LOCUS       NM_031453               3788 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 107 member B
            (FAM107B), transcript variant 2, mRNA.
ACCESSION   NM_031453
VERSION     NM_031453.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3788)
  AUTHORS   Guo,J., Bian,Y., Wang,Y., Chen,L., Yu,A. and Sun,X.
  TITLE     FAM107B is regulated by S100A4 and mediates the effect of S100A4 on
            the proliferation and migration of MGC803 gastric cancer cells
  JOURNAL   Cell Biol Int 41 (10), 1103-1109 (2017)
   PUBMED   28675500
  REMARK    GeneRIF: Authors first provide experimental evidence suggesting
            that FAM107B was downregulated by S100A4 in gastric cancer MGC803
            cells. And FAM107B at least partially mediates the biological
            effect of S100A4 in the cells.
REFERENCE   2  (bases 1 to 3788)
  AUTHORS   Patel,Y.M., Stram,D.O., Wilkens,L.R., Park,S.S., Henderson,B.E., Le
            Marchand,L., Haiman,C.A. and Murphy,S.E.
  TITLE     The contribution of common genetic variation to nicotine and
            cotinine glucuronidation in multiple ethnic/racial populations
  JOURNAL   Cancer Epidemiol Biomarkers Prev 24 (1), 119-127 (2015)
   PUBMED   25293881
REFERENCE   3  (bases 1 to 3788)
  AUTHORS   Nakajima,H., Koizumi,K., Tanaka,T., Ishigaki,Y., Yoshitake,Y.,
            Yonekura,H., Sakuma,T., Fukushima,T., Umehara,H., Ueno,S.,
            Minamoto,T. and Motoo,Y.
  TITLE     Loss of HITS (FAM107B) expression in cancers of multiple organs:
            tissue microarray analysis
  JOURNAL   Int J Oncol 41 (4), 1347-1357 (2012)
   PUBMED   22825356
  REMARK    GeneRIF: These results show that loss of HITS (FAM107B) expression
            is a common phenomenon observed in cancers of distinct organs and
            involved in tumor development and proliferation.
REFERENCE   4  (bases 1 to 3788)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 3788)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3788)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3788)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK127413.1 and AL136885.1.
            
            On Aug 13, 2020 this sequence version replaced NM_031453.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK127413.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000181796.7/ ENSP00000181796.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1228              AK127413.1         1-1228
            1229-3788           AL136885.1         715-3274
FEATURES             Location/Qualifiers
     source          1..3788
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p13"
     gene            1..3788
                     /gene="FAM107B"
                     /gene_synonym="C10orf45; HITS"
                     /note="family with sequence similarity 107 member B"
                     /db_xref="GeneID:83641"
                     /db_xref="HGNC:HGNC:23726"
     exon            1..645
                     /gene="FAM107B"
                     /gene_synonym="C10orf45; HITS"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..1155
                     /gene="FAM107B"
                     /gene_synonym="C10orf45; HITS"
                     /note="isoform b is encoded by transcript variant 2;
                     protein FAM107B; heat shock-inducible tumor small protein;
                     FAM107B/CDNF fusion"
                     /codon_start=1
                     /product="protein FAM107B isoform b"
                     /protein_id="NP_113641.2"
                     /db_xref="CCDS:CCDS7102.1"
                     /db_xref="GeneID:83641"
                     /db_xref="HGNC:HGNC:23726"
                     /translation="MSTWKARLTKRLKSPSRSMHPFPCSALLACFGNTRESASFNQSG
                     VADTHSTVRVQPVAKAGRQPRHPSAEGAPEKRQDSSTHAERNGSANRNSSHRTAAQPA
                     ETPEDVPGSLDDGADCEAVVFHASIPRPSIIDTPKEEEFREEPKCLELEQKMTSDSPP
                     EDIDHKDSYLITRSIMAEPDYIEDDNPELIRPQKLINPVKTSRNHQDLHRELLMNQKR
                     GLAPQNKPELQKVMEKRKRDQVIKQKEEEAQKKKSDLEIELLKRQQKLEQLELEKQKL
                     QEEQENAPEFVKVKGNLRRTGQEVAQAQES"
     exon            646..703
                     /gene="FAM107B"
                     /gene_synonym="C10orf45; HITS"
                     /inference="alignment:Splign:2.1.0"
     exon            704..887
                     /gene="FAM107B"
                     /gene_synonym="C10orf45; HITS"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1038
                     /gene="FAM107B"
                     /gene_synonym="C10orf45; HITS"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..3788
                     /gene="FAM107B"
                     /gene_synonym="C10orf45; HITS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2806..2811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM107B"
                     /gene_synonym="C10orf45; HITS"
                     /note="hexamer: AATAAA"
     polyA_site      2832
                     /gene="FAM107B"
                     /gene_synonym="C10orf45; HITS"
     regulatory      3757..3762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM107B"
                     /gene_synonym="C10orf45; HITS"
                     /note="hexamer: AATAAA"
     polyA_site      3788
                     /gene="FAM107B"
                     /gene_synonym="C10orf45; HITS"
                     /note="major polyA site"
ORIGIN      
        1 acagaaggaa gagcgcgaaa ttgcccagga tggacacttt caaaggggcc ccagcggcta
       61 agtgactctc agggaaggtg gccttgccat cccaacttct atttaggggc aaccactagc
      121 aagttcttct cttcgggcaa ttggaaagag ttcctataag caaagtggag gtgatgtgga
      181 cccctggaaa atttccttgc cccgtttgaa ctttgcaatg attcactgca agtcatgtcc
      241 acgtggaaag caagactcac caaaagactg aagtctccct ctagaagcat gcatccattt
      301 ccgtgctcag ctctgctcgc ctgttttggg aatacgaggg agagtgcttc cttcaatcag
      361 tccggcgtgg ctgatactca ttccaccgtc cgtgtgcagc ctgtggccaa agcaggcaga
      421 cagccaagac acccaagcgc agaaggagct ccagagaaaa ggcaagattc gagcacccat
      481 gcagagagaa atggcagtgc gaatcggaat tcaagtcacc gcactgcggc ccagcccgcg
      541 gagacgcctg aagatgtgcc cgggtccctg gatgatgggg cggactgtga agcagtggtg
      601 tttcacgctt ccatccccag accatcaatt attgacacgc ccaaggaaga agaatttcga
      661 gaagaaccta aatgcctcga gctggagcag aaaatgacat cagacagccc acctgaggat
      721 attgaccata aggactcata tctcattaca agaagcatca tggccgagcc agactacata
      781 gaagatgaca atcctgaact cattaggcct cagaaactga tcaatcctgt aaaaacctcc
      841 cggaaccatc aagatcttca cagagaactt cttatgaatc aaaaaagggg tcttgctcct
      901 cagaacaaac cagaattgca gaaggtgatg gaaaaaagaa aacgagacca agtaataaag
      961 cagaaggaag aagaagcaca gaagaagaaa tctgacttgg aaatagagct attaaaacgg
     1021 cagcagaagt tggagcagct tgaacttgag aagcagaaat tgcaagaaga gcaagaaaat
     1081 gcccccgagt ttgtgaaggt gaaaggcaat ctcaggagaa caggccaaga agtcgcccaa
     1141 gcccaggagt cctaggctga ggctgcacca agacctcgtg tgtcacccca cagagctgtc
     1201 tgtgggtgcc ttctcaatct cagggcaaaa gcccctggag aatatttcag ccagcagaga
     1261 attttgactt gcagtaggat ttggtttgat tttcctacga tctgggtgga tgccttgcct
     1321 gtgacagttg cagttcctat tcgccaaatg aagggcagtg ccccgcacgt aagttggaat
     1381 gatggacctg tgttcagaga cttaacagaa ccaacaagca aaacaagtga gaacaggaaa
     1441 aaggaagagg acactggaat caattcttga gagttgcact acttggtttt tcttccattc
     1501 caagtttcgt gggacccaga gccttttttc ttttaaaagc taaaaaacaa gtgtttaatt
     1561 cctctttttg ttatctgtta gataattgag atcacctaga aatgcgttta atctgttcac
     1621 tcactgtaaa ttttgaggac ccagaattgt cttgtttaat ttatactttc acccctgttg
     1681 cagttaacac cagagaagga acgtgaatgt cgagcacagc cactaccctt gttggcactt
     1741 aatttagaaa tagggtgaga agtttaaaag cccatcttga ttttattttc attccttttg
     1801 gttctctgtg taataatagc aggctacata gtgacattcc agttccaaga aggtacatcc
     1861 tgtccattca ttaattgctt tgattactag gagggtttct gttcagtttt gtttttaaat
     1921 gtcttgctga tctagttctt tcagatggaa taaccttcca gtcccttaga gagtggaact
     1981 agtccatata acccagcttc agtagcaaaa gtagaagccg ccacatcttt tcatttctcc
     2041 aagaggagag tggggaaggt tcccatgacc agctgggcag tcaggatttc tctaggcatt
     2101 ctaatgtgaa ataagtgtag actgctgtca aggaggcttc atcagaagat gtatagcatt
     2161 tgaatgtcta atgataatgc atatcattag aatccaagct ttgaaaattt ctgattaatg
     2221 ctcatgtatt tctttatctt tgtttttcct tgtgaagaaa gactttcacc actgtctgag
     2281 tgatgatgct gttgataagg atgatgtcga tgactactat attgcatctc tcaggaacag
     2341 ctgatgggaa gggaggggct gctgagttcc cttgttctag ctagcagcac gctcctcaga
     2401 gagggggccg agttacagac agcagccgca ttctcatgca aaattagttt taaactgcta
     2461 gtgtgggcat cggtaccttt tgcctgggtg ataccgaaga attgttgagg atttagtatg
     2521 ctccgtagag acagttcagc cagtcatttc tgcattggag agacttctca tactttcttt
     2581 gaagactcat agaaagctgg atctagagct tttgaatcct taattagcac agtagaaatt
     2641 agctttctat gggaatgctt tagtgttagc agttgacaat taggcccata ttcaatctga
     2701 atgggaacaa aagtaaatgc aatgataata tactgctagt tagagaaaca tgttagttga
     2761 ttatacctga aatggattat ttatctcatc agcaagtatt atttgaataa aatgagaaat
     2821 gcttaagaaa aattgttgct ctacagtaat ttggtttcga agaatggaat ggtaactatt
     2881 ttttcccatc gttcttttga gagaaggaag tgtgatgact gatgatcttg aaaagcccat
     2941 ttctgattgc acgttgactg gaattctttc tttgtgtctg tggactagcg atgctgtttg
     3001 taaaatgaag attcgggact ggctcatatc tttttatcta actagatgtc agatcttgaa
     3061 atctgtattc tcgaagcaat tctgccactt gatcgtattc acaggggccc tggtaggctc
     3121 ctttagaagg accatttctg ttcctagagc ttaactagaa ttcattcttc actgaaaaaa
     3181 aaaaaagtta cttaagaaag catttctttc ctaatctcac tcaaatctgc agaattattt
     3241 gtaattagta atacaaaatc tggccaaaag gagacttgta aatagcgtaa agtggtgtct
     3301 tatgctaaac ggtggaatgt ataggcagag aagctctttg aagttgtcag atgagctggg
     3361 ctcacaagcc tgattcaaac aggctgtcgg tctcctctca ccccttaata ctgtgcagcc
     3421 caaactccta ggactcttga acatctgagc agttttgtgc tttgagccac tttttgacaa
     3481 aaatggctcc atttttccac agcgtggttt tcttaaaata gtttaatgtt ttatagtctc
     3541 atagtagtag tgttgctttc taagctataa cagtcgactt tattcttcta ctctgaaaaa
     3601 tcttgacttg tttgagtgta tataatatat ataaagggag ccttaatgga ttggttttca
     3661 taatttaata ttttttgtat ttgctcttgt ataattgttt ttaacggaaa gtattaaaga
     3721 attgagggtg gaattcttag aaccaaagtt attcttaata aaaatcacca catgcttgga
     3781 ccatgcaa
//
