LOCUS       NM_001377989            3349 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 110 member B
            (FAM110B), transcript variant 1, mRNA.
ACCESSION   NM_001377989 XM_005251324
VERSION     NM_001377989.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3349)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 3349)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 3349)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3349)
  AUTHORS   Zeng,Z., Feingold,E., Wang,X., Weeks,D.E., Lee,M., Cuenco,D.T.,
            Broffitt,B., Weyant,R.J., Crout,R., McNeil,D.W., Levy,S.M.,
            Marazita,M.L. and Shaffer,J.R.
  TITLE     Genome-wide association study of primary dentition pit-and-fissure
            and smooth surface caries
  JOURNAL   Caries Res 48 (4), 330-338 (2014)
   PUBMED   24556642
REFERENCE   5  (bases 1 to 3349)
  AUTHORS   He,J., Kelly,T.N., Zhao,Q., Li,H., Huang,J., Wang,L., Jaquish,C.E.,
            Sung,Y.J., Shimmin,L.C., Lu,F., Mu,J., Hu,D., Ji,X., Shen,C.,
            Guo,D., Ma,J., Wang,R., Shen,J., Li,S., Chen,J., Mei,H., Chen,C.S.,
            Chen,S., Chen,J., Li,J., Cao,J., Lu,X., Wu,X., Rice,T.K., Gu,C.C.,
            Schwander,K., Hamm,L.L., Liu,D., Rao,D.C., Hixson,J.E. and Gu,D.
  TITLE     Genome-wide association study identifies 8 novel loci associated
            with blood pressure responses to interventions in Han Chinese
  JOURNAL   Circ Cardiovasc Genet 6 (6), 598-607 (2013)
   PUBMED   24165912
REFERENCE   6  (bases 1 to 3349)
  AUTHORS   Vainio,P., Wolf,M., Edgren,H., He,T., Kohonen,P., Mpindi,J.P.,
            Smit,F., Verhaegh,G., Schalken,J., Perala,M., Iljin,K. and
            Kallioniemi,O.
  TITLE     Integrative genomic, transcriptomic, and RNAi analysis indicates a
            potential oncogenic role for FAM110B in castration-resistant
            prostate cancer
  JOURNAL   Prostate 72 (7), 789-802 (2012)
   PUBMED   21919029
  REMARK    GeneRIF: FAM110B was able to regulate androgen receptor signaling
            in prostate cancer cells and FAM110B itself was regulated by
            androgens. FAM110B siRNA inhibited the growth of prostate cancer
            cells in vitro.
REFERENCE   7  (bases 1 to 3349)
  AUTHORS   Wang,K.S., Liu,X.F. and Aragam,N.
  TITLE     A genome-wide meta-analysis identifies novel loci associated with
            schizophrenia and bipolar disorder
  JOURNAL   Schizophr Res 124 (1-3), 192-199 (2010)
   PUBMED   20889312
REFERENCE   8  (bases 1 to 3349)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 3349)
  AUTHORS   Hauge,H., Patzke,S. and Aasheim,H.C.
  TITLE     Characterization of the FAM110 gene family
  JOURNAL   Genomics 90 (1), 14-27 (2007)
   PUBMED   17499476
  REMARK    GeneRIF: Localizes to centrosomes and accumulates at the
            microtubule organization center in interphase and at spindle poles
            in mitosis; ectopic expression impairs cell cycle progression in
            the G1 phase.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104350.6 and AC110013.5.
            
            On Jan 23, 2020 this sequence version replaced XM_005251324.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.768690.1,
                                           SRR14038194.1572439.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000519262.6/ ENSP00000509301.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               AC104350.6         59084-59367
            285-382             AC104350.6         96167-96264
            383-471             AC104350.6         140096-140184
            472-3349            AC110013.5         82019-84896         c
FEATURES             Location/Qualifiers
     source          1..3349
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q12.1"
     gene            1..3349
                     /gene="FAM110B"
                     /gene_synonym="C8orf72"
                     /note="family with sequence similarity 110 member B"
                     /db_xref="GeneID:90362"
                     /db_xref="HGNC:HGNC:28587"
                     /db_xref="MIM:611394"
     exon            1..284
                     /gene="FAM110B"
                     /gene_synonym="C8orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            285..382
                     /gene="FAM110B"
                     /gene_synonym="C8orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            383..471
                     /gene="FAM110B"
                     /gene_synonym="C8orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            472..3349
                     /gene="FAM110B"
                     /gene_synonym="C8orf72"
                     /inference="alignment:Splign:2.1.0"
     CDS             796..1908
                     /gene="FAM110B"
                     /gene_synonym="C8orf72"
                     /codon_start=1
                     /product="protein FAM110B"
                     /protein_id="NP_001364918.1"
                     /db_xref="CCDS:CCDS6170.1"
                     /db_xref="GeneID:90362"
                     /db_xref="HGNC:HGNC:28587"
                     /db_xref="MIM:611394"
                     /translation="MPTETLQTGSMVKPVSPAGTFTSAVPLRILNKGPDYFRRQAEPN
                     PKRLSAVERLEADKAKYVKSQEVINAKQEPVKPAVLAKPPVCPAAKRALGSPTLKVFG
                     NHAKTESGVQRENLKLEILKNIINSSEGSSSGSGHKHSSRNWPPHRSEATDLHRHSFA
                     ESLKVYPTQGRRSPQEGGSHVGRRLLEQSAESFLHVSHSSSDIRKVTSVKPLKAIPCS
                     SSAPPLPPKPKIAAIASMKSPEADPVEPACGVSRRPSLQRSKSDLSDRYFRVDADVER
                     FFNYCGLDPEELENLGMENFARANSDIISLNFRSASMISSDCEQSQDSNSDLRNDDSA
                     NDRVPYGISAIERNARIIKWLYSIKQARESQKVSHV"
     regulatory      2244..2249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM110B"
                     /gene_synonym="C8orf72"
                     /note="hexamer: ATTAAA"
     polyA_site      2265
                     /gene="FAM110B"
                     /gene_synonym="C8orf72"
                     /note="major polyA site"
     regulatory      3327..3332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM110B"
                     /gene_synonym="C8orf72"
                     /note="hexamer: AATAAA"
     polyA_site      3349
                     /gene="FAM110B"
                     /gene_synonym="C8orf72"
                     /note="major polyA site"
ORIGIN      
        1 actctccggc gaagcctgcc tgagccctcc cactcggtgc agaccgaacc atcgcggccg
       61 ccgccagccg ggcccttcgc ggccgcgcgt cctgggcccg ttccgccagc cccgtctgct
      121 ctctacccgc ggccccgcgg cggcgaccgt gaacactcgg cggcccctac agcccgctct
      181 cggcccttcg tccctcgcgg gccccgactc tccctccttg cagtcccccg gagcctggct
      241 cccggctcgg gccgcaccgc cagggactgg ggtgagcggc ccagaaatct ccaaattgga
      301 catccagagc agcattcttg ttctgtctac gtcttgaatt agaaactatc aagctctgta
      361 agtcctgaaa aggaaataaa agcaatttcc tgctgcagag agcattttaa gaaaggacag
      421 cattcctgtg acctctgcct accatccata aaatactcat tcccctctca gctctgcctg
      481 cagttgaaca caaagacctg gaggagactc ccacctcctt cagggagaag aaaggaggca
      541 gcgaagcaga ttaaaggaac ttgtggcttg tggccttttt gtgcaagggc cgcctggaag
      601 gggagaaaag tgtatgaaag ccaccgtggc ggttaatgag ctgtgagatg aggcgctgct
      661 gcggccgctg ctgctgacac tcgctcccag gctgcacccg ccgcccttgg cgcttcatgt
      721 acatgtgtct attcaggcct tgcggaggcg cccagaagag catccaacac ggctgccggg
      781 gaaagaccgc ccaccatgcc cacggagacc ctacagacag gtagcatggt gaagccggtc
      841 agccccgcgg gcaccttcac ctctgctgtg cccctgcgca tcctgaacaa ggggccagac
      901 tacttccgca ggcaggccga gcccaacccc aagaggctca gcgccgtgga gaggctggag
      961 gccgacaagg ccaagtacgt caagagccag gaggtgatca acgccaagca ggagcccgtg
     1021 aagcccgccg tgctggccaa gcccccggtg tgcccggctg ccaagcgcgc actgggcagc
     1081 cccacgctca aagtgttcgg caaccacgcc aagaccgaga gcggcgtgca gagggagaac
     1141 ctgaagctgg agatcctgaa gaacatcatc aatagctccg agggctctag ctcgggctcg
     1201 gggcacaagc acagctcccg caactggccg ccccaccggt cggaagccac tgacctgcac
     1261 cgtcactcct tcgcggagtc cctgaaggtc taccccacgc agggccgcag gagcccgcag
     1321 gagggcggct cccacgtggg caggagactg ctggagcagt cagccgagtc cttcctccac
     1381 gtgtcccaca gctcttcgga catccgcaag gtgaccagcg tgaagcccct caaggccatc
     1441 ccctgcagta gctctgcccc tcccctgcct cccaagccca aaatcgcagc catcgcctcc
     1501 atgaagtccc ccgaggccga ccctgtggaa ccagcttgtg gagtcagccg aagaccctcc
     1561 ctccagcggt ctaagtcaga cttgagtgac agatatttcc gagtggacgc ggacgtggag
     1621 aggttcttca actactgtgg actggacccg gaagagctgg aaaacctggg aatggaaaac
     1681 tttgcaaggg ctaattctga cataatatcc ctcaacttcc gcagcgcaag catgatcagc
     1741 tcagactgtg aacagtctca ggacagtaac agtgacctta gaaatgatga cagtgccaat
     1801 gaccgcgtgc cgtatggcat ttctgccatc gaaagaaatg ctagaatcat caagtggtta
     1861 tatagcatca aacaagctag agagtcacag aaggtctccc atgtgtaaga cagtgcgtgg
     1921 aaaggaggga gcgtgggtct ctgtgcttac gcagttgtga aggttgtgag gtctccttga
     1981 agtgttgtga gcttctccac tctttgtgtt gcttgttgtg caatgttttc aagttgcatg
     2041 cttgtcaaca tggggactga cctggcttcc acgtcaccat cgctacagag cctggctgaa
     2101 cacgcgtcat ctgccaaaag tttcaggcca gaatctaatt agggctttgc tcgtaagcaa
     2161 aactgtttac atgaaaatgg tatacaactt cttcgatatt tatgtggttc ttgtgttttt
     2221 atatcccgcg ctattgtgtc ttaattaaaa gttttatcaa ctggctttta agttgagagc
     2281 agaatctttt tgaaataaaa agccactttg cctacatgtg agactattcc agtgggacag
     2341 taaatgggat ctgctaccaa acagataatg actgaccgaa catagaacca ggctgggttt
     2401 tctgtggaat aaagtggtga gcctgacgtt aatcgtttac atgttgaaat tctcttgcca
     2461 cttagtgaag cagtcattgg ggtaacaatg ctacgttttg tgtccgattc agtgtgtaaa
     2521 cgttggtggt tctatgtaat actgacccca aggaaagacg atcagataca aagaaagatg
     2581 gttaaatcta ggaggttggg tgtttggggg ttttgttgat gttgttctga ttgggataat
     2641 tcagaaattc ctaatattat ctttcgacag aatgaccacc ctaaaacaaa tactgaatgc
     2701 ctttaaaaaa aaaaaaagtt gtggtttttt gttttttttt tttttttttt tggtcgagaa
     2761 ctactaattt catgctattt ctttctctct ccctttgttg ttatttgatt tgggggaagg
     2821 gagtgaggct tgtgcagatt tgagctatct gaagacatga acagaagtca aataccagcc
     2881 atatcagtag agccttccat tcaaaagtga acacacttgg tagctgaacc atatctgagc
     2941 agcgtgattc tgttgtcttg catatgttat tctctcaggc tgtggatctt tgttacagct
     3001 ctaggaaact gtagaaatac aatgctatgt agcttttcca ccccatggtc tctagtgctg
     3061 cctatcaact tgtccccttt tttcccaata acctgtcttc caggtggtac agttagctgt
     3121 cactcagctg acaccatgat gtggcagcag agagggaaac ctacaagtgg tttgcctcat
     3181 tgcctttgcc acatctgaag ttctcagcag cactacctta gacttcatga gctaatagga
     3241 aactttttat ggtgtaaatg ctgtaagact ttgtacatac ttcagttgtt atgaaatctt
     3301 taaagaaaaa aagaaaaagt tacgctaata aattgctgtg gtgcaggca
//
