LOCUS       NM_014883               5866 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens family with sequence similarity 13 member A (FAM13A),
            transcript variant 1, mRNA.
ACCESSION   NM_014883 XM_376328
VERSION     NM_014883.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5866)
  AUTHORS   Howes,A., Rogerson,C., Belyaev,N., Karagyozova,T., Rapiteanu,R.,
            Fradique,R., Pellicciotta,N., Mayhew,D., Hurd,C., Crotta,S.,
            Singh,T., Dingwell,K., Myatt,A., Arad,N., Hasan,H., Bijlsma,H.,
            Panjwani,A., Vijayan,V., Young,G., Bridges,A., Petit-Frere,S.,
            Betts,J., Larminie,C., Smith,J.C., Hessel,E.M., Michalovich,D.,
            Walport,L., Cicuta,P., Powell,A.J., Beinke,S. and Wack,A.
  TITLE     The FAM13A Long Isoform Regulates Cilia Movement and Coordination
            in Airway Mucociliary Transport
  JOURNAL   Am J Respir Cell Mol Biol 71 (3), 282-293 (2024)
   PUBMED   38691660
  REMARK    GeneRIF: The FAM13A Long Isoform Regulates Cilia Movement and
            Coordination in Airway Mucociliary Transport.
REFERENCE   2  (bases 1 to 5866)
  AUTHORS   Hu,Y., Li,Z., Ren,Y. and Dai,H.
  TITLE     Association of family sequence similarity gene 13A gene
            polymorphism and interstitial lung disease susceptibility: A
            systematic review and meta-analysis
  JOURNAL   Mol Genet Genomic Med 11 (11), e2279 (2023)
   PUBMED   37786320
  REMARK    GeneRIF: Association of family sequence similarity gene 13A gene
            polymorphism and interstitial lung disease susceptibility: A
            systematic review and meta-analysis.
            Review article
REFERENCE   3  (bases 1 to 5866)
  AUTHORS   Chen,Q., Vasse,G.F., Nwozor,K.O., Bekker,N.J., van den Berge,M.,
            Brandsma,C.A., de Vries,M. and Heijink,I.H.
  TITLE     FAM13A regulates cellular senescence marker p21 and mitochondrial
            reactive oxygen species production in airway epithelial cells
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 325 (4), L460-L466 (2023)
   PUBMED   37605846
  REMARK    GeneRIF: FAM13A regulates cellular senescence marker p21 and
            mitochondrial reactive oxygen species production in airway
            epithelial cells.
REFERENCE   4  (bases 1 to 5866)
  AUTHORS   Hsieh,M.J., Lo,Y.S., Tsai,Y.J., Ho,H.Y., Lin,C.C., Chuang,Y.C.,
            Lin,S.H. and Chen,M.K.
  TITLE     FAM13A polymorphisms are associated with a specific susceptibility
            to clinical progression of oral cancer in alcohol drinkers
  JOURNAL   BMC Cancer 23 (1), 607 (2023)
   PUBMED   37391706
  REMARK    GeneRIF: FAM13A polymorphisms are associated with a specific
            susceptibility to clinical progression of oral cancer in alcohol
            drinkers.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5866)
  AUTHORS   Pham,K.H., Tran,N.T.C., Tran,H.D., Ngo,T.H., Tran,V., Ly,H.H.V.,
            Pham,N.T.N., Nguyen,T., Nguyen,B.H. and Nguyen,K.T.
  TITLE     Single Nucleotide Polymorphisms of FAM13A Gene in Chronic
            Obstructive Pulmonary Disease-A Case Control Study in Vietnam
  JOURNAL   Adv Respir Med 91 (3), 268-277 (2023)
   PUBMED   37366807
  REMARK    GeneRIF: Single Nucleotide Polymorphisms of FAM13A Gene in Chronic
            Obstructive Pulmonary Disease-A Case Control Study in Vietnam.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5866)
  AUTHORS   Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Association of gene polymorphisms with chronic kidney disease in
            Japanese individuals
  JOURNAL   Int J Mol Med 24 (4), 539-547 (2009)
   PUBMED   19724895
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5866)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   8  (bases 1 to 5866)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 5866)
  AUTHORS   Cohen,M., Reichenstein,M., Everts-van der Wind,A., Heon-Lee,J.,
            Shani,M., Lewin,H.A., Weller,J.I., Ron,M. and Seroussi,E.
  TITLE     Cloning and characterization of FAM13A1--a gene near a milk protein
            QTL on BTA6: evidence for population-wide linkage disequilibrium in
            Israeli Holsteins
  JOURNAL   Genomics 84 (2), 374-383 (2004)
   PUBMED   15234000
REFERENCE   10 (bases 1 to 5866)
  AUTHORS   Ranta,S., Lehesjoki,A.E., de Fatima Bonaldo,M., Knowles,J.A.,
            Hirvasniemi,A., Ross,B., de Jong,P.J., Soares,M.B., de la
            Chapelle,A. and Gilliam,T.C.
  TITLE     High-resolution mapping and transcript identification at the
            progressive epilepsy with mental retardation locus on chromosome 8p
  JOURNAL   Genome Res 7 (9), 887-896 (1997)
   PUBMED   9314494
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA692373.1 and BN000265.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014883.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BN000265.1, SRR14038191.4325406.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264344.10/ ENSP00000264344.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA692373.1         11-23
            14-5866             BN000265.1         1-5853
FEATURES             Location/Qualifiers
     source          1..5866
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22.1"
     gene            1..5866
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /note="family with sequence similarity 13 member A"
                     /db_xref="GeneID:10144"
                     /db_xref="HGNC:HGNC:19367"
                     /db_xref="MIM:613299"
     exon            1..248
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..3293
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /note="isoform a is encoded by transcript variant 1;
                     family with sequence similarity 13, member A1; FAM13A1_v2
                     protein; protein FAM13A"
                     /codon_start=1
                     /product="protein FAM13A isoform a"
                     /protein_id="NP_055698.2"
                     /db_xref="CCDS:CCDS34029.1"
                     /db_xref="GeneID:10144"
                     /db_xref="HGNC:HGNC:19367"
                     /db_xref="MIM:613299"
                     /translation="MGAGALAICQSKAAVRLKEDMKKIVAVPLNEQKDFTYQKLFGVS
                     LQELERQGLTENGIPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPV
                     ELGKDGDVCSAASLLKLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKEL
                     PDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCNK
                     IMAKILENYNTLFEVEYTENDHLRCENLARLIIVKEVYYKNSLPILLTRGLERDMPKP
                     PPKTKIPKSRSEGSIQAHRVLQPELSDGIPQLSLRLSYRKACLEDMNSAEGAISAKLV
                     PSSQEDERPLSPFYLSAHVPQVSNVSATGELLERTIRSAVEQHLFDVNNSGGQSSEDS
                     ESGTLSASSATSARQRRRQSKEQDEVRHGRDKGLINKENTPSGFNHLDDCILNTQEVE
                     KVHKNTFGCAGERSKPKRQKSSTKLSELHDNQDGLVNMESLNSTRSHERTGPDDFEWM
                     SDERKGNEKDGGHTQHFESPTMKIQEHPSLSDTKQQRNQDAGDQEESFVSEVPQSDLT
                     ALCDEKNWEEPIPAFSSWQRENSDSDEAHLSPQAGRLIRQLLDEDSDPMLSPRFYAYG
                     QSRQYLDDTEVPPSPPNSHSFMRRRSSSLGSYDDEQEDLTPAQLTRRIQSLKKKIRKF
                     EDRFEEEKKYRPSHSDKAANPEVLKWTNDLAKFRRQLKESKLKISEEDLTPRMRQRSN
                     TLPKSFGSQLEKEDEKKQELVDKAIKPSVEATLESIQRKLQEKRAESSRPEDIKDMTK
                     DQIANEKVALQKALLYYESIHGRPVTKNERQVMKPLYDRYRLVKQILSRANTIPIIGS
                     PSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDSNVKPDFMVTLKTDFSARCFLDQ
                     FEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMREEKKRIRKKLRDF
                     EDNFFRQNGRNVQKEDRTPMAEEYSEYKHIKAKLRLLEVLISKRDTDSKSM"
     exon            249..438
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..648
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     exon            649..826
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..980
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1064
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1228
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1270
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1312
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1492
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1679
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1756
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1799
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1947
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2161
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2300
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2382
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2603
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2687
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2783
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..2867
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..3064
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3166
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..5866
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5331..5336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /note="hexamer: AATAAA"
     polyA_site      5350
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /note="major polyA site"
     regulatory      5438..5443
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /note="hexamer: AAGAAA"
     regulatory      5464..5469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /note="hexamer: AATAAA"
     polyA_site      5469
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
     polyA_site      5481
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
     regulatory      5845..5850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
                     /note="hexamer: ATTAAA"
     polyA_site      5866
                     /gene="FAM13A"
                     /gene_synonym="ARHGAP48; FAM13A1"
ORIGIN      
        1 aactccaggc agtccttcca gccatgtggg ttcagcggaa agagaagcaa aaccactctt
       61 cctaaaatgt tagaagctgc tcttcgctta ccttggggcc tttgcattgg gagctgtttt
      121 tcacatcaaa gaatatgtgc tgaatggaat tttagtattt tgctgtcgtt ttaatatttt
      181 cgtctggtct tcctcagttc ttccagacgc tttctgagag aatgggggca ggagctctag
      241 ccatctgtca aagtaaagca gcggttcggc tgaaagaaga catgaaaaag atagtggcag
      301 tgccattaaa tgaacagaag gattttacct atcagaagtt atttggagtc agtctccaag
      361 aacttgaacg gcaggggctc accgagaatg gcattccagc agtagtgtgg aatatagtgg
      421 aatatttgac gcagcatgga cttacccaag aaggtctttt tagggtgaat ggtaacgtga
      481 aggtggtgga acaacttcga ctgaagttcg agagtggagt gcccgtggag ctcgggaagg
      541 acggtgatgt ctgctcagca gccagtctgt tgaagctgtt tctgagggag ctgcctgaca
      601 gtctgatcac ctcagcgttg cagcctcgat tcattcaact ctttcaggat ggcagaaatg
      661 atgttcagga gagtagctta agagacttaa taaaagagct gccagacacc cactactgcc
      721 tcctcaagta cctttgccag ttcttgacaa aagtagccaa gcatcatgtg cagaatcgca
      781 tgaatgttca caatctcgcc actgtatttg ggccaaattg ctttcatgtg ccacctgggc
      841 ttgaaggcat gaaggaacag gacctgtgca acaagataat ggctaaaatt ctagaaaatt
      901 acaataccct gtttgaagta gagtatacag aaaatgatca tctgagatgt gaaaacctgg
      961 ctaggcttat catagtaaaa gaggtctatt ataagaactc cctgcccatc cttttaacaa
     1021 gaggcttaga aagagacatg ccaaaaccac ctccaaaaac caagatccca aaatccagga
     1081 gtgagggatc tattcaggcc cacagagtac tgcaaccaga gctatctgat ggcattcctc
     1141 agctcagctt gcggctaagt tatagaaaag cctgcttgga agacatgaat tcagcagagg
     1201 gtgctattag tgccaagttg gtacccagtt cacaggaaga tgaaagacct ctgtcacctt
     1261 tctatttgag tgctcatgta ccccaagtca gcaatgtgtc tgcaaccgga gaactcttag
     1321 aaagaaccat ccgatcagct gtagaacaac atctttttga tgttaataac tctggaggtc
     1381 aaagttcaga ggactcagaa tctggaacac tatcagcatc ttctgccaca tctgccagac
     1441 agcgccgccg ccagtccaag gagcaggatg aagttcgaca tgggagagac aagggactta
     1501 tcaacaaaga aaatactcct tctgggttca accaccttga tgattgtatt ttgaatactc
     1561 aggaagtcga aaaggtacac aaaaatactt ttggttgtgc tggagaaagg agcaagccta
     1621 aacgtcagaa atccagtact aaactttctg agcttcatga caatcaggac ggtcttgtga
     1681 atatggaaag tctcaattcc acacgatctc atgagagaac tggacctgat gattttgaat
     1741 ggatgtctga tgaaaggaaa ggaaatgaaa aagatggtgg acacactcag cattttgaga
     1801 gccccacaat gaagatccag gagcatccca gcctatctga caccaaacag cagagaaatc
     1861 aagatgccgg tgaccaggag gagagctttg tctccgaagt gccccagtcg gacctgactg
     1921 cattgtgtga tgaaaagaac tgggaagagc ctatccctgc tttctcctcc tggcagcggg
     1981 agaacagtga ctctgatgaa gcccacctct cgccgcaggc tgggcgcctg atccgtcagc
     2041 tgctggacga agacagcgac cccatgctct ctcctcggtt ctacgcttat gggcagagca
     2101 ggcaatacct ggatgacaca gaagtgcctc cttccccacc aaactcccat tctttcatga
     2161 ggcggcgaag ctcctctctg gggtcctatg atgatgagca agaggacctg acacctgccc
     2221 agctcacacg aaggattcag agccttaaaa agaagatccg gaagtttgaa gatagattcg
     2281 aagaagagaa gaagtacaga ccttcccaca gtgacaaagc agccaatccg gaggttctga
     2341 aatggacaaa tgaccttgcc aaattccgga gacaacttaa agaatcaaaa ctaaagatat
     2401 ctgaagagga cctaactccc aggatgcggc agcgaagcaa cacactcccc aagagttttg
     2461 gttcccaact tgagaaagaa gatgagaaga agcaagagct ggtggataaa gcaataaagc
     2521 ccagtgttga agccacattg gaatctattc agaggaagct ccaggagaag cgagcggaaa
     2581 gcagccgccc tgaggacatt aaggatatga ccaaagacca gattgctaat gagaaagtgg
     2641 ctctgcagaa agctctgtta tattatgaaa gcattcatgg acggccggta acaaagaacg
     2701 aacggcaggt gatgaagcca ctatacgaca ggtaccggct ggtcaaacag atcctctccc
     2761 gagctaacac catacccatc attggttccc cctccagcaa gcggagaagc cctttgctgc
     2821 agccaattat cgagggcgaa actgcttcct tcttcaagga gataaaggaa gaagaggagg
     2881 ggtcagaaga cgatagcaat gtgaagccag acttcatggt cactctgaaa accgatttca
     2941 gtgcacgatg ctttctggac caattcgaag atgacgctga tggatttatt tccccaatgg
     3001 atgataaaat accatcaaaa tgcagccagg acacagggct ttcaaatctc catgctgcct
     3061 caatacctga actcctggaa cacctccagg aaatgagaga agaaaagaaa aggattcgaa
     3121 agaaacttcg ggattttgaa gacaactttt tcagacagaa tggaagaaat gtccagaagg
     3181 aagaccgcac tcctatggct gaagaataca gtgaatataa gcacataaag gcgaaactga
     3241 ggctcctgga ggtgctcatc agcaagagag acactgattc caagtccatg tgaggggcat
     3301 ggccaagcac agggggctgg cagctgcggt gagagtttac tgtccccaga gaaagtgcag
     3361 ctctggaagg cagccttggg gctggccctg caaagcatgc agcccttctg cctctagacc
     3421 atttggcatc ggctcctgtt tccattgcct gccttagaaa ctggctggaa gaagacaatg
     3481 tgacctgact taggcatttt gtaattggaa agtcaagact gcagtatgtg cacatgcgca
     3541 cgcgcatgca cgcacacaca cacacagtag tggagctttc ctaacactag cagagattaa
     3601 tcactacatt agacaacact catctacaga gaatatacac tgttcttccc tggataactg
     3661 agaaacaaga gaccattctc tgtctaactg tgataaaaac aagctcagga ctttattcta
     3721 tagagcaaac ttgctgtgga gggccatgct ctccttggac ccagttaact gcaaacgtgc
     3781 attggagccc tatttgctgc cgctgccatt ctagtgacct ttccacagag ctgcgccttc
     3841 ctcacgtgtg tgaaaggttt tccccttcag ccctcaggta gatggaagct gcatctgccc
     3901 acgatggcag tgcagtcatc atcttcagga tgtttcttca ggacttcctc agctgacaag
     3961 gaattttggt ccctgcctag gaccgggtca tctgcagagg acagagagat ggtaagcagc
     4021 tgtatgaatg ctgattttaa aaccaggtca tgggagaaga gcctggagat tctttcctga
     4081 acactgactg cacttaccag tctgatttta tcgtcaaaca ccaagccagg ctagcatgct
     4141 catggcaatc tgtttggggc tgttttgttg tggcactagc caaacataaa ggggcttaag
     4201 tcagcctgca tacagaggat cggggagaga aggggcctgt gttctcagcc tcctgagtac
     4261 ttaccagagt ttaatttttt taaaaaaaat ctgcactaaa atccccaaac tgacaggtaa
     4321 atgtagccct cagagctcag cccaaggcag aatctaaatc acactatttt cgagatcatg
     4381 tataaaaaga aaaaaaagaa gtcatgctgt gtggccaatt ataatttttt tcaaagactt
     4441 tgtcacaaaa ctgtctatat tagacatttt ggagggacca ggaaatgtaa gacaccaaat
     4501 cctccatctc ttcagtgtgc ctgatgtcac ctcatgattt gctgttactt ttttaactcc
     4561 tgcgccaagg acagtgggtt ctgtgtccac ctttgtgctt tgcgaggccg agcccaggca
     4621 tctgctcgcc tgccacggct gaccagagaa ggtgcttcag gagctctgcc ttagacgacg
     4681 tgttacagta tgaacacaca gcagaggcac cctcgtatgt tttgaaagtt gccttctgaa
     4741 agggcacagt tttaaggaaa agaaaaagaa tgtaaaacta tactgacccg ttttcagttt
     4801 taaagggtcg tgagaaactg gctggtccaa tgggatttac agcaacattt tccattgctg
     4861 aagtgaggta gcagctctct tctgtcagct gaatgttaag gatggggaaa aagaatgcct
     4921 ttaagtttgc tcttaatcgt atggaagctt gagctatgtg ttggaagtgc cctggtttta
     4981 atccatacac aaagacggta cataatccta caggtttaaa tgtacataaa aatatagttt
     5041 ggaattcttt gctctactgt ttacattgca gattgctata atttcaagga gtgagattat
     5101 aaataaaatg atgcacttta ggatgtttcc tatttttgaa atctgaacat gaatcattca
     5161 catgaccaaa aattgtgttt ttttaaaaat acatgtctag tctgtccttt aatagctctc
     5221 ttaaataagc tatgatatta atcagatcat taccagttag cttttaaagc acatttgttt
     5281 aagactatgt ttttggaaaa atacgctaca gaattttttt ttaagctaca aataaatgag
     5341 atgctactaa ttgttttgga atctgttgtt tctgccaaag gtaaattaac taaagattta
     5401 ttcaggaatc cccatttgaa tttgtatgat tcaataaaag aaaacaccaa gtaagttata
     5461 taaaataaat tgtgtatgag atgttgtgtt ttcctttgta atttccacta actaactaac
     5521 taacttatat tcttcatgga atggagccca gaagaaatga gaggaagccc ttttcacact
     5581 agatcttatt tgaagaaatg tttgttagtc agtcagtcag tggtttctgg ctctgccgag
     5641 ggagatgtgt tccccagcaa ccatttctgc agcccagaat ctcaaggcac tagaggcggt
     5701 gtcttaatta attggcttca caaagacaaa atgctctgga ctgggatttt tcctttgctg
     5761 tgttgggaat atgtgtttat taattagcac atgccaacaa aataaatgtc aagagttatt
     5821 tcataagtgt aagtaaactt aagaattaaa gagtgcagac ttataa
//
