LOCUS       NM_001031690            4343 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 131 member B
            (FAM131B), transcript variant a, mRNA.
ACCESSION   NM_001031690
VERSION     NM_001031690.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4343)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   2  (bases 1 to 4343)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093673.4.
            
            On Jul 3, 2019 this sequence version replaced NM_001031690.2.
            
            Transcript Variant: This variant (a) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC045611.1, SRR14038193.75947.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000443739.7/ ENSP00000410603.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AC093673.4         13389-13526         c
            139-248             AC093673.4         10853-10962         c
            249-284             AC093673.4         10545-10580         c
            285-378             AC093673.4         10139-10232         c
            379-576             AC093673.4         9640-9837           c
            577-720             AC093673.4         8093-8236           c
            721-4343            AC093673.4         4213-7835           c
FEATURES             Location/Qualifiers
     source          1..4343
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..4343
                     /gene="FAM131B"
                     /note="family with sequence similarity 131 member B"
                     /db_xref="GeneID:9715"
                     /db_xref="HGNC:HGNC:22202"
                     /db_xref="MIM:619282"
     exon            1..138
                     /gene="FAM131B"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1193
                     /gene="FAM131B"
                     /note="isoform a is encoded by transcript variant a;
                     protein FAM131B"
                     /codon_start=1
                     /product="protein FAM131B isoform a"
                     /protein_id="NP_001026860.2"
                     /db_xref="CCDS:CCDS47734.1"
                     /db_xref="GeneID:9715"
                     /db_xref="HGNC:HGNC:22202"
                     /db_xref="MIM:619282"
                     /translation="MGCIGSRTVGNEVIAVDWKGLKDVDQINMDSTSSLHGSSLHRPS
                     TEQTRTDFSWDGINLSMEDTTSILPKLKRNSNAYGIGALAKSSFSGISRSMKDHVTKP
                     TAMGQGRVAHMIEWQGWGKTPAVQPQHSHESVRRDTDAYSDLSDGEKEARFLAGVMEQ
                     FAISEATLMAWSSMDGEDMSVNSTQEPLGCNYSDNYQELMDSQDALAQAPMDGWPHSY
                     VSQGMYCLGSSDAWEASDQSLIASPATGSYLGPAFDDSQPSLHEMGPSQPASGYSALE
                     PPPLLGGDTDWAPGVGAVDLARGPAEEEKRPLAPEEEEDAGCRDLESLSPREDPEMST
                     ALSRKVSDVTSSGVQSFDEEEGEANN"
     exon            139..248
                     /gene="FAM131B"
                     /inference="alignment:Splign:2.1.0"
     exon            249..284
                     /gene="FAM131B"
                     /inference="alignment:Splign:2.1.0"
     exon            285..378
                     /gene="FAM131B"
                     /inference="alignment:Splign:2.1.0"
     exon            379..576
                     /gene="FAM131B"
                     /inference="alignment:Splign:2.1.0"
     exon            577..720
                     /gene="FAM131B"
                     /inference="alignment:Splign:2.1.0"
     exon            721..4343
                     /gene="FAM131B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4323..4328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM131B"
                     /note="hexamer: ACTAAA"
     polyA_site      4343
                     /gene="FAM131B"
                     /note="major polyA site"
ORIGIN      
        1 ggagacagcc gcggcgctgc agagcggctg gggcggcggc gcggctcccg gtgctccccc
       61 cggcgcgcgc cccgagtcgg tgagggcccg gctctgcggc ccccggagcc atgggctgca
      121 tcggctcccg gactgtgggg aatgaggtga ttgcagtgga ttggaagggc ctgaaggatg
      181 tcgatcaaat caacatggac agcaccagct cactgcacgg gagcagcctc catcggccat
      241 cgactgagca aactcgaact gatttctcct gggacggcat caacctctcc atggaggaca
      301 ccacttccat tcttccgaag cttaagcgaa actctaacgc ctatggcatt ggggccctgg
      361 ccaagtcatc attctcaggg atctcacgga gcatgaagga ccatgtgaca aagcccacag
      421 ccatggggca aggccgggtg gcccacatga ttgagtggca gggctggggg aagacaccag
      481 ctgttcagcc acaacacagc catgagtccg tgcgcaggga tacggatgcc tactccgacc
      541 tcagcgatgg cgagaaggag gcacgttttc tagcaggcgt catggagcag tttgctatct
      601 ctgaggccac actcatggcc tggtcttcca tggatggtga ggacatgagt gtgaactcca
      661 cccaggagcc attgggctgc aactacagtg acaactacca ggaactgatg gacagtcagg
      721 atgccctggc tcaagcaccc atggatggat ggcctcactc ttacgtgtcc cagggtatgt
      781 actgtctggg gtcgtcagat gcctgggaag ccagcgatca gtccctcatt gcctctccgg
      841 ccacaggatc ctatcttggg cctgcatttg atgactcaca acccagcttg catgaaatgg
      901 gaccttccca accagcttca ggatactctg ctctggagcc tccacctttg ctggggggag
      961 acactgactg ggctccgggg gtaggcgcag tggacctggc aaggggccct gctgaggagg
     1021 agaagaggcc attggcacct gaggaggaag aggatgcggg atgccgggac ctggagtcac
     1081 tttccccacg agaagaccct gagatgtcta ccgctctcag ccggaaggtg tctgacgtca
     1141 catcctcagg tgtgcagtcc tttgatgagg aggaaggcga ggccaacaac tagtttcctc
     1201 ccccaatgcc ctgccttcca ctcccacctg agggccatgg ctgtgaccca taccctccct
     1261 ccccccagca gtacagctga aactgggcag acaacattgg ggaacccagg agcttccagt
     1321 cctctcctgg aaatggagga ccaggatggg attttatcca ggcttacact ctagaaaccc
     1381 acaggcctgg gaactgagac ctgggcaact agatggccgt gagcttggtg tggctgtgga
     1441 gaaggacctg ggctgtgggc ttctgggtct gtgccgacaa agcctccagt gtgtgcaccc
     1501 tgaggacggg ggcagcgcag ctgtgctcaa gactggatct cagttcttca cgccccgatt
     1561 tcgtcttcca ggagctgtaa ctctgctgtc tgaatgcctc ctttctccat ttcactcttg
     1621 cttttcccaa ctctgttttc tctggctgtg gccccagctc atccctactg agagaacaga
     1681 cctcaggggc tgttggacat ggctggacag gcgcagggga ggctgcctga agggcacgtc
     1741 catggggagg gtggagaggc tgcctcagca ggtcatttgg cttctgagat caggagtcga
     1801 ggaggaggtg gatgtggcag ctgagatcta cagggggcac ggatgtggtt ctttctatca
     1861 aggcctgccc ggagacaaga gagtcactga ggagactaag aacaaacaca gccccttgct
     1921 ctgggatctt taatatccca tggctaaaag gaagatccta aggatctggg aaaagaccca
     1981 gccagggctg gctgctccag ctcttgcttc cctttcagct ttcttccatc cctgctccgg
     2041 gagcctgagg agggtgtggg gacacccatc ttggatacac caacgcagga tgcaggtgtc
     2101 gccaacagca gggggagcat gagggctgtc tccccttatt cacccctgtc ctctgaagct
     2161 gtttacactt ttctctttgc cttttctaca tttttataac ttcttgggca ctcagggttg
     2221 agtggagtgg agggaggagt ccggtgctgt cactccctca gccaggcagg gttgcagctg
     2281 agggccaggg tgggcactcg gcactttctg ccccttcttc agctcctccc aggactccca
     2341 aacagcctca cagctgtcct ccctgcctcc ccaggcctcc taccagagga agagaggaaa
     2401 atcagcggat tcttccttcc aggatggtgt atggtgaggc acaagcttgc cctcccacac
     2461 ttggcatcca tgctggtggg gactgagcag catatgcgcc ccagcactac cgtgagagca
     2521 caggcagagg atgggcggag caaagcagcg gtgctgtggg gttggagagc acttggccct
     2581 gccactgccc aggtagcccc tccccagccc ttggcacagg cagagttcgg gtaggagaga
     2641 gaggcctaag aggctcactg ccctatctcc ttctttcctc acgcccttcc aaggctccgg
     2701 ctcccaggcc tgtgtcctac ccacactctg tcaggagtcc taccacttgc atcctctgct
     2761 ggaagggagc actgttgtcc tctcctggcc ctgggcacaa actttgccct cacccccagg
     2821 ccccagaact tattattttg gagtgagaag gttgagagtt ggggtgtttc tgtccatcta
     2881 tggtcctgtc ccgccatcaa gttcatactc tcttactcac acttctggga tgcaagcagg
     2941 gcagggggtt ctgtgtcttc catggaaggg ggacaatggt tatcctgagg ttggtttttg
     3001 gaggaaacat gggcgtaggc aaggtgaacc aaggcaggtg cagtcaccta accgaatgct
     3061 gcctgtacag gggaagagtc ctcttgtgct tgctaacgtg tgctgactcc atgtcccagg
     3121 acctcatttc caggagctct gagaggtggt ctagcatgcc cgccctggca gctattcccc
     3181 acccgtctcc tgctgcaggc tctggggttt tgcatgttca tgtgaccttc cttccatggg
     3241 gtccctggtt cctcaccttc tccaatgtgt gctattccca catcacctct tcctgtcgtc
     3301 tcatcctctc agtgcccata tcataccccc agaccacggt ggacagctca cctagtgagt
     3361 gcgttcattc attacagttc gtttttgctc aggcccgggg gagttaggaa aggtagacca
     3421 cagcagcttt cgttcctcct tccctttccc aaggaagcca aatggtccct gacaaaagat
     3481 gactaaagat ctgaaggact ctagcagggt tcatacatga acctgctttc cccagggtgc
     3541 tggcatattg ctgcagatgg aagtcaggtg ggggtctgtc ttctgcaagg agctcctact
     3601 cgctctgaag agggagactg aggagctggc ctgggaccat cttaggactc ttctggtgct
     3661 gggggcaggg tgcatggggg ttgcttatcg tctatttcag ggggtgggga ggggcatgtg
     3721 caggaagagg ctgtttcggg gtgggaaagg gttgcttttc ctttggggtt aaggctgtgc
     3781 agcacgtttt acagcagtcc tggaacaggg ctgtttttat attcttgtga atgaaactgc
     3841 tcttgctaaa tgattttctt tttttggagg gggggtgcac tttcattttc aattgacttt
     3901 attaaatgaa aatccaaatc ttccactcct ccccctccat tgtcccctcc cccaccacac
     3961 accttccttc ttgtccttgt gttgaagagg gtatcttggg gaatgagttt attatcttct
     4021 ccacgacctc acctatacat cccacacacc atcctccagg tctgggaaat atccattttt
     4081 ctggccagtc ttagcatgtt ttcttaatgt cacattccca cgccaggccc aagagagatt
     4141 ctatgacata tattatagag agaattctat atcaatatat ataaatatta gagattatgt
     4201 acacaagggc atgggctcaa atgcccactg ccagtccccc acccaggctt cagcatctct
     4261 cttggcctgg ggaagtggga gggatgtgat gctggagaag gctacaggct gtgttcaatg
     4321 acactaaaca gaatgtggtg gca
//
