LOCUS       NM_024556               2016 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 118 member B
            (FAM118B), transcript variant 1, mRNA.
ACCESSION   NM_024556
VERSION     NM_024556.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2016)
  AUTHORS   Schieffer,K.M., Agarwal,V., LaHaye,S., Miller,K.E., Koboldt,D.C.,
            Lichtenberg,T., Leraas,K., Brennan,P., Kelly,B.J., Crist,E.,
            Rusin,J., Finlay,J.L., Osorio,D.S., Sribnick,E.A., Leonard,J.R.,
            Feldman,A., Orr,B.A., Serrano,J., Vasudevaraja,V., Snuderl,M.,
            White,P., Magrini,V., Wilson,R.K., Mardis,E.R., Boue,D.R. and
            Cottrell,C.E.
  TITLE     YAP1-FAM118B Fusion Defines a Rare Subset of Childhood and Young
            Adulthood Meningiomas
  JOURNAL   Am J Surg Pathol 45 (3), 329-340 (2021)
   PUBMED   33074854
  REMARK    GeneRIF: YAP1-FAM118B Fusion Defines a Rare Subset of Childhood and
            Young Adulthood Meningiomas.
REFERENCE   2  (bases 1 to 2016)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2016)
  AUTHORS   Hebert,M.D. and Poole,A.R.
  TITLE     Towards an understanding of regulating Cajal body activity by
            protein modification
  JOURNAL   RNA Biol 14 (6), 761-778 (2017)
   PUBMED   27819531
  REMARK    Review article
REFERENCE   4  (bases 1 to 2016)
  AUTHORS   Li,Y., Fong,K.W., Tang,M., Han,X., Gong,Z., Ma,W., Hebert,M.,
            Songyang,Z. and Chen,J.
  TITLE     Fam118B, a newly identified component of Cajal bodies, is required
            for Cajal body formation, snRNP biogenesis and cell viability
  JOURNAL   J Cell Sci 127 (Pt 9), 2029-2039 (2014)
   PUBMED   24569877
REFERENCE   5  (bases 1 to 2016)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB141933.1, BC001340.1 and BF448999.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_024556.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.91855.1,
                                           SRR1660809.61705.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000533050.6/ ENSP00000433343.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                CB141933.1         59-95
            38-1694             BC001340.1         1-1657
            1695-2016           BF448999.1         28-349              c
FEATURES             Location/Qualifiers
     source          1..2016
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..2016
                     /gene="FAM118B"
                     /note="family with sequence similarity 118 member B"
                     /db_xref="GeneID:79607"
                     /db_xref="HGNC:HGNC:26110"
                     /db_xref="MIM:616587"
     exon            1..49
                     /gene="FAM118B"
                     /inference="alignment:Splign:2.1.0"
     exon            50..118
                     /gene="FAM118B"
                     /inference="alignment:Splign:2.1.0"
     exon            119..211
                     /gene="FAM118B"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1181
                     /gene="FAM118B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM118B"
                     /codon_start=1
                     /product="protein FAM118B isoform 1"
                     /protein_id="NP_078832.1"
                     /db_xref="CCDS:CCDS8470.1"
                     /db_xref="GeneID:79607"
                     /db_xref="HGNC:HGNC:26110"
                     /db_xref="MIM:616587"
                     /translation="MASTGSQASDIDEIFGFFNDGEPPTKKPRKLLPSLKTKKPRELV
                     LVIGTGISAAVAPQVPALKSWKGLIQALLDAAIDFDLLEDEESKKFQKCLHEDKNLVH
                     VAHDLIQKLSPRTSNVRSTFFKDCLYEVFDDLESKMEDSGKQLLQSVLHLMENGALVL
                     TTNFDNLLELYAADQGKQLESLDLTDEKKVLEWAQEKRKLSVLHIHGVYTNPSGIVLH
                     PAGYQNVLRNTEVMREIQKLYENKSFLFLGCGWTVDDTTFQALFLEAVKHKSDLEHFM
                     LVRRGDVDEFKKLRENMLDKGIKVISYGDDYADLPEYFKRLTCEISTRGTSAGMVREG
                     QLNGSSAAHSEIRGCST"
     exon            212..464
                     /gene="FAM118B"
                     /inference="alignment:Splign:2.1.0"
     exon            465..692
                     /gene="FAM118B"
                     /inference="alignment:Splign:2.1.0"
     exon            693..821
                     /gene="FAM118B"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1107
                     /gene="FAM118B"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1167
                     /gene="FAM118B"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..2016
                     /gene="FAM118B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1675..1680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM118B"
                     /note="hexamer: ATTAAA"
     polyA_site      1704
                     /gene="FAM118B"
                     /note="major polyA site"
     regulatory      1956..1961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM118B"
                     /note="hexamer: TATAAA"
     polyA_site      1980
                     /gene="FAM118B"
                     /note="major polyA site"
     polyA_site      2016
                     /gene="FAM118B"
ORIGIN      
        1 gcgccggccg gtagctgcag ctggagcagt ggcgtttgga ggagactcgg atataccttc
       61 tcagaagctg cacaggagga aagcagtgac aaagaaagaa gttgtcattc tttgcacgaa
      121 actggatggc ttctacaggg agccaggcct ctgatataga cgagattttt ggattcttca
      181 acgatggcga acctcccacc aaaaagccca ggaagctgct tccaagctta aaaactaaga
      241 agcctcgaga acttgtgcta gtgattggaa caggcattag tgctgcagtt gcgccccaag
      301 ttccagccct caaatcctgg aaggggttaa ttcaggcctt actggatgct gccattgatt
      361 ttgatctttt agaagatgag gagagcaaaa agtttcagaa atgtctccat gaagacaaga
      421 acctggtcca tgttgcccat gaccttatcc agaaactctc tcctcgtacc agtaatgttc
      481 gatccacatt tttcaaggac tgtttatatg aagtatttga tgacttggag tcaaagatgg
      541 aagattctgg aaaacagcta cttcagtcag ttctccacct gatggaaaat ggagccctcg
      601 tattaactac aaattttgat aatctcttgg aactgtatgc agcagatcag gggaaacagc
      661 ttgaatccct tgaccttact gatgagaaaa aggtcctcga gtgggctcag gagaagcgta
      721 agctgagcgt gttgcatatt cacggagtct acaccaaccc tagtggcatt gtccttcatc
      781 cggctggata tcagaacgtg ctcaggaaca ctgaagtcat gagagaaatt cagaaactct
      841 acgaaaacaa gtcatttctt ttcctgggct gtggctggac tgtggatgac accactttcc
      901 aggccctttt cttggaggct gtcaagcata aatctgacct agaacatttc atgctggttc
      961 ggagaggaga cgtagatgag ttcaaaaagc ttcgagaaaa catgctggac aaggggatta
     1021 aagtcatctc ctatggagat gactatgccg atcttccaga atatttcaag cgactgacat
     1081 gtgagatctc cacaaggggt acatcagcag ggatggtgag agaaggtcag ctaaatggct
     1141 catctgcagc acacagtgaa ataagaggct gtagtacatg agcgagctag agaaatcacc
     1201 accgtttaga ccaagctgta aggccctact acagacagtg tttaacaagt aaacttacaa
     1261 gaacccaaca caattcccag aaagtaacaa tagccagagg ttgaagggcg gggtagaaga
     1321 ggggggaatg ttgcagcgta atccttcata ccacctggtt cttgatattc tgccgcctgt
     1381 tcaagttcaa gaataaaagc gacagcagga cccaaatgca gctcccaacc cactccccag
     1441 gctagacatg cttgtgtcca cacagcacac caatgtgata cttccactga ccggctgcag
     1501 ctctgcatga aggactcggg gtctggatgc catggaatca ctgtggctct tgttgcagtt
     1561 ttgtactcta tacttggttt ttcaattaag cttaatggct tttttaaaac atgacttgaa
     1621 gctctagttt tctagatctt ttacagtgta cagtatttta cataactaag ctgtattaaa
     1681 agcttgttca tttacttgcc aggaccctgg ctctactttt agagtcattg taagaaactc
     1741 taacttgcat caaggtacta ataagcttaa ttttaataac ccaaagttta aaggttccga
     1801 tctttctcct tggggtggag tgatctcatt ctcaggacaa ccgtttactt acctgattcc
     1861 tcggagcatt atcaacttct gctctgttgt cctgaccata catatgtcct agaactacag
     1921 ttaagtgtgt tgtggaattt tagttttgaa tcctgtataa aagaactcca agacctaaaa
     1981 ggcaatttat ttatgaaatt tattttctta tataaa
//
