LOCUS       NM_024869               2799 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens family with sequence similarity 110 member D
            (FAM110D), mRNA.
ACCESSION   NM_024869
VERSION     NM_024869.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2799)
  AUTHORS   Zhang,L., Sun,Y., Zhang,X., Shan,X., Li,J., Yao,Y., Shu,Y., Lin,K.,
            Huang,X., Yang,Z., Chu,J., Huang,L. and Sun,H.
  TITLE     Three Novel Genetic Variants in the FAM110D, CACNA1A, and NLRP12
            Genes Are Associated With Susceptibility to Hypertension Among Dai
            People
  JOURNAL   Am J Hypertens 34 (8), 874-879 (2021)
   PUBMED   33621312
  REMARK    GeneRIF: Three Novel Genetic Variants in the FAM110D, CACNA1A, and
            NLRP12 Genes Are Associated With Susceptibility to Hypertension
            Among Dai People.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AU119858.1, BC025658.1 and AL391650.18.
            
            On Nov 22, 2018 this sequence version replaced NM_024869.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA594135.1, BC025658.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374268.5/ ENSP00000363386.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               AU119858.1         60-454
            396-1465            BC025658.1         441-1510
            1466-2799           AL391650.18        148130-149463
FEATURES             Location/Qualifiers
     source          1..2799
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..2799
                     /gene="FAM110D"
                     /gene_synonym="GRRP1"
                     /note="family with sequence similarity 110 member D"
                     /db_xref="GeneID:79927"
                     /db_xref="HGNC:HGNC:25860"
     exon            1..48
                     /gene="FAM110D"
                     /gene_synonym="GRRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            49..2799
                     /gene="FAM110D"
                     /gene_synonym="GRRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..944
                     /gene="FAM110D"
                     /gene_synonym="GRRP1"
                     /note="glycine/arginine-rich protein 1"
                     /codon_start=1
                     /product="protein FAM110D"
                     /protein_id="NP_079145.2"
                     /db_xref="CCDS:CCDS41285.1"
                     /db_xref="GeneID:79927"
                     /db_xref="HGNC:HGNC:25860"
                     /translation="MLLAPPSTPSRGRTPSAVERLEADKAKYVKTHQVIARRQEPALR
                     GSPGPLTPHPCNELGPPASPRTPRPVRRGSGRRLPRPDSLIFYRQKRDCKASVNKENA
                     KGQGLVRRLFLGAPRDAAPSSPASTERPAASGGWAAPQDAPEAAGKRALCPTCSLPLS
                     EKERFFNYCGLERALVEVLGAERFSPQSWGADASPQAGTSPPPGSGDASDWTSSDRGV
                     DSPGGAGGGGGSEAAGSARDRRPPVSVVERNARVIQWLYGCQRARGPPRESEV"
     regulatory      1439..1444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM110D"
                     /gene_synonym="GRRP1"
                     /note="hexamer: AATAAA"
     polyA_site      1465
                     /gene="FAM110D"
                     /gene_synonym="GRRP1"
                     /note="major polyA site"
     regulatory      2781..2786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM110D"
                     /gene_synonym="GRRP1"
                     /note="hexamer: AATAAA"
     polyA_site      2799
                     /gene="FAM110D"
                     /gene_synonym="GRRP1"
ORIGIN      
        1 agtctggacc tgcccaagga cccctgcaat taggcctccc atgcagaggt cagtgagagc
       61 ccaagccaat tgctctaggc cccgtggctg gctacttatg gggcactgtc ctgaccagct
      121 ctgctaagat gctcctggcc cctccctcca ccccgtccag aggacggacc cccagcgccg
      181 tggagaggct ggaagccgac aaagccaagt atgtcaagac gcaccaggtg atagctaggc
      241 gacaggagcc agccctgcgt gggagtcctg ggccgctcac gccgcacccc tgcaacgagc
      301 tggggccccc tgcatcgccc aggacgccca ggccggtccg ccggggaagc ggcaggcggc
      361 tgccgaggcc tgattccctc atcttctacc gccagaagcg ggactgcaag gcttcggtga
      421 acaaagagaa cgccaagggc cagggtctgg tgcggcgcct ctttctgggt gccccgcggg
      481 acgctgcccc gagcagcccg gcctccacag agcgacctgc ggcttcaggg ggttgggctg
      541 cgccccagga tgccccggaa gcggcgggaa agcgggcgct gtgtcccacg tgctcgctgc
      601 ccctgtcgga gaaggagcgc ttcttcaact actgcggcct ggagcgcgcg ctggtggagg
      661 tgctgggcgc agagcgcttc tccccgcaga gctggggagc cgacgccagc ccgcaggccg
      721 gaacttcgcc gccgcccggc tccggggacg ccagcgactg gacatccagc gacaggggcg
      781 tggacagccc gggcggcgcg ggcggcggcg gcggctcgga ggcagcgggc tcggcgcggg
      841 accggcgccc cccggtgtcg gtggtggagc gcaacgcgcg cgtcatccag tggctgtacg
      901 gctgccagcg cgcccgcgga ccgccgcgcg agtccgaggt gtgaccgccg cggctccgga
      961 ctggccccgg gactggcccc gggcacggaa aaggacaccc ctcttctggc gcgctgggtg
     1021 cctttgcgta agcccttcct tctggaactc agtttcgcgt ctgaaccttg gggaggtgga
     1081 acaagttgct gccgaaggcc cttccctgct cccgcggcga agggggaggg agaggcctct
     1141 tggtccctgt ggagacccgg tctggggagt cacgattggg gtgggagatg agcaaacctg
     1201 ctgaataaag ttaaaacgtt atttaaatgg ggagctgagg aaggagcaaa cgggttttcg
     1261 cggttaaacc cgtgggtttt ggaatgtgtg ttcccggctg tgtgatcctg ggcaagaact
     1321 tgacctccct ggacgcagcg gcacccctcg gttattaagg agggaggagt aggggataga
     1381 agtatttcaa aatagttgta atgcgcatgg caaagtgccc agcatataga aagtgctcaa
     1441 taaacgataa ctgctgtgac ttctaccgaa tgagtactaa cactgttgtg atctccactg
     1501 gcctccaggt cgatccaaac tagagctggg agctgggaat aatgcgcttt gggagcccga
     1561 ggaggcgtct gctccagaaa tctgggctcc accagatcct aaaaggcccc attcccggag
     1621 ttttgctgcc ccagttgtgg tcactgggta tgaagggctg agatccaacc tttcggacac
     1681 aaaaagaagg gaaccgggcc gggcgcggtg gctcaggcct gtaatcccag cactttggga
     1741 ggctgaggag ggtagatcac gagatcagga gttcgagacc agcctggcca acatgggctc
     1801 tactaaaaat acaaaaatta gctgagcttg gaggcgcgcg cctgtaatcc cagctactcg
     1861 ggaggctgag gcaggagaat cgcttgaatc ccagaggcgg aggttgcagt gagccgagat
     1921 cgagccattg cactccagcc tgggcaacag ggccagactc cgtctcaaaa aataaaaata
     1981 aaaataaaaa aagaaaagaa ggaaaccttt cctgccagcc ggcaggctcc tgccactgcc
     2041 tccctttcct gcaaggacac acaagttcgc ctattttcat cacaggttcg cacctccaag
     2101 cctgcatcct tcatgcacct ccttcctttg cctgggttgc cgttcctttt ctctctgctc
     2161 ttccttctct tttttttttt tttttttttt tttttttttg agacggagtc tcgctctgtc
     2221 gcccaggctg gagtgcagtg gcgggatctc ggctcactgc aagctccgcc tcccgggttc
     2281 acgccattct cctgcctcag cctcccaagt agctgggact acaggcgccc gccactacgc
     2341 ccggctaatt ttttgtattt ttagtagaga cggggtttca ccgttttagc cgggatggtc
     2401 tcgatctcct gacctcgtga tccgcccgcc tcggcctccc aaagtgctgg gattacaggc
     2461 gtgagccacc gcgcccggcc cccttcttcc ttctcggaga taacgtatat tctcctccag
     2521 gaagccgtcc tgaatgcccc cagtcagcct cacctgctct gagctcccaa gtacagtcct
     2581 atttttgggc ctcaatttgt caccttttgt gggacccgct ggtactctgg gttctctagt
     2641 taatctttga cctttttcct agtacaggga cggcgcacat agtagggcca caggcacagt
     2701 ttgttgaatt aaatgaggct ggagagggcg atggacgcag tcctctggag ctctccaact
     2761 tcctggaaag ttgtacctta aataaaaaac ccatcctga
//
