LOCUS       NM_152789               2367 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens family with sequence similarity 133 member B
            (FAM133B), transcript variant 1, mRNA.
ACCESSION   NM_152789
VERSION     NM_152789.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2367)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC062706.1, BC090868.1 and BU581457.1.
            
            On May 17, 2019 this sequence version replaced NM_152789.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.224835.1,
                                           SRR1803611.267113.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000445716.6/ ENSP00000398401.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                BC062706.1         9-69
            62-951              BC090868.1         49-938
            952-2022            BC090868.1         940-2010
            2023-2367           BU581457.1         227-571
FEATURES             Location/Qualifiers
     source          1..2367
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.2"
     gene            1..2367
                     /gene="FAM133B"
                     /note="family with sequence similarity 133 member B"
                     /db_xref="GeneID:257415"
                     /db_xref="HGNC:HGNC:28629"
     exon            1..123
                     /gene="FAM133B"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..843
                     /gene="FAM133B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM133B"
                     /codon_start=1
                     /product="protein FAM133B isoform 1"
                     /protein_id="NP_690002.2"
                     /db_xref="CCDS:CCDS47640.1"
                     /db_xref="GeneID:257415"
                     /db_xref="HGNC:HGNC:28629"
                     /translation="MGKRDNRVAYMNPIAMARSRGPIQSSGPTIQDYLNRPRPTWEEV
                     KEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSG
                     RYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKK
                     KKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKA
                     TEKTKKKKKHKKHSKKKKKKAASSSPDSP"
     exon            124..221
                     /gene="FAM133B"
                     /inference="alignment:Splign:2.1.0"
     exon            222..300
                     /gene="FAM133B"
                     /inference="alignment:Splign:2.1.0"
     exon            301..375
                     /gene="FAM133B"
                     /inference="alignment:Splign:2.1.0"
     exon            376..408
                     /gene="FAM133B"
                     /inference="alignment:Splign:2.1.0"
     exon            409..471
                     /gene="FAM133B"
                     /inference="alignment:Splign:2.1.0"
     exon            472..564
                     /gene="FAM133B"
                     /inference="alignment:Splign:2.1.0"
     exon            565..615
                     /gene="FAM133B"
                     /inference="alignment:Splign:2.1.0"
     exon            616..708
                     /gene="FAM133B"
                     /inference="alignment:Splign:2.1.0"
     exon            709..756
                     /gene="FAM133B"
                     /inference="alignment:Splign:2.1.0"
     exon            757..2367
                     /gene="FAM133B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2308..2313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM133B"
                     /note="hexamer: AATAAA"
     polyA_site      2332
                     /gene="FAM133B"
                     /note="major polyA site"
ORIGIN      
        1 ggagtgggga ggcggcaaga ggacctgcgg caggccctct tcggcagtct ctccggcccg
       61 gtttccctcg gcgtgctact gtgcgctcga tccagcacca tggggaagcg ggacaatcgg
      121 gtggcctata tgaacccaat agcaatggcg agatcaaggg gtccaatcca gtcttcaggg
      181 ccaacaatac aggattatct gaatcgacca aggcctacct gggaagaagt aaaagagcaa
      241 ctagaaaaga aaaagaaagg ctccaaggct ttggctgaat ttgaagaaaa aatgaatgag
      301 aactggaaga aagaactgga aaaacacagg gagaaattgt taagtggaag tgagagctca
      361 tccaaaaaaa gacagagaaa gaaaaaagaa aagaagaaat ctggtaggta ttcatcttct
      421 tcttcatcaa gctctgattc ttccagcagt tcttctgatt ctgaagatga ggataagaaa
      481 caaggaaaac ggagaaagaa aaagaagaac cgttcacata aatcttctga aagctccatg
      541 tcagaaactg aatcagacag taaggatagt ttaaaaaaga aaaagaagtc aaaagatgga
      601 actgagaaag aaaaggatat taaaggactc agcaaaaaga gaaagatgta ttctgaagat
      661 aaacctttat catctgagtc cttgtcagaa tcagagtata ttgaggaggt gcgagcaaaa
      721 aagaagaaaa gcagtgaaga acgagaaaaa gcaacagaaa aaacaaaaaa gaaaaagaag
      781 cataagaaac acagtaagaa gaagaaaaag aaggctgcta gttcaagtcc tgactcacca
      841 taacattaag aaaaatcagg attcccttat aaagaaagtg caatgtctga ggaaatttca
      901 actgtgaaaa ctacaacata tttactaaaa tgcatgaatt ttcttgtttt tggaattatt
      961 cctggactat tcagtagcca ctcagatgcc actgtgtgaa agggccataa atgttgcctg
     1021 ctgcttgaac atctattttt ttctcttcca gtgcttgata actctgggag ataatacact
     1081 gcagtcgtac tagtggttaa gatatttggg aataaaatta atacttttga ctagaagcgt
     1141 ctaaggataa accaacagaa attgaatctg gatacatctt taagatgtaa tcagaaatga
     1201 ccagatgact ctagttagaa tttttgaagg agggattaca ttaatatttc aaaaccctta
     1261 ctctgtagat aagtgtattt taattttttc ccctcgtata cttttattta cctggggaag
     1321 gagcttttag ggttgggggg tggtttgcta tctctttagc tagcagaata gtgtgccttt
     1381 gatcctcaca catcctgtat tatggacaca gtagccatgc ttcacgggga ggtcagagct
     1441 ggctaccagc agtcttgccc tttactgagc ttagtgtcat ctttggatgc tgtcatatgc
     1501 tgctttgagt gaaccagaga aacagccatt tgcagcatga gaaagcccca aaagctctgg
     1561 gatttacctc cactttagta ataatgaata ttttttagca ttagaatgtg ttatgtcatt
     1621 tgaattaatt ttgactacac tttggcttgg gagaggaatt attttaaata gacattggta
     1681 ctttttgaac ttgatagcta aagattctaa aatgcatgtt ttatactaag ttttaaccag
     1741 tcaggaaaat tttatgtaac tagtgatagt ttattttttt gtatgaattt tgtttaggct
     1801 gcaatgttta gcttttgtta actcctcact cttgctgtct taagttcatt actatgttta
     1861 atggcctact tgccaagata tttagcatgt aaaaagcagg gttttgatta aaaaaaaaaa
     1921 acggcttcat attgaagctg agacttacaa taacaagttg agtggcaagc ctggtatgct
     1981 gtgtcttatt gccagaatct tagtaaatgt aatgttttaa aagtttgttg tctttgtata
     2041 ttaataacaa attatgacaa gttaagttta aataagagtt acattattgc tctccctgtg
     2101 tcatatttta ctaagatttt gtgcctcatg tctactgctg aattgtttac taggaatgtt
     2161 aaaaggaatt gataattcat tttcatttta catttttata taatcaggta acatgacata
     2221 caacttgatg tacaattttg cctgttacaa agggtgtgct aattatagtg gtatatgcac
     2281 agaacatgtt ggcatgacaa caggctgaat aaatagctat tttacttaaa aatagctgtg
     2341 ttcttatcag ctccctttgg actgcaa
//
