LOCUS       NM_007177               3092 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 107 member A
            (FAM107A), transcript variant 1, mRNA.
ACCESSION   NM_007177
VERSION     NM_007177.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3092)
  AUTHORS   Zhang,J., Di,S., Li,M., Dong,Y., Xie,S., Gong,T., Hu,P., Jia,Q. and
            Fan,B.
  TITLE     FAM107A as a tumor suppressor in esophageal squamous carcinoma
            inhibits growth and metastasis
  JOURNAL   Pathol Res Pract 252, 154945 (2023)
   PUBMED   37977035
  REMARK    GeneRIF: FAM107A as a tumor suppressor in esophageal squamous
            carcinoma inhibits growth and metastasis.
REFERENCE   2  (bases 1 to 3092)
  AUTHORS   Ou,L., Wei,Z., Xu,J., Li,W., Zhou,Y., Wang,Y. and Shi,B.
  TITLE     FAM107A as a Tumor Suppressor in Bladder Cancer Inhibits Cell
            Proliferation, Migration, and Invasion
  JOURNAL   Ann Clin Lab Sci 52 (2), 260-268 (2022)
   PUBMED   35414505
  REMARK    GeneRIF: FAM107A as a Tumor Suppressor in Bladder Cancer Inhibits
            Cell Proliferation, Migration, and Invasion.
REFERENCE   3  (bases 1 to 3092)
  AUTHORS   Wang,D., Feng,M., Ma,X., Tao,K. and Wang,G.
  TITLE     Transcription factor SP1-induced microRNA-146b-3p facilitates the
            progression and metastasis of colorectal cancer via regulating
            FAM107A
  JOURNAL   Life Sci 277, 119398 (2021)
   PUBMED   33831429
  REMARK    GeneRIF: Transcription factor SP1-induced microRNA-146b-3p
            facilitates the progression and metastasis of colorectal cancer via
            regulating FAM107A.
REFERENCE   4  (bases 1 to 3092)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3092)
  AUTHORS   Xu,Y., Kim,Y.H., Jeong,P., Piao,X.M., Byun,Y.J., Kang,H.W.,
            Kim,W.T., Lee,J.Y., Kim,I.Y., Moon,S.K., Choi,Y.H., Yun,S.J. and
            Kim,W.J.
  TITLE     Diagnostic value of combined IQGAP3/BMP4 and IQGAP3/FAM107A
            expression ratios in urinary cell-free DNA for discriminating
            bladder cancer from hematuria
  JOURNAL   Urol Oncol 37 (1), 86-96 (2019)
   PUBMED   30446454
  REMARK    GeneRIF: Both IQGAP3/BMP4 and IQGAP3/FAM107A ratios in ucfDNA were
            significantly higher in patients with BC than in those with
            hematuria.
REFERENCE   6  (bases 1 to 3092)
  AUTHORS   Awakura,Y., Nakamura,E., Ito,N., Kamoto,T. and Ogawa,O.
  TITLE     Methylation-associated silencing of TU3A in human cancers
  JOURNAL   Int J Oncol 33 (4), 893-899 (2008)
   PUBMED   18813805
  REMARK    GeneRIF: TU3A is epigenetically inactivated in human cancer
REFERENCE   7  (bases 1 to 3092)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   8  (bases 1 to 3092)
  AUTHORS   Kholodnyuk,I.D., Kozireva,S., Kost-Alimova,M., Kashuba,V., Klein,G.
            and Imreh,S.
  TITLE     Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of
            human chromosome 3-mouse fibrosarcoma hybrids in severe combined
            immunodeficiency mice
  JOURNAL   Int J Cancer 119 (1), 99-107 (2006)
   PUBMED   16432833
  REMARK    GeneRIF: Expression of the down-regulated in renal cell carcinoma
            gene (DRR1) gene at 3p14.2 was lost in 7 and down regulated in 2
            'chr3+' tumours.
REFERENCE   9  (bases 1 to 3092)
  AUTHORS   Wang,L., Darling,J., Zhang,J.S., Liu,W., Qian,J., Bostwick,D.,
            Hartmann,L., Jenkins,R., Bardenhauer,W., Schutte,J., Opalka,B. and
            Smith,D.I.
  TITLE     Loss of expression of the DRR 1 gene at chromosomal segment 3p21.1
            in renal cell carcinoma
  JOURNAL   Genes Chromosomes Cancer 27 (1), 1-10 (2000)
   PUBMED   10564580
REFERENCE   10 (bases 1 to 3092)
  AUTHORS   Yamato,T., Orikasa,K., Fukushige,S., Orikasa,S. and Horii,A.
  TITLE     Isolation and characterization of the novel gene, TU3A, in a
            commonly deleted region on 3p14.3-->p14.2 in renal cell carcinoma
  JOURNAL   Cytogenet Cell Genet 87 (3-4), 291-295 (1999)
   PUBMED   10702698
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX645008.1, BC010561.1, EU569833.1 and AF089853.1.
            
            On May 31, 2019 this sequence version replaced NM_007177.3.
            
            Transcript Variant: This variant (1) encodes the shortest isoform
            (a). Both variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.50405.1, AF089854.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BX645008.1         184-209
            27-1135             BC010561.1         1-1109
            1136-1364           EU569833.1         1066-1294
            1365-1773           AF089853.1         1729-2137
            1774-3092           AF089853.1         2140-3458
FEATURES             Location/Qualifiers
     source          1..3092
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.3-p14.2"
     gene            1..3092
                     /gene="FAM107A"
                     /gene_synonym="DRR1; TU3A"
                     /note="family with sequence similarity 107 member A"
                     /db_xref="GeneID:11170"
                     /db_xref="HGNC:HGNC:30827"
                     /db_xref="MIM:608295"
     exon            1..83
                     /gene="FAM107A"
                     /gene_synonym="DRR1; TU3A"
                     /inference="alignment:Splign:2.1.0"
     exon            84..181
                     /gene="FAM107A"
                     /gene_synonym="DRR1; TU3A"
                     /inference="alignment:Splign:2.1.0"
     exon            182..356
                     /gene="FAM107A"
                     /gene_synonym="DRR1; TU3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..621
                     /gene="FAM107A"
                     /gene_synonym="DRR1; TU3A"
                     /note="isoform a is encoded by transcript variant 1;
                     down-regulated in renal cell carcinoma 1; protein FAM107A;
                     actin-associated protein FAM107A"
                     /codon_start=1
                     /product="actin-associated protein FAM107A isoform a"
                     /protein_id="NP_009108.1"
                     /db_xref="CCDS:CCDS2892.1"
                     /db_xref="GeneID:11170"
                     /db_xref="HGNC:HGNC:30827"
                     /db_xref="MIM:608295"
                     /translation="MYSEIQRERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSH
                     QELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLR
                     RQQRLNQLEKPPEKEEDHAPEFIKVRENLRRIATLTSEEREL"
     exon            357..513
                     /gene="FAM107A"
                     /gene_synonym="DRR1; TU3A"
                     /inference="alignment:Splign:2.1.0"
     exon            514..3092
                     /gene="FAM107A"
                     /gene_synonym="DRR1; TU3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2460..2465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM107A"
                     /gene_synonym="DRR1; TU3A"
                     /note="hexamer: AATAAA"
     polyA_site      2483
                     /gene="FAM107A"
                     /gene_synonym="DRR1; TU3A"
     regulatory      3071..3076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM107A"
                     /gene_synonym="DRR1; TU3A"
                     /note="hexamer: AATAAA"
     polyA_site      3092
                     /gene="FAM107A"
                     /gene_synonym="DRR1; TU3A"
                     /note="major polyA site"
ORIGIN      
        1 cttgctagtc tgggacttcc cggtggagtg aggaacccag caacacgctc ctgacttccc
       61 ttcccaagga ctcgacctga gaaggacaca gcagtctctg aatttcatgc tctcctcttt
      121 gatgtgaaga aaatgaaaag ctgaacagtt gtggaactgt ggatagagtt agacaataag
      181 gccgccatgt actcggagat ccagagggag cgggcagaca ttgggggcct gatggcccgg
      241 ccagaataca gagagtggaa tccggagctc atcaagccca agaagctgct gaaccccgtg
      301 aaggcctctc ggagtcacca ggagctccac cgggagctgc tcatgaacca cagaaggggc
      361 cttggtgtgg acagcaagcc agagctgcag cgtgtcctag agcaccgccg gcggaaccag
      421 ctcatcaaga agaagaagga ggagctggaa gccaagcggc tgcagtgccc ctttgagcag
      481 gagctgctga gacggcagca gaggctgaac cagctggaaa aaccaccaga gaaggaagag
      541 gatcacgccc ccgagtttat taaagtcagg gaaaacctgc ggagaattgc cacactgacc
      601 agcgaagaga gagagctgta gggccagctg ccgggctcag gccactgccc accctggcct
      661 ggacagcctc cttcagccct tctgtacctg gcagccctgg gccccaggcc ctgggacgtc
      721 tgtgatgttc ccacctgctt ctgtagaaat gtgtcacccc agagggcctg gctctccctg
      781 ggaggctggg gcccctaagc tcctaggttt tccttccaag cacccagccc tcctgctcca
      841 agagggataa cctgcacccc tccctgcaag gggttcagag cccagcacag gagctttctc
      901 tggcagaatt gaggaggaag aggtggccct ctgacttgac aagccttctg ttctgcccag
      961 gccttcccac caggaatctc cgaggctccc cagggccccg cttctccgta caccccagct
     1021 cctaggtctc agagaactcc cccacctgtg gttttacctg cagccagcag agcttagctt
     1081 caaggacacc tgccttcaaa gccactgagg ggaggaaggg cagggcagac tgcagatggc
     1141 cttgttgctg gcatcccggc caggtgggcg gggactaaca aagacagctg tttagggtct
     1201 tctcccctca cccatgcttt catcatcccc tccgcacagc ctccccgtcc aggccttcta
     1261 accacaccta cccagggctg ccgcattcct gcactcagaa gtctgcagcg gtgcctcaca
     1321 aacttgattg tgcataaaaa tcactgggga tcttgttaat acagcttcta actcaataga
     1381 tctgggagat cctgcatttc taacaagctc ccaggtaagg cggaggctgc tggtgtgagg
     1441 accatgctgt gagcagcagg gcgagagtgc ccagggctga tatatattgg aaatatcacc
     1501 cctgaagcca tcgctggccc ccacctcctg tggactgatg ccccagggat tcccacccca
     1561 cttctgcaac cccaggtatc cttcattatc caccccatcc cagactccca ccccagggat
     1621 tgcccgtgaa gactttggcc tagcaaattg tgttggttat gtgagtgttg ttttaatcag
     1681 agatgtacat gattgccaat ctgcatttct taccagtgtg accacactgt tacgatgcaa
     1741 ttctagccaa aaaaaaaaaa aaaaaaaaaa aaattttttt tttttacttt ttcctagtct
     1801 tatggaaagc aaatatacaa tgattttcag taggcttctg gaatagaaac agtggtttga
     1861 agaccccact gccaccttta tggactggcc cctttgagtc tgaatccccg gcctctgtca
     1921 cctgagaccc aacccctagc tgggccaact ccagtgaatt cacccatttt tcttcttcag
     1981 aaggcctttc ctgtgtgaga cccacatatt ttaacctttt gctcctatcc catttttaaa
     2041 gaattagaga ataaaccagg cctgtttctt ttcccctgaa atccctgcct ctggcttcct
     2101 aaacccatca tctaaggtga cagagcagtg ctggaatagc atctcctttc actttcccaa
     2161 aactgccaca gatagctgcc actggcatgc tctttgattc ctggaagcaa acgtgggact
     2221 gtcggaggaa agggattgtt ctggtcttac tcataactgg gtggtttgag ggtgactgaa
     2281 gtcgtgcttt tcctgtgtgt gctgccagca cagggctgta aatgcagata ttgcgcctgt
     2341 gtgcgtgtgt ataagtcaag ctccaagagg ctcctgaatg tgactggcgt gctgagaatg
     2401 tgtttacgct gtttaatgtc tgccaggtga gggttacact gaagatgcac aatccctaaa
     2461 ataaagatca ccacttcccc aaagaagcag ccctcgggtc catgtgttgt tcagacatgt
     2521 gaagagaagc aagacagagg gtctcagatg gacgagggct ctccaaggga atgcctgggg
     2581 attcacccag tggtccccag aggtgctcca tggaggcaac aagtcattcc atgaagcccc
     2641 agaggtagaa gggacctcaa gcaccacgcc ctccagggca gccgtgcaga cgaccttggt
     2701 tcacttttca ggggtcgtcc caactctgta tctccagcca ctccaactgt ggaggctgta
     2761 aatccagatt ttcactgttc cagtctcctt tgcagcttag gatggctatg tgatcaggtg
     2821 tggccaatga aattgaagag gaagtctacc tgggcttctg ggaaagcttt tccaataaaa
     2881 gacacaggca tggctaacac ctccctgggc ctcttcttcc taccttgatt gagggtgtga
     2941 tgcctggagc cacagcagcc actttgctac catgacaaaa aggccaagag aatcacagag
     3001 tcattgaccc tatcattatt tcaccaagcc aataccagcc gccatccttc tccagaattc
     3061 ttgtaaataa aataaatccc tctttgttta aa
//
