LOCUS       NM_001330446            2090 bp    mRNA    linear   PRI 03-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 118 member B
            (FAM118B), transcript variant 2, mRNA.
ACCESSION   NM_001330446 XM_005271665
VERSION     NM_001330446.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2090)
  AUTHORS   Schieffer,K.M., Agarwal,V., LaHaye,S., Miller,K.E., Koboldt,D.C.,
            Lichtenberg,T., Leraas,K., Brennan,P., Kelly,B.J., Crist,E.,
            Rusin,J., Finlay,J.L., Osorio,D.S., Sribnick,E.A., Leonard,J.R.,
            Feldman,A., Orr,B.A., Serrano,J., Vasudevaraja,V., Snuderl,M.,
            White,P., Magrini,V., Wilson,R.K., Mardis,E.R., Boue,D.R. and
            Cottrell,C.E.
  TITLE     YAP1-FAM118B Fusion Defines a Rare Subset of Childhood and Young
            Adulthood Meningiomas
  JOURNAL   Am J Surg Pathol 45 (3), 329-340 (2021)
   PUBMED   33074854
  REMARK    GeneRIF: YAP1-FAM118B Fusion Defines a Rare Subset of Childhood and
            Young Adulthood Meningiomas.
REFERENCE   2  (bases 1 to 2090)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2090)
  AUTHORS   Hebert,M.D. and Poole,A.R.
  TITLE     Towards an understanding of regulating Cajal body activity by
            protein modification
  JOURNAL   RNA Biol 14 (6), 761-778 (2017)
   PUBMED   27819531
  REMARK    Review article
REFERENCE   4  (bases 1 to 2090)
  AUTHORS   Li,Y., Fong,K.W., Tang,M., Han,X., Gong,Z., Ma,W., Hebert,M.,
            Songyang,Z. and Chen,J.
  TITLE     Fam118B, a newly identified component of Cajal bodies, is required
            for Cajal body formation, snRNP biogenesis and cell viability
  JOURNAL   J Cell Sci 127 (Pt 9), 2029-2039 (2014)
   PUBMED   24569877
REFERENCE   5  (bases 1 to 2090)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB141933.1, BI522660.1 and AP001318.6.
            
            On Aug 29, 2016 this sequence version replaced XM_005271665.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.150095.1,
                                           SRR1803613.109549.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                CB141933.1         1-81
            82-889              BI522660.1         1-808
            890-1165            AP001318.6         28849-29124
            1166-1222           AP001318.6         33700-33756
            1223-2090           AP001318.6         34392-35259
FEATURES             Location/Qualifiers
     source          1..2090
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..2090
                     /gene="FAM118B"
                     /note="family with sequence similarity 118 member B"
                     /db_xref="GeneID:79607"
                     /db_xref="HGNC:HGNC:26110"
                     /db_xref="MIM:616587"
     exon            1..107
                     /gene="FAM118B"
                     /inference="alignment:Splign:2.1.0"
     exon            108..176
                     /gene="FAM118B"
                     /inference="alignment:Splign:2.1.0"
     exon            177..269
                     /gene="FAM118B"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1236
                     /gene="FAM118B"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein FAM118B"
                     /codon_start=1
                     /product="protein FAM118B isoform 2"
                     /protein_id="NP_001317375.1"
                     /db_xref="CCDS:CCDS81647.1"
                     /db_xref="GeneID:79607"
                     /db_xref="HGNC:HGNC:26110"
                     /db_xref="MIM:616587"
                     /translation="MASTGSQASDIDEIFGFFNDGEPPTKKPRKLLPSLKTKKPRELV
                     LVIGTGISAAVAPQVPALKSWKGLIQALLDAAIDFDLLEDEESKKFQKCLHEDKNLVH
                     VAHDLIQKLSPRTSNVRSTFFKDCLYEVFDDLESKMEDSGKQLLQSVLHLMENGALVL
                     TTNFDNLLELYAADQGKQLESLDLTDEKKVLEWAQEKRKLSVLHIHGVYTNPSGIVLH
                     PAGYQNVLRNTEVMREIQKLYENKSFLFLGCGWTVDDTTFQALFLEAVKHKSDLEHFM
                     LVRRGDVDEFKKLRENMLDKGIKVISYGDDYADLPEYFKRLTCEISTRGTSGMVREGQ
                     LNGSSAAHSEIRGCST"
     exon            270..522
                     /gene="FAM118B"
                     /inference="alignment:Splign:2.1.0"
     exon            523..750
                     /gene="FAM118B"
                     /inference="alignment:Splign:2.1.0"
     exon            751..879
                     /gene="FAM118B"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1165
                     /gene="FAM118B"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1222
                     /gene="FAM118B"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..2090
                     /gene="FAM118B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1730..1735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM118B"
                     /note="hexamer: ATTAAA"
     polyA_site      1759
                     /gene="FAM118B"
                     /note="major polyA site"
     regulatory      2011..2016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM118B"
                     /note="hexamer: TATAAA"
     polyA_site      2035
                     /gene="FAM118B"
                     /note="major polyA site"
     regulatory      2066..2071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM118B"
                     /note="hexamer: TATAAA"
     polyA_site      2071
                     /gene="FAM118B"
     polyA_site      2090
                     /gene="FAM118B"
ORIGIN      
        1 gtggtgcggg gtggggcctg ggcgagtcac gtggggacgg tgcgcgctca gtgcggctgc
       61 gccggccggt agctgcagct ggagcagtgg cgtttggagg agactcggat ataccttctc
      121 agaagctgca caggaggaaa gcagtgacaa agaaagaagt tgtcattctt tgcacgaaac
      181 tggatggctt ctacagggag ccaggcctct gatatagacg agatttttgg attcttcaac
      241 gatggcgaac ctcccaccaa aaagcccagg aagctgcttc caagcttaaa aactaagaag
      301 cctcgagaac ttgtgctagt gattggaaca ggcattagtg ctgcagttgc gccccaagtt
      361 ccagccctca aatcctggaa ggggttaatt caggccttac tggatgctgc cattgatttt
      421 gatcttttag aagatgagga gagcaaaaag tttcagaaat gtctccatga agacaagaac
      481 ctggtccatg ttgcccatga ccttatccag aaactctctc ctcgtaccag taatgttcga
      541 tccacatttt tcaaggactg tttatatgaa gtatttgatg acttggagtc aaagatggaa
      601 gattctggaa aacagctact tcagtcagtt ctccacctga tggaaaatgg agccctcgta
      661 ttaactacaa attttgataa tctcttggaa ctgtatgcag cagatcaggg gaaacagctt
      721 gaatcccttg accttactga tgagaaaaag gtcctcgagt gggctcagga gaagcgtaag
      781 ctgagcgtgt tgcatattca cggagtctac accaacccta gtggcattgt ccttcatccg
      841 gctggatatc agaacgtgct caggaacact gaagtcatga gagaaattca gaaactctac
      901 gaaaacaagt catttctttt cctgggctgt ggctggactg tggatgacac cactttccag
      961 gcccttttct tggaggctgt caagcataaa tctgacctag aacatttcat gctggttcgg
     1021 agaggagacg tagatgagtt caaaaagctt cgagaaaaca tgctggacaa ggggattaaa
     1081 gtcatctcct atggagatga ctatgccgat cttccagaat atttcaagcg actgacatgt
     1141 gagatctcca caaggggtac atcagggatg gtgagagaag gtcagctaaa tggctcatct
     1201 gcagcacaca gtgaaataag aggctgtagt acatgagcga gctagagaaa tcaccaccgt
     1261 ttagaccaag ctgtaaggcc ctactacaga cagtgtttaa caagtaaact tacaagaacc
     1321 caacacaatt cccagaaagt aacaatagcc agaggttgaa gggcggggta gaagaggggg
     1381 gaatgttgca gcgtaatcct tcataccacc tggttcttga tattctgccg cctgttcaag
     1441 ttcaagaata aaagcgacag caggacccaa atgcagctcc caacccactc cccaggctag
     1501 acatgcttgt gtccacacag cacaccaatg tgatacttcc actgaccggc tgcagctctg
     1561 catgaaggac tcggggtctg gatgccatgg aatcactgtg gctcttgttg cagttttgta
     1621 ctctatactt ggtttttcaa ttaagcttaa tggctttttt aaaacatgac ttgaagctct
     1681 agttttctag atcttttaca gtgtacagta ttttacataa ctaagctgta ttaaaagctt
     1741 gttcatttac ttgccaggac cctggctcta cttttagagt cattgtaaga aactctaact
     1801 tgcatcaagg tactaataag cttaatttta ataacccaaa gtttaaaggt tccgatcttt
     1861 ctccttgggg tggagtgatc tcattctcag gacaaccgtt tacttacctg attcctcgga
     1921 gcattatcaa cttctgctct gttgtcctga ccatacatat gtcctagaac tacagttaag
     1981 tgtgttgtgg aattttagtt ttgaatcctg tataaaagaa ctccaagacc taaaaggcaa
     2041 tttatttatg aaatttattt tcttatataa attacttatt tctctgggca
//
