LOCUS       NM_176782               1975 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 151 member A
            (FAM151A), mRNA.
ACCESSION   NM_176782
VERSION     NM_176782.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1975)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (bases 1 to 1975)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 1975)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1975)
  AUTHORS   Sanna-Cherchi,S., Caridi,G., Weng,P.L., Dagnino,M., Seri,M.,
            Konka,A., Somenzi,D., Carrea,A., Izzi,C., Casu,D., Allegri,L.,
            Schmidt-Ott,K.M., Barasch,J., Scolari,F., Ravazzolo,R.,
            Ghiggeri,G.M. and Gharavi,A.G.
  TITLE     Localization of a gene for nonsyndromic renal hypodysplasia to
            chromosome 1p32-33
  JOURNAL   Am J Hum Genet 80 (3), 539-549 (2007)
   PUBMED   17273976
REFERENCE   5  (bases 1 to 1975)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK091901.1, BC020874.1, DB335516.1 and AY358629.1.
            
            On Nov 22, 2018 this sequence version replaced NM_176782.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020874.1, AK091901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153932 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302250.7/ ENSP00000306888.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-646               AK091901.1         32-677
            647-1376            BC020874.1         647-1376
            1377-1566           DB335516.1         346-535
            1567-1975           AY358629.1         1555-1963
FEATURES             Location/Qualifiers
     source          1..1975
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..1975
                     /gene="FAM151A"
                     /gene_synonym="C1orf179"
                     /note="family with sequence similarity 151 member A"
                     /db_xref="GeneID:338094"
                     /db_xref="HGNC:HGNC:25032"
     exon            1..248
                     /gene="FAM151A"
                     /gene_synonym="C1orf179"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1888
                     /gene="FAM151A"
                     /gene_synonym="C1orf179"
                     /note="hyporthetical protein MGC27169"
                     /codon_start=1
                     /product="protein FAM151A"
                     /protein_id="NP_788954.2"
                     /db_xref="CCDS:CCDS594.1"
                     /db_xref="GeneID:338094"
                     /db_xref="HGNC:HGNC:25032"
                     /translation="MVCREQLSKNQVKWVFAGITCVSVVVIAAIVLAITLRRPGCELE
                     ACSPDADMLDYLLSLGQISRRDALEVTWYHAANSKKAMTAALNSNITVLEADVNVEGL
                     GTANETGVPIMAHPPTIYSDNTLEQWLDAVLGSSQKGIKLDFKNIKAVGPSLDLLRQL
                     TEEGKVRRPIWINADILKGPNMLISTEVNATQFLALVQEKYPKATLSPGWTTFYMSTS
                     PNRTYTQAMVEKMHELVGGVPQRVTFPVRSSMVRAAWPHFSWLLSQSERYSLTLWQAA
                     SDPMSVEDLLYVRDNTAVHQVYYDIFEPLLSQFKQLALNATRKPMYYTGGSLIPLLQL
                     PGDDGLNVEWLVPDVQGSGKTATMTLPDTEGMILLNTGLEGTVAENPVPIVHTPSGNI
                     LTLESCLQQLATHPGHWGIHLQIAEPAALRPSLALLARLSSLGLLHWPVWVGAKISHG
                     SFSVPGHVAGRELLTAVAEVFPHVTVAPGWPEEVLGSGYREQLLTDMLELCQGLWQPV
                     SFQMQAMLLGHSTAGAIGRLLASSPRATVTVEHNPAGGDYASVRTALLAARAVDRTRV
                     YYRLPQGYHKDLLAHVGRN"
     exon            249..392
                     /gene="FAM151A"
                     /gene_synonym="C1orf179"
                     /inference="alignment:Splign:2.1.0"
     exon            393..545
                     /gene="FAM151A"
                     /gene_synonym="C1orf179"
                     /inference="alignment:Splign:2.1.0"
     exon            546..705
                     /gene="FAM151A"
                     /gene_synonym="C1orf179"
                     /inference="alignment:Splign:2.1.0"
     exon            706..930
                     /gene="FAM151A"
                     /gene_synonym="C1orf179"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1070
                     /gene="FAM151A"
                     /gene_synonym="C1orf179"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1214
                     /gene="FAM151A"
                     /gene_synonym="C1orf179"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1975
                     /gene="FAM151A"
                     /gene_synonym="C1orf179"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1952..1957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM151A"
                     /gene_synonym="C1orf179"
                     /note="hexamer: AATAAA"
     polyA_site      1975
                     /gene="FAM151A"
                     /gene_synonym="C1orf179"
                     /note="major polyA site"
ORIGIN      
        1 agagcagacc aggcccggtg gagaattagg tgctgctggg agctcctgcc tcccacagga
       61 ttccagctgc agggagcctc agggactctg ggccgcacgg agttgggggc attccccaga
      121 gagcgtcgcc atggtctgca gggagcagtt atcaaagaat caggtcaagt gggtgtttgc
      181 cggcattacc tgtgtgtctg tggtggtcat tgccgcaata gtccttgcca tcaccctgcg
      241 gcggccaggc tgtgagctgg aggcctgcag ccctgatgcc gacatgctgg actacctgct
      301 gagcctgggc cagatcagcc ggcgagatgc cttggaggtc acctggtacc acgcagccaa
      361 cagcaagaaa gccatgacag ctgccctgaa cagcaacatc acagtcctgg aggctgacgt
      421 caatgtagaa gggctcggca cagccaatga gacaggagtt cccatcatgg cacacccccc
      481 cactatctac agtgacaaca cactggagca gtggctggac gctgtgctgg gctcttccca
      541 aaagggcatc aaactggact tcaagaacat caaggcagtg ggcccctccc tggacctcct
      601 gcggcagctg acagaggaag gcaaagtccg gcggcccata tggatcaacg ctgacatctt
      661 aaagggcccc aacatgctca tctcaactga ggtcaatgcc acacagttcc tggccctggt
      721 ccaggagaag tatcccaagg ctaccctatc tccaggctgg accaccttct acatgtccac
      781 gtccccaaac aggacgtaca cccaagccat ggtggagaag atgcacgagc tggtgggagg
      841 agtgccccag agggtcacct tccctgtacg gtcttccatg gtgcgggctg cctggcccca
      901 cttcagctgg ctgctgagcc aatctgagag gtacagcctg acgctgtggc aggctgcctc
      961 ggaccccatg tcggtggaag atctgctcta cgtccgggat aacactgctg tccaccaagt
     1021 ctactatgac atctttgagc ctctcctgtc acagttcaag cagctggcct tgaatgccac
     1081 acggaaacca atgtactaca cgggaggcag cctgatccct cttctccagc tgcctgggga
     1141 tgacggtctg aatgtggagt ggctggttcc tgacgtccag ggcagcggta aaacagcaac
     1201 aatgaccctc ccagacacag aaggcatgat cctgctgaac actggcctcg agggaactgt
     1261 ggctgaaaac cccgtgccca ttgttcatac tccaagtggc aacatcctga cgctggagtc
     1321 ctgcctgcag cagctggcca cacatcccgg acactggggc atccatttgc aaatagcgga
     1381 gcccgcagcc ctccggccat ccctggcctt gctggcacgc ctctccagcc ttggcctctt
     1441 gcattggcct gtgtgggttg gggccaaaat ctcccacggg agtttttcgg tccccggcca
     1501 tgtggctggc agagagctgc ttacagctgt ggctgaggtc ttcccccacg tgactgtggc
     1561 accaggctgg cctgaggagg tgctgggcag tggctacagg gaacagctgc tcacagatat
     1621 gctagagttg tgccaggggc tctggcaacc tgtgtccttc cagatgcagg ccatgctgct
     1681 gggccacagc acagctggag ccataggcag gctgctggca tcctcccccc gggccaccgt
     1741 cacagtggag cacaacccag ctgggggcga ctatgcctct gtgaggacag cattgctggc
     1801 agctagggct gtggacagga cccgagtcta ctacaggcta ccccagggct accacaagga
     1861 cttgctggct catgttggta gaaactgagc acccaggggt ggtgggccag cggacctcag
     1921 ggcggaggct tcccacgggg aggcaggaag aaataaaggt ctttggcttt ctcca
//
