LOCUS       NM_001171109            3179 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 133 member A
            (FAM133A), transcript variant 3, mRNA.
ACCESSION   NM_001171109
VERSION     NM_001171109.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3179)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3179)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3179)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3179)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA414074.1 and AL009173.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001171109.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.229524.1,
                                           SRR1803617.179304.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683942.1/ ENSP00000507109.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-569               DA414074.1         4-572
            570-3179            AL009173.2         82503-85112
FEATURES             Location/Qualifiers
     source          1..3179
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.32"
     gene            1..3179
                     /gene="FAM133A"
                     /gene_synonym="CT115"
                     /note="family with sequence similarity 133 member A"
                     /db_xref="GeneID:286499"
                     /db_xref="HGNC:HGNC:26748"
     exon            1..69
                     /gene="FAM133A"
                     /gene_synonym="CT115"
                     /inference="alignment:Splign:2.1.0"
     exon            70..141
                     /gene="FAM133A"
                     /gene_synonym="CT115"
                     /inference="alignment:Splign:2.1.0"
     exon            142..230
                     /gene="FAM133A"
                     /gene_synonym="CT115"
                     /inference="alignment:Splign:2.1.0"
     exon            231..3179
                     /gene="FAM133A"
                     /gene_synonym="CT115"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..1080
                     /gene="FAM133A"
                     /gene_synonym="CT115"
                     /note="cancer/testis antigen 115"
                     /codon_start=1
                     /product="protein FAM133A"
                     /protein_id="NP_001164580.1"
                     /db_xref="CCDS:CCDS14466.1"
                     /db_xref="GeneID:286499"
                     /db_xref="HGNC:HGNC:26748"
                     /translation="MGKRDNRVAYMNPIAMARWRGPTQSVGPTIQDYLNRPRPTWEEV
                     KKQLENKKTGSKALAEFEEKMNENWKKELEKSREKLLSGNESSSKKRERKKKRKKKSC
                     RSSSSSSSSDSSSSSSDSEDEEKKQGKRRKKKKNRSYKSSQSSTHESESESKESVKKK
                     KKSKDETEKEKDVRSLSKKRKKSYPDDKPLSSESSSESDYEEDVQAKKKRRCEEREQA
                     KEKVKKKKKKQHKKHSKKKKKKSGSSHKSR"
     regulatory      3159..3164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM133A"
                     /gene_synonym="CT115"
                     /note="hexamer: AATAAA"
     polyA_site      3179
                     /gene="FAM133A"
                     /gene_synonym="CT115"
                     /note="major polyA site"
ORIGIN      
        1 aagtgctgtc tgtgatgttt ggcaagcctg gtttatatcc atctacaagg tttgcgaacc
       61 catgttgccg attttttttt ctgctacaga acaactccct tggtacaata aaaaagacga
      121 gtatttactt ttcattgaaa gtggagaacc tgaaaaggaa cctggaaaga agcagctgga
      181 aaaggtgaga ggaaaaccta gagtgtgtgt tatcctgcaa gccaattgag aatggagctt
      241 gcttgatatt tcactagata aagaatttaa ggcgagtatc tatctttgtt ctccttggca
      301 actgagagtc tgcccttgga aacatcaggc accatgggga agcgggataa tcgggtagcc
      361 tatatgaatc ctatagcaat ggccagatgg agaggcccaa ctcaatctgt gggcccaaca
      421 atccaagatt atctaaatcg accaagaccc acctgggaag aagtaaagaa acaattagaa
      481 aataaaaaaa caggttcaaa agcattagct gaatttgaag aaaaaatgaa tgaaaattgg
      541 aagaaagaac ttgaaaaaag cagagagaaa ttattaagtg gaaatgagag ctcatctaaa
      601 aaaagagaaa gaaagaaaaa gagaaagaag aaatcttgtc ggtcttcatc ttcttcatca
      661 agctctgatt cttcaagcag ttcttcagat tctgaggatg aggaaaagaa acaaggaaaa
      721 aggagaaaga aaaagaagaa ccgttcatac aaatcatccc aaagctctac gcatgaatca
      781 gaatcagaga gcaaggagtc tgtaaaaaag aaaaagaagt caaaggatga aacagagaaa
      841 gaaaaggatg taagaagcct cagcaaaaaa agaaagaaaa gttaccctga tgataaacct
      901 ttatcatctg agtcctcatc tgaatcagat tatgaagagg atgtgcaagc aaaaaagaag
      961 agaaggtgtg aagagcgaga acaagcaaag gaaaaagtaa agaagaagaa gaagaaacag
     1021 cacaagaaac atagtaagaa gaagaaaaag aagtctggat caagtcacaa gtcaaggtaa
     1081 catcaagaaa aaaagcaaga atgagtttgc cgagttcccc tgtgttagta gaattatttc
     1141 tggactttga gttgcctatc aaatcccact gtgccagtaa ggggcatagt ggctgctggc
     1201 aacttcaata tacatttttg tttgtttgct tgtccttcct tctaatggtt aattcctctg
     1261 agagctaaaa ttctgttgtc ataccagtga ataaaatgtt tgaaattaaa gtaaaatgtg
     1321 ttagataatg aataactttg acaaaaaaaa gtgtatctaa ggttaaatgt atctaattcg
     1381 aatacatctt tgaaatatca ccatcaatga aacataaatg taatttccag acaattgtag
     1441 ttggtatttt tgatgcaagg acttaatatt gatgtctcaa attccttgct tttgtaaata
     1501 agtttagttc attttccttt tttctttaat gaatctttgt ttacatgggg aaagagcatg
     1561 tggggtggga agggcaagtg tttgctaatc actgtggcta gctgaatagt gtgcctttga
     1621 ctcttacaca tcctattttt gccagagcag cagccgtcct tttcttactt tatgaaattc
     1681 tggggtgttg tatgctgctt caagtgaaca agaaggacag gagtttacag cataagtaag
     1741 cccccatatc tatgaaattt acctcttctt cagcactgtt tactatacag tactgaataa
     1801 tatttagtat tacaatatta catgatttga aataacttta tacccatttt gtatgggaac
     1861 cattctaaac agaccctgat gttgtttgat taagaaatat tctgaaattt tttttgcatg
     1921 ttttatactg ttaagtttta attatctgac catattctat ataactgatg atcctttttt
     1981 aagatatgat ttatgcttag gatataagtt tcaagttttt agtttcttag ccttgctata
     2041 ttaatttcat tactgtgttt aattgcaccc ttgccaaaat atttagcatg tgaaaaggtt
     2101 ttttttaaaa aatatgtaat gccttcatat tgaagctggt tactgtacgc aagttgagtg
     2161 ccagacctct agtacgccgt atgttacatg aaactactgc caaaatctta gtaagattgt
     2221 tgttgaaaag attgttgtct taagcattaa tattgaattt atatagaagt taaatgtaga
     2281 tgataatgac atcattgatc ttcctgtgtc cgtattttcc tacaatttgg tgccttgtat
     2341 ctgttgctga ttcactttta ccactagtgt aaaaataagt gaaaaaatat ttttacttta
     2401 catttttata tatcagagta acataaatta taaatttgtg tctcaaaacc acctgtgatg
     2461 gaggatgtgc taattgtaat gtcataggta caaagtattt tggcatgatg aaaagctcaa
     2521 tagctattgt ttttcaatag cagattttat ctcggctacc ttcaatcaca agtaaaatta
     2581 taaagataaa aaacatctac ataaacatgt tggctgccaa attttttgca ttggaaatac
     2641 tggaatctct cattaaagtt cttggaacat tatagtgatg ccatgttaga ttaccttgga
     2701 gcttcataac tttagctttt tcctaaaaat atatgtttat gctgataaaa actattacat
     2761 ttatgggata ttttgtatcc atatagagtt tttcagaatt gttcattaaa atgcttttta
     2821 taagcttata ttatttgtag aatatggcaa aagcatttac agctcatcat gtatctatct
     2881 gctcctgttc acttccaaac ctcttgtagt taggcaatgc catttgacta cttcaagcag
     2941 agggattgta aacagaagtg attttctatt tccatgttgg actgtaaaaa gttctgcatg
     3001 accctccagt tttcttttgc ctgtcatggt gacctgaaag caagatgttc caaatggcat
     3061 acttacaaga cggatgcaac ctgggtcctt aggtcgctgt ttagaaggga cctgactgga
     3121 gtgctgatgg acttgcagta aactttttaa gtgtaagaaa taaactgtta tgtgttaaa
//
