LOCUS       NM_001122779            2582 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 124 member B
            (FAM124B), transcript variant 1, mRNA.
ACCESSION   NM_001122779
VERSION     NM_001122779.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2582)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2582)
  AUTHORS   Kovacs,I.A., Luck,K., Spirohn,K., Wang,Y., Pollis,C., Schlabach,S.,
            Bian,W., Kim,D.K., Kishore,N., Hao,T., Calderwood,M.A., Vidal,M.
            and Barabasi,A.L.
  TITLE     Network-based prediction of protein interactions
  JOURNAL   Nat Commun 10 (1), 1240 (2019)
   PUBMED   30886144
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2582)
  AUTHORS   Batsukh,T., Schulz,Y., Wolf,S., Rabe,T.I., Oellerich,T., Urlaub,H.,
            Schaefer,I.M. and Pauli,S.
  TITLE     Identification and characterization of FAM124B as a novel component
            of a CHD7 and CHD8 containing complex
  JOURNAL   PLoS One 7 (12), e52640 (2012)
   PUBMED   23285124
  REMARK    GeneRIF: Fam124B is a novel protein possibly involved in the
            pathogenesis of CHARGE syndrome and neurodevelopmental disorders.
REFERENCE   4  (bases 1 to 2582)
  AUTHORS   Xin,X., Rual,J.F., Hirozane-Kishikawa,T., Hill,D.E., Vidal,M.,
            Boone,C. and Thierry-Mieg,N.
  TITLE     Shifted Transversal Design smart-pooling for high coverage
            interactome mapping
  JOURNAL   Genome Res 19 (7), 1262-1269 (2009)
   PUBMED   19447967
REFERENCE   5  (bases 1 to 2582)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008072.3, BC025754.1 and AK026399.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001122779.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026399.1, SRR1660807.243893.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409685.4/ ENSP00000386895.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AC008072.3         48034-48146
            114-529             BC025754.1         1-416
            530-1131            AK026399.1         457-1058
            1132-2582           BC025754.1         1144-2594
FEATURES             Location/Qualifiers
     source          1..2582
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q36.2"
     gene            1..2582
                     /gene="FAM124B"
                     /note="family with sequence similarity 124 member B"
                     /db_xref="GeneID:79843"
                     /db_xref="HGNC:HGNC:26224"
                     /db_xref="MIM:618403"
     exon            1..1071
                     /gene="FAM124B"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..1707
                     /gene="FAM124B"
                     /note="isoform a is encoded by transcript variant 1;
                     protein FAM124B; family with sequence similarity 124B"
                     /codon_start=1
                     /product="protein FAM124B isoform a"
                     /protein_id="NP_001116251.1"
                     /db_xref="CCDS:CCDS46527.1"
                     /db_xref="GeneID:79843"
                     /db_xref="HGNC:HGNC:26224"
                     /db_xref="MIM:618403"
                     /translation="MDETQGPLAMTVHLLANSGHGSLLQRTLDQLLDCICPEVRLFQV
                     SERASPVKYCEKSHSKRSRFPGMSVLLFLHESPGEDRLFRVLDSLQHSPWQCYPTQDT
                     RGRLCPYFFANQEFYSLDSQLPIWGVRQVHCGSEILRVTLYCSFDNYEDAIRLYEMIL
                     QREATLQKSNFCFFVLYASKSFALQLSLKQLPPGMSVDPKESSVLQFKVQEIGQLVPL
                     LPNPCMPISSTRWQTQDYDGNKILLQVQLNPELGVKNGILGAGMLPLGSRLTSVSAKR
                     TSEPRSQRNQGKRSQGHSLELPEPSGSPTSDRCAGTSWKSPGRSFQVSSPAMGAHLHL
                     SSHHLESGARMKVLNRENSFQKLEAETNVDTGLTIINSEPRQTYFGGFPRDLQTSQPP
                     FCLPASSLGVATSKNNSVLKERVSPLPLAGQRDLGTRKTISECLLHLQVQGEEKEEDE
                     EEFFI"
     exon            1072..2582
                     /gene="FAM124B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2560..2565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM124B"
                     /note="hexamer: AATAAA"
     polyA_site      2582
                     /gene="FAM124B"
                     /note="major polyA site"
ORIGIN      
        1 aggattatag gtttttaggt cacgcagaaa ccctggggaa cgcctgaaaa ggctaaacac
       61 aagcagttac attatgcaca agctggatga cgtgaccccg ctgctgctgt gtggagaggg
      121 aggctgctga acccgagctg gtgtgagctt ctcttgccgt aagtccacgg gtggccagga
      181 gcacgtgtta gtctggttaa gagctctgct cagaagtagc cgctgcagct gaaggttttc
      241 aggcgggctg aaggctgggc cgcttcttca ttcatttcag aaacttgaac agtgggcctt
      301 ctacacacgc tgtctttgtc agcctcaggc agttcctcca tggatgagac acaggggcct
      361 ctggccatga ctgtccatct tcttgccaac tctgggcacg gctcccttct gcagaggact
      421 ctggaccagc tcctggattg catttgccca gaggtccggc tctttcaggt gtctgaacgg
      481 gccagtcctg tgaaatactg tgaaaagtcc cattccaagc ggtcccggtt tccagggatg
      541 tccgtgttgc tcttcctgca cgaaagcccg ggagaggata ggctatttcg cgtcctggac
      601 tctctccagc attcgccatg gcagtgctac cccacccagg acactcgggg aaggctgtgt
      661 ccctactttt ttgccaatca ggagttctac agcctggaca gtcagctgcc catctggggg
      721 gtgaggcagg tgcactgtgg ctccgagatc ctgagggtga cgctgtactg cagttttgat
      781 aactatgaag acgccatcag actctacgag atgatcctgc agagagaagc gaccttgcaa
      841 aagagcaatt tttgtttctt cgtgctctat gcctccaaga gctttgctct gcagctctcc
      901 ctgaagcagc tgcccccggg aatgtcagtg gaccccaaag agtcttcggt gctgcagttt
      961 aaggttcaag agatcggcca gttagtgcct ctgctaccca atccatgcat gcctatcagc
     1021 agcaccaggt ggcagactca ggactacgat ggcaacaaga ttctgcttca ggttcagctg
     1081 aatccagaac ttggtgttaa gaatggcatc ttgggagctg gcatgcttcc cctgggctcc
     1141 aggctgactt ctgtctctgc aaagaggacc tcagaaccca ggagccagag gaaccagggc
     1201 aagaggtccc aggggcattc tctggagctt cctgagccca gtgggagccc cacatcagac
     1261 aggtgtgctg gcacttcgtg gaaaagccct ggccggtcat tccaggtcag cagcccagct
     1321 atgggtgccc acctgcacct gtcttctcat caccttgaat ccggggccag aatgaaggtc
     1381 ctcaaccggg aaaacagctt tcagaagctt gaggccgaga cgaatgttga caccggcttg
     1441 accatcataa attctgaacc caggcagact tattttggcg gatttccaag ggatttacag
     1501 accagccagc caccattctg cttgccagcc tcttccttgg gggtggctac ctccaaaaac
     1561 aacagtgtcc ttaaggaaag agtctctcct ttgccacttg ctggccaaag ggaccttggt
     1621 accaggaaga caatttcaga atgtctcctt catctgcaag ttcagggtga agaaaaagaa
     1681 gaagatgaag aagaattctt tatatagcat aaaataaatg tggttttcta aaacacaaga
     1741 tcagataaaa tgttctagaa atggagtact gacccagaat cagcctgtta gttgttcatc
     1801 tgaggggggc tgaatgctcc ccatgcacaa tctgtattga ttttatttca aatgttcaaa
     1861 gtctaaaggt gctgggaatg attgtttatt tgccgtcaca gtcataagag aacacagcca
     1921 acacacaggg aaaaaaaccg aatgcttttg ttccgtggag atgcactaac ccagctggat
     1981 gtgttgaatc cagcacctat caggataatt gcattgtatg caaatgaatc ggtatgttat
     2041 acaacactaa ttagtgtctg taatttggtt ttaattttta cttaggttgc atagctcatc
     2101 cccctggaca atatggactg ctatttactc ttgaatgctt tttaattttc atgtgacctc
     2161 ttttggtaac taggccttgt tcacataccc tccttgtgat tttgtcttta aagttgtttg
     2221 tatctggaat gagtgaaaat gcaaagtgtt ttgaaaatta taaacagtta attttgtttt
     2281 cctgtttaat gagccaaaat actggaagcc agaaaatcag gttgaacatg aatgctaggc
     2341 tctagggctt tcctgctcat ctgcttctca tttgtttctg cactatgtca aagaggacag
     2401 tggttcttgt tacaaaccaa agaggaacat tgagcacagt gggaaaattg gactggttga
     2461 tctggtcact ggagcaggac ttgggttctt ctggccagat tttgactccc agattccttt
     2521 acaaaacgca ctcattcatt catttatata tgttcattca ataaacattt tttgaatacc
     2581 ta
//
