LOCUS       NM_198215               3328 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 13 member C (FAM13C),
            transcript variant 1, mRNA.
ACCESSION   NM_198215 XM_166142
VERSION     NM_198215.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3328)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3328)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3328)
  AUTHORS   Burdelski,C., Borcherding,L., Kluth,M., Hube-Magg,C., Melling,N.,
            Simon,R., Moller-Koop,C., Weigand,P., Minner,S., Haese,A.,
            Michl,H.U., Tsourlakis,M.C., Jacobsen,F., Hinsch,A., Wittmer,C.,
            Lebok,P., Steurer,S., Izbicki,J.R., Sauter,G., Krech,T.,
            Buscheck,F., Clauditz,T., Schlomm,T. and Wilczak,W.
  TITLE     Family with sequence similarity 13C (FAM13C) overexpression is an
            independent prognostic marker in prostate cancer
  JOURNAL   Oncotarget 8 (19), 31494-31508 (2017)
   PUBMED   28415558
  REMARK    GeneRIF: the results of our study demonstrate that expression of
            FAM13C is an independent prognostic marker in prostate cancer.
REFERENCE   4  (bases 1 to 3328)
  AUTHORS   Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
            Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
            King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
            Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
            Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
            Ferrucci,L., Fornage,M. and Mozaffarian,D.
  TITLE     Genome-wide association study identifies novel loci associated with
            concentrations of four plasma phospholipid fatty acids in the de
            novo lipogenesis pathway: results from the Cohorts for Heart and
            Aging Research in Genomic Epidemiology (CHARGE) consortium
  JOURNAL   Circ Cardiovasc Genet 6 (2), 171-183 (2013)
   PUBMED   23362303
REFERENCE   5  (bases 1 to 3328)
  AUTHORS   Karasik,D., Hsu,Y.H., Zhou,Y., Cupples,L.A., Kiel,D.P. and
            Demissie,S.
  TITLE     Genome-wide pleiotropy of osteoporosis-related phenotypes: the
            Framingham Study
  JOURNAL   J Bone Miner Res 25 (7), 1555-1563 (2010)
   PUBMED   20200953
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            KF459662.1, AL355474.15 and AC025038.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_198215.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.132551.1,
                                           SRR1660807.144079.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000618804.5/ ENSP00000481854.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                KF459662.1         44-127
            85-151              AL355474.15        96875-96941         c
            152-208             AL355474.15        90363-90419         c
            209-413             AL355474.15        86746-86950         c
            414-532             AC025038.6         21843-21961
            533-596             AC025038.6         43085-43148
            597-681             AC025038.6         62502-62586
            682-892             AC025038.6         75840-76050
            893-1031            AC025038.6         77258-77396
            1032-1113           AC025038.6         81783-81864
            1114-1325           AC025038.6         83304-83515
            1326-1421           AC025038.6         91506-91601
            1422-1621           AC025038.6         92951-93150
            1622-1723           AC025038.6         94273-94374
            1724-3328           AC025038.6         98212-99816
FEATURES             Location/Qualifiers
     source          1..3328
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.1"
     gene            1..3328
                     /gene="FAM13C"
                     /gene_synonym="FAM13C1"
                     /note="family with sequence similarity 13 member C"
                     /db_xref="GeneID:220965"
                     /db_xref="HGNC:HGNC:19371"
     exon            1..151
                     /gene="FAM13C"
                     /gene_synonym="FAM13C1"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1847
                     /gene="FAM13C"
                     /gene_synonym="FAM13C1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     family with sequence similarity 13, member C1; protein
                     FAM13C"
                     /codon_start=1
                     /product="protein FAM13C isoform 1"
                     /protein_id="NP_937858.2"
                     /db_xref="CCDS:CCDS7255.1"
                     /db_xref="GeneID:220965"
                     /db_xref="HGNC:HGNC:19371"
                     /translation="MFSCFCFSLQDNSFSSTTVTECDEDPVSLHEDQTDCSSLRDENN
                     KENYPDAGALVEEHAPPSWEPQQQNVEATVLVDSVLRPSMGNFKSRKPKSIFKAESGR
                     SHGESQETEHVVSSQSECQVRAGTPAHESPQNNAFKCQETVRLQPRIDQRTAISPKDA
                     FETRQDLNEEEAAQVHGVKDPAPASTQSVLADGTDSADPSPVHKDGQNEADSAPEDLH
                     SVGTSRLLYHITDGDNPLLSPRCSIFSQSQRFNLDPESAPSPPSTQQFMMPRSSSRCS
                     CGDGKEPQTITQLTKHIQSLKRKIRKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLA
                     KGRKQLKELKLKLSEEQGSAPKGPPRNLLCEQPTVPRENGKPEAAGPEPSSSGEETPD
                     AALTCLKERREQLPPQEDSKVTKQDKNLIKPLYDRYRIIKQILSTPSLIPTIQEEEDS
                     DEDRPQGSQQPSLADPASHLPVGDHLTYSNETEPVRALLPDEKKEVKPPALSMSNLHE
                     ATMPVLLDHLRETRADKKRLRKALREFEEQFFKQTGRSPQKEDRIPMADEYYEYKHIK
                     AKLRLLEVLISKQDVAKTI"
     exon            152..208
                     /gene="FAM13C"
                     /gene_synonym="FAM13C1"
                     /inference="alignment:Splign:2.1.0"
     exon            209..413
                     /gene="FAM13C"
                     /gene_synonym="FAM13C1"
                     /inference="alignment:Splign:2.1.0"
     exon            414..532
                     /gene="FAM13C"
                     /gene_synonym="FAM13C1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..596
                     /gene="FAM13C"
                     /gene_synonym="FAM13C1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..681
                     /gene="FAM13C"
                     /gene_synonym="FAM13C1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..892
                     /gene="FAM13C"
                     /gene_synonym="FAM13C1"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1031
                     /gene="FAM13C"
                     /gene_synonym="FAM13C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1113
                     /gene="FAM13C"
                     /gene_synonym="FAM13C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1325
                     /gene="FAM13C"
                     /gene_synonym="FAM13C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1421
                     /gene="FAM13C"
                     /gene_synonym="FAM13C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1621
                     /gene="FAM13C"
                     /gene_synonym="FAM13C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1723
                     /gene="FAM13C"
                     /gene_synonym="FAM13C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..3328
                     /gene="FAM13C"
                     /gene_synonym="FAM13C1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3307..3312
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM13C"
                     /gene_synonym="FAM13C1"
                     /note="hexamer: AATAAA"
     polyA_site      3328
                     /gene="FAM13C"
                     /gene_synonym="FAM13C1"
                     /note="major polyA site"
ORIGIN      
        1 ggagacttgc cttgcaatgc catgtttgtg tatgtgctct aactcccgga gagcaatcag
       61 ggagacggct ccccggccag acttggctga tgttttcttg tttctgtttc agccttcagg
      121 ataattcctt cagcagcacc actgtaacag agtgtgacga agatccagtc tctctacatg
      181 aagaccagac tgattgctcc agtctcagag atgaaaacaa taaagagaac taccccgacg
      241 caggggctct ggtagaagag cacgcgccgc cctcttggga gccgcagcag cagaatgtag
      301 aggcgaccgt gctggtggac agcgtattgc gacccagcat gggcaacttc aagtccagga
      361 agcccaagtc catcttcaaa gcggagagcg ggaggagcca cggagaaagt caggagacag
      421 agcatgtggt atccagccag tcagagtgtc aggtgagagc aggaacacca gctcatgaga
      481 gtccacaaaa caatgccttc aagtgccaag aaacagtgcg acttcaacca agaatagacc
      541 agaggactgc catttcgcca aaggatgctt ttgaaactcg gcaggactta aatgaggaag
      601 aagctgctca ggtgcatgga gtcaaggacc cggcgccagc atcaacccag agcgtgcttg
      661 ccgatgggac agattctgca gacccctcac cagtccacaa agatgggcag aatgaggccg
      721 acagtgcacc agaagacctc cactctgtgg ggaccagcag gctgctctat cacatcactg
      781 atggtgataa cccactgctg tcgccacgat gctccatctt cagccaaagc cagagattca
      841 acttagaccc cgagtcagcc ccatctccac ccagcactca gcagtttatg atgccgcgga
      901 gttcttcacg ctgcagctgt ggagatggca aggagccaca gaccatcacc cagctcacca
      961 agcacatcca gagcctcaag cggaaaattc ggaaatttga agaaaaattt gaacaagaaa
     1021 agaaataccg gccttcacat ggtgacaaga cttctaatcc tgaagtcctg aaatggatga
     1081 atgatttggc taaaggtcgt aaacagctca aagaactaaa gctaaagctg tcagaagaac
     1141 aagggagtgc tcccaaaggt ccacctagaa acctgttgtg tgagcaaccc acagtcccca
     1201 gagaaaatgg gaaaccggaa gctgcgggcc cggagccaag ctcctctgga gaagagactc
     1261 cagatgctgc cttgacatgc ctgaaggaga gaagagagca acttcctccc caggaggatt
     1321 ctaaggtaac taagcaagac aagaacctca taaagccgct ttatgaccga tacagaatta
     1381 tcaagcaaat cttgtcaaca ccttccctta ttccaacaat tcaggaggaa gaggactctg
     1441 atgaagaccg tccacaggga agccaacaac cttctttggc agatccagca tctcaccttc
     1501 ctgttggtga ccacctcacc tactctaatg agactgagcc tgttagggcc cttttaccag
     1561 atgaaaagaa agaagtaaaa ccaccagctc tctccatgtc taatttacat gaggctacca
     1621 tgcctgtact tcttgaccat ctccgagaaa ctagggctga caagaagaga ctgcggaaag
     1681 ccttaagaga atttgaagaa cagtttttta aacaaacagg aagaagtcca caaaaggaag
     1741 ataggatacc aatggcagat gagtattatg aatataagca cataaaagcc aaactgagac
     1801 tattagaggt cctcatcagc aagcaagatg tggccaaaac tatttgaggt tcaggaaatg
     1861 ttatgatcac tttcacccat gatataaagt aaagtttatt ttcctctgcc atccttgcta
     1921 agtagttttg acacaatgaa aatggaagca ctttagtggt agtattagct gtttttaaga
     1981 aggaatagca agtttaatta tatacaagga gaagggattt aaacgggggg aagaatacaa
     2041 caggtagcca tataattggg aaaaaattca gtgtcctcca tgccaagcag aaaactcata
     2101 gtcaatacaa gtatttttaa aaatgtctaa tattttatca aatctaaata acatagctag
     2161 gacacttgtt agggaaagtt tatttagtat ccaaagactg tttatgttga tgtatggaaa
     2221 agagcatgat tttaaaaaat caatcatagg aggaaaagaa attcgctttt caagtaggaa
     2281 ggaatacagc tagcaagaaa gcaatttatt tgaaacttct aatggatttt tgagtgataa
     2341 aacatttact accttgtcct ttaagtctgc taggctctca gtaccctaaa ataaactaga
     2401 ttgtgttgct atttttttct ttctctataa aaataacaca ttattttatc cgttatttga
     2461 aattttacat ttctggttac caaagttcat tctgatagca tgtactttgt gaattattat
     2521 ctttgtctat aactgacaga tgtttatatt aaaataaaat attgtattaa aaatttaaaa
     2581 taggtatttt ggatagatat gtgtctgtag tatataatct aatgtgtcca tagtattatt
     2641 gctaatcttt tggtttacta taagatgata taactatttt ttcattggga atatacattt
     2701 ttcttaatgt tccaacatct atactttgta aagtcaaaac atttcccatg agctgtagtt
     2761 attcatcctt ctgtacaaaa tgaaaagttt ggaaattgtt tgccctgata ccttgaaaaa
     2821 gaagccagaa tatttatttg cttcatcaac ttcagtgtat atcattttgt gttattttat
     2881 acgaaaacat gtttattatt ttcatttttg taaaaggaag taaaaggtca acattttctc
     2941 tcatgtacca accttgtttg tatttctatt ttctgtaatg tttaagtatg atgttgaaga
     3001 aattcacatt ctcttatagt ttggatggga agactattga ctatttcaga aacagactta
     3061 tttcagaggc ttattgtttt ctctgtattt acctaatatt ttataacttt tatgaatcag
     3121 aataatgtcc ttcataaatt tgtttaattg aagtcatcta cttctaacag gacagataca
     3181 caactatttg aggtttacaa attacatctt tgataaggga aatggtttcg tgacatgtac
     3241 acagttgcta ttaaaatgta actctatata ttctatatga ttgtaaatat tttatacaac
     3301 aatacaaata aaatattttt ctattata
//
