LOCUS       NM_144635               2437 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 131 member A
            (FAM131A), transcript variant 1, mRNA.
ACCESSION   NM_144635
VERSION     NM_144635.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2437)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB472892.1, BC037299.1 and CA416923.1.
            
            On Nov 23, 2018 this sequence version replaced NM_144635.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript (1) and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.112221.1,
                                           SRR3476690.362238.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000383847.7/ ENSP00000373360.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-423               DB472892.1         36-458
            424-2164            BC037299.1         415-2155
            2165-2437           CA416923.1         18-290              c
FEATURES             Location/Qualifiers
     source          1..2437
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.1"
     gene            1..2437
                     /gene="FAM131A"
                     /gene_synonym="C3orf40; FLAT715; PRO1378"
                     /note="family with sequence similarity 131 member A"
                     /db_xref="GeneID:131408"
                     /db_xref="HGNC:HGNC:28308"
     exon            1..119
                     /gene="FAM131A"
                     /gene_synonym="C3orf40; FLAT715; PRO1378"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1132
                     /gene="FAM131A"
                     /gene_synonym="C3orf40; FLAT715; PRO1378"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM131A"
                     /codon_start=1
                     /product="protein FAM131A isoform 1"
                     /protein_id="NP_653236.3"
                     /db_xref="CCDS:CCDS3262.2"
                     /db_xref="GeneID:131408"
                     /db_xref="HGNC:HGNC:28308"
                     /translation="MPMISVLGKMFLWQREGPGGRWTCQTSRRVSSDPAWAVEWIELP
                     RGLSLSSLGSARTLRGWSRSSRPSSVDSQDLPEVNVGDTVAMLPKSRRALTIQEIAAL
                     ARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWSKPSDSPAALESAFSSYSDLSE
                     GEQEARFAAGVAEQFAIAEAKLRAWSSVDGEDSTDDSYDEDFAGGMDTDMAGQLPLGP
                     HLQDLFTGHRFSRPVRQGSVEPESDCSQTVSPDTLCSSLCSLEDGLLGSPARLASQLL
                     GDELLLAKLPPSRESAFRSLGPLEAQDSLYNSPLTESCLSPAEEEPAPCKDCQPLCPP
                     LTGSWERQRQASDLASSGVVSLDEDEAEPEEQ"
     exon            120..262
                     /gene="FAM131A"
                     /gene_synonym="C3orf40; FLAT715; PRO1378"
                     /inference="alignment:Splign:2.1.0"
     exon            263..356
                     /gene="FAM131A"
                     /gene_synonym="C3orf40; FLAT715; PRO1378"
                     /inference="alignment:Splign:2.1.0"
     exon            357..539
                     /gene="FAM131A"
                     /gene_synonym="C3orf40; FLAT715; PRO1378"
                     /inference="alignment:Splign:2.1.0"
     exon            540..656
                     /gene="FAM131A"
                     /gene_synonym="C3orf40; FLAT715; PRO1378"
                     /inference="alignment:Splign:2.1.0"
     exon            657..2437
                     /gene="FAM131A"
                     /gene_synonym="C3orf40; FLAT715; PRO1378"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1729
                     /gene="FAM131A"
                     /gene_synonym="C3orf40; FLAT715; PRO1378"
                     /note="major polyA site"
     regulatory      2404..2409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM131A"
                     /gene_synonym="C3orf40; FLAT715; PRO1378"
                     /note="hexamer: ATTAAA"
     regulatory      2414..2419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM131A"
                     /gene_synonym="C3orf40; FLAT715; PRO1378"
                     /note="hexamer: TATAAA"
     polyA_site      2425
                     /gene="FAM131A"
                     /gene_synonym="C3orf40; FLAT715; PRO1378"
     polyA_site      2437
                     /gene="FAM131A"
                     /gene_synonym="C3orf40; FLAT715; PRO1378"
                     /note="major polyA site"
ORIGIN      
        1 gcttttggtt ctctgcatca acacagccag catgcctatg atttctgtgc tgggcaaaat
       61 gtttctgtgg cagcgtgaag ggcctggagg acgatggact tgtcagacaa gtcgcagagt
      121 gtcctcggac cccgcttggg ctgtggagtg gatcgaactt cctcggggtc tctctctatc
      181 ctctttggga tctgctcgaa ccctccgagg ctggagcagg tcctcccgcc cttcctcggt
      241 ggacagtcag gacttgccag aggtgaatgt tggagacaca gtcgcgatgc tgcccaagtc
      301 ccggcgagcc ctaactatcc aggagatcgc tgcgctggcc aggtcctccc tgcatggtat
      361 ttcccaggtg gtgaaggacc acgtgaccaa gcctaccgcc atggcccagg gccgagtggc
      421 tcacctcatt gagtggaagg gctggagcaa gccgagtgac tcacctgctg ccctggaatc
      481 agccttttcc tcctattcag acctcagcga gggcgaacaa gaggctcgct ttgcagcagg
      541 agtggctgag cagtttgcca tcgcggaagc caagctccga gcatggtctt cggtggatgg
      601 cgaggactcc actgatgact cctatgatga ggactttgct gggggaatgg acacagacat
      661 ggctgggcag ctgcccctgg ggccgcacct ccaggacctg ttcaccggcc accggttctc
      721 ccggcctgtg cgccagggct ccgtggagcc tgagagcgac tgctcacaga ccgtgtcccc
      781 agacaccctg tgctctagtc tgtgcagcct ggaggatggg ttgttgggct ccccggcccg
      841 gctggcctcc cagctgctgg gcgatgagct gcttctcgcc aaactgcccc ccagccggga
      901 aagtgccttc cgcagcctgg gcccactgga ggcccaggac tcactctaca actcgcccct
      961 cacagagtcc tgcctttccc ccgcggagga ggagccagcc ccctgcaagg actgccagcc
     1021 actctgccca ccactaacgg gcagctggga acggcagcgg caagcctctg acctggcctc
     1081 ttctggggtg gtgtccttag atgaggatga ggcagagcca gaggaacagt gacccacatc
     1141 atgcctggca gtggcatgca tcccccggct gctgccaggg gcagagcctc tgtgcccaag
     1201 tgtgggctca aggctcccag cagagctcca cagcctagag ggctcctggg agcgctcgct
     1261 tctccgttgt gtgttttgca tgaaagtgtt tggagaggag gcaggggctg ggctgggggc
     1321 gcatgtcctg cccccactcc cggggcttgc cgggggttgc ccggggcctc tggggcatgg
     1381 ctacagctgt ggcagacagt gatgttcatg ttcttaaaat gccacacaca catttcctcc
     1441 tcggataatg tgaaccacta agggggttgt gactgggctg tgtgagggtg gggtgggagg
     1501 gggcccagca accccccacc ctccccatgc ctctctcttc tctgcttttc ttctcacttc
     1561 cgagtccatg tgcagtgctt gatagaatca cccccacctg gaggggctgg ctcctgccct
     1621 cccggagcct atgggttgag ccgtccctca agggcccctg cccagctggg ctcgtgctgt
     1681 gcttcattca cctctccatc gtctctaaat cttcctcttt tttcctaaag acagaaggtt
     1741 tttggtctgt tttttcagtc ggatcttctc ttctctggga ggctttggaa tgatgaaagc
     1801 atgtaccctc cacccttttc ctggccccct aatggggcct gggccctttc ccaacccctc
     1861 ctaggatgtg cgggcagtgt gctggcgcct cacagccagc cgggctgccc attcacgcag
     1921 agctctctga gcgggaggtg gaagaaagga tggctctggt tgccacagag ctgggacttc
     1981 atgttcttct agagagggcc acaagagggc cacaggggtg gccgggagtt gtcagctgat
     2041 gcctgctgag aggcaggaat tgtgccagtg agtgacagtc atgagggagt gtctcttctt
     2101 ggggaggaaa gaaggtagag cctttctgtc tgaatgaaag gccaaggcta cagtacaggg
     2161 ccccacccca gccagggtgt taatgcccac gtagtggagg cctctggcag atcctgcatt
     2221 ccaaggtcac tggactgtac gtttttatgg ttgtgggaag ggtgggtggc tttagaatta
     2281 agggccttgt aggctttggc aggtaagagg gcccaaggta agaacgagag ccaacgggca
     2341 caagcattct atatataagt ggctcattag gtgtttattt tgttctattt aagaatttgt
     2401 tttattaaat taatataaaa atctttgtaa atctcta
//
