LOCUS       NM_001042353            1807 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens family with sequence similarity 110 member A
            (FAM110A), transcript variant 3, mRNA.
ACCESSION   NM_001042353
VERSION     NM_001042353.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1807)
  AUTHORS   Aquino-Perez,C., Safaralizade,M., Podhajecky,R., Wang,H.,
            Lansky,Z., Grosse,R. and Macurek,L.
  TITLE     FAM110A promotes mitotic spindle formation by linking microtubules
            with actin cytoskeleton
  JOURNAL   Proc Natl Acad Sci U S A 121 (29), e2321647121 (2024)
   PUBMED   38995965
  REMARK    GeneRIF: FAM110A promotes mitotic spindle formation by linking
            microtubules with actin cytoskeleton.
REFERENCE   2  (bases 1 to 1807)
  AUTHORS   Zhong,H., Shi,Q., Wen,Q., Chen,J., Li,X., Ruan,R., Zeng,S., Dai,X.,
            Xiong,J., Li,L., Lei,W. and Deng,J.
  TITLE     Pan-cancer analysis reveals potential of FAM110A as a prognostic
            and immunological biomarker in human cancer
  JOURNAL   Front Immunol 14, 1058627 (2023)
   PUBMED   36923407
  REMARK    GeneRIF: Pan-cancer analysis reveals potential of FAM110A as a
            prognostic and immunological biomarker in human cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1807)
  AUTHORS   Aquino Perez,C., Burocziova,M., Jenikova,G. and Macurek,L.
  TITLE     CK1-mediated phosphorylation of FAM110A promotes its interaction
            with mitotic spindle and controls chromosomal alignment
  JOURNAL   EMBO Rep 22 (7), e51847 (2021)
   PUBMED   34080749
REFERENCE   4  (bases 1 to 1807)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 1807)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1807)
  AUTHORS   Kovacs,I.A., Luck,K., Spirohn,K., Wang,Y., Pollis,C., Schlabach,S.,
            Bian,W., Kim,D.K., Kishore,N., Hao,T., Calderwood,M.A., Vidal,M.
            and Barabasi,A.L.
  TITLE     Network-based prediction of protein interactions
  JOURNAL   Nat Commun 10 (1), 1240 (2019)
   PUBMED   30886144
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1807)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1807)
  AUTHORS   Vinayagam,A., Stelzl,U., Foulle,R., Plassmann,S., Zenkner,M.,
            Timm,J., Assmus,H.E., Andrade-Navarro,M.A. and Wanker,E.E.
  TITLE     A directed protein interaction network for investigating
            intracellular signal transduction
  JOURNAL   Sci Signal 4 (189), rs8 (2011)
   PUBMED   21900206
REFERENCE   9  (bases 1 to 1807)
  AUTHORS   Hauge,H., Patzke,S. and Aasheim,H.C.
  TITLE     Characterization of the FAM110 gene family
  JOURNAL   Genomics 90 (1), 14-27 (2007)
   PUBMED   17499476
  REMARK    GeneRIF: Protein with cell cycle-regulated expression and distinct
            conserved motifs, which localizes to centrosomes and spindle poles.
REFERENCE   10 (bases 1 to 1807)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA915382.1, BI911808.1, AL118502.38 and BC004222.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001042353.2.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 encode the
            same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.54092.1,
                                           SRR3476690.394801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381941.8/ ENSP00000371367.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               DA915382.1         3-178
            177-478             BI911808.1         152-453
            479-565             AL118502.38        114388-114474
            566-1399            BC004222.2         376-1209
            1400-1807           AL118502.38        115309-115716
FEATURES             Location/Qualifiers
     source          1..1807
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..1807
                     /gene="FAM110A"
                     /gene_synonym="bA371L19.3; C20orf55; F10"
                     /note="family with sequence similarity 110 member A"
                     /db_xref="GeneID:83541"
                     /db_xref="HGNC:HGNC:16188"
                     /db_xref="MIM:611393"
     exon            1..237
                     /gene="FAM110A"
                     /gene_synonym="bA371L19.3; C20orf55; F10"
                     /inference="alignment:Splign:2.1.0"
     exon            238..1807
                     /gene="FAM110A"
                     /gene_synonym="bA371L19.3; C20orf55; F10"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..1222
                     /gene="FAM110A"
                     /gene_synonym="bA371L19.3; C20orf55; F10"
                     /codon_start=1
                     /product="protein FAM110A"
                     /protein_id="NP_001035812.1"
                     /db_xref="CCDS:CCDS13008.1"
                     /db_xref="GeneID:83541"
                     /db_xref="HGNC:HGNC:16188"
                     /db_xref="MIM:611393"
                     /translation="MPVHTLSPGAPSAPALPCRLRTRVPGYLLRGPADGGARKPSAVE
                     RLEADKAKYVKSLHVANTRQEPVQPLLSKQPLFSPETRRTVLTPSRRALPGPCRRPQL
                     DLDILSSLIDLCDSPVSPAEASRTPGRAEGAGRPPPATPPRPPPSTSAVRRVDVRPLP
                     ASPARPCPSPGPAAASSPARPPGLQRSKSDLSERFSRAAADLERFFNFCGLDPEEARG
                     LGVAHLARASSDIVSLAGPSAGPGSSEGGCSRRSSVTVEERARERVPYGVSVVERNAR
                     VIKWLYGLRQARESPAAEG"
     regulatory      1782..1787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM110A"
                     /gene_synonym="bA371L19.3; C20orf55; F10"
                     /note="hexamer: AATAAA"
     polyA_site      1807
                     /gene="FAM110A"
                     /gene_synonym="bA371L19.3; C20orf55; F10"
                     /note="major polyA site"
ORIGIN      
        1 acttcccctt ccacggcgcc ccagggactt tccctgcggt gggggccttc gacagtgagg
       61 gccacccgct cagctcgacc gcggagggca gctccaaagg ggaccccaaa ggtgcccacg
      121 cggggctggg gcctcctggg cgtcgttggg agcggccact accggcccgg gtccgagctg
      181 tcagcctctc caaagcctgc gcgagaggag ccgggacacg cctagcgcgg gctccagcag
      241 tggccggtgt ccagctgcct actttctgcc cggatctctg gctcctcatc tctccggtct
      301 ccgcagacta aagccctcgg gatatgcagc agccatgcct gtgcacacgc tgagccccgg
      361 agccccgtcc gcccccgccc taccttgccg cctgcggacc agggtccctg gctacctgct
      421 acgggggccg gcagatggtg gagcccggaa accgagcgct gtggagcgcc tggaggccga
      481 caaggccaag tacgtcaaga gcctgcacgt ggccaacacc cgccaggagc ctgtgcagcc
      541 cctgctgtcc aaacagccgc tctttagccc tgagactcgc cgcacagtgc tcacgcccag
      601 ccgccgagcc ctgcctggcc cctgccgacg gccccagctg gacctggaca tcctcagcag
      661 cctcatcgac ttgtgtgaca gccccgtgtc ccctgccgag gccagccgca ctcctggacg
      721 ggccgaggga gccggccgtc ctcccccagc cacccctccg cgaccgccgc ccagtacctc
      781 tgcggtccgc cgggtggacg tccgccccct gcccgcctcg cctgcccggc cctgcccatc
      841 acccggccct gccgccgcct ccagcccagc ccggccgccg ggtttgcaac gctccaagtc
      901 ggacttgagc gagcgctttt ctagggcagc cgctgatctc gagcgctttt ttaacttctg
      961 cggcctggac ccggaggagg cgagagggtt gggtgtggcc cacctggcac gggccagctc
     1021 ggatatcgtg tccctggcag ggcccagtgc tgggccgggc agctctgaag ggggctgctc
     1081 ccgccgcagc tcggtgactg ttgaggagcg ggcccgggag cgcgttccct atggcgtgtc
     1141 ggtggtggag cgcaatgccc gcgtgatcaa gtggttgtat gggctaaggc aggctcggga
     1201 gagcccagca gctgaaggct aggcgccact gggcctggaa ttcgccacag gacggatctt
     1261 acagaggcaa gtggtccctg gacctctctt gcatccattc tctagacggc cgtgtcagag
     1321 gctccaccct gttgtgaact tggtatggag gcaaaggctt agaggctgga ccagcattgt
     1381 tgggcaagga ctgactctcc aagggttttg ttcttggctt tggacacctg agaaccccct
     1441 cctcccctcc cccaatacaa ggtttttgac atgagtgtac tcctgcttag ttcctcttgt
     1501 ggggctgcat ttgcggtgct ttgccctccc cactgtgagt gaggggccaa gggatctcct
     1561 caatcctgtc tccccagcgg ctctgtttcc tccttccttc cttggcctct gtcctttgct
     1621 gacttcctct tccttaccca gcagaactca ccctggggtc ggggcagtgg ggaggggcct
     1681 atccactgct cttcctagtc cttggcagct ggcctaggtg ggcagactat aggagggact
     1741 ggttaggagt ctgcattgct ttgacttccc tctccttggt taataaacac aaatgcttgt
     1801 ttctcaa
//
