LOCUS       NM_001076778            2994 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 107 member A
            (FAM107A), transcript variant 2, mRNA.
ACCESSION   NM_001076778
VERSION     NM_001076778.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2994)
  AUTHORS   Zhang,J., Di,S., Li,M., Dong,Y., Xie,S., Gong,T., Hu,P., Jia,Q. and
            Fan,B.
  TITLE     FAM107A as a tumor suppressor in esophageal squamous carcinoma
            inhibits growth and metastasis
  JOURNAL   Pathol Res Pract 252, 154945 (2023)
   PUBMED   37977035
  REMARK    GeneRIF: FAM107A as a tumor suppressor in esophageal squamous
            carcinoma inhibits growth and metastasis.
REFERENCE   2  (bases 1 to 2994)
  AUTHORS   Ou,L., Wei,Z., Xu,J., Li,W., Zhou,Y., Wang,Y. and Shi,B.
  TITLE     FAM107A as a Tumor Suppressor in Bladder Cancer Inhibits Cell
            Proliferation, Migration, and Invasion
  JOURNAL   Ann Clin Lab Sci 52 (2), 260-268 (2022)
   PUBMED   35414505
  REMARK    GeneRIF: FAM107A as a Tumor Suppressor in Bladder Cancer Inhibits
            Cell Proliferation, Migration, and Invasion.
REFERENCE   3  (bases 1 to 2994)
  AUTHORS   Wang,D., Feng,M., Ma,X., Tao,K. and Wang,G.
  TITLE     Transcription factor SP1-induced microRNA-146b-3p facilitates the
            progression and metastasis of colorectal cancer via regulating
            FAM107A
  JOURNAL   Life Sci 277, 119398 (2021)
   PUBMED   33831429
  REMARK    GeneRIF: Transcription factor SP1-induced microRNA-146b-3p
            facilitates the progression and metastasis of colorectal cancer via
            regulating FAM107A.
REFERENCE   4  (bases 1 to 2994)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2994)
  AUTHORS   Xu,Y., Kim,Y.H., Jeong,P., Piao,X.M., Byun,Y.J., Kang,H.W.,
            Kim,W.T., Lee,J.Y., Kim,I.Y., Moon,S.K., Choi,Y.H., Yun,S.J. and
            Kim,W.J.
  TITLE     Diagnostic value of combined IQGAP3/BMP4 and IQGAP3/FAM107A
            expression ratios in urinary cell-free DNA for discriminating
            bladder cancer from hematuria
  JOURNAL   Urol Oncol 37 (1), 86-96 (2019)
   PUBMED   30446454
  REMARK    GeneRIF: Both IQGAP3/BMP4 and IQGAP3/FAM107A ratios in ucfDNA were
            significantly higher in patients with BC than in those with
            hematuria.
REFERENCE   6  (bases 1 to 2994)
  AUTHORS   Awakura,Y., Nakamura,E., Ito,N., Kamoto,T. and Ogawa,O.
  TITLE     Methylation-associated silencing of TU3A in human cancers
  JOURNAL   Int J Oncol 33 (4), 893-899 (2008)
   PUBMED   18813805
  REMARK    GeneRIF: TU3A is epigenetically inactivated in human cancer
REFERENCE   7  (bases 1 to 2994)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   8  (bases 1 to 2994)
  AUTHORS   Kholodnyuk,I.D., Kozireva,S., Kost-Alimova,M., Kashuba,V., Klein,G.
            and Imreh,S.
  TITLE     Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of
            human chromosome 3-mouse fibrosarcoma hybrids in severe combined
            immunodeficiency mice
  JOURNAL   Int J Cancer 119 (1), 99-107 (2006)
   PUBMED   16432833
  REMARK    GeneRIF: Expression of the down-regulated in renal cell carcinoma
            gene (DRR1) gene at 3p14.2 was lost in 7 and down regulated in 2
            'chr3+' tumours.
REFERENCE   9  (bases 1 to 2994)
  AUTHORS   Wang,L., Darling,J., Zhang,J.S., Liu,W., Qian,J., Bostwick,D.,
            Hartmann,L., Jenkins,R., Bardenhauer,W., Schutte,J., Opalka,B. and
            Smith,D.I.
  TITLE     Loss of expression of the DRR 1 gene at chromosomal segment 3p21.1
            in renal cell carcinoma
  JOURNAL   Genes Chromosomes Cancer 27 (1), 1-10 (2000)
   PUBMED   10564580
REFERENCE   10 (bases 1 to 2994)
  AUTHORS   Yamato,T., Orikasa,K., Fukushige,S., Orikasa,S. and Horii,A.
  TITLE     Isolation and characterization of the novel gene, TU3A, in a
            commonly deleted region on 3p14.3-->p14.2 in renal cell carcinoma
  JOURNAL   Cytogenet Cell Genet 87 (3-4), 291-295 (1999)
   PUBMED   10702698
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX645008.1, AL050264.1, EU569833.1 and AF089853.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001076778.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF089853.1, SRR1803616.258378.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360997.7/ ENSP00000354270.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BX645008.1         184-197
            15-1037             AL050264.1         1-1023
            1038-1266           EU569833.1         1066-1294
            1267-1675           AF089853.1         1729-2137
            1676-2994           AF089853.1         2140-3458
FEATURES             Location/Qualifiers
     source          1..2994
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.3-p14.2"
     gene            1..2994
                     /gene="FAM107A"
                     /gene_synonym="DRR1; TU3A"
                     /note="family with sequence similarity 107 member A"
                     /db_xref="GeneID:11170"
                     /db_xref="HGNC:HGNC:30827"
                     /db_xref="MIM:608295"
     exon            1..83
                     /gene="FAM107A"
                     /gene_synonym="DRR1; TU3A"
                     /inference="alignment:Splign:2.1.0"
     exon            84..258
                     /gene="FAM107A"
                     /gene_synonym="DRR1; TU3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..523
                     /gene="FAM107A"
                     /gene_synonym="DRR1; TU3A"
                     /note="isoform a is encoded by transcript variant 2;
                     down-regulated in renal cell carcinoma 1; protein FAM107A;
                     actin-associated protein FAM107A"
                     /codon_start=1
                     /product="actin-associated protein FAM107A isoform a"
                     /protein_id="NP_001070246.1"
                     /db_xref="CCDS:CCDS2892.1"
                     /db_xref="GeneID:11170"
                     /db_xref="HGNC:HGNC:30827"
                     /db_xref="MIM:608295"
                     /translation="MYSEIQRERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSH
                     QELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLR
                     RQQRLNQLEKPPEKEEDHAPEFIKVRENLRRIATLTSEEREL"
     exon            259..415
                     /gene="FAM107A"
                     /gene_synonym="DRR1; TU3A"
                     /inference="alignment:Splign:2.1.0"
     exon            416..2994
                     /gene="FAM107A"
                     /gene_synonym="DRR1; TU3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2362..2367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM107A"
                     /gene_synonym="DRR1; TU3A"
                     /note="hexamer: AATAAA"
     polyA_site      2385
                     /gene="FAM107A"
                     /gene_synonym="DRR1; TU3A"
     regulatory      2973..2978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM107A"
                     /gene_synonym="DRR1; TU3A"
                     /note="hexamer: AATAAA"
     polyA_site      2994
                     /gene="FAM107A"
                     /gene_synonym="DRR1; TU3A"
                     /note="major polyA site"
ORIGIN      
        1 cttgctagtc tgggacttcc cggtggagtg aggaacccag caacacgctc ctgacttccc
       61 ttcccaagga ctcgacctga gaaccgccat gtactcggag atccagaggg agcgggcaga
      121 cattgggggc ctgatggccc ggccagaata cagagagtgg aatccggagc tcatcaagcc
      181 caagaagctg ctgaaccccg tgaaggcctc tcggagtcac caggagctcc accgggagct
      241 gctcatgaac cacagaaggg gccttggtgt ggacagcaag ccagagctgc agcgtgtcct
      301 agagcaccgc cggcggaacc agctcatcaa gaagaagaag gaggagctgg aagccaagcg
      361 gctgcagtgc ccctttgagc aggagctgct gagacggcag cagaggctga accagctgga
      421 aaaaccacca gagaaggaag aggatcacgc ccccgagttt attaaagtca gggaaaacct
      481 gcggagaatt gccacactga ccagcgaaga gagagagctg tagggccagc tgccgggctc
      541 aggccactgc ccaccctggc ctggacagcc tccttcagcc cttctgtacc tggcagccct
      601 gggccccagg ccctgggacg tctgtgatgt tcccacctgc ttctgtagaa atgtgtcacc
      661 ccagagggcc tggctctccc tgggaggctg gggcccctaa gctcctaggt tttccttcca
      721 agcacccagc cctcctgctc caagagggat aacctgcacc cctccctgca aggggttcag
      781 agcccagcac aggagctttc tctggcagaa ttgaggagga agaggtggcc ctctgacttg
      841 acaagccttc tgttctgccc aggccttccc accaggaatc tccgaggctc cccagggccc
      901 cgcttctccg tacaccccag ctcctaggtc tcagagaact cccccacctg tggttttacc
      961 tgcagccagc agagcttagc ttcaaggaca cctgccttca aagccactga ggggaggaag
     1021 ggcagggcag actgcagatg gccttgttgc tggcatcccg gccaggtggg cggggactaa
     1081 caaagacagc tgtttagggt cttctcccct cacccatgct ttcatcatcc cctccgcaca
     1141 gcctccccgt ccaggccttc taaccacacc tacccagggc tgccgcattc ctgcactcag
     1201 aagtctgcag cggtgcctca caaacttgat tgtgcataaa aatcactggg gatcttgtta
     1261 atacagcttc taactcaata gatctgggag atcctgcatt tctaacaagc tcccaggtaa
     1321 ggcggaggct gctggtgtga ggaccatgct gtgagcagca gggcgagagt gcccagggct
     1381 gatatatatt ggaaatatca cccctgaagc catcgctggc ccccacctcc tgtggactga
     1441 tgccccaggg attcccaccc cacttctgca accccaggta tccttcatta tccaccccat
     1501 cccagactcc caccccaggg attgcccgtg aagactttgg cctagcaaat tgtgttggtt
     1561 atgtgagtgt tgttttaatc agagatgtac atgattgcca atctgcattt cttaccagtg
     1621 tgaccacact gttacgatgc aattctagcc aaaaaaaaaa aaaaaaaaaa aaaaattttt
     1681 tttttttact ttttcctagt cttatggaaa gcaaatatac aatgattttc agtaggcttc
     1741 tggaatagaa acagtggttt gaagacccca ctgccacctt tatggactgg cccctttgag
     1801 tctgaatccc cggcctctgt cacctgagac ccaaccccta gctgggccaa ctccagtgaa
     1861 ttcacccatt tttcttcttc agaaggcctt tcctgtgtga gacccacata ttttaacctt
     1921 ttgctcctat cccattttta aagaattaga gaataaacca ggcctgtttc ttttcccctg
     1981 aaatccctgc ctctggcttc ctaaacccat catctaaggt gacagagcag tgctggaata
     2041 gcatctcctt tcactttccc aaaactgcca cagatagctg ccactggcat gctctttgat
     2101 tcctggaagc aaacgtggga ctgtcggagg aaagggattg ttctggtctt actcataact
     2161 gggtggtttg agggtgactg aagtcgtgct tttcctgtgt gtgctgccag cacagggctg
     2221 taaatgcaga tattgcgcct gtgtgcgtgt gtataagtca agctccaaga ggctcctgaa
     2281 tgtgactggc gtgctgagaa tgtgtttacg ctgtttaatg tctgccaggt gagggttaca
     2341 ctgaagatgc acaatcccta aaataaagat caccacttcc ccaaagaagc agccctcggg
     2401 tccatgtgtt gttcagacat gtgaagagaa gcaagacaga gggtctcaga tggacgaggg
     2461 ctctccaagg gaatgcctgg ggattcaccc agtggtcccc agaggtgctc catggaggca
     2521 acaagtcatt ccatgaagcc ccagaggtag aagggacctc aagcaccacg ccctccaggg
     2581 cagccgtgca gacgaccttg gttcactttt caggggtcgt cccaactctg tatctccagc
     2641 cactccaact gtggaggctg taaatccaga ttttcactgt tccagtctcc tttgcagctt
     2701 aggatggcta tgtgatcagg tgtggccaat gaaattgaag aggaagtcta cctgggcttc
     2761 tgggaaagct tttccaataa aagacacagg catggctaac acctccctgg gcctcttctt
     2821 cctaccttga ttgagggtgt gatgcctgga gccacagcag ccactttgct accatgacaa
     2881 aaaggccaag agaatcacag agtcattgac cctatcatta tttcaccaag ccaataccag
     2941 ccgccatcct tctccagaat tcttgtaaat aaaataaatc cctctttgtt taaa
//
