LOCUS       NM_001321178            3757 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 156 member B
            (FAM156B), transcript variant 1, mRNA.
ACCESSION   NM_001321178 XM_005262024
VERSION     NM_001321178.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3757)
  AUTHORS   Tian,T., Bi,H., Zhang,D., Liu,Y., Sun,H., Jia,C., Zheng,T.,
            Huang,H., Fu,J., Zhu,L. and Zhao,Y.
  TITLE     Methylation of three genes encoded by X chromosome in blood
            leukocytes and colorectal cancer risk
  JOURNAL   Cancer Med 10 (14), 4964-4976 (2021)
   PUBMED   34145793
  REMARK    GeneRIF: Methylation of three genes encoded by X chromosome in
            blood leukocytes and colorectal cancer risk.
REFERENCE   2  (bases 1 to 3757)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3757)
  AUTHORS   Chen,Y.T., Iseli,C., Venditti,C.A., Old,L.J., Simpson,A.J. and
            Jongeneel,C.V.
  TITLE     Identification of a new cancer/testis gene family, CT47, among
            expressed multicopy genes on the human X chromosome
  JOURNAL   Genes Chromosomes Cancer 45 (4), 392-400 (2006)
   PUBMED   16382448
REFERENCE   4  (bases 1 to 3757)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   5  (bases 1 to 3757)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC234031.3.
            
            On Jan 5, 2021 this sequence version replaced NM_001321178.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX649013.1, SRR14038196.2788568.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000416841.8/ ENSP00000424864.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2212              AC234031.3         118659-120870       c
            2213-2305           AC234031.3         117540-117632       c
            2306-3757           AC234031.3         109640-111091       c
FEATURES             Location/Qualifiers
     source          1..3757
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..3757
                     /gene="FAM156B"
                     /gene_synonym="TMEM29B"
                     /note="family with sequence similarity 156 member B"
                     /db_xref="GeneID:727866"
                     /db_xref="HGNC:HGNC:31962"
     exon            1..2212
                     /gene="FAM156B"
                     /gene_synonym="TMEM29B"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2305
                     /gene="FAM156B"
                     /gene_synonym="TMEM29B"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..3757
                     /gene="FAM156B"
                     /gene_synonym="TMEM29B"
                     /inference="alignment:Splign:2.1.0"
     CDS             2423..3064
                     /gene="FAM156B"
                     /gene_synonym="TMEM29B"
                     /note="transmembrane protein 29B; protein FAM156A;
                     transmembrane protein 29/29B"
                     /codon_start=1
                     /product="protein FAM156A/FAM156B"
                     /protein_id="NP_001308107.1"
                     /db_xref="CCDS:CCDS43957.1"
                     /db_xref="GeneID:727866"
                     /db_xref="HGNC:HGNC:31962"
                     /translation="MDPLQKRNPASPSKSSPMTAAETSQEGPAPSQPSYSEQPMMGLS
                     NLSPGPGPSQAVPLPEGLLRQRYREEKTLEERRWERLEFLQRKKAFLRHVRRRHRDHM
                     APYAVGREARISPLGDRSQNRFRCECRYCQSHRPNLSGIPGESNRAPHPSSWETLVQG
                     LSGLTLSLGTNQPGPLPEAALQPQETEEKRQRERQQESKIMFQRLLKQWLEEN"
     regulatory      3737..3742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM156B"
                     /gene_synonym="TMEM29B"
                     /note="hexamer: AATATA"
     polyA_site      3757
                     /gene="FAM156B"
                     /gene_synonym="TMEM29B"
                     /note="major polyA site"
ORIGIN      
        1 gctgcgtttc cagggcagag gaaacgaggc gccgcgttgg cgcttggacg gcgggaaccg
       61 gctccggagc gagaacgcgc gtgagagagc ccgagagaga cggagagcga gcgagcgcgc
      121 gggagagact gagagcgggg gggtgggaga gagacttcca gagagacaga gcgagaggcc
      181 gagacggagg ctgtccctag cacaggccag ggtgtcttgg gactcgaatc cctgggttgg
      241 gctggccggg agtggggctt tcgaaggaag cgggtgattt tccacgtcgt ccatatctcc
      301 ccggtgtggg aatggcggtc gtgcactctg ggggtggcgt tgttctcgtt ccctacttgg
      361 gggtggcctt tttcagcgga gaaagaggat gccgcgggca ttggtagccg gcgggactac
      421 acttgggcta ggatcagtgt tcagcgggtt cagaaatcac cgtgtccttg gcatcacctc
      481 cctccccacc tcctctccca tcgcacagca ggagacagtg actggagggt tttcaaggag
      541 gactgcattg cccctattga aacaaaccgt ccgacaaacc ctttctccga cgtgtgacag
      601 agggacggtc gtaatgtgaa atacgactag acatgcgttt aatgggcggt gtgattgctg
      661 cattcgtgcg caatgaatgg tccaggccat ttgtgtccag tagccgcaca agctgcaggg
      721 tctcatgttt agagagggag ggcctctccg ccgtccacct tgctggagta caggcgaccc
      781 tgggcggtag ccctctccgc catcagaaat gtggtgctct gagtagccac agattcccat
      841 ctgcatctcc aataccattt ccctctactc actgacccgt tgggtgcgtt ggatttgtgc
      901 gtgggtgtga gggtagtttg gtgtgtttgc ttgcaaatgg aaaagcgaat ggccttggtt
      961 ggctgagctt atcagggcac tagcagtgga gagagaaagg actactgtat tcttaggagc
     1021 agaatctcaa caacttccta taaaacgggc agtgtgtctt acctggaatg ctttggcatt
     1081 taataaaatg tcctgtgaat acttttcata gggaagcact ttgtttttac tgtttctggt
     1141 tggacagtgg ttacatttca aatcgtagtt cagaattcgt gaaataccca aattaaatct
     1201 ctacgtggca gtaatccatt ttctttcctt ggtgtgtggt tggaagatta atttgagata
     1261 agtgttcagt tctgggctgg gcagtcgtgc cgggcacggg aaattcaggt tctttaaggg
     1321 aaaggcctga tgtgctaaga cgaaatctat accgtgtgta gccgcttatg agaatatgaa
     1381 actaaggaga gccacaggta agtatacgtc tatgaatgcg aattaaaacg ggtgacaata
     1441 taaagagaga ttggtgtcac aaatggtgga gtgacttttg tatttcagca gacctcagtg
     1501 agaaatggtc accaccactc cctagatgtg tgaccttgag tgagttgctt aacctctctg
     1561 atcctgttac ctcatctgca actggggatg agaatatata tcatagcatg ccctgggaga
     1621 agctgttcct gaccacctgg gctatggtga ttttgacttc ctctgtgtca gaagtacccc
     1681 cgtctcatgc ctgccatagt tgtctttttg ttttgttttg tgatttcaga tggactcacc
     1741 ctgtcaccca ggttggactg cactggcctc aacctcctga gttcaagtga tcgtcccacc
     1801 tcagcctccc cagtagctgg gaccatagct gtgcagcatc atgcctggct aattttttaa
     1861 gttttttgtt gagatggtgg tctcgccctg ttgctcaggc tggcctcaaa ctcctgggct
     1921 gaagcagtcc tcccacctca gcctcccaaa gtgcttggat tagaggcgtg agccaccatt
     1981 cctggctcct tggacaatat tttattcctc agattaagac acgtccttgg gatggggctg
     2041 cattggataa ttcaccgaag gcaccgctga atggagtggg ccctcagtaa atacctggag
     2101 gaatgtgacc tggccagtga ggttattttc ttttgtaggt gaaaggtgta gcagtcactc
     2161 ggcctacacc cacagcatcg accttgtgaa cccagcgacc tgactgcctt gggagaattg
     2221 aagcgaatga gagtggggag tgtgagaggt gcgtttggtg cagcatttct ggcatgggaa
     2281 cagaactggc caggaggaag tgacgtctgg gttctgcccg cacacattcc tcgccacctt
     2341 cttggtgtct gagaacctcc agcttcacct ccttttctgg acccgagggc ctggcggagc
     2401 ttccagctgg gaccagacct ccatggatcc actccagaaa cggaatccag catcgccttc
     2461 caaatcttcc ccgatgacag ctgcagagac ttcccaggaa ggtccagcgc cctctcagcc
     2521 ttcgtactca gaacagccga tgatgggcct cagtaacctg agccccggtc ctggccccag
     2581 ccaggccgtg cctctcccag aggggctgct ccgccagcgg tacagagagg agaagaccct
     2641 ggaagagcgg cggtgggaga ggctggagtt ccttcagagg aagaaagcat tcctgcggca
     2701 tgtgaggagg agacaccgcg atcacatggc cccctatgct gttgggaggg aagccagaat
     2761 ctccccatta ggtgacagaa gtcagaatcg attccgatgt gaatgtcgat actgccagag
     2821 ccacaggccg aatctttctg ggatccctgg ggagagtaac agggccccac atccctcctc
     2881 ctgggagacg ctggtgcagg gcctcagtgg cttgactctc agcctaggca ccaaccagcc
     2941 cgggcctctg cctgaagcgg cactccagcc acaggagaca gaggagaagc gccagcgaga
     3001 gaggcagcag gagagcaaaa taatgtttca gaggctgctc aagcagtggt tagaggaaaa
     3061 ctgagacgtg cacccccatg ggatggagac ccgaagggac tcagacggag ccgccgtgtt
     3121 ggcagcgcct gggtgtgggc ccattttggg gaccaaacag caagctgtgg tcggatgagt
     3181 gccaggacct gtgtaccggg acacgtggga gtcctcccag catgatgctt gactgacccg
     3241 aggaaggtcc tcatgtttcg tgcctgtcat tctcggatgg ctgtgaggca ttccttggca
     3301 agggacgctg cgtaccagcg gtcctcaccg catctcacat ggctcctgtg atgcatgttg
     3361 tcgctttccc acccgggatc tccatctctc ttcccttcct gctgtcagta agagatcaca
     3421 tgtctgtgta gtgtgaatgc cttgtcgctg tcctgtgctt ttgcaccatt gagttgactg
     3481 cctctgagaa gcagcactag gcctgttgaa atgcaatgtg ctgccctgag atccagtttc
     3541 aagaatgggc aggtaaacgc agtgtgggaa aggaatgtgg aatgagaact tggtggttca
     3601 ccgctgtact atttgtgtaa atgtttacgt atgtgataag ctacatgtat gtaaatgttg
     3661 caatacccct aacagtcgag tagtagtctc ccttacagga atttttgacg gggttcctca
     3721 tcatcaatac caaataaata tatgtaggaa tggaaaa
//
