LOCUS       NM_014613               4485 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens Fas associated factor family member 2 (FAF2), mRNA.
ACCESSION   NM_014613
VERSION     NM_014613.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4485)
  AUTHORS   Guo,Z. and Liang,J.
  TITLE     Role of ubiquitin regulatory X domain-containing protein 3B in the
            development of hepatocellular carcinoma (Review)
  JOURNAL   Oncol Rep 49 (3) (2023)
   PUBMED   36799187
  REMARK    GeneRIF: Role of ubiquitin regulatory X domaincontaining protein 3B
            in the development of hepatocellular carcinoma (Review).
            Review article
REFERENCE   2  (bases 1 to 4485)
  AUTHORS   Geng,T., Yang,D., Lin,T., Cahoon,J.G. and Wang,P.
  TITLE     UBXN3B Controls Immunopathogenesis of Arthritogenic Alphaviruses by
            Maintaining Hematopoietic Homeostasis
  JOURNAL   mBio 13 (6), e0268722 (2022)
   PUBMED   36377866
  REMARK    GeneRIF: UBXN3B Controls Immunopathogenesis of Arthritogenic
            Alphaviruses by Maintaining Hematopoietic Homeostasis.
REFERENCE   3  (bases 1 to 4485)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 4485)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   5  (bases 1 to 4485)
  AUTHORS   Gwon,Y., Maxwell,B.A., Kolaitis,R.M., Zhang,P., Kim,H.J. and
            Taylor,J.P.
  TITLE     Ubiquitination of G3BP1 mediates stress granule disassembly in a
            context-specific manner
  JOURNAL   Science 372 (6549), eabf6548 (2021)
   PUBMED   34739333
  REMARK    GeneRIF: Ubiquitination of G3BP1 mediates stress granule
            disassembly in a context-specific manner.
REFERENCE   6  (bases 1 to 4485)
  AUTHORS   Ernst,R., Mueller,B., Ploegh,H.L. and Schlieker,C.
  TITLE     The otubain YOD1 is a deubiquitinating enzyme that associates with
            p97 to facilitate protein dislocation from the ER
  JOURNAL   Mol Cell 36 (1), 28-38 (2009)
   PUBMED   19818707
REFERENCE   7  (bases 1 to 4485)
  AUTHORS   Alexandru,G., Graumann,J., Smith,G.T., Kolawa,N.J., Fang,R. and
            Deshaies,R.J.
  TITLE     UBXD7 binds multiple ubiquitin ligases and implicates p97 in
            HIF1alpha turnover
  JOURNAL   Cell 134 (5), 804-816 (2008)
   PUBMED   18775313
REFERENCE   8  (bases 1 to 4485)
  AUTHORS   Mueller,B., Klemm,E.J., Spooner,E., Claessen,J.H. and Ploegh,H.L.
  TITLE     SEL1L nucleates a protein complex required for dislocation of
            misfolded glycoproteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (34), 12325-12330 (2008)
   PUBMED   18711132
REFERENCE   9  (bases 1 to 4485)
  AUTHORS   Fujimoto,Y., Itabe,H., Sakai,J., Makita,M., Noda,J., Mori,M.,
            Higashi,Y., Kojima,S. and Takano,T.
  TITLE     Identification of major proteins in the lipid droplet-enriched
            fraction isolated from the human hepatocyte cell line HuH7
  JOURNAL   Biochim Biophys Acta 1644 (1), 47-59 (2004)
   PUBMED   14741744
REFERENCE   10 (bases 1 to 4485)
  AUTHORS   Imai,Y., Nakada,A., Hashida,R., Sugita,Y., Tanaka,T., Tsujimoto,G.,
            Matsumoto,K., Akasawa,A., Saito,H. and Oshida,T.
  TITLE     Cloning and characterization of the highly expressed ETEA gene from
            blood cells of atopic dermatitis patients
  JOURNAL   Biochem Biophys Res Commun 297 (5), 1282-1290 (2002)
   PUBMED   12372427
  REMARK    GeneRIF: ETEA may play a role in the regulating the resistance to
            apoptosis that is observed in T cells and eosinophils of AD
            patients
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL706430.1, BC014001.2 and
            AC010316.7.
            
            On Nov 22, 2018 this sequence version replaced NM_014613.2.
            
            Summary: The protein encoded by this gene is highly expressed in
            peripheral blood of patients with atopic dermatitis (AD), compared
            to normal individuals. It may play a role in regulating the
            resistance to apoptosis that is observed in T cells and eosinophils
            of AD patients. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.59113.1,
                                           SRR1803611.33592.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261942.7/ ENSP00000261942.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AL706430.1         34-44
            12-2048             BC014001.2         1-2037
            2049-4485           AC010316.7         31279-33715
FEATURES             Location/Qualifiers
     source          1..4485
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.2"
     gene            1..4485
                     /gene="FAF2"
                     /gene_synonym="ETEA; UBXD8; UBXN3B"
                     /note="Fas associated factor family member 2"
                     /db_xref="GeneID:23197"
                     /db_xref="HGNC:HGNC:24666"
                     /db_xref="MIM:616935"
     exon            1..86
                     /gene="FAF2"
                     /gene_synonym="ETEA; UBXD8; UBXN3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1361
                     /gene="FAF2"
                     /gene_synonym="ETEA; UBXD8; UBXN3B"
                     /note="UBX domain containing 8; UBX domain protein 3B;
                     expressed in T-cells and eosinophils in atopic dermatitis;
                     UBX domain-containing protein 8; UBX domain-containing
                     protein 3B"
                     /codon_start=1
                     /product="FAS-associated factor 2"
                     /protein_id="NP_055428.1"
                     /db_xref="CCDS:CCDS34296.1"
                     /db_xref="GeneID:23197"
                     /db_xref="HGNC:HGNC:24666"
                     /db_xref="MIM:616935"
                     /translation="MAAPEERDLTQEQTEKLLQFQDLTGIESMDQCRHTLEQHNWNIE
                     AAVQDRLNEQEGVPSVFNPPPSRPLQVNTADHRIYSYVVSRPQPRGLLGWGYYLIMLP
                     FRFTYYTILDIFRFALRFIRPDPRSRVTDPVGDIVSFMHSFEEKYGRAHPVFYQGTYS
                     QALNDAKRELRFLLVYLHGDDHQDSDEFCRNTLCAPEVISLINTRMLFWACSTNKPEG
                     YRVSQALRENTYPFLAMIMLKDRRMTVVGRLEGLIQPDDLINQLTFIMDANQTYLVSE
                     RLEREERNQTQVLRQQQDEAYLASLRADQEKERKKREERERKRRKEEEVQQQKLAEER
                     RRQNLQEEKERKLECLPPEPSPDDPESVKIIFKLPNDSRVERRFHFSQSLTVIHDFLF
                     SLKESPEKFQIEANFPRRVLPCIPSEEWPNPPTLQEAGLSHTEVLFVQDLTDE"
     exon            87..155
                     /gene="FAF2"
                     /gene_synonym="ETEA; UBXD8; UBXN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            156..290
                     /gene="FAF2"
                     /gene_synonym="ETEA; UBXD8; UBXN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            291..367
                     /gene="FAF2"
                     /gene_synonym="ETEA; UBXD8; UBXN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            368..506
                     /gene="FAF2"
                     /gene_synonym="ETEA; UBXD8; UBXN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            507..592
                     /gene="FAF2"
                     /gene_synonym="ETEA; UBXD8; UBXN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            593..684
                     /gene="FAF2"
                     /gene_synonym="ETEA; UBXD8; UBXN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            685..862
                     /gene="FAF2"
                     /gene_synonym="ETEA; UBXD8; UBXN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1034
                     /gene="FAF2"
                     /gene_synonym="ETEA; UBXD8; UBXN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1178
                     /gene="FAF2"
                     /gene_synonym="ETEA; UBXD8; UBXN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..4485
                     /gene="FAF2"
                     /gene_synonym="ETEA; UBXD8; UBXN3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4459..4464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAF2"
                     /gene_synonym="ETEA; UBXD8; UBXN3B"
                     /note="hexamer: ATTAAA"
     polyA_site      4485
                     /gene="FAF2"
                     /gene_synonym="ETEA; UBXD8; UBXN3B"
                     /note="major polyA site"
ORIGIN      
        1 aggagcgtag aggcggcggc aaaatggcgg cgcctgagga gcgggatcta acccaggagc
       61 agacagagaa gctgctgcag tttcaggatc tcactggcat cgaatctatg gatcagtgtc
      121 gccatacctt ggaacagcat aactggaaca tagaggctgc tgtacaggac agattgaatg
      181 agcaagaggg cgtacctagt gttttcaacc cacctccatc acgacccctg caggttaata
      241 cagctgacca caggatctac agctatgttg tctcaagacc tcaaccaagg gggctgcttg
      301 gatggggtta ttacttgata atgcttccat tccggtttac ctattacacg atacttgata
      361 tatttaggtt tgctcttcgt tttatacggc ctgaccctcg cagccgggtc actgaccccg
      421 ttggggacat tgtttcattt atgcactctt ttgaagagaa atatgggagg gcacaccctg
      481 tcttctacca gggaacgtac agccaggcac ttaacgatgc caaaagggag cttcgctttc
      541 ttttggttta tcttcatgga gatgatcacc aggactctga tgagttttgt cgcaacacac
      601 tctgtgcacc tgaagttatt tcactaataa acactaggat gctcttctgg gcatgctcta
      661 caaacaaacc tgagggatac agggtctcac aggctttacg agagaacacc tatccattcc
      721 tggccatgat tatgctgaag gatcgaagga tgactgtggt gggacggcta gaaggcctca
      781 ttcaacctga tgacctcatt aaccaactga catttatcat ggatgctaac cagacttacc
      841 tggtgtcaga acgcctagaa agggaagaaa gaaaccagac ccaagtgctg agacaacagc
      901 aggatgaggc ctacctggcc tctctcagag ctgaccagga gaaagaaaga aagaaacggg
      961 aggagcggga gcgtaagcgg cggaaggagg aggaggtgca acagcaaaag ttggcagagg
     1021 agagacggcg gcagaattta caggaggaaa aggaaaggaa gttggaatgc ctgccccctg
     1081 aaccttcccc tgatgaccct gaaagtgtca agatcatctt caaattacct aatgattctc
     1141 gagtagagag acgattccac ttttcacagt ctctaacagt aatccacgac ttcttattct
     1201 ccttgaagga aagcccagaa aagtttcaga ttgaagccaa ttttcccagg cgagtgctgc
     1261 cctgcatccc ttcagaggag tggcccaatc cccctacgct acaggaggcc ggactcagcc
     1321 acacagaagt tctttttgtt caggacctaa ctgacgaatg acattttttt cttcctgtcc
     1381 cctcctaccc cagtccctaa aagaaatggg gaaaaaagaa aacaacagca agtcagaaaa
     1441 aaaaaacaag agagagaaat tcatattatt attattatta taatacaata ttttttttaa
     1501 aagactgctg catccttagg aaggatcaga aaccatgctg cccgtaagag tcacaacctg
     1561 tgtgtgcgcg caaggttagc aacaaacgta cccgcttggc aagcccaccc ttcctgtggc
     1621 ctctgtgcac gcaccttcca gtgaacagag actcttcacc ttcgacccat ccattgtccc
     1681 agctgggaag gggacattcc cactagttct cattcattct tgcttttatg aaaaataaaa
     1741 gtgaaaaacc tccatcaacc agctacttgc agcatctcct gaggacttgc ttctcctgcc
     1801 tctggggaag agagggaaga gaaagcacag agcagagaag cagagatgtt ccttgaactg
     1861 cccacaagtt ttcaataact tttatttctg ttttgtaatg accaaaggaa tgaggctgac
     1921 ataggtatat atatatattt ttttccttta tttgataaag agccaattct ttaaacccat
     1981 gagtttatgc cctgggctcc ttagcccaca atagtgtaat aaaagtgccc cgggctggtt
     2041 tgtgcttatt tctgccattg tccctctcac gttcccagag aggtcattct ttttggtcca
     2101 actcttgctg tcctttctta ccacctgtgc accccacttg gagcagtggg aggaaatctg
     2161 ggtttgtggc cccacaaagg ctgtatatgt aaagatacac ctatgtatgt ggtggaactc
     2221 acctttacac acaactgcag cttttccttg gagtctgtac caggtggtgg ttatggggtc
     2281 tgaaccaaag gatagcagct cttcattcct cttctgacat gtgcatgctg ctccccccag
     2341 ccctgggctt tcctgaattg ccaagcctgg tgcctttcca aaggactagc agggcctgtg
     2401 gtggagccag cagaaccaca ggagagtgcc ctgcctgtct cagtggaagt gtattattgt
     2461 tttaaggata gaaccagagg ccttgaaggg agccaagaca gaactcccag cctgtgtaat
     2521 ctattggaag gcacattttc atttctgatg cagccacctt ctggaggcag cttttatcct
     2581 ttctctctat tgctatgttg aagtaatagg gtttttttta acctctggat gtctcgtctg
     2641 tggttgagtt tatggtaatg ggtacatggg tcaggccatg tattaacaga tgccagtgcg
     2701 ctctgacaag tattccaaag tgttctgtag ctagactggt gcaggctcgt tgtaccactg
     2761 caaccgactg acgttactgt agttcctaga atgctgtgag ggcggggggt tcagatcaac
     2821 ataaagccta acttgctgga gttgtagtct caaggctttc tctcttgctt aactaaaacc
     2881 taaggaccac tgtttttggt agcaattata tggttactat ccactgcagt cctcagttgt
     2941 tggggtaaat cccacatggc agagtaaggc accccacaga aattaacttg gagagcctga
     3001 gaaattccca gtggccttgg catagctgtc tagaacacca tctctaggaa aatttaattc
     3061 tgtccctggc cagctattgt tcttccactt cgttttctgc tgtcccaagg ccagatgagt
     3121 ggaatcacca tctgactgct gtcaataaaa tgtatctggc gtgaacagca ggataaccca
     3181 tgttctccac ataaggataa ccttacgtga aaccttcctg ctgacaacca tgcagaggaa
     3241 tttttccact taagtcagag ccttcctccc catctggaat tcacagctgt tccctggcag
     3301 cacacaggag ggtattaagg acctttgtga ggctaggtac actgtccaca cctctttggg
     3361 gaagttacga tttttttttt ccatcataat tcagtctctt cttattctac agtgtgcact
     3421 ttatgcctct cgccttttga taatagttgt tcagtgaagg aagtcagctg ccagaatatt
     3481 aagaagggtc tccctttatg tcagtacaac tgttagggcg gccttcccat ttactttagg
     3541 tttcaagagg attcaccgga agcacatgcc ccggtctagt cccatttgaa acagttctgc
     3601 tttactgaga ccctaggccg gtctccttgc tgaccctagc gctgctgcct aggtgccatt
     3661 tcctttcctc ctcagtcaaa tacaggctgc acattttgtc acttaatgcc agtacaatct
     3721 gtgttactcc taaggacttt tgggattttg atgagacctg cgagggagaa gacactgaga
     3781 agccagtgat ctgcaagcat ttgctcttgt ttccacatca cctctgggat atttcagctg
     3841 ttgtttccaa atggcaaatc atcaactaaa agcacttgtt tcaagttttg ttctgcactc
     3901 ccacgactga agttgtagat tgagctgaat aaccatggga agtgaccaag caaagacact
     3961 cgattggagt cagttgaata tttgtaccct cagtggagcc cttctggtct tttcttccac
     4021 ttctgcagaa tttcctctag caaatacttc tttctccttg cttgcctcca ccatgatatt
     4081 tgaataagag atggccagag gataacactt gtctcttaaa aactaagcta aaaagaacct
     4141 agaaccttca attgagcagt tgtgaaaatt gctaatggtg ccaaggccaa gcaaagagtt
     4201 tcagaaaatg actgagaagg agcgataacc cccagaatgc aaaatcaggg gcatcattat
     4261 ccggtgcttg aacaaggagc tccgctctac aactggtttt tttaggactt gtgaggaaca
     4321 cagcaacgga aatccatcca caaaggatgc agtgccccaa cttgtactgc gcctgaatag
     4381 tcatgtgata atttactgaa gaaatctagt gtactttaaa tttttttcat aaaagtttac
     4441 attgtattgt aggttaacat taaatgtttt atagcaaaaa cttca
//
