LOCUS       NM_001033031            1086 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens Fas apoptotic inhibitory molecule (FAIM), transcript
            variant 2, mRNA.
ACCESSION   NM_001033031 XM_005247573
VERSION     NM_001033031.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1086)
  AUTHORS   Kaku,H., Balaj,A.R. and Rothstein,T.L.
  TITLE     Small Heat Shock Proteins Collaborate with FAIM to Prevent
            Accumulation of Misfolded Protein Aggregates
  JOURNAL   Int J Mol Sci 23 (19), 11841 (2022)
   PUBMED   36233145
  REMARK    GeneRIF: Small Heat Shock Proteins Collaborate with FAIM to Prevent
            Accumulation of Misfolded Protein Aggregates.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1086)
  AUTHORS   Han,T., Wang,P., Wang,Y., Xun,W., Lei,J., Wang,T., Lu,Z., Gan,M.,
            Zhang,W., Yu,B. and Wang,J.B.
  TITLE     FAIM regulates autophagy through glutaminolysis in lung
            adenocarcinoma
  JOURNAL   Autophagy 18 (6), 1416-1432 (2022)
   PUBMED   34720024
  REMARK    GeneRIF: FAIM regulates autophagy through glutaminolysis in lung
            adenocarcinoma.
REFERENCE   3  (bases 1 to 1086)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1086)
  AUTHORS   Wang,P., Xun,W., Han,T. and Cheng,Z.
  TITLE     FAIM-S functions as a negative regulator of NF-kappaB pathway and
            blocks cell cycle progression in NSCLC cells
  JOURNAL   Cell Cycle 19 (24), 3458-3467 (2020)
   PUBMED   33249986
  REMARK    GeneRIF: FAIM-S functions as a negative regulator of NF-kappaB
            pathway and blocks cell cycle progression in NSCLC cells.
REFERENCE   5  (bases 1 to 1086)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1086)
  AUTHORS   Segura,M.F., Sole,C., Pascual,M., Moubarak,R.S., Perez-Garcia,M.J.,
            Gozzelino,R., Iglesias,V., Badiola,N., Bayascas,J.R., Llecha,N.,
            Rodriguez-Alvarez,J., Soriano,E., Yuste,V.J. and Comella,J.X.
  TITLE     The long form of Fas apoptotic inhibitory molecule is expressed
            specifically in neurons and protects them against death
            receptor-triggered apoptosis
  JOURNAL   J Neurosci 27 (42), 11228-11241 (2007)
   PUBMED   17942717
  REMARK    GeneRIF: Expression of the long form of Fas apoptotic inhibitory
            molecule (FAIML) results in the protection of neurons from the
            cytotoxic actions of death ligands.
REFERENCE   7  (bases 1 to 1086)
  AUTHORS   Choi,C.Y., Reimers,K., Allmeling,C., Kall,S., Choi,Y.H. and
            Vogt,P.M.
  TITLE     Inhibition of apoptosis by expression of antiapoptotic proteins in
            recombinant human keratinocytes
  JOURNAL   Cell Transplant 16 (6), 663-674 (2007)
   PUBMED   17912957
  REMARK    GeneRIF: Human keratinocytes were transfected with either Flip,
            Faim, or Lifeguard (LFG). Our results suggest that heterotopic
            expression of antiapoptotic proteins can induce the resistance of
            keratinocytes to a major mechanism of rejection.
REFERENCE   8  (bases 1 to 1086)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   9  (bases 1 to 1086)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1086)
  AUTHORS   Schneider,T.J., Fischer,G.M., Donohoe,T.J., Colarusso,T.P. and
            Rothstein,T.L.
  TITLE     A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM)
            isolated from inducibly Fas-resistant B lymphocytes
  JOURNAL   J Exp Med 189 (6), 949-956 (1999)
   PUBMED   10075978
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK125477.1, BQ638715.1 and
            BC012478.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001033031.1.
            
            Summary: The protein encoded by this gene protects against death
            receptor-triggered apoptosis and regulates B-cell signaling and
            differentiation. Several transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2011].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (b)
            has a shorter and distinct N-terminus compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.146362.1, BQ638715.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360570.8/ ENSP00000353775.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               AK125477.1         166-332
            168-227             BQ638715.1         73-132
            228-1086            BC012478.1         88-946
FEATURES             Location/Qualifiers
     source          1..1086
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.3"
     gene            1..1086
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /note="Fas apoptotic inhibitory molecule"
                     /db_xref="GeneID:55179"
                     /db_xref="HGNC:HGNC:18703"
                     /db_xref="MIM:617535"
     exon            1..167
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            168..227
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..789
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /note="isoform b is encoded by transcript variant 2; fas
                     apoptotic inhibitory molecule 1"
                     /codon_start=1
                     /product="fas apoptotic inhibitory molecule 1 isoform b"
                     /protein_id="NP_001028203.1"
                     /db_xref="CCDS:CCDS33865.1"
                     /db_xref="GeneID:55179"
                     /db_xref="HGNC:HGNC:18703"
                     /db_xref="MIM:617535"
                     /translation="MASGDDSPIFEDDESPPYSLEKMTDLVAVWDVALSDGVHKIEFE
                     HGTTSGKRVVYVDGKEEIRKEWMFKLVGKETFYVGAAKTKATINIDAISGFAYEYTLE
                     INGKSLKKYMEDRSKTTNTWVLHMDGENFRIVLEKDAMDVWCNGKKLETAGEFVDDGT
                     ETHFSIGNHDCYIKAVSSGKRKEGIIHTLIVDNREIPEIAS"
     exon            228..360
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            361..589
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            590..639
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..1086
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1067..1072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /note="hexamer: AATAAA"
     polyA_site      1086
                     /gene="FAIM"
                     /gene_synonym="FAIM1"
                     /note="major polyA site"
ORIGIN      
        1 agtcggcgcg tttggtactc gcgcctgcag agctttcaac ctccgcgccg gctgcgcctg
       61 tttctcggcc aggggagcaa ggccacgcgg cctacgcagc cgagtcggaa ccaaccggtt
      121 gtttggtgaa acctacccca gagcctcccg cggcccacag agcacagact gtttttgcca
      181 accatggcat ctggagatga cagtcctatc tttgaagatg atgaaagccc tccttacagc
      241 ctagaaaaaa tgacagatct cgtagctgtt tgggatgttg ctttaagtga cggagtccac
      301 aagatcgaat ttgaacatgg gactacatca ggcaaacgag tagtatatgt agatggaaag
      361 gaagagataa gaaaagagtg gatgttcaaa ttagtgggca aagaaacatt ctatgttgga
      421 gctgcaaaga caaaagcgac cataaatata gacgctatca gtggttttgc ttatgaatat
      481 actctggaaa ttaatgggaa aagtctcaag aagtatatgg aggacagatc aaaaaccacc
      541 aatacttggg tattacacat ggatggtgag aactttagaa ttgttttgga aaaagatgct
      601 atggacgtat ggtgcaatgg taaaaaattg gagacagcgg gtgagtttgt agatgatggg
      661 actgaaactc acttcagtat cgggaaccat gactgttaca taaaggctgt cagtagtggg
      721 aagcggaaag aagggattat tcatactctc attgtggata atagagaaat cccagagatt
      781 gcaagttaat gaattttcat cttaagaagt aaagatcagg actttttaat tactgtggta
      841 attaaatgtg ttcagtatgt acttatcagt acatttagtc tgcaatgttt taatttttta
      901 aaaagttaca tgaaactaac attccaaggg tcaggaaaaa aaccaattat gtatagtcat
      961 aaaaattaca atttatgatg caaataatgt aaaatgtttt aaagacaaat ggcaaataag
     1021 atatggacca aagtcactaa tgttttacaa cagtaacctt tactataata aatactttta
     1081 aaaaaa
//
