qualifiers
     source          1..3777
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p15"
     gene            1..3777
                     /gene="FAM161A"
                     /gene_synonym="RP28"
                     /note="FAM161 centrosomal protein A"
                     /db_xref="GeneID:84140"
                     /db_xref="HGNC:HGNC:25808"
                     /db_xref="MIM:613596"
     exon            1..202
                     /gene="FAM161A"
                     /gene_synonym="RP28"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..2170
                     /gene="FAM161A"
                     /gene_synonym="RP28"
                     /note="isoform 1 is encoded by transcript variant 1;
                     retinitis pigmentosa 28 (autosomal recessive); protein
                     FAM161A; family with sequence similarity 161 member A;
                     FAM161A, centrosomal protein"
                     /codon_start=1
                     /product="protein FAM161A isoform 1"
                     /protein_id="NP_001188472.1"
                     /db_xref="CCDS:CCDS56120.1"
                     /db_xref="GeneID:84140"
                     /db_xref="HGNC:HGNC:25808"
                     /db_xref="MIM:613596"
                     /translation="MATSHRVAKLVASSLQTPVNPITGARVAQYEREDPLKALAAAEA
                     ILEDEEEEKVAQPAGASADLNTSFSGVDEHAPISYEDFVNFPDIHHSNEEYFKKVEEL
                     KAAHIETMAKLEKMYQDKLHLKEVQPVVIREDSLSDSSRSVSEKNSYHPVSLMTSFSE
                     PDLGQSSSLYVSSSEEELPNLEKEYPRKNRMMTYAKELINNMWTDFCVEDYIRCKDTG
                     FHAAEKRRKKRKEWVPTITVPEPFQMMIREQKKKEESMKSKSDIEMVHKALKKQEEDP
                     EYKKKFRANPVPASVFLPLYHDLVKQKEERRRSLKEKSKEALLASQKPFKFIAREEQK
                     RAAREKQLRDFLKYKKKTNRFKARPIPRSTYGSTTNDKLKEEELYRNLRTQLRAQEHL
                     QNSSPLPCRSACGCRNPRCPEQAVKLKCKHKVRCPTPDFEDLPERYQKHLSEHKSPKL
                     LTVCKPFDLHASPHASIKREKILADIEADEENLKETRWPYLSPRRKSPVRCAGVNPVP
                     CNCNPPVPTVSSRGREQAVRRSLEEKKMLEEERNRILTKQKQRMKELQKLLTTRAKAY
                     DSHQSLAQISKSRVKCLRKSEKERMREYQRELEEREEKLKKRPLLFERVAQKNARMAA
                     EKHYSNTLKALGISDEFVSKKGQSGKVLEYFNNQETKSVTEDKESFNEEEKIEERENG
                     EENYFIDTNSQDSYKEKDEANEESEEEKSVEESH"
     exon            203..441
                     /gene="FAM161A"
                     /gene_synonym="RP28"
                     /inference="alignment:Splign:2.1.0"
     exon            442..1602
                     /gene="FAM161A"
                     /gene_synonym="RP28"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1770
                     /gene="FAM161A"
                     /gene_synonym="RP28"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1870
                     /gene="FAM161A"
                     /gene_synonym="RP28"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2025
                     /gene="FAM161A"
                     /gene_synonym="RP28"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..3777
                     /gene="FAM161A"
                     /gene_synonym="RP28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3748..3753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM161A"
                     /gene_synonym="RP28"
                     /note="hexamer: AATAAA"
     polyA_site      3777
                     /gene="FAM161A"
                     /gene_synonym="RP28"
                     /note="major polyA site"
ORIGIN      
        1 aggcctcgga ggcggggcga tggccacctc ccaccgagtg gcgaagctgg tggcctccag
       61 tctccagacc ccggtaaatc ccatcactgg agcgcgggtc gcccagtacg aacgcgaaga
      121 ccccttaaag gccctggcgg cagcggaggc gatcttggag gacgaagagg aggagaaagt
      181 ggctcagccc gctggggcat cggctgattt gaacaccagc ttttctgggg tggatgaaca
      241 tgcaccgata agctatgagg actttgtgaa ctttcctgat attcaccact ctaatgagga
      301 gtatttcaag aaagtagaag agttgaaggc tgcccacata gaaactatgg caaaattaga
      361 gaaaatgtac caggataaat tacatttaaa ggaagttcag ccagtggtca tcagagaaga
      421 ctctcttagt gactcttcca gatctgtatc agaaaagaac tcctatcacc ctgtctcatt
      481 aatgacatca ttttcagagc ctgatttagg ccagtcttcc tccttgtatg tgtcctcctc
      541 tgaagaggag ttacccaacc tagaaaaaga gtatcctagg aaaaacagaa tgatgaccta
      601 tgctaaggag ctcatcaaca atatgtggac agacttttgt gttgaggatt atattcgctg
      661 taaagatact ggcttccatg cagctgaaaa aagaaggaag aaacgaaaag aatgggtgcc
      721 cacaattaca gtaccggagc cttttcaaat gatgataaga gaacagaaga aaaaagaaga
      781 gtccatgaaa tctaaatcag atatcgaaat ggtacataaa gcgctcaaaa aacaagaaga
      841 ggatccagag tataagaaga aattccgagc caatccagtt cctgcatctg tctttctccc
      901 cctttaccat gatttagtca agcaaaaaga agaacggaga aggtctctga aggagaaaag
      961 caaagaagct cttttggcct cacaaaagcc atttaaattt atagcaaggg aggaacagaa
     1021 gcgagcagcc cgggaaaagc agctgagaga ctttcttaag tataaaaaga aaacaaatcg
     1081 atttaaagcc agacccattc ctcgatctac ttatggttca actaccaatg acaagttaaa
     1141 agaagaagag ctctatcgaa accttaggac acagctgaga gcccaggagc atttacagaa
     1201 ctcatctcct ctgccttgta ggtcagcttg tggatgcagg aaccccaggt gtcctgaaca
     1261 ggctgtaaag ttgaagtgta aacacaaggt taggtgccca actcctgatt ttgaggacct
     1321 tcctgagaga taccagaaac acctctcaga acacaagtct ccaaaactct taacagtgtg
     1381 taaaccattt gatcttcatg catctccaca tgcatctatt aaaagagaaa aaattttggc
     1441 agacatcgaa gcagatgaag aaaatttaaa agaaacacgt tggccttatt tgtctccaag
     1501 gcgtaagtca ccagtaagat gtgcaggtgt aaaccctgtg ccttgtaact gcaaccctcc
     1561 cgtgcccacg gtatcttcca gaggacgaga acaagccgta aggagatcac ttgaggaaaa
     1621 gaaaatgttg gaagaagaga gaaatcggat cctaactaaa cagaagcaaa gaatgaaaga
     1681 attgcagaaa ctcctgacaa cccgggctaa ggcttatgac tcacatcaaa gtttagctca
     1741 aatatctaaa tccagagtaa aatgtctcag aaagagcgaa aaggaaagga tgagagaata
     1801 ccaacgagaa ctagaagaaa gagaagaaaa attaaaaaag aggccactgc tatttgaaag
     1861 agttgctcag aaaaatgcaa gaatggcagc agaaaagcat tattctaata ccctaaaagc
     1921 actaggaata tctgatgagt ttgtttcaaa gaaaggccaa agtggaaaag tacttgagta
     1981 cttcaacaat caagagacga aaagtgtcac tgaagacaaa gaaagcttta atgaagaaga
     2041 aaaaatagaa gaaagagaga atggggaaga aaattatttt attgatacca acagccagga
     2101 ttcttacaag gaaaaagatg aagccaatga ggaaagtgaa gaagagaaat ctgttgaaga
     2161 atcacactga atcatcaagg tctcctctct atgcccttgc tgttgtttgc agcgtcaggg
     2221 tgtcagcagc cgcatttgtg tttagaacat ctgtggggac gcttctgata tgtgcagggc
     2281 tgttgatcaa agtcatctgt agcctgaaaa gcctgaatcc agctgattgg tcatttgatc
     2341 agttagagta aggctttgcc tattcagttt taaaaatcat tgtgtattat ctgtttgcaa
     2401 ctatgatttt gtatttttaa aaagtgagaa ccacagctgt cacaaactga ttagttataa
     2461 aaatatacat tatttcatta attttactgg aaaaaatggc ttagtattga aaggagagag
     2521 aagtattggt ctttggtggt ttacttttta aaaattttgg aaagtgtgaa tcaataacta
     2581 tttttaatta tactatttgc ccattctttt tctctgcagt gcatttcaca gaataaatcc
     2641 tctaacttgt tttgctgctc tgagccattt ttaaaagtat agaaaaaacg ccgggtatgg
     2701 tggctcatgc ctgtaatccc agcattttgg gaggccgaga cgggtggatc acgaggtcag
     2761 gagatcgaga ccatcctggc taacacgatg aaaccccgtc tctactaaaa atacaaaaaa
     2821 ttagccaggc gtggtggtgg gcgcctgtag tcccagctac ttgggaggca gaggcaggag
     2881 aatggcatga acccaggagg cagagcttgc agtgagccga gatcgcgcca ctgcactcca
     2941 gcttgggcaa cagagcgaga ctccgtctcc aaaaaaaaaa aaaaagtata gaaaaaaatg
     3001 gatacttgca aatttacatt tatttttgca ctgagagttt actgttaaat tgtctacacc
     3061 atcatccctt tttcttttta tccttagttc tagtccaaat tatttttgat ttgtaaatta
     3121 ttaggaaagt ttttatacta gtttttttaa ccctatgtat tattacagat ggaagtaatt
     3181 atggcatgtg tgagttataa tctaaattag gggcaagtat cccttttttt atatgatgaa
     3241 attgtgcata ataacttggc tagggcaagt ctccaaagta attcagattt aactcttcac
     3301 tgctagaccc agttgtgttc aactttttac atattattgc caacacactt tatctctctg
     3361 tgtacagtgt taatctgatt ttataaatct atattttttt ctttaagcaa atttttgttt
     3421 taaaatttga agccaatcat aaagataata tagcataaga cattttcttt tctaaaaaca
     3481 atcagcatca ttttaaaagg atgaactaat acaggtgtat gtaatagcag tgtttccaaa
     3541 ctggcaattt atgctttaaa tttaaaaata aggtcatttt tctccatcag gggcaaatgt
     3601 ttacttgtaa ttttcttcct acagttcgtg ttaaattact ttttactatt attatattgt
     3661 aaactccttg ggatttggca ccatttaaaa attcatcttt gtattccctt aatatttgga
     3721 acagtattgt acatatggta ggtacttaat aaaggtttga atgagtgtgt agatgaa
//
