LOCUS       NM_001242312            4728 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens family with sequence similarity 124 member A
            (FAM124A), transcript variant 2, mRNA.
ACCESSION   NM_001242312
VERSION     NM_001242312.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4728)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4728)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4728)
  AUTHORS   Bossini-Castillo,L., de Kovel,C., Kallberg,H., van 't Slot,R.,
            Italiaander,A., Coenen,M., Tak,P.P., Posthumus,M.D., Wijmenga,C.,
            Huizinga,T., van der Helm-van Mil,A.H., Stoeken-Rijsbergen,G.,
            Rodriguez-Rodriguez,L., Balsa,A., Gonzalez-Alvaro,I.,
            Gonzalez-Gay,M.A., Gomez-Vaquero,C., Franke,B., Vermeulen,S., van
            der Horst-Bruinsma,Ie., Dijkmans,B.A., Wolbink,G.J., Ophoff,R.A.,
            Maehlen,M.T., van Riel,P., Merriman,M., Klareskog,L., Lie,B.A.,
            Merriman,T., Crusius,J.B., Brouwer,E., Martin,J., de Vries,N.,
            Toes,R., Padyukov,L. and Koeleman,B.P.
  CONSRTM   LifeLines Cohort Study
  TITLE     A genome-wide association study of rheumatoid arthritis without
            antibodies against citrullinated peptides
  JOURNAL   Ann Rheum Dis 74 (3), e15 (2015)
   PUBMED   24532677
REFERENCE   4  (bases 1 to 4728)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG771560.1, BC051771.1, DB549067.1, BM931534.1 and BX109426.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001242312.1.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            coding sequence, compared to variant 1. The resulting isoform (2)
            lacks an internal segment, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.62856.1,
                                           SRR1660805.103915.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322475.13/ ENSP00000324625.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BG771560.1         70-90
            22-3703             BC051771.1         1-3682
            3704-4283           BC051771.1         3684-4263
            4284-4316           DB549067.1         3-35
            4317-4724           BM931534.1         23-430
            4725-4728           BX109426.1         434-437
FEATURES             Location/Qualifiers
     source          1..4728
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.3"
     gene            1..4728
                     /gene="FAM124A"
                     /note="family with sequence similarity 124 member A"
                     /db_xref="GeneID:220108"
                     /db_xref="HGNC:HGNC:26413"
     exon            1..172
                     /gene="FAM124A"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1745
                     /gene="FAM124A"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein FAM124A; family with sequence similarity 124A"
                     /codon_start=1
                     /product="protein FAM124A isoform 2"
                     /protein_id="NP_001229241.1"
                     /db_xref="CCDS:CCDS55900.1"
                     /db_xref="GeneID:220108"
                     /db_xref="HGNC:HGNC:26413"
                     /translation="MDPKAGGGGEEDDCVDSGAETGGSDYSHLSSTSSELSVEEAQDP
                     FLVSIHIIADPGESQPLQEAIDNVLAWIHPDLPLFRVSERRASRRRRKPPKGAQPALA
                     VVLFLQEEYGEEQILQLHRTLQQPPWRHHHTEQVHGRFLPYLPCSQDFFTLAPGTPLW
                     AIRPVHYGKEIVRFTVYCRYDNYADSLRFYQLILRRSPSQKKADFCIFPIFSNLDVDI
                     QFSLKRLPCDQCPVPTDSSVLEFRVRDIGELVPLLPNPCSPISEGRWQTEDHDGNKIL
                     LQAQRVHKKFPKPGRVHHASEKKRHSTPLPSTAVPSHTPGSSQQSPLNSPHPGPIRTG
                     LPPGHQQEFAGRANSTPNPPWSFQRSKSLFCLPTGGPSLASSAEPQWFSNTGAPGHRA
                     SEWRHGHLLSIDDLEGAQETDVDTGLRLSSSDLSVVSAYSAPSRFCSTVETPLPSERC
                     SSHWAAHKDSREGPLPTVSRVTTEASWASLPFFTKRSSSSSATARAAPPAPSTSTLTD
                     SSPQLPCDTPKVKQTDGDMPPPPGSAGPGDNDMEEFYI"
     exon            173..204
                     /gene="FAM124A"
                     /inference="alignment:Splign:2.1.0"
     exon            205..938
                     /gene="FAM124A"
                     /inference="alignment:Splign:2.1.0"
     exon            939..4728
                     /gene="FAM124A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4706..4711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM124A"
                     /note="hexamer: AATAAA"
     polyA_site      4728
                     /gene="FAM124A"
                     /note="major polyA site"
ORIGIN      
        1 agacgctcgg agggagcccg gccggctcgg actgggcggc cgggagggag ggcgccccgg
       61 gtcacgacgg cgcccgcaag ccgagcgcgg ccgggacgtg caccatggac ccaaaggcgg
      121 gcggcggcgg cgaggaggac gactgcgtgg actcgggcgc cgagaccgga gggtccgact
      181 acagccacct gtcctccacg agcagtgagc tttccgttga agaggcgcag gaccctttcc
      241 tggtcagcat ccacataatc gcagacccag gggagtccca gcccctgcag gaggccatcg
      301 acaacgtcct ggcgtggatc caccccgacc tcccgctgtt ccgggtgtcc gagaggcggg
      361 cgtcccggcg gcggcggaag ccccccaagg gcgctcagcc agcgctggct gtggtgctgt
      421 tcctgcagga ggagtacggc gaagagcaga tcctgcagct gcaccgcaca ctgcagcagc
      481 cgccctggcg ccaccaccac accgagcagg tgcacggccg gttcctgccc tacctgccct
      541 gcagccagga cttcttcacg ctggcccctg ggacgccgct ttgggccatc cggcccgtgc
      601 actacggcaa ggaaatcgtg cgcttcaccg tctactgtcg ctacgacaac tatgctgaca
      661 gcctcaggtt ctaccagctg attctccgga ggagccccag ccagaagaaa gcggacttct
      721 gcatcttccc tattttttcc aacctggatg tggacatcca gttctccctg aaaagactgc
      781 cctgtgacca gtgcccggtg cccaccgact cctccgtgct ggagttccga gtgagggaca
      841 taggcgagct cgtgcctctc ctgcccaacc cttgcagccc catcagcgag gggcgctggc
      901 agacggagga ccatgatggg aacaagatcc tcctacaggc acaaagggtg cataagaagt
      961 ttcctaaacc tggcagagta catcatgcct ccgagaagaa acgtcattcc actcctttgc
     1021 cgagcactgc tgtaccaagc catacacctg gcagcagcca gcagtccccg ctcaacagtc
     1081 ctcacccggg gcccatccgg acaggcctgc ctcctgggca ccagcaggaa tttgccggac
     1141 gagccaacag cacccccaac cctccctggt ctttccagag aagcaagtcc ttgttttgtt
     1201 tgcccacggg aggcccctcc ctggcctcct cagctgaacc acagtggttt tcaaacacag
     1261 gtgccccagg gcacagggca tcagagtgga ggcatggcca cctcctctcc atcgatgacc
     1321 tagagggggc ccaggagaca gacgtggaca caggcctgcg gctgtcctca tcggacctgt
     1381 ctgtggtctc tgcatattct gcacccagta ggttctgcag cacagtggag acacccctcc
     1441 cctccgaaag atgcagcagc cactgggcag ctcacaagga ttccagggag ggaccactgc
     1501 ccactgtcag cagggtgacc acagaggcct cctgggcttc cctccctttc ttcaccaaaa
     1561 ggtcttccag ctcctcagcg acagctcgtg ctgctccccc agctcccagc acctccaccc
     1621 tcacagactc ctccccacag ctcccatgcg atacccccaa agtcaagcag actgatggag
     1681 acatgccacc acccccaggg tcggctggcc ccggggataa cgacatggag gaattctaca
     1741 tctgaatgcc ctctgctctt gttctcgaaa cacacaaact cagagacaca gactcaggcc
     1801 ccactgcccc tctggccact gagcacacca cattcttcat gatccatttc ccaggagccc
     1861 gtagcacatt tgcctaccac ccactcttag ctggggggtg gtatatctct agagacacag
     1921 cagaaaaata ctggcatttt tatgcaaata aattctcaac aaacttgtca taaaatatat
     1981 tttttgaata ttcagcattt gaggtatggt ttagtgggtt tatacaattt aaatggctta
     2041 tataattatt tgaaatgaaa agaaaaccta gtcagccaga accaatttgg caatttttcc
     2101 atggtatgaa ggcaaatcaa ttaaggccaa aacgttgaat gtgggagaga tagtaagtga
     2161 cttgtatgag ggattactgc ataataacgt aacgcacacc ttactggatt ctccatatat
     2221 atttacatta ccagagaaca gtggccctag ggatgtttaa gcactgctta taatggaaaa
     2281 agtcagcttg agaagtaaac gtatatcaga ctacaggtaa ttcctcatct tgaagccatg
     2341 caacacctgc aaatctggat ttatacaaaa gttgctaatg tgtttcataa agatttagca
     2401 tgagtaacag actcttggtg catttaaaat atgtgagttc cagaaagtag atttgcatac
     2461 accttttcaa cagcacattt cactggaatg gatgaggggc ttctgaagac cactccacta
     2521 cctgaattta tttggatcac tgaggaagag catttgttgg gattacagaa ttataggcca
     2581 ttagacatca tgggtaggta gtcttaagat ccttcaactt tcaaaaacca cagtctaagg
     2641 actatattca aatgacaaga gccgcactgt atactgcttt ctgcagtgac catgctgggt
     2701 cacgcatcct atgtttctca tttttaaatg atttggaaca ttttagccag cattttgatc
     2761 acacagatta ataatgctgt tctccccaaa acgggaaact ttacctgaaa cgctctcctg
     2821 aacaaacacc agtgcactgc cagcctcaca tgattgcatg ggagctttaa ttaacgctgg
     2881 agcccagcaa ccttggcttt tcctgcctgt tatctgctac tgtcacaccg tgaatggtat
     2941 ttgaatctca cctccctctc acctcagtaa gagtatgttt gtttacagcc ccaacctcag
     3001 caatgccaaa ggctggcatc gggggcagtg ccaagctgtc cctggatact atttaccttt
     3061 gaggaagaac agcatgggtt tgccaagctc aattcccagg ctggtgctcc ttgaattaat
     3121 catggcacag tgttcatctc tctggaaatg cccacgccag cccagacaca gcctcagagt
     3181 cctttccaac acgaccctcc aggcagcagt taccaaccat cagtcttcag ctgaagcttc
     3241 aagtctttgc catccttgta atgacagcct taggccttgc cccaagcatt ctggactctc
     3301 taacactcag aattgtaatg taatattctg ctctaattta aatttttaaa aatatagtct
     3361 cctaattcag gataaggagt aagcaaactt tctgaaaagg gctagataat aagtatttta
     3421 ggctttgcca gtcatatggt ctcttgcagc tactcaactc tgccactgta gtatgaaagc
     3481 agccatgagt aatatgttaa tgaatgggaa tggctgagtt ccaataaagc tttatttttt
     3541 ttttatttga gacggggtct tgctctgttg cccaggctgg agtgcaatgg cgcaatctca
     3601 gctcactgca agctctgcct cctgggttca agccattctc ctgcctcagc ctcccaagta
     3661 gctgcgacta caggtgcgca ccacaatgcc tggctaattt tttgtatttt tagtagagac
     3721 agagtttcac catgttggcc aggttggtct caaactcctg acttcgtgat ccacccacct
     3781 tggcctccca aagcactggg attacaggca tgagccacca ttcccagcca ataaaacttt
     3841 atttacaaga acagctggtg ggccagattt ggcccaaggg tcatagttta ttatcccttg
     3901 agctaggctg ctgcctgagg ttgattcaac atcccagctc cagtcaacaa caaaaattct
     3961 aagtctcccg cctaatgctg ctgtggtgtg tcatgccaaa aaagtgggct actcaggtta
     4021 gaccaatgac ttcagaacca cagggctcag aacaggaagg agcttctttc tgcagagctg
     4081 attcctggaa agccaccagc actccacctt ctgcccagaa atgtgattca gtcaatagct
     4141 gatgaggaaa agcaacctgc aaacattagg aagaaggaga aaaataattc agaggtgatg
     4201 ataccacctc caatgaacag ggaagcaagt tcatcagtaa caaaagtcag tgaggcaaaa
     4261 aaaaaaaaaa aaaaaaaaaa aaaaggctaa tggccgaggg ctggctcctt ctttctccct
     4321 aatcagtgtc cttatttcag tgtgctcaca tgctcgccta ggactgcttt agagtacaac
     4381 tctggacccg ccctcatcac agtccaatct accaaactga gtgaccctaa aggacatcat
     4441 agacaacatt tgaaagcaag aaatgcaaaa tgttcccata gcatcaggtg agcagggaga
     4501 ggatgcccac tgtagaccac atggaaatgg cagtccctcc acggagaggg aatcacagga
     4561 acacatttac caaagccttc ccttccattc ctggccattc cagtagcatc ttcctcatcc
     4621 agaagggctt ccaatactct ctggaggatc ctgactcgtt tggagtatta tccttgtaaa
     4681 agatgctggc acattgtagg tgctcaataa atgtgttcaa ttgaaaaa
//
