LOCUS       NM_001162529            6215 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens family with sequence similarity 135 member A
            (FAM135A), transcript variant 3, mRNA.
ACCESSION   NM_001162529 XM_005248745
VERSION     NM_001162529.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6215)
  AUTHORS   Xu,J., Hu,M., Gao,Y., Wang,Y., Yuan,X., Yang,Y., Song,W., Yin,W.,
            Gong,P., Wei,L. and Zhang,J.
  TITLE     LncRNA MIR17HG Suppresses Breast Cancer Proliferation and Migration
            as ceRNA to Target FAM135A by Sponging miR-454-3p
  JOURNAL   Mol Biotechnol 65 (12), 2071-2085 (2023)
   PUBMED   36943627
  REMARK    GeneRIF: LncRNA MIR17HG Suppresses Breast Cancer Proliferation and
            Migration as ceRNA to Target FAM135A by Sponging miR-454-3p.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL365226.9 and AL078591.18.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 13, 2020 this sequence version replaced NM_001162529.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1831384.1,
                                           SRR1803614.243317.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000418814.7/ ENSP00000410768.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AL365226.9         58541-58735
            196-281             AL365226.9         60324-60409
            282-375             AL078591.18        9245-9338
            376-491             AL078591.18        11110-11225
            492-571             AL078591.18        35298-35377
            572-711             AL078591.18        58216-58355
            712-782             AL078591.18        58469-58539
            783-956             AL078591.18        59965-60138
            957-1083            AL078591.18        63707-63833
            1084-1237           AL078591.18        64807-64960
            1238-1287           AL078591.18        73840-73889
            1288-1443           AL078591.18        85442-85597
            1444-1517           AL078591.18        105319-105392
            1518-1672           AL078591.18        106773-106927
            1673-4028           AL078591.18        107149-109504
            4029-4189           AL078591.18        111098-111258
            4190-4281           AL078591.18        115966-116057
            4282-4379           AL078591.18        116563-116660
            4380-4531           AL078591.18        119066-119217
            4532-4642           AL078591.18        121097-121207
            4643-4756           AL078591.18        139556-139669
            4757-6215           AL078591.18        142522-143980
FEATURES             Location/Qualifiers
     source          1..6215
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q13"
     gene            1..6215
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /note="family with sequence similarity 135 member A"
                     /db_xref="GeneID:57579"
                     /db_xref="HGNC:HGNC:21084"
     exon            1..195
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /inference="alignment:Splign:2.1.0"
     exon            196..281
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /inference="alignment:Splign:2.1.0"
     exon            282..375
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /inference="alignment:Splign:2.1.0"
     exon            376..491
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /inference="alignment:Splign:2.1.0"
     CDS             415..4962
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /note="isoform c is encoded by transcript variant 3;
                     protein FAM135A"
                     /codon_start=1
                     /product="protein FAM135A isoform c"
                     /protein_id="NP_001156001.1"
                     /db_xref="CCDS:CCDS55028.1"
                     /db_xref="GeneID:57579"
                     /db_xref="HGNC:HGNC:21084"
                     /translation="MTEVQAMVEFSVELNKFYNVDLFQRGFYQIRASMKIPSRIPHRV
                     EASLLHATGMTLAFPASVHDSLICSKTFQILYKNEEVVLNDVMIFKVKMLLDERKIEE
                     TLEEMNFLLSLDLHFTDGDYSADDLNALQLISSRTLKLHFSPHRGLHHHVNVMFDYFH
                     LSVVSVTVHASLVALHQPLISFPRPVKTTWLNRNAPAQNKDSVIPTLESVVFGINYTK
                     QLSPDGCSFIIADSFLHHAYRFHYTLCATLLLAFKGLHSYFITVTEEIPSCQKLELEE
                     MDVEARLTELCEEVKKIENPDELAELINMNLAQLCSLLMALWGQFLEVITLHEELRIL
                     LAQEHHTLRVRRFSEAFFCFEHPREAAIAYQELHAQSHLQMCTAIKNTSFCSSLPPLP
                     IECSELDGDLNSLPIIFEDRYLDSVTEDLDAPWMGIQNLQRSESSKMDKYETEESSVA
                     GLSSPELKVRPAGASSIWYTEGEKQLTKSLKGKNEESNKSKVKVTKLMKTMKSENTKK
                     LIKQNSKDSVVLVGYKCLKSTASNDLIKCFEGNPSHSQKEGLDPTICGYNFDPKTYMR
                     QTSQKEASCLPTNTERTEQKSPDIENVQPDQFDPLNSGNLNLCANLSISGKLDISQDD
                     SEITQMEHNLASRRSSDDCHDHQTTPSLGVRTIEIKPSNKDPFSGENITVKLGPWTEL
                     RQEEILVDNLLPNFESLESNGKSKSIEITFEKEALQEAKCLSIGESLTKLRSNLPAPS
                     TKEYHVVVSGDTIKLPDISATYASSRFSDSGVESEPSSFATHPNTDLVFETVQGQGPC
                     NSERLFPQLLMKPDYNVKFSLGNHCTESTSAISEIQSSLTSINSLPSDDELSPDENSK
                     KSVVPECHLNDSKTVLNLGTTDLPKCDDTKKSSITLQQQSVVFSGNLDNETVAIHSLN
                     SSIKDPLQFVFSDEETSSDVKSSCSSKPNLDTMCKGFQSPDKSNNSTGTAITLNSKLI
                     CLGTPCVISGSISSNTDVSEDRTMKKNSDVLNLTQMYSEIPTVESETHLGTSDPFSAS
                     TDIVKQGLVENYFGSQSSTDISDTCAVSYSNALSPQKETSEKEISNLQQEQDKEDEEE
                     EQDQQMVQNGYYEETDYSALDGTINAHYTSRDELMEERLTKSEKINSDYLRDGINMPT
                     VCTSGCLSFPSAPRESPCNVKYSSKSKFDAITKQPSSTSYNFTSSISWYESSPKPQIQ
                     AFLQAKEELKLLKLPGFMYSEVPLLASSVPYFSVEEEDGSEDGVHLIVCVHGLDGNSA
                     DLRLVKTYIELGLPGGRIDFLMSERNQNDTFADFDSMTDRLLDEIIQYIQIYSLTVSK
                     ISFIGHSLGNLIIRSVLTRPRFKYYLNKLHTFLSLSGPHLGTLYNSSALVNTGLWFMQ
                     KWKKSGSLLQLTCRDHSDPRQTFLYKLSNKAGLHYFKNVVLVGSLQDRYVPYHSARIE
                     MCKTALKDKQSGQIYSEMIHNLLRPVLQSKDCNLVRYNVINALPNTADSLIGRAAHIA
                     VLDSEIFLEKFFLVAALKYFQ"
     exon            492..571
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /inference="alignment:Splign:2.1.0"
     exon            572..711
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /inference="alignment:Splign:2.1.0"
     exon            712..782
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /inference="alignment:Splign:2.1.0"
     exon            783..956
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1083
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1237
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1287
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1443
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1517
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1672
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..4028
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /inference="alignment:Splign:2.1.0"
     exon            4029..4189
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /inference="alignment:Splign:2.1.0"
     exon            4190..4281
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /inference="alignment:Splign:2.1.0"
     exon            4282..4379
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /inference="alignment:Splign:2.1.0"
     exon            4380..4531
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /inference="alignment:Splign:2.1.0"
     exon            4532..4642
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /inference="alignment:Splign:2.1.0"
     exon            4643..4756
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /inference="alignment:Splign:2.1.0"
     exon            4757..6215
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6177..6182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /note="hexamer: AATAAA"
     regulatory      6185..6190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /note="hexamer: AACAAA"
     polyA_site      6202
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /note="major polyA site"
     polyA_site      6215
                     /gene="FAM135A"
                     /gene_synonym="KIAA1411"
                     /note="major polyA site"
ORIGIN      
        1 gctggccgcg ctgggccagt agccgagccg cggtgacgaa ccggctccgc ggttgcggtg
       61 tttgcggttg ctgtgatggc gatgtgaggg ggcccggggc gggatggtgc tgacccgggt
      121 cgggccgtct tcttgcagct ggacaacgag ctcctccgtt cgacaggcgg gggaagaggc
      181 cgagccgggc gagagggttg aagatcaact ggattatgta tttggttctg gaatctcaaa
      241 gcagtccaca aacaaattct tccttatgtt gtctgtgtca gggggaacgg tgtattttta
      301 acaacgggaa tcagtaactg gaagtacaag attggttatt taataatgtt aaaaatgagg
      361 ctttgaaaag cagaggtgct gttatcagaa tagtcttctg ggtataaatt aaaaatgact
      421 gaagttcaag caatggtaga attctctgtg gagctaaaca agttctacaa tgtggatttg
      481 tttcagagag gtttttacca gattcgtgct tctatgaaaa ttccatcaag aattccccac
      541 agagtagaag ctagtttgtt gcatgcaaca ggtatgactt tagcctttcc agcctcagtt
      601 catgattctc taatttgcag taaaacattt caaattttgt acaaaaatga agaggttgtt
      661 ttaaatgatg ttatgatctt caaagtaaaa atgctattgg atgaaagaaa gattgaagaa
      721 acccttgagg aaatgaattt tctattatcc ttggatctac acttcacaga tggagattat
      781 tcggcagatg atctgaatgc cttgcaacta ataagtagcc gaacattgaa gctgcacttt
      841 agcccccata gaggccttca tcatcatgtt aatgttatgt ttgattactt ccacctttct
      901 gttgtgtctg ttacagttca tgcatcattg gttgcactac accagccact aataagcttt
      961 cctcgccctg tgaagacaac ttggttaaat agaaatgcac cagcacaaaa caaagattcc
     1021 gtgattccta ctcttgaaag tgtggtcttt ggtattaact acacaaaaca gttatcacca
     1081 gatggttgta gcttcatcat tgcagactcc ttcctacatc atgcgtatcg ttttcattat
     1141 acactttgtg ccactttgct gctagccttc aagggattgc acagctactt cattacagta
     1201 acagaagaga ttccttcttg tcagaaacta gaactggagg aaatggatgt agaagctcga
     1261 cttactgaac tatgtgaaga agttaagaaa atagagaatc ctgatgaact ggcagaactt
     1321 ataaatatga atcttgcgca actttgctca cttttgatgg ctttatgggg acagtttctg
     1381 gaagttataa cgctacacga agaactaaga atattattag cacaagagca ccatactttg
     1441 agggtacgca gattttctga ggcattcttt tgttttgagc atccaagaga agctgccatt
     1501 gcataccagg aacttcatgc tcagagtcat ctacagatgt gcaccgctat caaaaatact
     1561 tccttctgca gttctcttcc acccttacct attgaatgta gtgaattaga tggagatctc
     1621 aattcattac ctataatctt tgaagatagg tatttagatt cagttactga agacttagat
     1681 gcaccctgga tgggaattca gaatcttcag agatcagagt ccagtaaaat ggataaatat
     1741 gagactgaag aaagctctgt agcaggactt tctagcccag agttgaaagt cagacctgct
     1801 ggtgcctcca gtatttggta tacagaaggt gaaaagcagc taacaaaatc tctaaaagga
     1861 aagaatgaag aatcaaataa atccaaagtt aaggttacta agcttatgaa aacaatgaaa
     1921 tctgaaaaca caaaaaaatt aataaaacag aactctaagg attctgtggt tttggtaggc
     1981 tacaaatgtt tgaaaagtac agcatcaaat gatctcatta aatgctttga aggcaatcct
     2041 tcacatagtc agaaggaagg tctggatccc acaatatgtg gatataattt tgacccaaag
     2101 acctacatga gacagacaag tcaaaaggaa gctagctgtt tgccaactaa tacagagaga
     2161 actgaacaaa agtctccaga tattgaaaat gttcaaccag accagtttga tcctttgaac
     2221 tctggcaacc taaatctttg tgcaaatttg tccatttcag gtaaacttga tatctcccag
     2281 gacgatagtg aaattacaca aatggaacac aatctggcat ccagaaggtc atcagacgat
     2341 tgccatgatc atcaaacaac cccatctttg ggagttagaa caattgaaat aaagcccagt
     2401 aataaagatc ctttcagtgg agagaatata actgtcaaac taggaccttg gacagagctt
     2461 cgacaagagg aaatacttgt ggataattta ctacccaact ttgagtcctt agaatctaat
     2521 ggtaaatcta aatctataga aataacattt gaaaaggaag ctttgcaaga agcaaagtgt
     2581 ctttctattg gagaatcatt aactaaatta cgaagtaatc tacctgcccc ttctacaaaa
     2641 gaatatcatg ttgtagtaag tggagataca attaagttac cagatattag tgccacatat
     2701 gcctcatcta gattttcaga ttcaggtgtt gaaagtgaac cgagttcttt tgcgacacat
     2761 ccaaacactg atttagtctt tgaaactgtg caagggcaag gtccttgcaa tagtgaaaga
     2821 ttatttcctc agcttttgat gaaacctgat tataatgtaa aattttcatt aggaaatcat
     2881 tgtactgaga gtacaagtgc tataagtgaa atacagtcat ctttgacatc cataaactct
     2941 ctaccctccg atgatgaact gtcacctgat gaaaattcta agaaatctgt tgtacctgaa
     3001 tgccatctaa atgatagcaa aactgtatta aatctaggaa cgactgattt gccaaaatgt
     3061 gatgatacta aaaagtcaag tatcactttg caacagcaga gtgttgtatt ttcagggaac
     3121 ttggacaatg aaactgtagc aatacattcc ttaaattcaa gcattaaaga ccctttacaa
     3181 tttgtttttt cagatgaaga gacttccagt gatgtgaaaa gtagttgcag ctccaaacct
     3241 aacttggata ctatgtgtaa aggcttccag agtcctgata aatctaataa ctctacaggg
     3301 acagcaatta cattaaattc aaaactgatt tgtttaggca ctccttgtgt catttcaggt
     3361 tccatttcta gtaatacaga tgttagtgaa gatagaacta tgaaaaaaaa tagtgatgta
     3421 ttaaatctca cacagatgta ttcagaaatc cctacagttg aaagtgaaac tcatctgggt
     3481 acaagtgatc ctttttcagc cagtactgat atagtaaagc aagggcttgt ggaaaattat
     3541 tttggttctc aaagcagtac ggatatttct gacacatgtg ctgttagcta cagcaatgca
     3601 cttagccctc agaaggaaac ttctgaaaaa gaaattagta atcttcagca ggaacaggat
     3661 aaagaggatg aggaggaaga gcaggatcaa caaatggttc aaaatgggta ctatgaagaa
     3721 acagattatt cagctttgga tggaacaata aatgctcact atacaagcag agatgaacta
     3781 atggaagaaa gacttacaaa atctgaaaaa ataaacagtg actatctgag agatggtata
     3841 aacatgccta ctgtctgtac ttctggttgt ttgtccttcc cgtctgcacc acgagagtct
     3901 ccttgtaatg ttaaatattc ttccaaaagt aaatttgatg ccattacaaa gcagccaagc
     3961 agtacttctt acaacttcac ttcttcgatt tcctggtatg aaagttcacc aaaacctcaa
     4021 atacaagcct tccttcaggc aaaagaagaa ctgaagctac taaaacttcc tgggttcatg
     4081 tacagtgaag ttcctctgct ggcatcctca gtaccttatt ttagtgtaga agaagaggat
     4141 ggttctgaag atggagtaca tctgattgtc tgtgtgcacg gtttagatgg aaacagtgca
     4201 gatctccgat tagtaaaaac ttacattgaa cttggattgc ctgggggaag aattgatttt
     4261 cttatgtctg agagaaatca gaatgatact tttgctgatt ttgatagcat gactgatcgt
     4321 cttttggatg agataataca gtatattcag atatatagtc taacagtctc aaaaataagc
     4381 tttattggac attcgttggg caatttaata attcgttcag tgcttacaag gccaaggttt
     4441 aaatattacc tcaacaaact tcataccttt ctgtctcttt ctggacctca ccttggtaca
     4501 ctctacaaca gcagtgctct tgttaataca ggtctctggt ttatgcagaa atggaaaaaa
     4561 tcaggttcgc ttttgcagct gacatgtcga gatcactcag accctcgcca aactttttta
     4621 tataagctta gtaacaaagc agggcttcat tatttcaaaa atgttgtgct agtgggatcc
     4681 ctacaggatc gctatgttcc ttatcactct gcccgcattg aaatgtgtaa aacagcttta
     4741 aaggacaaac agtcaggaca gatctattca gaaatgatcc acaacttgct tcgacccgtt
     4801 ctgcaaagca aggactgtaa tttggttcgc tataatgtca tcaatgcatt gcccaataca
     4861 gctgattcac tcattgggag agctgcacat atagctgttc ttgattcgga aatattttta
     4921 gagaaattct ttctggttgc tgccctcaaa tatttccaat agtataaaag cattgttagc
     4981 gactggacaa ttacctcatt caacaatgtt tcaaataatg tattatatta aaatgtagat
     5041 gctgataagt tctaagaaat atttatacct ttttatatgg aagataattt atatcatcca
     5101 tgtttagtgc tttttaaaca tcaactttac tttctaggta atgtggctgt gcaatatttt
     5161 tttaatttta tctttttact tttctattac tttttcatat attttgctac ctaagtattt
     5221 cagtgaaact ttaagcccat acctgtgtct gattgtttat tattggcttt ccacaattct
     5281 tacatcagac tacattatat tagagaccat tattgctaga atagcatggg atttaaaatt
     5341 ttctaatact gggggtatta tttagttaat tataaatttt tcttttcaca ttttactgtg
     5401 ttttaactgg aaataaaatt atggctgcta caatatattt tttgaaatca acttctgtag
     5461 ttctaaaata caactttatc atacaatcaa accaggtagt tcatataaaa cagtgtaata
     5521 caagttttct ataaagtcat tactgttgct taaacatatt tcatgcctat taaaatatat
     5581 tttctactgg tgatttcaac attatttctc atactgactt ttattactgg aaatgttcct
     5641 gtacatgttg gcagcagata aagatttttg aatgtttgaa tgccctctgc cttgatttgg
     5701 ttggaatttt tgctaaattg gtaatgttgc ttgaacttta tgactacatt ttcttttaac
     5761 ttttttcatg gacttcctta tatgtacata ataattaaat gttgaaattt atgaaatact
     5821 tttatgaatt tagataattt ttaaatattg ttaaaattta ttgaactaaa aagtaatgta
     5881 aataaaataa ttcatgttaa agatggaaca aaataattaa ctttacatgt ttggtgatac
     5941 agatgcaaat gtttttgata tatggagatg ttgagtcttt tgactttact aaaggtgctg
     6001 aatagcatta aattcactat tttccttttc tgttttactt gtgaaaataa aaatgcacta
     6061 aggttgggta gaagttctgt ttgcactcac taattgtgac agacagaggt ttttgtaagt
     6121 atttattgta caattgatgc atgtttattt ttagcgttgt tattgcctct ggtgttaata
     6181 aatgaacaaa tggctatctg gaggaacagc tacaa
//
