LOCUS       NM_001077710            3880 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens family with sequence similarity 110 member C
            (FAM110C), mRNA.
ACCESSION   NM_001077710 XM_925823 XM_936290
VERSION     NM_001077710.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3880)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3880)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   3  (bases 1 to 3880)
  AUTHORS   Varjosalo,M., Sacco,R., Stukalov,A., van Drogen,A., Planyavsky,M.,
            Hauri,S., Aebersold,R., Bennett,K.L., Colinge,J., Gstaiger,M. and
            Superti-Furga,G.
  TITLE     Interlaboratory reproducibility of large-scale human
            protein-complex analysis by standardized AP-MS
  JOURNAL   Nat Methods 10 (4), 307-314 (2013)
   PUBMED   23455922
REFERENCE   4  (bases 1 to 3880)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3880)
  AUTHORS   Luciano,M., Hansell,N.K., Lahti,J., Davies,G., Medland,S.E.,
            Raikkonen,K., Tenesa,A., Widen,E., McGhee,K.A., Palotie,A.,
            Liewald,D., Porteous,D.J., Starr,J.M., Montgomery,G.W.,
            Martin,N.G., Eriksson,J.G., Wright,M.J. and Deary,I.J.
  TITLE     Whole genome association scan for genetic polymorphisms influencing
            information processing speed
  JOURNAL   Biol Psychol 86 (3), 193-202 (2011)
   PUBMED   21130836
REFERENCE   6  (bases 1 to 3880)
  AUTHORS   Hauge,H., Fjelland,K.E., Sioud,M. and Aasheim,H.C.
  TITLE     Evidence for the involvement of FAM110C protein in cell spreading
            and migration
  JOURNAL   Cell Signal 21 (12), 1866-1873 (2009)
   PUBMED   19698782
  REMARK    GeneRIF: Depletion of FAM110C by short interfering RNA reduced
            integrin-mediated filopodia formation, hepatocyte growth
            factor-induced migration, and phosphorylation of the Akt1 kinase in
            the epithelial cell line HepG2.
REFERENCE   7  (bases 1 to 3880)
  AUTHORS   Hauge,H., Patzke,S. and Aasheim,H.C.
  TITLE     Characterization of the FAM110 gene family
  JOURNAL   Genomics 90 (1), 14-27 (2007)
   PUBMED   17499476
  REMARK    GeneRIF: Ectopic eexpression impairs cell cycle progression through
            the G1 phase; overexpression induces aberrant microtubules.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC097643.3.
            
            On Nov 22, 2018 this sequence version replaced NM_001077710.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.43040.1,
                                           SRR1803612.253096.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327669.5/ ENSP00000328347.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1066              AC097643.3         10315-11380         c
            1067-3880           AC097643.3         3689-6502           c
FEATURES             Location/Qualifiers
     source          1..3880
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.3"
     gene            1..3880
                     /gene="FAM110C"
                     /note="family with sequence similarity 110 member C"
                     /db_xref="GeneID:642273"
                     /db_xref="HGNC:HGNC:33340"
                     /db_xref="MIM:611395"
     exon            1..1066
                     /gene="FAM110C"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1086
                     /gene="FAM110C"
                     /codon_start=1
                     /product="protein FAM110C"
                     /protein_id="NP_001071178.2"
                     /db_xref="CCDS:CCDS42645.1"
                     /db_xref="GeneID:642273"
                     /db_xref="HGNC:HGNC:33340"
                     /db_xref="MIM:611395"
                     /translation="MRALAALSAPPNERLLPRDPAATRDPDAARPARRSAVERLAADR
                     AKYVRGRPGTGRGVASEGSGPGAIKCPGNDPGPPARAPAPVARRAIARKPLRPDSLII
                     YRQKCEFVRGSGADGPRASLVKKLFQGPGKDKAPVPRTGDEGKAGNPETVPTTPGPAA
                     DPAIPETPAPAARSAAPSSVPAAPPGPEPRVVRRRGLQRSQSDLSSRYSAALAESDTF
                     FQYCGLDPEVVEALGRENFTAGSDCVTLKVRSVSVATSGSGFSRHSGGDDEGLQEEEL
                     IEQVPSTTSVIERNARIIKWLYTCKKAKETPSQEQSRTRGSKPSR"
     exon            1067..3880
                     /gene="FAM110C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1451..1456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM110C"
                     /note="hexamer: AATAAA"
     polyA_site      1474
                     /gene="FAM110C"
     regulatory      3855..3860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM110C"
                     /note="hexamer: AATAAA"
     polyA_site      3880
                     /gene="FAM110C"
                     /note="major polyA site"
ORIGIN      
        1 actggggcgc cgttccccac ccggcgcgga cttcggaacc ggccctggga ctgactggct
       61 ctaccactcg agcgcgtctc cgctggaccc ggaaccccgg tcggtccatt ccccgcgaag
      121 atgcgcgccc tggcggccct gagcgcgccc ccgaacgagc ggctccttcc ccgggacccc
      181 gcggctaccc gggaccccga cgccgcgcgg ccggcgcgca ggagcgcagt ggagaggctg
      241 gcggcggatc gcgccaagta tgtgcggggt cggccgggga ctggccgggg cgtcgcttcc
      301 gagggcagcg gcccgggggc gatcaagtgc ccggggaacg accctgggcc cccggcccgc
      361 gccccggccc cggtggcgcg cagggctatt gcgcggaagc cgttgagacc ggactcgctg
      421 atcatctacc ggcagaaatg cgaattcgtg cgaggatcgg gcgccgacgg ccccagggca
      481 agcctggtga agaagctctt ccaggggccg ggtaaggaca aggcgccggt gccccggacg
      541 ggagacgagg gcaaggccgg gaacccggag acggtcccga ccactcctgg ccccgcggcg
      601 gaccccgcaa tccccgagac cccagcccca gccgcgcggt ccgcggcgcc ctccagtgtc
      661 ccggccgcgc cccctgggcc agagccgcgg gtggtgaggc gtcgggggct gcagcgctca
      721 cagtcggacc tcagctcccg ctattccgct gccttggccg agtctgacac cttcttccag
      781 tactgcggcc tggaccccga ggtggtggag gccctgggga gggagaactt caccgcgggg
      841 tcggactgtg tgaccctcaa ggtgcgcagc gtgagcgtcg ccacctccgg cagcggcttc
      901 tcccggcaca gcggcggcga cgacgagggg ctgcaggagg aggagctgat agagcaggtg
      961 cccagcacca cttcggtcat cgagaggaac gcccgcatca tcaagtggct gtacacctgt
     1021 aagaaggcca aggagacccc cagccaggag cagagccgga cccgaggaag caaaccttcc
     1081 cgatgatgaa gacttcttga aggatttcat gggtgatttg ggatcccagg accatttggc
     1141 tagtgtgcct aggtgaccac atgattgctg ttttaccagg aatgcagcat cccattgaca
     1201 aaacaagtgc tctgagaagg tttaaaatac tacagagaat atgggaacac agaccttgaa
     1261 atttagctga gttgtaacag ctgaaactcc aagaggtgtc ttccttgttt gaggtgaaac
     1321 tagtgttgct tccagagggc agctggaaac cgtaaagctg tttggaaatc tttttgactg
     1381 acttgctgac aaagaggtac tgtgatgcat tttaacaata tctaagttga ttttttttta
     1441 aatcaaggaa aataaaaacc aagcatgaat gctatggtat gtgccccttt tgaccatcct
     1501 gggctgatta acatcattta aatcaaagta atcataaaaa ggcatattct acttcaatta
     1561 tgtggtcaaa taagagtaaa cacacacact cacacatgct gaccccaatt gccagagcat
     1621 tactgcacta taaattacgg ttaattccca aattatacta ctgtttatct tatttaacaa
     1681 gtcagaaagc acttttaaaa taacttgagg gctacaaggt cattctatta atgtcattct
     1741 ccattcgggt tgtaggcatg tggaagtacc cattaaaaga taagttagag tttaaatact
     1801 gataaacaaa accttttatt gcaactggac agtttctgga gagttagcgg aagaatcttg
     1861 gagtttcctt tggtcagatg aatacaacat ttcacttttg cagcactatt tagaatgtac
     1921 tccatggttc tcttgttccc aacttccaaa aagaacagaa aactttggtt tacacagaac
     1981 acgggcatct gaggcaggac ctcttccctg ccctttgatc tgactcacac ctccacatat
     2041 gacgtaatca acccaaattt gacaccaatt cactcttttc tgcaaagggc atattttgaa
     2101 acaagggaca gcctgagggc ggctataatg agaatgttca tgggggttac tgggtcccta
     2161 attctgaact tgcttatgac acccagagtg aatagattca gattcagaac cttctgagaa
     2221 ataacccaaa gaaaatttgt tacccagcca attcttcgaa agcttaatat caaaatatat
     2281 cttttcaaga agaaaatcgt tagagagaag aatgtggagg ggagagaaat gggtttctca
     2341 ttgatatgat attttgttaa ccatttcatt ttgaattatt caagttttgg ttaatattgt
     2401 attctttttt cgtaactatt ttaccgtgag agtaggtcat tgggttactt agatatttat
     2461 ttttacacag ttattagtct tcagatagtt ttattttact tcatatgatt ttagtttttg
     2521 tcagtataat tttaaatcat gtttttcttg gtcatctctt tgtgtatatt gtgtaattgg
     2581 attttcattg actgcaagtg gagtgtttgc cactcaattc agtactcagt actatggtga
     2641 cttgttttca aataagtctc agatacacat ttagggagcc tttgctggcc gaatatagac
     2701 tctgtcagga cagcaggtcc cctgatctaa gaattttccc caatggttgc tctaaaaatg
     2761 ctgctatttt gctgttcact gtattgcact tagttaaaaa gaagataatg tgaaagatga
     2821 gagcagtttt ttaaaggatc ttttcatata cccaattccc ttattttcag atgtcccatc
     2881 aattttagat atgaaagctt taagtaaaag tgtgtatgcc tttctactgt cagaacagga
     2941 tggatgcagc ctgggtcaga tttatttaag ataaaaatca tgcagactca tcattcatat
     3001 cataggtgaa aaatgtaaaa accaaatggt ttccactaaa gccaccaaga tcttttagaa
     3061 atgtttgcac ctttggtggt ggcacaggaa aagagaagaa ttcagctgga gtgaattcta
     3121 gaagtagata tcagaaacgg ggcatgaaga acaggggaac tgggtggcat cagactccta
     3181 aagaagtgag ttaattttcc ttcccttcca ttcagattca tgccacagct ccatatcttg
     3241 agtatgtgta agaggtgagt tccttcttca gccaggggcg gtggctcatg cctttaatcc
     3301 caatgctttg ggaggccaag gtgggaggat cacttgtgcc ttggggttca aggttgcagt
     3361 gaaccatgat tgcaccactg cactccagcc tgagtgacag agcaagaccc tgtctctaaa
     3421 aatatatata aaaagtaaaa ctaaagaact tcttgcctaa acctgaatta ccgcaatttg
     3481 ctgagtgact ttgagaaaaa tcagactgtt tagttcagtc gggatgaaaa gcttgcgatt
     3541 gcttcccaca agaatgggca atagtgacgg ctgcaaggta cttttatttg ttcatgaaag
     3601 aacgacaatt tttcaaaatg taattaaaca taatagaatg ttttaaacta ctgggcactg
     3661 aaactggaag aaaaaggagg ctttattgaa cattcccctt tttcagttgg ttcaaagttc
     3721 agcactgtgg ttatcattgg tgatgccaga aaacattagt agacttagac aattgctatg
     3781 gcagtttcta aacagagctt tttctataca ctatttgcaa ctggagtgca atattgtata
     3841 ttctgtgtta aagaaataaa gtatttttat catttattaa
//
