LOCUS       NM_018691               4414 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens family with sequence similarity 114 member A2
            (FAM114A2), transcript variant 1, mRNA.
ACCESSION   NM_018691
VERSION     NM_018691.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4414)
  AUTHORS   Welch,L.G., Muschalik,N. and Munro,S.
  TITLE     The FAM114A proteins are adaptors for the recycling of Golgi
            enzymes
  JOURNAL   J Cell Sci 137 (17) (2024)
   PUBMED   39129673
REFERENCE   2  (bases 1 to 4414)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4414)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4414)
  AUTHORS   Wei,X.H., Gu,X.L., Zhou,X.T., Ma,M. and Lou,C.X.
  TITLE     miR-497 promotes the progression of cutaneous squamous cell
            carcinoma through FAM114A2
  JOURNAL   Eur Rev Med Pharmacol Sci 22 (21), 7348-7355 (2018)
   PUBMED   30468480
  REMARK    GeneRIF: miR-497 was down-regulated in squamous cell carcinoma
            tissues and cells, which can inhibit the expression of FAM114A2 and
            regulate tumor cell proliferation.
REFERENCE   5  (bases 1 to 4414)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 4414)
  AUTHORS   Boultwood,J., Fidler,C., Strickson,A.J., Watkins,F., Kostrzewa,M.,
            Jaju,R.J., Muller,U. and Wainscoat,J.S.
  TITLE     Transcription mapping of the 5q- syndrome critical region: cloning
            of two novel genes and sequencing, expression, and mapping of a
            further six novel cDNAs
  JOURNAL   Genomics 66 (1), 26-34 (2000)
   PUBMED   10843801
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA351656.1, AK024664.1, BC050701.1 and AC010232.10.
            
            On Nov 23, 2018 this sequence version replaced NM_018691.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1, 2, and 3 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.84120.1, HM005704.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000351797.9/ ENSP00000341597.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 DA351656.1         29-35
            8-430               AK024664.1         1-423
            431-434             BC050701.1         420-423
            435-1595            AK024664.1         428-1588
            1596-2063           BC050701.1         1584-2051
            2064-2657           AK024664.1         2057-2650
            2658-4414           AC010232.10        59747-61503
FEATURES             Location/Qualifiers
     source          1..4414
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.2"
     gene            1..4414
                     /gene="FAM114A2"
                     /gene_synonym="133K02; C5orf3"
                     /note="family with sequence similarity 114 member A2"
                     /db_xref="GeneID:10827"
                     /db_xref="HGNC:HGNC:1333"
     exon            1..54
                     /gene="FAM114A2"
                     /gene_synonym="133K02; C5orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            55..278
                     /gene="FAM114A2"
                     /gene_synonym="133K02; C5orf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1586
                     /gene="FAM114A2"
                     /gene_synonym="133K02; C5orf3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM114A2; testis tissue sperm-binding protein Li
                     81P"
                     /codon_start=1
                     /product="protein FAM114A2 isoform 1"
                     /protein_id="NP_061161.2"
                     /db_xref="CCDS:CCDS4323.1"
                     /db_xref="GeneID:10827"
                     /db_xref="HGNC:HGNC:1333"
                     /translation="MSDKDDIETPLLTEAAPILEDGNCEPAKNSESVDQGAKPESKSE
                     PVVSTRKRPETKPSSDLETSKVLPIQDNVSKDVPQTRWGYWGSWGKSILSSASATVAT
                     VGQGISNVIEKAETSLGIPGPSEISTEVKYVAGETNAKENENSSPVAGAFGVFSTIST
                     AVQSTGKSVISGGLDALEFIGKKTMDVIAEGDPGFKRTKGLMNRNATLSQVLREAKEK
                     EEIRTSNEVTVETDKKTHYGLLFDEFQGLSHLEALEMLSQESEIKVKSILNSLSGEEL
                     ETLKVELEQLKETFSLAEFCEEEEEEKKGDEDFTKDITELFSQLHVSSKPEKLARARN
                     TAHEWIRKSLTKPLAENEEGEKQSEAENTEQVNKNSIEDIHAFAIRSLAELTACSIEL
                     FHKTAALVLHGRKQEVTAIERSQTLSQMTIVLCKELSSLSKEFTTCLTTAGVKEMADV
                     LNPLITAVFLEASNSASYIQDAFQLLLPVLEISLIENKIESHRHELQGQKPLLEH"
     exon            279..378
                     /gene="FAM114A2"
                     /gene_synonym="133K02; C5orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            379..471
                     /gene="FAM114A2"
                     /gene_synonym="133K02; C5orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            472..563
                     /gene="FAM114A2"
                     /gene_synonym="133K02; C5orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            564..698
                     /gene="FAM114A2"
                     /gene_synonym="133K02; C5orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            699..857
                     /gene="FAM114A2"
                     /gene_synonym="133K02; C5orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            858..981
                     /gene="FAM114A2"
                     /gene_synonym="133K02; C5orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1061
                     /gene="FAM114A2"
                     /gene_synonym="133K02; C5orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1184
                     /gene="FAM114A2"
                     /gene_synonym="133K02; C5orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1324
                     /gene="FAM114A2"
                     /gene_synonym="133K02; C5orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1397
                     /gene="FAM114A2"
                     /gene_synonym="133K02; C5orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1451
                     /gene="FAM114A2"
                     /gene_synonym="133K02; C5orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..4414
                     /gene="FAM114A2"
                     /gene_synonym="133K02; C5orf3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2039..2044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM114A2"
                     /gene_synonym="133K02; C5orf3"
                     /note="hexamer: AATAAA"
     polyA_site      2063
                     /gene="FAM114A2"
                     /gene_synonym="133K02; C5orf3"
                     /note="major polyA site"
     regulatory      2775..2780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM114A2"
                     /gene_synonym="133K02; C5orf3"
                     /note="hexamer: AATAAA"
     polyA_site      2797
                     /gene="FAM114A2"
                     /gene_synonym="133K02; C5orf3"
     regulatory      4391..4396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM114A2"
                     /gene_synonym="133K02; C5orf3"
                     /note="hexamer: ATTATA"
     polyA_site      4414
                     /gene="FAM114A2"
                     /gene_synonym="133K02; C5orf3"
ORIGIN      
        1 agtaggaacg ccgagtcggc tgccgtggct gtgctgaggg tggcggccgg atagctgatg
       61 ttctaatcat gtcagataaa gatgatattg agactccact gctaactgaa gcagccccca
      121 tccttgaaga tggaaactgt gagccagcca agaattctga gtctgttgac caaggtgcca
      181 aaccagagag taaatcagaa cctgtagttt ccactcggaa aagaccagag accaaacctt
      241 ccagtgacct tgagacttca aaagttctcc ctattcagga taatgtttcc aaagatgtac
      301 cccagaccag atggggttat tgggggagct ggggcaagtc catactctcc tcagcctcgg
      361 ctacagtagc tacagtagga caaggcattt caaatgtcat cgagaaggca gagacttccc
      421 ttggaatccc tggtcccagt gaaatttcaa ctgaagtcaa gtatgtagca ggagagacaa
      481 atgccaaaga gaatgaaaac tcctccccag tggctggggc atttggtgta ttctctacca
      541 tctctactgc tgttcagagc acaggaaaga gtgttataag tgggggtttg gatgccttag
      601 aattcattgg aaaaaagaca atggatgtga tagcagaagg ggatcctgga tttaaaagaa
      661 ccaagggtct gatgaaccga aatgctacac tatctcaggt tttacgagag gcgaaggaga
      721 aagaagagat acggacctcc aatgaggtta ccgtggaaac agacaagaaa actcattatg
      781 ggctactctt tgatgaattt caaggccttt cacatctaga agctctggag atgctttccc
      841 aagaaagtga aataaaggtg aaatctatcc ttaattctct gagtggagaa gaattagaga
      901 ctctaaaagt tgaattagag caactcaaag aaacattttc tctagcagaa ttttgtgaag
      961 aagaggaaga agagaaaaaa ggggatgaag attttaccaa ggacataaca gagctgtttt
     1021 cccagctgca cgtttcctcc aaaccagaga aacttgccag ggcaagaaat accgcccacg
     1081 aatggatcag gaagtctctg accaagccat tagcagagaa tgaagaagga gaaaaacagt
     1141 cggaagcaga aaatactgag caagtcaaca aaaattcaat agaggatatc catgcgtttg
     1201 caatccggag cctggctgaa ctgactgcct gctcaattga actattccac aaaacagctg
     1261 cattggttct gcatggcagg aagcaggaag tgacagccat agaaaggagc caaactcttt
     1321 cccagatgac aattgtgttg tgtaaagagt tgtcctctct gtctaaagag ttcactacct
     1381 gcctaacaac tgctggggtc aaagaaatgg cagatgtcct taacccatta atcactgcag
     1441 tatttctaga ggcatcaaac agtgcctcct acatccagga cgcctttcag ctactcttac
     1501 ctgtgctaga gatctctctc attgagaaca agattgaatc acacagacat gagctgcagg
     1561 gccagaaacc tttgttagaa cattgaagaa tggagacgtt ttgacctggg acttgtgacg
     1621 gccaaggaat gccaccttat tctggctact cctgcagaaa tgaaggagtg gggttatttt
     1681 agtatataaa aattcaggca ggagagatgg tttaaagagg aagattgttg ccttcagtgt
     1741 ttgattgaag tattcaggtt ctcacagtat tctttccagt tgttgtaatt cataaattat
     1801 ttgaaaagaa acttttgtag aaagtccaag aataataact ctagataaag attagtggga
     1861 cactcaggca aaaatgttgg tctttctttg acatgttgca aaatgttatc aattttgtca
     1921 tggatataat ttgcagccca tggatataac tggttgataa gccagagaaa aataatttag
     1981 tgttctaaaa ttcatggcat gtgtggttta ttaatgccat gtactttctc ctttctggaa
     2041 taaaatctat ggctttaaga aaactgagca tatgtaaact ctgtgatgat taccctttat
     2101 cacatgaatt cttggaaata gaaagtttca tctgcttttt taaattctta gtagatattt
     2161 ggcattgagg agaaacttgt agactattat agccatgtga attaactgta gcaaagtgcc
     2221 ctttttcttc aaattgctcc ccctccccag gatgacacac ttcatgtcat agctgaaccc
     2281 tactctactg gattcaaggc cagtaaatgc aatttagaga agcagtttta tgtttgcaga
     2341 tattctgagt ctcttcagga tgtgtttcgt gtctaccata tatgcaggat aaattcttta
     2401 acagcaaact ccaaaggaat gttgaagctg ttttagcaat gaggattttt ttgtttgagt
     2461 gttgaagtgg gccatagtcc tttagaaatg atgttcattt atgataggat ttaacttcta
     2521 aggcatagtt tattttttcc tctttccttt ttgtttgttt taatgtattc tttagcatgt
     2581 ttttgatata acttttatcc tccagatctt aagctttctt ttgctctctt cagcaattta
     2641 agagactatt aagctgtcgt cttcctaaaa gctattttgg tatccactct ttttaaaaaa
     2701 attctccaac tttgtggttt tttaatgatt aaggtaattt gttagctctg cccctcatct
     2761 tctaaaacct ttgtaataaa atgtattaat catgttattt gatcctttca tttacttttg
     2821 taaacacgag ccctaatatc ttacttagac caaaaaaaaa aaaaaaaaat agcaaagcaa
     2881 agccataaca tagattagta taaagactgt ttctacgtaa tcttctttgg ggcaggagtc
     2941 agttagtaag caaggaagag aaataaattt ggtttaaaaa ggtataccaa cagcactaca
     3001 atgttactct gcctatattc tgtcttaata tgatcagaaa gtttttgaat attccttttt
     3061 aaagacaaat ttcacccttt ccagcttgaa tatttctgaa gtttcagaaa aacagttgcc
     3121 ttctggttac aaaggctggt gtcaccagtt ctgaattgtt gcctcaagct tggttgatgt
     3181 gtctgaacct gtatcccttg agggcaaagt ttagaaactg gtcactctgc ctactgtctg
     3241 ttcagcctct tgtacaatgg cagtttggca gctttaaatc cttaacctag aaatgtattt
     3301 aaggtttttc tttcaagaaa tggggtatac atatgaagga gagagtaaca actcttttta
     3361 tacacctatt cagatttcag ccctgaattt ggcaaatttt agattaggtc tcacataagg
     3421 taaatatgac tcactaactc tttttttctc atcttcccca cccccccata tatatttatt
     3481 tattttaatg gagttaggga ccactagtga aatgatgaaa ggcccaattc tgagtaacaa
     3541 ttgtctactc ttcacataaa atatactgaa aaagaattaa gattccttga tccagtagac
     3601 atagagaaac ataaacattc atgacagatg agtaggtaaa ttcagggatc actttggaac
     3661 ttgctggatt atggtgatgg tttttggata gtatgtgctt cattatttta tttggggtag
     3721 ttacagtgtt ttagtttttt gttaacagct acacttttgg tactattttc cttttaaatt
     3781 tttggtgtct aagatttacc actaattact aatatatgcc tttccaattc acttaaaacc
     3841 ttaataagtg aaatgttcag gtattgctag ggtaaatgtg tcttttccta ctattgagat
     3901 tttaaaaggc tgtgattaag agagacttta ttaatttgat ctgaaagaag tagaaacctc
     3961 tatgaaacaa tttttatttt cctttgcata ataccttaga aatgtgttaa ggacaagcta
     4021 tattttcctt acttgctttt gatagttttt tttttttttt ttaagcatag atatccaggt
     4081 tggcaggcct ctgaaatgtg aaattgtaat ttttatagat ggcattacta tgaatctgaa
     4141 atcagtgcta ggtgtacaaa tgtgaatttt tcaatcctgt aatcaaagaa caagatcttg
     4201 tgggttccta ctgctgaaaa aggatgcttt cttttgtact tgtttttagt gaaagacctt
     4261 tttgagggag agctatttta taggtagttg ctattgatat ctccatttga gaaatagaca
     4321 tttttctgta tttctagagg tgttctgaat tttaaacctg aattcttcag tttagaaaac
     4381 ccagaataaa attataccca cagtgggcac tcaa
//
