LOCUS       NM_012306               4667 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens Fas apoptotic inhibitory molecule 2 (FAIM2), mRNA.
ACCESSION   NM_012306
VERSION     NM_012306.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4667)
  AUTHORS   Littleton,S.H., Trang,K.B., Volpe,C.M., Cook,K., DeBruyne,N.,
            Maguire,J.A., Weidekamp,M.A., Hodge,K.M., Boehm,K., Lu,S.,
            Chesi,A., Bradfield,J.P., Pippin,J.A., Anderson,S.A., Wells,A.D.,
            Pahl,M.C. and Grant,S.F.A.
  TITLE     Variant-to-function analysis of the childhood obesity chr12q13
            locus implicates rs7132908 as a causal variant within the 3' UTR of
            FAIM2
  JOURNAL   Cell Genom 4 (5), 100556 (2024)
   PUBMED   38697123
  REMARK    GeneRIF: Variant-to-function analysis of the childhood obesity
            chr12q13 locus implicates rs7132908 as a causal variant within the
            3' UTR of FAIM2.
REFERENCE   2  (bases 1 to 4667)
  AUTHORS   Hu,T. and Lin,Y.
  TITLE     miR-127-5p regulates FAIM2-mediated cell apoptosis and participates
            in cerebral ischemia-reperfusion injury
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (2), 189-196 (2024)
   PUBMED   38430020
  REMARK    GeneRIF: miR-127-5p regulates FAIM2-mediated cell apoptosis and
            participates in cerebral ischemia-reperfusion injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4667)
  AUTHORS   Zhou,X. and Zhao,H.
  TITLE     FAIM2 is correlated with metastasis of medulloblastoma through
            bioinformatics analysis
  JOURNAL   Medicine (Baltimore) 102 (16), e33591 (2023)
   PUBMED   37083768
  REMARK    GeneRIF: FAIM2 is correlated with metastasis of medulloblastoma
            through bioinformatics analysis.
REFERENCE   4  (bases 1 to 4667)
  AUTHORS   Soliman,H.A.N., Toso,E.A., Darwish,I.E., Ali,S.M. and Kyba,M.
  TITLE     Antiapoptotic Protein FAIM2 is targeted by miR-3202, and DUX4 via
            TRIM21, leading to cell death and defective myogenesis
  JOURNAL   Cell Death Dis 13 (4), 405 (2022)
   PUBMED   35468884
  REMARK    GeneRIF: Antiapoptotic Protein FAIM2 is targeted by miR-3202, and
            DUX4 via TRIM21, leading to cell death and defective myogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4667)
  AUTHORS   Ziaee,F., Hajjari,M., Kazeminezhad,R.S. and Behmanesh,M.
  TITLE     SNHG7 and FAIM2 are up-regulated and co-expressed in colorectal
            adenocarcinoma tissues
  JOURNAL   Klin Onkol 33 (6), 445-449 (2020)
   PUBMED   33685194
  REMARK    GeneRIF: SNHG7 and FAIM2 are up-regulated and co-expressed in
            colorectal adenocarcinoma tissues.', trans 'SNHG7 a FAIM2 jsou ve
            tkani kolorektalniho karcinomu up-regulovany a koexprimovany.
REFERENCE   6  (bases 1 to 4667)
  AUTHORS   Zhou,J., Zhu,T., Hu,C., Li,H., Chen,G., Xu,G., Wang,S., Zhou,J. and
            Ma,D.
  TITLE     Comparative genomics and function analysis on BI1 family
  JOURNAL   Comput Biol Chem 32 (3), 159-162 (2008)
   PUBMED   18440869
  REMARK    GeneRIF: The tmbim2 may participate in cell death regulation by
            interacting with proteins of Bcl-2 family, promoting tumor
            metastasis, which is deduced from the evolutionary conservation of
            the membrane protein family containing multiple membrane spanning
            segments
REFERENCE   7  (bases 1 to 4667)
  AUTHORS   Fernandez,M., Segura,M.F., Sole,C., Colino,A., Comella,J.X. and
            Cena,V.
  TITLE     Lifeguard/neuronal membrane protein 35 regulates Fas
            ligand-mediated apoptosis in neurons via microdomain recruitment
  JOURNAL   J Neurochem 103 (1), 190-203 (2007)
   PUBMED   17635665
REFERENCE   8  (bases 1 to 4667)
  AUTHORS   Choi,C.Y., Reimers,K., Allmeling,C., Kall,S., Choi,Y.H. and
            Vogt,P.M.
  TITLE     Inhibition of apoptosis by expression of antiapoptotic proteins in
            recombinant human keratinocytes
  JOURNAL   Cell Transplant 16 (6), 663-674 (2007)
   PUBMED   17912957
  REMARK    GeneRIF: Human keratinocytes were transfected with either Flip,
            Faim, or Lifeguard (LFG). Our results suggest that heterotopic
            expression of antiapoptotic proteins can induce the resistance of
            keratinocytes to a major mechanism of rejection.
REFERENCE   9  (bases 1 to 4667)
  AUTHORS   Reimers,K., Choi,C.Y., Mau-Thek,E. and Vogt,P.M.
  TITLE     Sequence analysis shows that Lifeguard belongs to a new
            evolutionarily conserved cytoprotective family
  JOURNAL   Int J Mol Med 18 (4), 729-734 (2006)
   PUBMED   16964429
REFERENCE   10 (bases 1 to 4667)
  AUTHORS   Somia,N.V., Schmitt,M.J., Vetter,D.E., Van Antwerp,D.,
            Heinemann,S.F. and Verma,I.M.
  TITLE     LFG: an anti-apoptotic gene that provides protection from
            Fas-mediated cell death
  JOURNAL   Proc Natl Acad Sci U S A 96 (22), 12667-12672 (1999)
   PUBMED   10535980
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131157.4 and BC000051.2.
            
            On Nov 23, 2018 this sequence version replaced NM_012306.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.98929.1,
                                           SRR1660803.118439.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320634.8/ ENSP00000321951.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AC131157.4         145349-145373       c
            26-1160             BC000051.2         1-1135
            1161-4667           AC131157.4         108369-111875       c
FEATURES             Location/Qualifiers
     source          1..4667
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..4667
                     /gene="FAIM2"
                     /gene_synonym="LFG; LFG2; NGP35; NMP35; TMBIM2"
                     /note="Fas apoptotic inhibitory molecule 2"
                     /db_xref="GeneID:23017"
                     /db_xref="HGNC:HGNC:17067"
                     /db_xref="MIM:604306"
     exon            1..123
                     /gene="FAIM2"
                     /gene_synonym="LFG; LFG2; NGP35; NMP35; TMBIM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1059
                     /gene="FAIM2"
                     /gene_synonym="LFG; LFG2; NGP35; NMP35; TMBIM2"
                     /note="neural membrane protein 35; transmembrane BAX
                     inhibitor motif-containing protein 2"
                     /codon_start=1
                     /product="protein lifeguard 2"
                     /protein_id="NP_036438.2"
                     /db_xref="CCDS:CCDS8791.1"
                     /db_xref="GeneID:23017"
                     /db_xref="HGNC:HGNC:17067"
                     /db_xref="MIM:604306"
                     /translation="MTQGKLSVANKAPGTEGQQQVHGEKKEAPAVPSAPPSYEEATSG
                     EGMKAGAFPPAPTAVPLHPSWAYVDPSSSSSYDNGFPTGDHELFTTFSWDDQKVRRVF
                     VRKVYTILLIQLLVTLAVVALFTFCDPVKDYVQANPGWYWASYAVFFATYLTLACCSG
                     PRRHFPWNLILLTVFTLSMAYLTGMLSSYYNTTSVLLCLGITALVCLSVTVFSFQTKF
                     DFTSCQGVLFVLLMTLFFSGLILAILLPFQYVPWLHAVYAALGAGVFTLFLALDTQLL
                     MGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNRE"
     exon            124..319
                     /gene="FAIM2"
                     /gene_synonym="LFG; LFG2; NGP35; NMP35; TMBIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            320..423
                     /gene="FAIM2"
                     /gene_synonym="LFG; LFG2; NGP35; NMP35; TMBIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            424..488
                     /gene="FAIM2"
                     /gene_synonym="LFG; LFG2; NGP35; NMP35; TMBIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            489..542
                     /gene="FAIM2"
                     /gene_synonym="LFG; LFG2; NGP35; NMP35; TMBIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            543..593
                     /gene="FAIM2"
                     /gene_synonym="LFG; LFG2; NGP35; NMP35; TMBIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            594..633
                     /gene="FAIM2"
                     /gene_synonym="LFG; LFG2; NGP35; NMP35; TMBIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            634..671
                     /gene="FAIM2"
                     /gene_synonym="LFG; LFG2; NGP35; NMP35; TMBIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            672..759
                     /gene="FAIM2"
                     /gene_synonym="LFG; LFG2; NGP35; NMP35; TMBIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            760..855
                     /gene="FAIM2"
                     /gene_synonym="LFG; LFG2; NGP35; NMP35; TMBIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            856..909
                     /gene="FAIM2"
                     /gene_synonym="LFG; LFG2; NGP35; NMP35; TMBIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            910..4667
                     /gene="FAIM2"
                     /gene_synonym="LFG; LFG2; NGP35; NMP35; TMBIM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1143..1148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAIM2"
                     /gene_synonym="LFG; LFG2; NGP35; NMP35; TMBIM2"
                     /note="hexamer: TATAAA"
     polyA_site      1164
                     /gene="FAIM2"
                     /gene_synonym="LFG; LFG2; NGP35; NMP35; TMBIM2"
                     /note="major polyA site"
     regulatory      4644..4649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAIM2"
                     /gene_synonym="LFG; LFG2; NGP35; NMP35; TMBIM2"
                     /note="hexamer: AATAAA"
     polyA_site      4667
                     /gene="FAIM2"
                     /gene_synonym="LFG; LFG2; NGP35; NMP35; TMBIM2"
ORIGIN      
        1 agtggatgtt gctagaaccc acgcggagga aggaagagac gcaggcaggc tgcggttacc
       61 caagcggcca cccgggcctc agggacccct tccccgagag acggcaccat gacccaggga
      121 aagctctccg tggctaacaa ggcccctggg accgaggggc agcagcaggt gcatggcgag
      181 aagaaggagg ctccagcagt gccctcagcc ccaccctcct atgaggaagc cacctctggg
      241 gaggggatga aggcaggggc cttcccccca gcccccacag cggtgcctct ccaccctagc
      301 tgggcctatg tggaccccag cagcagctcc agctatgaca acggtttccc caccggagac
      361 catgagctct tcaccacttt cagctgggat gaccagaaag ttcgtcgagt ctttgtcaga
      421 aaggtctaca ccatcctgct gattcagctg ctggtgacct tggctgtcgt ggctctcttt
      481 actttctgtg accctgtcaa ggactatgtc caggccaacc caggctggta ctgggcatcc
      541 tatgctgtgt tctttgcaac ctacctgacc ctggcttgct gttctggacc caggaggcat
      601 ttcccctgga acctgattct cctgaccgtc tttaccctgt ccatggccta cctcactggg
      661 atgctgtcca gctactacaa caccacctcc gtgctgctgt gcctgggcat cacggccctt
      721 gtctgcctct cagtcaccgt cttcagcttc cagaccaagt tcgacttcac ctcctgccag
      781 ggcgtgctct tcgtgcttct catgactctt ttcttcagcg gactcatcct ggccatcctc
      841 ctacccttcc aatatgtgcc ctggctccat gcagtttatg cagcactggg agcgggtgta
      901 tttacattgt tcctggcact tgacacccag ttgctgatgg gtaaccgacg ccactcgctg
      961 agccctgagg agtatatttt tggagccctc aacatttacc tagacatcat ctatatcttc
     1021 accttcttcc tgcagctttt tggcactaac cgagaatgag gagccctccc tgccccaccg
     1081 tcctccagag aatgcgcccc tcctggttcc ctgtccctcc cctgcgctcc tgcgagacca
     1141 gatataaaac tagctgccaa cccagcctgt ggccaggtca ctgtctaccc cagcccagcc
     1201 cagccctctg ccgcttgtac atacgccatg gggaccctga ggaactgagg ccacgtcaat
     1261 ccctgtgccg ccccattcgc ccgttacatc ttccaaactg ggacggtcaa ggctgaaggc
     1321 tcctctgggt ttgagggtcc aagggacaag gaggagaagc ctagcaggat ttcagatgca
     1381 ggagagagac ccaggaagcc cggcagagcc ctgagcccca ctgcaattcc tcctagggct
     1441 gcacaatcat gtggccttag ggcacactgt cctgcatcca gtctgtgtcc tcctgtcttt
     1501 ctcatccagg tcaggcattg acactttgta agaaaggggg taggggacac agctgggcag
     1561 gtggagtggg tgggcaggat ggctgtccca gtctgcccat cttctcttgg ctctgggacc
     1621 agcggcttgt tctagggatt tggacctgga ggccaagggc aataggagag ggtctgaagc
     1681 ctgtgctgtc tgctgcttgc tgtgaatggc cctcccgggt catgacagag ctcttttggg
     1741 gcaggaggtg agggcagggg gccccgctcc ttggtaaggg cctgccctgg ggctcccagg
     1801 gaagtgggag ctggggagcc aatccaccca gacccgcgtc cacctgggag gcatttgggg
     1861 ttgcaggacc gagacccaca tcctctcact cacttctcca cccgccaggc agctgccaca
     1921 ggcctaaggc tgagtgaggt gtgattgggc cctccggctg gatgttctgg gggaggaggc
     1981 aatcgctgta gctgccaggc cagccccatc tggaaggagt ccctgctctg cctcagccct
     2041 aacccgaggc tgtgtgggag tcccttctgc acctcttatt tcctaaaccc ttcctgtcag
     2101 ctgctgtttg ctggctcgtc cccagccagg cctcctgagg tcttcatagt tggcacagtc
     2161 cacatctctt ctagcttcac tggccactca ctcagcccag agtccctaag tgctccccca
     2221 cttatctctg catctctcca atttggaagc catccagctg atgctaacag ccagggccag
     2281 tccctccagc tggtcccatg taatgaggcc agggctcctt atcagcttcc aggcggctgg
     2341 gatctcaggc agggtgtgcg tcagccctcc aacccccaga ggggcgcctg tggggaggga
     2401 accaggaggc cacactgggg gagcgtgcag ccagcatgtg cagtggccaa ctccaggcca
     2461 gtggaaagtt actgtgtgga tacaggaagg ctctgagtgg ctagcaggac cctcccttgg
     2521 cttcgccctc ctcctcttct ctctcccctg tgctgggagc tccgtctgcc ttgggaaggg
     2581 agacgaggtg tgctgttcct tcccagcccc atccctcccc acccttccta ctcccagctt
     2641 tcaagaaaca ttgcagaagc atttgaagtt ttgttccatc ttggatattt gaagagaaaa
     2701 ggagccaaga actggcgggt ggtgtgtgtg cagcaaaggc attgggggca cgggtgagat
     2761 gcccactgtg tgctggtcta aattaatcca tcgcagtgat cctccagaga cagcgctctg
     2821 ctcatgtccg tagcagaggg aaaagccgag gtgctcagaa aggctcggta atgagtccca
     2881 ggtcatacgg ctagcgagtg gcgggcctgg ggttcagacc cacagctgcc tcaagcaaac
     2941 agggtatcac gcttgcccct gggcctgggt gggggccgga atgagaccac atgagagcgc
     3001 agagaggtgg gtggtcaggc cctgatgtcc tggggatttc ttgtcctcag tgccacccgg
     3061 cctcccgtct ttcctgaaac ccctcgccag attttgcact ctgaggtttc tatcttccag
     3121 acaagagctg ggaggcaaga tttctggttt ctggttccta gcctcactgc cagcgggctc
     3181 ctgctattag gtgagggttt cttgctgtct ggaattcagt ttttccatct gccacatgga
     3241 agttcatagc caggataggg cgggagaggc accagaacat ttctctccac tgactttctc
     3301 acccggttcc caccctcctc cacctcctct cctccgggcc cctcagtttc ctctcctcat
     3361 ctctggcctc agttccagag ggttagcccc agcaccccac tctcctgcca ctgtcagata
     3421 gccttggtca tgcttcctag aatctacttg tccaagttct cctctccctg ggataagtta
     3481 ctgcagaaac tggggattta gaagcttatt cagggctgag tgccaaaagc ttgggggagg
     3541 agggacaggt cctcggcaat aaacagtgtc acacacgcat cacagccatt tgagaaatgg
     3601 cttctttgca gagctgggga agccgggcag aagatgccgc agcctcctac tctgggtcct
     3661 gagggggggt ggcaggtacc acagtgtagg cagcagggtc agggccaaag tctatgcgtt
     3721 ccatctccaa tccaggcagt gaggaatcct gaaacaccag gagaggcgtc agaagtagga
     3781 agggcagggg aacaggaatg caagattaag gaaaccgcag ctgagcaggt gtcacaagct
     3841 gtaaaggagg aagggagtct gcaggccctt cacatttttg gcctgggtgg ggctgggccc
     3901 aggaaggggt gggctggatt ttgtaaagct ggaggcagcc aggaatctga ctgtccggaa
     3961 tgtgagttga ggggtctccc actgaagtcc tcttctggaa gctgcagatg ggggcccggg
     4021 aggcacacac gagtctggga ctcattcccg ggcacaccta tggctccttc ggtatcacct
     4081 ggggaagccc cggaatctta gttcttccat tccctactct tccttccgag ggagtcagga
     4141 tgggacagac acccattttc caaaaggctc cttgcctcct tccctggccc acctgaagcc
     4201 aagtcccagg tgtcctggct gctctcctgg gcggggtggg atttttgcat aagcactttg
     4261 ctgccctcca gtggctgctt gaggaaacgc agggcctggt ttgggagagt caccgagggc
     4321 ccatgtggct ggaggttggg ggcaggatct ggcccgagct ctcctcagac ctccccagac
     4381 ctgtcttctc atcagccacc gctgttttct tttgccgaac gatggttgca tctctcggac
     4441 acagtgtacc ccctcccaag ccctccctga gccgttctcc tgagtccctg agggcagaca
     4501 cagctccagg gacccaggcc agctgccaca cccccgacac tcctgctgtc cactggcctt
     4561 agctcctgca agttccccag tgtccgcacc tgttcccttc cctgacctca ccttcctggg
     4621 gtctgtgact gactggagat aaaaataaaa gcaattgtga cacctga
//
