LOCUS       NP_056996               1406 aa            linear   PRI 28-APR-2025
DEFINITION  protein FAM135B [Homo sapiens].
ACCESSION   NP_056996
VERSION     NP_056996.2
DBSOURCE    REFSEQ: accession NM_015912.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1406)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (residues 1 to 1406)
  AUTHORS   Bi,L., Wang,H. and Tian,Y.
  TITLE     Silencing FAM135B enhances radiosensitivity of esophageal carcinoma
            cell
  JOURNAL   Gene 772, 145358 (2021)
   PUBMED   33340561
  REMARK    GeneRIF: Silencing FAM135B enhances radiosensitivity of esophageal
            carcinoma cell.
REFERENCE   3  (residues 1 to 1406)
  AUTHORS   Dong,D., Zhang,W., Xiao,W., Wu,Q., Cao,Y., Gao,X., Huang,L.,
            Wang,Y., Chen,J., Wang,W. and Zhan,Q.
  TITLE     A GRN Autocrine-Dependent FAM135B/AKT/mTOR Feedforward Loop
            Promotes Esophageal Squamous Cell Carcinoma Progression
  JOURNAL   Cancer Res 81 (4), 910-922 (2021)
   PUBMED   33323378
  REMARK    GeneRIF: A GRN Autocrine-Dependent FAM135B/AKT/mTOR Feedforward
            Loop Promotes Esophageal Squamous Cell Carcinoma Progression.
REFERENCE   4  (residues 1 to 1406)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (residues 1 to 1406)
  AUTHORS   Sheila,M., Narayanan,G., Ma,S., Tam,W.L., Chai,J. and Stanton,L.W.
  TITLE     Phenotypic and molecular features underlying neurodegeneration of
            motor neurons derived from spinal and bulbar muscular atrophy
            patients
  JOURNAL   Neurobiol Dis 124, 1-13 (2019)
   PUBMED   30391288
  REMARK    GeneRIF: Using microarray analysis reveals novel genes such as
            FAM135B, dysregulated in Spinal and bulbar muscular atrophy (SBMA).
            Knockdown of FAM135B results in neurodegeneration, indicating its
            role in SBMA.
REFERENCE   6  (residues 1 to 1406)
  AUTHORS   Butland,S.L., Sanders,S.S., Schmidt,M.E., Riechers,S.P., Lin,D.T.,
            Martin,D.D., Vaid,K., Graham,R.K., Singaraja,R.R., Wanker,E.E.,
            Conibear,E. and Hayden,M.R.
  TITLE     The palmitoyl acyltransferase HIP14 shares a high proportion of
            interactors with huntingtin: implications for a role in the
            pathogenesis of Huntington's disease
  JOURNAL   Hum Mol Genet 23 (15), 4142-4160 (2014)
   PUBMED   24705354
REFERENCE   7  (residues 1 to 1406)
  AUTHORS   Teumer,A., Holtfreter,B., Volker,U., Petersmann,A., Nauck,M.,
            Biffar,R., Volzke,H., Kroemer,H.K., Meisel,P., Homuth,G. and
            Kocher,T.
  TITLE     Genome-wide association study of chronic periodontitis in a general
            German population
  JOURNAL   J Clin Periodontol 40 (11), 977-985 (2013)
   PUBMED   24024966
REFERENCE   8  (residues 1 to 1406)
  AUTHORS   Aslibekyan,S., Kabagambe,E.K., Irvin,M.R., Straka,R.J.,
            Borecki,I.B., Tiwari,H.K., Tsai,M.Y., Hopkins,P.N., Shen,J.,
            Lai,C.Q., Ordovas,J.M. and Arnett,D.K.
  TITLE     A genome-wide association study of inflammatory biomarker changes
            in response to fenofibrate treatment in the Genetics of Lipid
            Lowering Drug and Diet Network
  JOURNAL   Pharmacogenet Genomics 22 (3), 191-197 (2012)
   PUBMED   22228203
REFERENCE   9  (residues 1 to 1406)
  AUTHORS   Cirulli,E.T., Kasperaviciute,D., Attix,D.K., Need,A.C., Ge,D.,
            Gibson,G. and Goldstein,D.B.
  TITLE     Common genetic variation and performance on standardized cognitive
            tests
  JOURNAL   Eur J Hum Genet 18 (7), 815-820 (2010)
   PUBMED   20125193
  REMARK    Erratum:[Eur J Hum Genet. 2010 Jul;18(7):820]
REFERENCE   10 (residues 1 to 1406)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068467.7, AK091433.1, BC037288.1, AC103777.14 and BX110118.1.
            
            On Sep 8, 2006 this sequence version replaced NP_056996.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.82870.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395297.6/ ENSP00000378710.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1406
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.23"
     Protein         1..1406
                     /product="protein FAM135B"
                     /calculated_mol_wt=155639
     Region          111..172
                     /region_name="DUF3657"
                     /note="Protein FAM135; pfam12394"
                     /db_xref="CDD:463558"
     Region          519..548
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q49AJ0.2)"
     Region          770..820
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q49AJ0.2)"
     Site            777
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9DAI6; propagated from
                     UniProtKB/Swiss-Prot (Q49AJ0.2)"
     Site            778
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9DAI6; propagated from
                     UniProtKB/Swiss-Prot (Q49AJ0.2)"
     Region          1136..1330
                     /region_name="DUF676"
                     /note="Putative serine esterase (DUF676); pfam05057"
                     /db_xref="CDD:309968"
     CDS             1..1406
                     /gene="FAM135B"
                     /gene_synonym="C8ORFK32"
                     /coded_by="NM_015912.4:611..4831"
                     /db_xref="CCDS:CCDS6375.2"
                     /db_xref="GeneID:51059"
                     /db_xref="HGNC:HGNC:28029"
ORIGIN      
        1 mseiqgtvef svelhkfynv dlfqrgyyqi rvtlkvssri phrlsasiag qtessslhsa
       61 cvhdstvhsr vfqilyrnee vpindavvfr vhlllggerm edalsevdfq lkvdlhftds
      121 eqqlrdvaga pmvssrtlgl hfhprnglhh qvpvmfdyfh lsvisvtvha alvalqqpli
      181 sftrpgrgsw lgkggpdtgq eqsiislenl vfgagyckpt ssegsfyits encmqhahkw
      241 hrdlcllllh ayrglrlhfl vimrdipelp htelealave etlsqlcsel qmlnnpekia
      301 eqiskdlawl tshmmtlwtq fldtvtlhsq vttyltqehh tlrvrrfsea ffymehqkla
      361 vltfqenliq thsqlsldir nseyltsmpp lpaecldidg dwntlpvife dryvdcpatg
      421 hnlsvypnfd vpvtsptimn lkdkedncmv nsnlsfredl vlstikpsqm dsdeevircp
      481 epgenvatqn hmdmcsesqv yisigefqnk agvpedecwt gqtsdagtyp vadvdtsrrs
      541 pgpedgqapv ltyidvkssn knpsraeplv afnaqhesrs srdkygldrt glskvvvggs
      601 hqnaissdkt tlhelstlgk gidqegkmvl lslkltpsep cdplsstlre pldirsslkd
      661 shteeqeels vlsgvikrss siisdsgies epssvawsea rsralelpsd revlhpfvrr
      721 halhrnsleg ghtesntslp sgiqasltsi sslpfeeder evaltkltks vsaphisspe
      781 eaaedadtkq qdggfaepsd mhsksqgspg scsqlcgdsg tdagadhplv eivldadnqq
      841 gpgyidipkg kgkqfdaqgh clpdgrtent pgvetkglnl kiprvialen prtrslhral
      901 eetpkgmpkd lnvgqqalsn sgisevegls qhqvpelsct saadainrns tgqqsqsgsp
      961 cimddtafnr gvnafpeakh kagtvcptvt hsvhsqvlkn qelkagtsim gshltsaetf
     1021 tldslkavev vnlsvsctat clpfssvpke tparagfssk qtlfpithqp lgsfgvvsth
     1081 sstldeevse rmfsfyqake kfkkelkieg flysdltvla sdipyfppee eeenledgih
     1141 lvvcvhgldg nsadlrlvkt fielglpggk ldflmseknq mdtfadfdtm tdrlldeiiq
     1201 hiqlynlsis risfighslg niiirsvltr prfryylnkl htflslsgph lgtlynnstl
     1261 vstglwlmqk lkksgsllql tfrdnadlrk cflyqlsqkt glqyfknvvl vaspqdryvp
     1321 fhsariemck talkdrhtgp vyaeminnll gplveakdct lirhnvfhal pntantligr
     1381 aahiavldse lflekfflva glnyfk
//
