LOCUS       NM_015912               7401 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 135 member B
            (FAM135B), transcript variant 1, mRNA.
ACCESSION   NM_015912
VERSION     NM_015912.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7401)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 7401)
  AUTHORS   Bi,L., Wang,H. and Tian,Y.
  TITLE     Silencing FAM135B enhances radiosensitivity of esophageal carcinoma
            cell
  JOURNAL   Gene 772, 145358 (2021)
   PUBMED   33340561
  REMARK    GeneRIF: Silencing FAM135B enhances radiosensitivity of esophageal
            carcinoma cell.
REFERENCE   3  (bases 1 to 7401)
  AUTHORS   Dong,D., Zhang,W., Xiao,W., Wu,Q., Cao,Y., Gao,X., Huang,L.,
            Wang,Y., Chen,J., Wang,W. and Zhan,Q.
  TITLE     A GRN Autocrine-Dependent FAM135B/AKT/mTOR Feedforward Loop
            Promotes Esophageal Squamous Cell Carcinoma Progression
  JOURNAL   Cancer Res 81 (4), 910-922 (2021)
   PUBMED   33323378
  REMARK    GeneRIF: A GRN Autocrine-Dependent FAM135B/AKT/mTOR Feedforward
            Loop Promotes Esophageal Squamous Cell Carcinoma Progression.
REFERENCE   4  (bases 1 to 7401)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 7401)
  AUTHORS   Sheila,M., Narayanan,G., Ma,S., Tam,W.L., Chai,J. and Stanton,L.W.
  TITLE     Phenotypic and molecular features underlying neurodegeneration of
            motor neurons derived from spinal and bulbar muscular atrophy
            patients
  JOURNAL   Neurobiol Dis 124, 1-13 (2019)
   PUBMED   30391288
  REMARK    GeneRIF: Using microarray analysis reveals novel genes such as
            FAM135B, dysregulated in Spinal and bulbar muscular atrophy (SBMA).
            Knockdown of FAM135B results in neurodegeneration, indicating its
            role in SBMA.
REFERENCE   6  (bases 1 to 7401)
  AUTHORS   Butland,S.L., Sanders,S.S., Schmidt,M.E., Riechers,S.P., Lin,D.T.,
            Martin,D.D., Vaid,K., Graham,R.K., Singaraja,R.R., Wanker,E.E.,
            Conibear,E. and Hayden,M.R.
  TITLE     The palmitoyl acyltransferase HIP14 shares a high proportion of
            interactors with huntingtin: implications for a role in the
            pathogenesis of Huntington's disease
  JOURNAL   Hum Mol Genet 23 (15), 4142-4160 (2014)
   PUBMED   24705354
REFERENCE   7  (bases 1 to 7401)
  AUTHORS   Teumer,A., Holtfreter,B., Volker,U., Petersmann,A., Nauck,M.,
            Biffar,R., Volzke,H., Kroemer,H.K., Meisel,P., Homuth,G. and
            Kocher,T.
  TITLE     Genome-wide association study of chronic periodontitis in a general
            German population
  JOURNAL   J Clin Periodontol 40 (11), 977-985 (2013)
   PUBMED   24024966
REFERENCE   8  (bases 1 to 7401)
  AUTHORS   Aslibekyan,S., Kabagambe,E.K., Irvin,M.R., Straka,R.J.,
            Borecki,I.B., Tiwari,H.K., Tsai,M.Y., Hopkins,P.N., Shen,J.,
            Lai,C.Q., Ordovas,J.M. and Arnett,D.K.
  TITLE     A genome-wide association study of inflammatory biomarker changes
            in response to fenofibrate treatment in the Genetics of Lipid
            Lowering Drug and Diet Network
  JOURNAL   Pharmacogenet Genomics 22 (3), 191-197 (2012)
   PUBMED   22228203
REFERENCE   9  (bases 1 to 7401)
  AUTHORS   Cirulli,E.T., Kasperaviciute,D., Attix,D.K., Need,A.C., Ge,D.,
            Gibson,G. and Goldstein,D.B.
  TITLE     Common genetic variation and performance on standardized cognitive
            tests
  JOURNAL   Eur J Hum Genet 18 (7), 815-820 (2010)
   PUBMED   20125193
  REMARK    Erratum:[Eur J Hum Genet. 2010 Jul;18(7):820]
REFERENCE   10 (bases 1 to 7401)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068467.7, AK091433.1, BC037288.1, AC103777.14 and BX110118.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015912.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.82870.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395297.6/ ENSP00000378710.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-439               AC068467.7         45973-46411
            440-655             AK091433.1         1-216
            656-687             BC037288.1         174-205
            688-1656            AK091433.1         249-1217
            1657-2038           BC037288.1         1253-1634
            2039-3668           AC103777.14        60222-61851         c
            3669-4608           BC037288.1         3265-4204
            4609-5055           BX110118.1         29-475
            5056-7401           AC103777.14        38828-41173         c
FEATURES             Location/Qualifiers
     source          1..7401
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.23"
     gene            1..7401
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /note="family with sequence similarity 135 member B"
                     /db_xref="GeneID:51059"
                     /db_xref="HGNC:HGNC:28029"
     exon            1..591
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /inference="alignment:Splign:2.1.0"
     exon            592..687
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /inference="alignment:Splign:2.1.0"
     CDS             611..4831
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /codon_start=1
                     /product="protein FAM135B"
                     /protein_id="NP_056996.2"
                     /db_xref="CCDS:CCDS6375.2"
                     /db_xref="GeneID:51059"
                     /db_xref="HGNC:HGNC:28029"
                     /translation="MSEIQGTVEFSVELHKFYNVDLFQRGYYQIRVTLKVSSRIPHRL
                     SASIAGQTESSSLHSACVHDSTVHSRVFQILYRNEEVPINDAVVFRVHLLLGGERMED
                     ALSEVDFQLKVDLHFTDSEQQLRDVAGAPMVSSRTLGLHFHPRNGLHHQVPVMFDYFH
                     LSVISVTVHAALVALQQPLISFTRPGRGSWLGKGGPDTGQEQSIISLENLVFGAGYCK
                     PTSSEGSFYITSENCMQHAHKWHRDLCLLLLHAYRGLRLHFLVIMRDIPELPHTELEA
                     LAVEETLSQLCSELQMLNNPEKIAEQISKDLAWLTSHMMTLWTQFLDTVTLHSQVTTY
                     LTQEHHTLRVRRFSEAFFYMEHQKLAVLTFQENLIQTHSQLSLDIRNSEYLTSMPPLP
                     AECLDIDGDWNTLPVIFEDRYVDCPATGHNLSVYPNFDVPVTSPTIMNLKDKEDNCMV
                     NSNLSFREDLVLSTIKPSQMDSDEEVIRCPEPGENVATQNHMDMCSESQVYISIGEFQ
                     NKAGVPEDECWTGQTSDAGTYPVADVDTSRRSPGPEDGQAPVLTYIDVKSSNKNPSRA
                     EPLVAFNAQHESRSSRDKYGLDRTGLSKVVVGGSHQNAISSDKTTLHELSTLGKGIDQ
                     EGKMVLLSLKLTPSEPCDPLSSTLREPLDIRSSLKDSHTEEQEELSVLSGVIKRSSSI
                     ISDSGIESEPSSVAWSEARSRALELPSDREVLHPFVRRHALHRNSLEGGHTESNTSLP
                     SGIQASLTSISSLPFEEDEREVALTKLTKSVSAPHISSPEEAAEDADTKQQDGGFAEP
                     SDMHSKSQGSPGSCSQLCGDSGTDAGADHPLVEIVLDADNQQGPGYIDIPKGKGKQFD
                     AQGHCLPDGRTENTPGVETKGLNLKIPRVIALENPRTRSLHRALEETPKGMPKDLNVG
                     QQALSNSGISEVEGLSQHQVPELSCTSAADAINRNSTGQQSQSGSPCIMDDTAFNRGV
                     NAFPEAKHKAGTVCPTVTHSVHSQVLKNQELKAGTSIMGSHLTSAETFTLDSLKAVEV
                     VNLSVSCTATCLPFSSVPKETPARAGFSSKQTLFPITHQPLGSFGVVSTHSSTLDEEV
                     SERMFSFYQAKEKFKKELKIEGFLYSDLTVLASDIPYFPPEEEEENLEDGIHLVVCVH
                     GLDGNSADLRLVKTFIELGLPGGKLDFLMSEKNQMDTFADFDTMTDRLLDEIIQHIQL
                     YNLSISRISFIGHSLGNIIIRSVLTRPRFRYYLNKLHTFLSLSGPHLGTLYNNSTLVS
                     TGLWLMQKLKKSGSLLQLTFRDNADLRKCFLYQLSQKTGLQYFKNVVLVASPQDRYVP
                     FHSARIEMCKTALKDRHTGPVYAEMINNLLGPLVEAKDCTLIRHNVFHALPNTANTLI
                     GRAAHIAVLDSELFLEKFFLVAGLNYFK"
     exon            688..767
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /inference="alignment:Splign:2.1.0"
     exon            768..907
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /inference="alignment:Splign:2.1.0"
     exon            908..978
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1152
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1279
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1433
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1483
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1639
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1713
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1868
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..3891
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /inference="alignment:Splign:2.1.0"
     exon            3892..4058
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /inference="alignment:Splign:2.1.0"
     exon            4059..4150
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /inference="alignment:Splign:2.1.0"
     exon            4151..4248
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /inference="alignment:Splign:2.1.0"
     exon            4249..4400
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /inference="alignment:Splign:2.1.0"
     exon            4401..4511
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /inference="alignment:Splign:2.1.0"
     exon            4512..4625
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /inference="alignment:Splign:2.1.0"
     exon            4626..7401
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7276..7281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /note="hexamer: AACAAA"
     polyA_site      7297
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /note="major polyA site"
     regulatory      7375..7380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /note="hexamer: AATAAA"
     polyA_site      7401
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcgcag cgtctaccca cgcggtgcgc agcggctgcg gagcggagcc agcgggagca
       61 gcagggcggg ctctcccggc cgcgagggcg cgcggcgcgg cgcggagggt ctggccgcgt
      121 cccggcggag gaaggagagg agtgagggcg ccagaggtga gcgcagcccg ggaggcgcca
      181 gcccagcggc gcgggcgcag ccggtcggtc cttgctttct tgcggcgctg gcggctgcgt
      241 tcccccgacc gcgctgacag cctcgcgtcc tggcgcctgc tcgctggggc tgcccggagg
      301 ccgcggccgg gcagctgttg cacggagagg ggggcagttg cggggttcca taaccatagc
      361 aaccgcatca gcaccggcgg cggcgggcga gggcagcatc cgctcgctcc tcctccaggc
      421 agcctcgccg cggggaccca acaccagctc gcaggtgctg cggactcccc agtccgcccg
      481 ccgccgccgc cgccgcaact gttggcggcc agagacggcg aaagaggaga gagagggacc
      541 caggagcgcg gcccccgggg gagagagagg ggagccctgc agtggagaca ggtaatgagc
      601 caaaaagatc atgtctgaaa tacaaggaac ggttgagttt tcggtagagc tacataaatt
      661 ttataatgtg gatctctttc agagagggta ttaccagatc cgagtgacct tgaaggtgtc
      721 ttcaaggatc ccccacagac tgagtgcctc catcgctggg cagacagaga gcagcagcct
      781 gcattcagcc tgtgtccatg acagcaccgt gcacagccgg gtctttcaga tcttataccg
      841 gaatgaagag gtacccataa atgatgctgt ggtcttccga gttcatttac tcttgggtgg
      901 tgaaaggatg gaagacgcac tgagtgaagt agattttcaa ctcaaggtgg atctgcactt
      961 tacggacagt gaacagcagt tgagggatgt ggctggggca ccgatggtca gcagccgaac
     1021 gcttggcctg cacttccacc cccggaatgg tctgcaccac caggtcccgg tcatgttcga
     1081 ctatttccac ctgtctgtga tctcggtgac cgtccatgct gccctggtgg ctctgcagca
     1141 gccattgatc agttttactc gtccaggaag aggctcctgg cttggtaaag gtggcccaga
     1201 caccggacaa gaacagtcta tcatttctct ggaaaacttg gtctttggag ctgggtactg
     1261 caagccgact tcctcagagg gaagcttcta catcacctct gagaactgca tgcagcacgc
     1321 acacaagtgg caccgagacc tgtgcctgtt gctcctccac gcttaccggg gtctccgtct
     1381 ccacttcctg gtgatcatgc gggacatccc agagctgcca cacacggagc tggaggccct
     1441 tgctgttgaa gaaacacttt ctcagctgtg ctcagagcta cagatgttga acaatccaga
     1501 gaagatcgct gagcagataa gcaaggatct ggcctggctc acgtcccaca tgatgactct
     1561 gtggacccag ttcctggaca cagtcactct gcactcccaa gtgaccactt atctcaccca
     1621 ggaacaccac accctgaggg tccgaaggtt ttctgaggcc ttcttttaca tggagcacca
     1681 aaaacttgca gtcctgacat ttcaggagaa tctgatacag acgcacagcc agctgtccct
     1741 ggatatccgg aactcggagt acctcactag catgcccccg ctgcctgcag agtgcctgga
     1801 catcgacggc gattggaaca ccctgccggt gatctttgag gacagatacg tggactgccc
     1861 tgcgacaggg cataacttga gtgtttatcc taattttgat gttccagtga caagtcctac
     1921 aataatgaat ctgaaagaca aggaagataa ctgtatggta aatagcaatt tatcttttag
     1981 ggaagacctt gtcttgtcta ccataaaacc atcccaaatg gattctgatg aagaagttat
     2041 aaggtgtcca gagccaggtg agaatgtggc cacacaaaat catatggaca tgtgctctga
     2101 atctcaggtg tatatatcaa ttggtgaatt tcaaaacaaa gcaggtgtgc ctgaagatga
     2161 atgttggact ggccaaacat ctgatgctgg gacatatcca gtggcagatg tggatacttc
     2221 tagaaggagt ccaggtccag aggatggaca ggccccagtg ctgacctaca ttgacgtaaa
     2281 atctagcaat aagaacccct ccagagctga acccctggtg gccttcaatg ctcagcatga
     2341 gagtaggagc tctagagata agtatggatt agacaggact gggctaagca aagtggtagt
     2401 aggtggaagc caccaaaatg ccatctcttc agacaaaaca actctccatg aattaagtac
     2461 tctaggaaag ggaatagatc aagaggggaa gatggtgctg ctaagcttga aactcacccc
     2521 ctctgagccc tgtgatccac taagttctac cctgagggag cccttagata ttaggtcttc
     2581 cctaaaggac tctcacacag aagagcagga ggaactctca gtgctatccg gggtcatcaa
     2641 gagatcttca tccatcatat ctgattcagg cattgagagt gagccaagct ccgtcgcctg
     2701 gtcagaggcc cgaagcaggg ctctggagtt gcccagtgat cgggaagtct tgcacccgtt
     2761 tgttcgaaga catgccctcc accggaactc cctagagggt ggacacacag aaagtaacac
     2821 aagtttgcca agcggcatcc aggcttctct cacctccatt agctctttac cttttgagga
     2881 ggatgagcgg gaggtggcac tcactaagtt aaccaagtct gtatctgctc cccacatcag
     2941 tagcccagag gaggctgctg aagatgcgga caccaagcag caagatggag gttttgctga
     3001 accttcagat atgcacagca agagccaagg ttccccagga tcttgctctc aactttgtgg
     3061 tgactctgga acagatgctg gagcagacca tcccctggtg gagatagttt tagatgctga
     3121 caaccagcag ggccccggat acatagacat ccccaaaggg aaagggaagc agtttgatgc
     3181 tcaaggacac tgtcttcctg atggcaggac tgagaacact ccaggtgttg aaaccaaagg
     3241 tcttaattta aaaataccac gcgtcatagc acttgaaaac cccaggacca gatctcttca
     3301 tagagcactt gaggaaaccc caaagggcat gcctaaagac ttgaatgtgg gtcagcaagc
     3361 tctttccaac agtggcatct cagaggttga gggtctctct caacatcagg tgcctgaatt
     3421 gagctgtacg tcagctgctg atgccatcaa caggaactca acaggccagc aaagccaaag
     3481 cggttcacct tgcattatgg atgacacagc atttaataga ggagtgaatg ccttcccgga
     3541 ggctaaacat aaagcaggca ctgtgtgccc cactgtgacc cattccgttc attcccaggt
     3601 tttgaaaaac caagagctga aggcaggcac ttccatcatg gggtcccatc tgacttctgc
     3661 agagaccttt actctggaca gcctgaaggc tgtggaggtt gtgaacttat ctgtgtcttg
     3721 cactgccacc tgtctccctt tctcatctgt gcccaaggag acccctgcca gggctggatt
     3781 ctcttccaaa cagaccctgt ttcccatcac ccatcagcct ttgggatcct ttggagttgt
     3841 ttctacccat tccagcacgt tggatgagga agtcagtgag aggatgttta gtttttatca
     3901 ggccaaagaa aaatttaaaa aagaactgaa gattgaagga tttctgtaca gtgacttaac
     3961 tgtactagct tctgatatac catatttccc accagaggaa gaggaagaaa atttggaaga
     4021 tggaattcac ctggttgtct gtgtccatgg cctggatggg aacagtgcag acctccggct
     4081 ggtaaagact ttcatagaac tggggctccc tggaggaaaa ctggacttcc taatgtctga
     4141 aaagaatcag atggacacat ttgcagattt tgatactatg acggatcggt tattggatga
     4201 aatcattcaa cacattcagt tgtacaacct ctccatatcc cgaattagct tcattggcca
     4261 ttctcttggc aacatcatca tccgatcggt cctcacacgg ccccggttcc ggtattacct
     4321 caacaaactc cacacgttcc tgtcactctc tgggcctcac ctgggaaccc tgtacaacaa
     4381 cagcaccctg gttagtacag gcttatggct catgcagaaa ctgaagaaat ccgggtctct
     4441 actgcagctg accttcaggg ataatgctga tttgcgcaaa tgtttcctct accaactaag
     4501 ccaaaaaaca gggctgcagt attttaaaaa cgtcgtgctg gttgcttctc cccaagaccg
     4561 ttatgtgcca tttcattcag ccaggattga aatgtgtaaa actgccctca aagacagaca
     4621 cacagggcca gtttatgcag aaatgatcaa caacctcctg ggccctctgg ttgaagccaa
     4681 ggactgcact ttaatccgac acaacgtgtt ccacgccctg cccaacactg ccaacaccct
     4741 gatcggccga gccgctcaca tcgctgtgct ggattcagaa ctcttcctgg agaagttttt
     4801 cttggtggca ggactcaact acttcaagta gtggctttga gggagcaggt ctttggtaat
     4861 gcttacgatc ggtggagagc tttagctgag acctgctttt acagacctca ccatttcaga
     4921 atgaagcttc aacagcattg ggggacggag gctcgggtgg aacctgacat gagaggtgct
     4981 tttgttttgg agattcgaga aagctgagca aatagactaa atgacaacaa actttgcttg
     5041 aatttgtata gttacctgga gtgtcattca agatgttttc taggaaaaat atgagagaat
     5101 aaacagaata cttgggagtt ggtgagctcc ccttgctagc cactactggc ttactgagag
     5161 attactccaa tttaactaga cttgccgaat atgttactag cttatagctt tatcatttct
     5221 gattaagtgc acacaagcat ttcagaactc aggttaatct ctgtgcagca gtggaacata
     5281 tttgtgtaaa tagaatcctc aatagattca aatgtgtcag ttgttcaaga aaatgtgatg
     5341 cccatattca tattctctcc tcatgttttc taaacaaggg agcaaggaat gtgttacaaa
     5401 tcccagttct atttcataac agcagtgagc agggtgactt aaggtaaaga gggataaagg
     5461 tgacactatt ggtaaataca agtttgttac aaagaaacat gactctaggg acatactgaa
     5521 ctatgaatag ttgctccacc tacttcccca gaattcttct atgcagagcc ctgatccaca
     5581 aattatttta gtgattgctt acatctttgt ctgtagtagg gaacactgag tgagactaac
     5641 ctagcagaag ggggcactga gatgaatgca cacacgtgtg aagctcctgc tgatacactt
     5701 ccaaagacat gctatgttag catttgatgc aattgcaaaa aattaaatcc attaaagtgg
     5761 ccagctgctt ctcctctcca tggaaggagg aaaacatcta aatggaggag tgctggatta
     5821 aaacctcagg ggagctctaa gaagggtgct ggctatcttt caatagaaat gtcttcttgc
     5881 cttaggaaaa taaagggcta ggaaaggtca ctgcgttgat aaaaaccaat agacgacagg
     5941 gacaaaagtg agatcagata ggaggagaac aaccagactg aagactcaac ataagctgtt
     6001 attggtaagt gactcaaagg ggagttttga aaattaccag gatgtttaat agtcaggtct
     6061 caaagactga gtatgttgta tgggctaaag taagcctaaa gaatcatttc gttgtatgga
     6121 agagatgaat gaacctggac agtagggata agtaagacag gagcctaatc ttttggagat
     6181 gaaagctcct gcttctgcaa aaatcccttc tgaagtgtgg aaacgcatct aggaccaggg
     6241 ttctcaatac ctagaccatg actctaggtc actgatgcca tggtaacaaa accaagtaaa
     6301 tctaagctca tttgagaatt ttagatcctc ttatgttaac aatgtgactt tgaaaaataa
     6361 aagcagacca tgggaatgag tccagatggg cagctttgca ggagtgtaga catgtggtat
     6421 tcttttgaag aaagagaggg tcgttgaggg agagttgaat gtcttgcaaa ggcagagttc
     6481 cacacaatgg atttagggtt tctcagtgag tcctttctaa atgcttgtta tatcctggtc
     6541 ataatgcata tgggttcact gagtcctctg gtcactttcc actggggatt tttatctgag
     6601 ctcccgagtc agagctgggc atagactctg gttcttcatg aggagtgctg tatttgctct
     6661 gtaacctggg agacatttgt tccctagtcg tgcagcacat ggtattgtgt ttcctgacct
     6721 aggcaagtgc ccatgctcag tacagaacca taagttggta gcagcttctc ctttctggcc
     6781 aaatgatggg ccctgtccct ctgatgagtg catttcatgt tgtgtttcca attttcatca
     6841 gcaatgttcg tcattccctg gtcctttgaa agactgtgta gcccgcggtt atggagccgg
     6901 gatgaatctg atgatcatca tcttctccaa taaccagatg ccatttttaa cttcaatatg
     6961 ctgtctggac atagtgagaa ctaatggcaa taaacgtcca gctgcatggt gcacctcttt
     7021 tttatagggg tgctctgctg tctttgtaaa ccctctctgg cctctgagca tctattataa
     7081 ttgtgtagaa agtacatctc tatattgtaa ataagagtgt cgagtgttgc gtgtcatgcc
     7141 tcatttgaaa aggctttttt atgtctcttt ctattgaaat atagatatcg aatatataaa
     7201 tatatataca taaaatatat ataaatatat attatgtaaa acagggacat tctattattg
     7261 attgtaaaaa ttataaacaa aatgcctgcc aagataatgg tcttgtatgt cttcattctc
     7321 tgcgtaattt ttgtttttgt ttttatgatt tgttgtttcc caaaatgagt tagaaataaa
     7381 aatgcccaat attgagatta a
//
