LOCUS       NM_138389               4060 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens family with sequence similarity 114 member A1
            (FAM114A1), transcript variant 1, mRNA.
ACCESSION   NM_138389
VERSION     NM_138389.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4060)
  AUTHORS   Welch,L.G., Muschalik,N. and Munro,S.
  TITLE     The FAM114A proteins are adaptors for the recycling of Golgi
            enzymes
  JOURNAL   J Cell Sci 137 (17) (2024)
   PUBMED   39129673
REFERENCE   2  (bases 1 to 4060)
  AUTHORS   Subbaiah,K.C.V., Wu,J., Tang,W.H.W. and Yao,P.
  TITLE     FAM114A1 influences cardiac pathological remodeling by regulating
            angiotensin II signaling
  JOURNAL   JCI Insight 7 (13), e152783 (2022)
   PUBMED   35671117
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4060)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4060)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4060)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4060)
  AUTHORS   Sung,H., Camargo,M.C., Yu,K., Weinstein,S.J., Morgan,D.R.,
            Albanes,D. and Rabkin,C.S.
  TITLE     Association of 4p14 TLR locus with antibodies to Helicobacter
            pylori
  JOURNAL   Genes Immun 16 (8), 567-570 (2015)
   PUBMED   26312625
  REMARK    GeneRIF: Study annotated variants at 4p14 as expression
            quantitative trait loci (eQTL) associated with TLR6/10 and
            FAM114A1; findings suggest that 4p14 polymorphisms are linked to
            host immune response to H. pylori infection but not to its
            acquisition.
REFERENCE   7  (bases 1 to 4060)
  AUTHORS   Bonnelykke,K., Matheson,M.C., Pers,T.H., Granell,R., Strachan,D.P.,
            Alves,A.C., Linneberg,A., Curtin,J.A., Warrington,N.M., Standl,M.,
            Kerkhof,M., Jonsdottir,I., Bukvic,B.K., Kaakinen,M., Sleimann,P.,
            Thorleifsson,G., Thorsteinsdottir,U., Schramm,K., Baltic,S.,
            Kreiner-Moller,E., Simpson,A., St Pourcain,B., Coin,L., Hui,J.,
            Walters,E.H., Tiesler,C.M.T., Duffy,D.L., Jones,G., Ring,S.M.,
            McArdle,W.L., Price,L., Robertson,C.F., Pekkanen,J., Tang,C.S.,
            Thiering,E., Montgomery,G.W., Hartikainen,A.L., Dharmage,S.C.,
            Husemoen,L.L., Herder,C., Kemp,J.P., Elliot,P., James,A.,
            Waldenberger,M., Abramson,M.J., Fairfax,B.P., Knight,J.C.,
            Gupta,R., Thompson,P.J., Holt,P., Sly,P., Hirschhorn,J.N.,
            Blekic,M., Weidinger,S., Hakonarsson,H., Stefansson,K.,
            Heinrich,J., Postma,D.S., Custovic,A., Pennell,C.E., Jarvelin,M.R.,
            Koppelman,G.H., Timpson,N., Ferreira,M.A., Bisgaard,H. and
            Henderson,A.J.
  CONSRTM   AAGC
  TITLE     Meta-analysis of genome-wide association studies identifies ten
            loci influencing allergic sensitization
  JOURNAL   Nat Genet 45 (8), 902-906 (2013)
   PUBMED   23817571
REFERENCE   8  (bases 1 to 4060)
  AUTHORS   Mayerle,J., den Hoed,C.M., Schurmann,C., Stolk,L., Homuth,G.,
            Peters,M.J., Capelle,L.G., Zimmermann,K., Rivadeneira,F.,
            Gruska,S., Volzke,H., de Vries,A.C., Volker,U., Teumer,A., van
            Meurs,J.B., Steinmetz,I., Nauck,M., Ernst,F., Weiss,F.U.,
            Hofman,A., Zenker,M., Kroemer,H.K., Prokisch,H., Uitterlinden,A.G.,
            Lerch,M.M. and Kuipers,E.J.
  TITLE     Identification of genetic loci associated with Helicobacter pylori
            serologic status
  JOURNAL   JAMA 309 (18), 1912-1920 (2013)
   PUBMED   23652523
  REMARK    Erratum:[JAMA. 2013 Jul 3;310(1):99. Kuipers, Ernst [corrected to
            Kuipers, Ernst J]]
REFERENCE   9  (bases 1 to 4060)
  AUTHORS   Boucquey,M., De Plaen,E., Locker,M., Poliard,A.,
            Mouillet-Richard,S., Boon,T. and Kellermann,O.
  TITLE     Noxp20 and Noxp70, two new markers of early neuronal
            differentiation, detected in teratocarcinoma-derived
            neuroectodermic precursor cells
  JOURNAL   J Neurochem 99 (2), 657-669 (2006)
   PUBMED   17029606
  REMARK    GeneRIF: This paper discusses the structure of the human Noxp20
            gene.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA755915.1, HY086889.1,
            DA722033.1, CN255669.1, DA130633.1, CB306584.1, AC108044.5 and
            AI073679.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_138389.3.
            
            Summary: The protein encoded by this gene belongs to the FAM114
            family and may play a role in neuronal cell development.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Apr 2017].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292831.1, BC040452.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358869.5/ ENSP00000351740.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-557               DA755915.1         29-585
            558-721             HY086889.1         253-416
            722-1208            DA722033.1         95-581
            1209-1595           CN255669.1         127-513
            1596-1911           DA130633.1         251-566
            1912-2128           CB306584.1         15-231              c
            2129-3975           AC108044.5         164028-165874
            3976-4060           AI073679.1         20-104              c
FEATURES             Location/Qualifiers
     source          1..4060
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p14"
     gene            1..4060
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
                     /note="family with sequence similarity 114 member A1"
                     /db_xref="GeneID:92689"
                     /db_xref="HGNC:HGNC:25087"
     exon            1..29
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
                     /inference="alignment:Splign:2.1.0"
     exon            30..178
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
                     /inference="alignment:Splign:2.1.0"
     exon            179..534
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1878
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein NOXP20; nervous system over-expressed protein 20"
                     /codon_start=1
                     /product="protein NOXP20 isoform 1"
                     /protein_id="NP_612398.2"
                     /db_xref="CCDS:CCDS3447.1"
                     /db_xref="GeneID:92689"
                     /db_xref="HGNC:HGNC:25087"
                     /translation="MSDDAGDTLATGDKAEVTEMPNSDSLPEDAEVHCDSAAVSHEPT
                     PADPRGEGHENAAVQGAGAAAIGPPVQPQDANALEPPLNGDVTEDTLAECIDSVSLEA
                     EPRSEIPLQEQNYLAVDSPPSGGGWAGWGSWGKSLLSSASATVGHGLTAVKEKAGATL
                     RIHGVNSGSSEGAQPNTENGVPEITDAATDQGPAESPPTSPSSASRGMLSAITNVVQN
                     TGKSVLTGGLDALEFIGKKTMNVLAESDPGFKRTKTLMERTVSLSQMLREAKEKEKQR
                     LAQQLTMERTAHYGMLFDEYQGLSHLEALEILSNESESKVQSFLASLDGEKLELLKND
                     LISIKDIFAAKELENEENQEEQGLEEKGEEFARMLTELLFELHVAATPDKLNKAMKRA
                     HDWVEEDQTVVSVDVAKVSEEETKKEEKEEKSQDPQEDKKEEKKTKTIEEVYMSSIES
                     LAEVTARCIEQLHKVAELILHGQEEEKPAQDQAKVLIKLTTAMCNEVASLSKKFTNSL
                     TTVGSNKKAEVLNPMISSVLLEGCNSTTYIQDAFQLLLPVLQVSHIQTSCLKAQP"
     exon            535..622
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
                     /inference="alignment:Splign:2.1.0"
     exon            623..736
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
                     /inference="alignment:Splign:2.1.0"
     exon            737..843
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
                     /inference="alignment:Splign:2.1.0"
     exon            844..978
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1131
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1255
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1347
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1509
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1649
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1722
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1776
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..4060
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3234..3239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
                     /note="hexamer: AATAAA"
     polyA_site      3263
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
     regulatory      3983..3988
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
                     /note="hexamer: AATAGA"
     polyA_site      4025
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
     regulatory      4041..4046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
                     /note="hexamer: ATTAAA"
     polyA_site      4060
                     /gene="FAM114A1"
                     /gene_synonym="Noxp20"
                     /note="major polyA site"
ORIGIN      
        1 actcccgcgc gtactcggcc gcctgagcgc cgacccacgc cctgcctgct cttccagtcc
       61 agccaacact ctaagcaggc accgcctcca ctcgcagccc ccgggatggg tcccactccc
      121 taccgcagat ccccaggccc cctccaccca gtcggctagc cctcgcctct gccatccgat
      181 actaaaatgt ctgatgatgc tggtgacacc ttagccactg gagacaaagc agaagttact
      241 gagatgccta atagtgattc tttacctgag gatgcagaag tgcattgtga ttcagctgca
      301 gtttcacatg agccaacacc agctgacccc agaggggagg ggcatgaaaa tgcagctgtg
      361 cagggtgcag gggctgccgc cattgggccc cctgtgcagc ctcaggatgc caacgccctg
      421 gagccccctc tcaatggaga cgtgactgag gatacacttg ctgaatgtat tgattccgtc
      481 agccttgagg cagaacccag atccgaaata cccctgcaag aacagaatta tctggctgtg
      541 gattcccctc caagtggagg aggatgggca ggctggggat cctggggcaa atctctgctg
      601 tcgtcagcat ctgccacagt aggtcatgga ttgacggcag tcaaggaaaa agcaggagcc
      661 actctacgga ttcatggtgt aaattctgga tcttctgaag gagcccaacc aaatactgaa
      721 aacggagtcc ctgaaataac agatgcagcc acagatcagg gccctgcaga aagcccaccc
      781 acttcccctt catcagcctc tcggggtatg ctgtctgcca tcaccaatgt ggttcaaaac
      841 acaggtaaaa gtgtcttaac tggaggcctt gatgcgttgg aattcatcgg caagaaaacc
      901 atgaatgtcc ttgcagaaag tgacccgggc tttaagcgga ccaagacgct catggagaga
      961 actgtttcct tgtctcagat gttaagggaa gctaaggaga aggagaagca gagactggca
     1021 cagcagctca cgatggagag aaccgcgcac tacgggatgc tgtttgatga atatcaaggc
     1081 ttgtcacacc tggaagccct ggaaattctg tccaatgaaa gcgaaagcaa ggttcagtca
     1141 tttttagcat cacttgatgg agagaagctg gaactcttaa aaaatgacct aatttccatt
     1201 aaagacatct ttgcagccaa agaattagag aatgaagaaa atcaagaaga acaaggctta
     1261 gaagaaaagg gagaagaatt tgctcgcatg cttacagagc ttctctttga attacatgtg
     1321 gcggccacac ctgacaaact caataaggcc atgaagaggg ctcatgactg ggtggaagag
     1381 gatcaaaccg tggtgtcagt agatgtggca aaagtgtccg aagaagaaac aaagaaggaa
     1441 gaaaaggaag agaaatctca agaccctcaa gaagacaaaa aggaggaaaa gaaaactaag
     1501 accatagagg aagtatacat gtcgtccatt gaaagtctgg cggaggtaac agcgcgctgt
     1561 attgagcagc ttcataaagt agcagaatta attcttcatg gacaagaaga ggaaaaacca
     1621 gctcaggacc aagcaaaagt tctaataaaa ttaactactg caatgtgcaa tgaagtggcc
     1681 tctttatcaa agaagtttac gaattcttta accactgttg ggagcaacaa gaaggccgag
     1741 gtccttaacc ccatgatcag tagtgtattg ttagagggct gcaacagtac aacgtacata
     1801 caggatgcct tccagctgct gctgcctgtt ctgcaggtct cacatatcca gaccagttgt
     1861 ttgaaagcac agccgtgacc tggccagact ccatctagtt aaaggagaca gctggccgcc
     1921 ttgcctcaat atgtaccatt taaggggatg ttctctgtgc gcctggccac agacatccat
     1981 ttgaggacac tacaagcaat tttgcacaga caatattgag aatgcaaatt tagagagagt
     2041 tatcatttct ctcaatgtgt ataattgttt ttacaaacaa ttgtgttttc tttatgttaa
     2101 tttaaactta cacagcttat attgaaaatt tcctttcatc tgaaatttat ttacaaatat
     2161 tcgtgttcat tttcctggtt aagcatgcta tatttagaaa ctcatgggga gaccttagac
     2221 ttttgtttaa tcctttatgt ttcaaccttt aaatgttcca ttcttatagt attactttaa
     2281 atcaattcta aaactgaact ttgttttgtt acataaatgt cgcaggcaaa aataacacta
     2341 cttatagatt ttacctatta tggtaaaaaa taggaacata ttgtcattct tttttttttt
     2401 ttttttttga gacagagtct cactctgtcg ccaggctgga gtgcgttggc acaatctcgg
     2461 ctcactgcaa cctccgcctc ctgggttcaa tcgattctcc tgcctcagcc tcctgagtag
     2521 ctgggactac aggtgtgtgc caccacgccc agccaatttt ttttgtattt ttagtagaga
     2581 cagggtttca ccatgttggc caggatggtc tcgatctcct gacctcgtga tctgcccgcc
     2641 tcagcctccc aaagtgctgg gattacaggc ttgagccacc gcgcccggcc ggtcattcat
     2701 tcttgcaaca agcatttatt gagcacctac tgtgtgctca cagtaaagaa acgtgatctt
     2761 atcccagtag aggtagatat tctgaaaaag aataattctt aaactgctta aaacaggggt
     2821 ccccaccccc aggccacaga ccagtaccag tccgtggcac tggttaggaa ccaggccaca
     2881 cagcaggggg tgagcggtgg gtgagtgagc acagcttcat ctgtatttac agctgctccc
     2941 cagagcttgc attactgcct gagctctgcc tcccgtcagg tcagcagcag cattagagtc
     3001 tcatgggagt gcgaaccctg ttgtgaactg cacatgcgag ggatctaggt tgtgcactcc
     3061 ttatgagaat ctaatgcctg atgaatctaa tgcctcatga tctgaggttg aatagcttcg
     3121 tgccgaaacc atcccccacc cccatcccgc taccccgagt ccgtgaaaaa attgtcttcc
     3181 atgaaaccgg tccctggtac cagaaaggtt ggggaccact ggcttaaaat accaataaat
     3241 ttttgaacct taaaaacttt gaagaacaag gtaaattggt gttttattta atgtcctacc
     3301 ctttaatttg ttgcattttc ctatactctt tacactattt tatcccaaac tatgtatatg
     3361 aggtgaaaat atatatgaaa agggatactg aagaatattt agtttaaaat taatttctta
     3421 cgatcacgag cacatggtgg cataattaca aagcttggaa gtattcaaat agaaaatcaa
     3481 aggtgtttca atacagtaga atcccaggac tgcattttaa aatcgcctca cagatcacac
     3541 tcgctggtgg caaatatcat catcgttgct aaaggacaga aaatactgat gtgtgtttta
     3601 actaactggt atattgatcc atgggaggct gcacagaaga ccctgcggcc aggaggggca
     3661 ttgtcagtgg ctgcttctcc tgagctccac gccttcattg cagctgcatg ttcgatacaa
     3721 tacacctgct tcacagcccc atggacatcc ctacaggtac tgtcatgtga agccttgcct
     3781 agtagttctc tccagggcaa atgaagctca cagttttgca aggtggaaac ctcttattca
     3841 catttgcttt gattccccga tggagtagac tgcctttgtt ccatacaggc aaagtaagga
     3901 tattttaata tcatcctact tcttattagc atttcatttg tctatgtact gtatttcatt
     3961 tgtatgtctc ctgaaacatc caaatagaga acataagaac actttatgta caatctggaa
     4021 aaaaattacc tgagaaatca attaaagatt tttccccttt
//
