LOCUS       NM_007051               6821 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens Fas associated factor 1 (FAF1), mRNA.
ACCESSION   NM_007051
VERSION     NM_007051.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6821)
  AUTHORS   Sun,J.L., Shi,J.Y., Yin,B., Lin,Y.S., Shi,B. and Jia,Z.L.
  TITLE     Association analysis of SNPs in GRHL3, FAF1, and KCNJ2 with NSCPO
            sub-phenotypes in Han Chinese
  JOURNAL   Oral Dis 28 (8), 2204-2214 (2022)
   PUBMED   34255421
  REMARK    GeneRIF: Association analysis of SNPs in GRHL3, FAF1, and KCNJ2
            with NSCPO sub-phenotypes in Han Chinese.
REFERENCE   2  (bases 1 to 6821)
  AUTHORS   Franz,A., Valledor,P., Ubieto-Capella,P., Pilger,D., Galarreta,A.,
            Lafarga,V., Fernandez-Llorente,A., de la Vega-Barranco,G., den
            Brave,F., Hoppe,T., Fernandez-Capetillo,O. and Lecona,E.
  TITLE     USP7 and VCPFAF1 define the SUMO/Ubiquitin landscape at the DNA
            replication fork
  JOURNAL   Cell Rep 37 (2), 109819 (2021)
   PUBMED   34644576
  REMARK    GeneRIF: USP7 and VCP(FAF1) define the SUMO/Ubiquitin landscape at
            the DNA replication fork.
REFERENCE   3  (bases 1 to 6821)
  AUTHORS   Gao,F.F., Quan,J.H., Choi,I.W., Lee,Y.J., Jang,S.G., Yuk,J.M.,
            Lee,Y.H. and Cha,G.H.
  TITLE     FAF1 downregulation by Toxoplasma gondii enables host IRF3
            mobilization and promotes parasite growth
  JOURNAL   J Cell Mol Med 25 (19), 9460-9472 (2021)
   PUBMED   34464509
  REMARK    GeneRIF: FAF1 downregulation by Toxoplasma gondii enables host IRF3
            mobilization and promotes parasite growth.
REFERENCE   4  (bases 1 to 6821)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 6821)
  AUTHORS   Park,G., Kim,B.S. and Kim,E.
  TITLE     A novel function of FAF1, which induces dopaminergic neuronal death
            through cell-to-cell transmission
  JOURNAL   Cell Commun Signal 18 (1), 133 (2020)
   PUBMED   32831099
  REMARK    GeneRIF: A novel function of FAF1, which induces dopaminergic
            neuronal death through cell-to-cell transmission.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6821)
  AUTHORS   Buchberger,A., Howard,M.J., Proctor,M. and Bycroft,M.
  TITLE     The UBX domain: a widespread ubiquitin-like module
  JOURNAL   J Mol Biol 307 (1), 17-24 (2001)
   PUBMED   11243799
REFERENCE   7  (bases 1 to 6821)
  AUTHORS   Ryu,S.W., Chae,S.K., Lee,K.J. and Kim,E.
  TITLE     Identification and characterization of human Fas associated factor
            1, hFAF1
  JOURNAL   Biochem Biophys Res Commun 262 (2), 388-394 (1999)
   PUBMED   10462485
REFERENCE   8  (bases 1 to 6821)
  AUTHORS   Kusk,M., Ahmed,R., Thomsen,B., Bendixen,C., Issinger,O.G. and
            Boldyreff,B.
  TITLE     Interactions of protein kinase CK2beta subunit within the
            holoenzyme and with other proteins
  JOURNAL   Mol Cell Biochem 191 (1-2), 51-58 (1999)
   PUBMED   10094392
REFERENCE   9  (bases 1 to 6821)
  AUTHORS   Juo,P., Kuo,C.J., Yuan,J. and Blenis,J.
  TITLE     Essential requirement for caspase-8/FLICE in the initiation of the
            Fas-induced apoptotic cascade
  JOURNAL   Curr Biol 8 (18), 1001-1008 (1998)
   PUBMED   9740801
REFERENCE   10 (bases 1 to 6821)
  AUTHORS   Chu,K., Niu,X. and Williams,L.T.
  TITLE     A Fas-associated protein factor, FAF1, potentiates Fas-mediated
            apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 92 (25), 11894-11898 (1995)
   PUBMED   8524870
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359977.16, BC004970.1,
            AL049637.44 and KF495936.1.
            
            On Nov 23, 2018 this sequence version replaced NM_007051.2.
            
            Summary: Interaction of Fas ligand (TNFSF6) with the FAS antigen
            (TNFRSF6) mediates programmed cell death, also called apoptosis, in
            a number of organ systems. The protein encoded by this gene binds
            to FAS antigen and can initiate apoptosis or enhance apoptosis
            initiated through FAS antigen. Initiation of apoptosis by the
            protein encoded by this gene requires a ubiquitin-like domain but
            not the FAS-binding domain. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.133155.1,
                                           SRR1803614.56116.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396153.7/ ENSP00000379457.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL359977.16        63178-63180         c
            4-2586              BC004970.1         1-2583
            2587-4658           AL049637.44        80936-83007
            4659-4976           KF495936.1         1-318
            4977-6821           AL049637.44        83326-85170
FEATURES             Location/Qualifiers
     source          1..6821
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..6821
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /note="Fas associated factor 1"
                     /db_xref="GeneID:11124"
                     /db_xref="HGNC:HGNC:3578"
                     /db_xref="MIM:604460"
     exon            1..501
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..2409
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /note="UBX domain protein 3A; TNFRSF6-associated factor 1;
                     UBX domain-containing protein 12; UBX domain-containing
                     protein 3A; Fas (TNFRSF6) associated factor 1"
                     /codon_start=1
                     /product="FAS-associated factor 1"
                     /protein_id="NP_008982.1"
                     /db_xref="CCDS:CCDS554.1"
                     /db_xref="GeneID:11124"
                     /db_xref="HGNC:HGNC:3578"
                     /db_xref="MIM:604460"
                     /translation="MASNMDREMILADFQACTGIENIDEAITLLEQNNWDLVAAINGV
                     IPQENGILQSEYGGETIPGPAFNPASHPASAPTSSSSSAFRPVMPSRQIVERQPRMLD
                     FRVEYRDRNVDVVLEDTCTVGEIKQILENELQIPVSKMLLKGWKTGDVEDSTVLKSLH
                     LPKNNSLYVLTPDLPPPSSSSHAGALQESLNQNFMLIITHREVQREYNLNFSGSSTIQ
                     EVKRNVYDLTSIPVRHQLWEGWPTSATDDSMCLAESGLSYPCHRLTVGRRSSPAQTRE
                     QSEEQITDVHMVSDSDGDDFEDATEFGVDDGEVFGMASSALRKSPMMPENAENEGDAL
                     LQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHDESVLTNVFCS
                     QMLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPL
                     FLIIMGKRSSNEVLNVIQGNTTVDELMMRLMAAMEIFTAQQQEDIKDEDEREARENVK
                     REQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALPPEPK
                     EENAEPVSKLRIRTPSGEFLERRFLASNKLQIVFDFVASKGFPWDEYKLLSTFPRRDV
                     TQLDPNKSLLEVKLFPQETLFLEAKE"
     exon            502..570
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /inference="alignment:Splign:2.1.0"
     exon            571..617
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /inference="alignment:Splign:2.1.0"
     exon            618..823
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /inference="alignment:Splign:2.1.0"
     exon            824..915
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1007
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1113
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1200
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1296
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1423
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1487
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1569
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1724
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1861
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1950
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2031
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2109
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2325
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..6821
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2557..2562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /note="hexamer: AATAAA"
     polyA_site      2584
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /note="major polyA site"
     regulatory      4352..4357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /note="hexamer: AATATA"
     polyA_site      4376
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
     regulatory      4390..4395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /note="hexamer: ATTAAA"
     polyA_site      4410
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
     regulatory      6800..6805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
                     /note="hexamer: AATAAA"
     polyA_site      6821
                     /gene="FAF1"
                     /gene_synonym="CGI-03; hFAF1; HFAF1s; UBXD12; UBXN3A"
ORIGIN      
        1 aaccaggggc ggaggcggcg gccagggagg aagcggagga ggcggaggcg gccgcggcgt
       61 tcgcccgccc gctcgctcgc tcggtttccc cgcccccgcc gggcttaacg ccgctgaagg
      121 tatccgggtg cgcgctgtcg caacctgccc tcatcctggc ccgcgactgt aagaccggac
      181 ccacatccag accaatcttc ctgtccgggc tgctgcgacg cgggctccgc aggttgcagg
      241 cgggcggccg gggcgcctga aggttaccga gtgcatgagc gcctagcgct tcccgcgctg
      301 ccccgcccgc tggcccgccg acccgcccgc cggctcgccc gccagcccct cggcgcccgg
      361 cggcggcggc ggcggtggcg gcgacggtcg caggaggtgc cgtctgcctc ccaggtgcgc
      421 gcttcgctcc cggagccgcg gaactcggcg gccgccatgg cgtccaacat ggaccgggag
      481 atgatcctgg cggattttca ggcatgtact ggcattgaaa acattgacga agctattaca
      541 ttgcttgaac aaaataattg ggacttagtg gcagctatca atggtgtaat accacaggaa
      601 aatggcattc tacaaagtga atatggaggt gagaccatac caggacctgc atttaatcca
      661 gcaagtcatc cagcttcagc tcctacttcc tcttcttctt cagcgtttcg acctgtaatg
      721 ccatccaggc agattgtaga aaggcaacct cggatgctgg acttcagggt tgaatacaga
      781 gacagaaatg ttgatgtggt acttgaagac acctgtactg ttggagagat taaacagatt
      841 ctagaaaatg aacttcagat acctgtgtcc aaaatgctgt taaaaggctg gaagacggga
      901 gatgtggaag acagtacggt cctaaaatct ctacacttgc caaaaaacaa cagtctttat
      961 gtccttacac cagatttgcc accaccttca tcatctagtc atgctggtgc cctgcaggag
     1021 tcattaaatc aaaacttcat gctgatcatc acccaccgag aagtccagcg ggagtacaac
     1081 ctgaacttct caggaagcag tactattcaa gaggtaaaga gaaatgtgta tgaccttaca
     1141 agtatccccg ttcgccacca attatgggag ggctggccaa cttctgctac agacgactca
     1201 atgtgtcttg ctgaatcagg gctctcttat ccctgccatc gacttacagt gggaagaaga
     1261 tcttcacctg cacagacccg ggaacagtcg gaagaacaaa tcaccgatgt tcatatggtt
     1321 agtgatagcg atggagatga ctttgaagat gctacagaat ttggggtgga tgatggagaa
     1381 gtatttggca tggcgtcatc tgccttgaga aaatctccaa tgatgccaga aaacgcagaa
     1441 aatgaaggag atgccttatt acaatttaca gcagagtttt cttcaagata tggtgattgc
     1501 catcctgtat tttttattgg ctcattagaa gctgcttttc aagaggcctt ctatgtgaaa
     1561 gcccgagata gaaagcttct tgctatctac ctccaccatg atgaaagtgt gttaaccaac
     1621 gtgttctgct cacaaatgct ttgtgctgaa tccattgttt cttatctgag tcaaaatttt
     1681 ataacctggg cttgggatct gacaaaggac tccaacagag caagatttct cactatgtgc
     1741 aatagacact ttggcagtgt tgtggcacaa accattcgga ctcaaaaaac ggatcagttt
     1801 ccgcttttcc tgattattat gggaaagcga tcatctaatg aagtgttgaa tgtgatacaa
     1861 gggaacacaa cagtagatga gttaatgatg agactcatgg ctgcaatgga gatcttcaca
     1921 gcccaacaac aggaagatat aaaggacgag gatgaacgtg aagccagaga aaatgtgaag
     1981 agagagcaag atgaggccta tcgcctttca cttgaggctg acagagcaaa gagggaagct
     2041 cacgagagag agatggcaga acagtttcgt ttggagcaga ttcgcaaaga acaagaagag
     2101 gaacgtgagg ccatccggct gtccttagag caagccctgc ctcctgagcc aaaggaagaa
     2161 aatgctgagc ctgtgagcaa actgcggatc cggaccccca gtggcgagtt cttggagcgg
     2221 cgtttcctgg ccagcaacaa gctccagatt gtctttgatt ttgtagcttc caaaggattt
     2281 ccatgggatg agtacaagtt actgagcacc tttcctagga gagacgtaac tcaactggac
     2341 ccaaataaat cattattgga ggtaaagttg ttccctcaag aaaccctttt ccttgaagca
     2401 aaagagtaaa cacggcccag cggtggaacc agccattcct tgacaagcca gcagcctgcg
     2461 tcaggagaag ggctcctcgc caacccaccc acacgctcgt ctcactcaat tcaatgtcac
     2521 acttctgcct cttgcaaaat tgctggaaaa agtaataata aatatagcta cttaagattt
     2581 cccatccatg agtatatatt cccaaccctt attacagaga attacaactc tgccaccctc
     2641 ccctaccccc tgcacttcac cctccttcaa tgacgaatgc attgttcaag tgtgagtgat
     2701 cactaaatag aatttttacc tctccagtgc ccatcttttc cccacagtgt ctaggacagt
     2761 tctgtctgtt ctgtgacacc aggatgctgt atatttgata tatgtctttt tattttcatg
     2821 actgaatttc tacttcatca cctaatttta aggggcagag ggaaaaaaag tcaaatgaga
     2881 cattgtcggc atggagatta aacattgtag gaaaaaagta taccattttt gttagaactt
     2941 tctgatggct ttactaagat gtcaggtttt gtttgaggac tgaatttgac atatatgcaa
     3001 gatatttatt tactgctgct gccttgggtc tccaggttct acctaggagg tatttgctgt
     3061 tccattgcag catagggaaa ctgttcaagc acacaatgtg aatgttgaga tcatgtgcag
     3121 agaggccagt accaaaactt cagtatctgg cccaatggca agaggctact gttaggtttg
     3181 catttgggca gttagaacct cacagatacc agctcccaag ttgctagtcc atcagtgtaa
     3241 actgaacaca attctctctt gctttctctc tctctactcc ctcacacatt tggaccttgt
     3301 cacttggtgt ttaagcacct tgcctatcaa caaaatctga tgagcagccc catggactct
     3361 cctgtaataa ggaacttgct ctactatttt attcttttaa tgttttagta tttgatattg
     3421 gactcaaatg aaagggatct cattctgtgg ctgaaaaatc agacttcata tgttgaagag
     3481 agcaaacttg gggactcaac tcagaagaca tgtgttgcct gaaacctgca tataataatt
     3541 tttgatttga tttagtaagt gtggattttt cttaatctac agatttgggg tttggggttt
     3601 agatcatgag aacaccgttt ataccttcac agccaatgat ttatttttag tcttgaaata
     3661 tttctccata tctgtttttg tgtcacctgt gggttttatc ctaggggttg ggatcctgat
     3721 tttaacattt tgtacttgtc caaaaaagag ttcaaatgct gggtttgttc ccccagcctc
     3781 ggccaagggg ttctcagaag attctaacca aagctggaga taggtctgct cattttcctt
     3841 ctgcccagaa gtggatgttg gccaggaaaa ttacaccttg tgtcttctct gatgctccaa
     3901 ccagggacct ctccagatta ctatctagca cagactagtg ctacatctgc ctaggtatgg
     3961 gctttctctg gcagcagggg tctctctagg gaggctgaga gacccatggg tctcccttca
     4021 ggggaagtgt tcaggggagt tcaaactgaa cacttctctc cagctctatt cctatcttcc
     4081 taatctaatg gctctacaag atagtcattt ccagtgctac agatgcacca gggcaccacc
     4141 tctttttttt tctaggtaga ccttgttctg tagctgctgt gaagaagctg cagccctgaa
     4201 ctcaggtcat actcaggaac agcagcaggg gtgtgggtgg ggtttgaggg aaggtactct
     4261 gaattcacct tcatgtttaa cctgttccat ctgacttggg tttcttcatt atattgttcc
     4321 ctcccactca ccttcacttc tgtattacaa caatatagac tttactctaa agccaatttc
     4381 atggaagtta ttaaatgcta cttgaatgtg tgtgaagttg atacaacctt tttcaacctg
     4441 ccttagaaag ttcttttggc ctactcagcc ccatgatttc ctatgctcta ggcctcataa
     4501 ctgggaaagg cctcagctaa ttgtcactgt tcactcagga catgatggtc tactaagctt
     4561 cagacaaaag gccaaagcaa ttttatcctt ttcatacaag cagagcatta aaatgacttc
     4621 ccatcaccac agaaatagca gtgtcctctg cagttcttcc tcctaccatt aggcttcctt
     4681 gggctttaca tcccagcctc caggcccagt aagtgagtca gtctgaatat ttgcttggca
     4741 ttcttatgcc caactgttga cagtgaagct ccaggactct ttgtcatccc ccattccagt
     4801 ttactccctt gtgttcttgg actgctggat gtgcagttgc agcattagtt tgaaagttaa
     4861 aggaagtgtt gccaatttcc cattgccttt aagaaggtgc agggattttt ttggaggttt
     4921 ctgatttcgg atgttgccat tctctggcac tactagtttt atagcacaca cagatgttca
     4981 tctctggatt gtaagcatcc agaatcaaag atgaatgaga gcatctttta tggaatctac
     5041 ctttttaaca taagagagta agatttatgc ttttatagat tttacttgct gctgacatta
     5101 gaaacatatt agtcacataa taacatctaa gtgtgctggt cagtagaata ggtttttaag
     5161 aggtggagag ctctggcaaa tttcccccaa agtatagact ttttcatttg aatgtgggag
     5221 agggtcttaa ttctctccac aacagcatca ctgattgaca catttctacc catccttttc
     5281 tgtcccttag ccatccagtc ctgggtcccc acaagtggat gggacttgga gtctttagtt
     5341 cagtccagga gtaactcata taggcattgc acattatagt ctgtgtaacc ctttcacctg
     5401 tattttctct tttgatcctt tttaaaattc ttagaggaag agagatcttc acatacatat
     5461 aaccacagcc acatacacac acattccaga gacttcagtg tcttccaagt tgaacctctc
     5521 ttctgccact tagtagctgc gtgaccttaa ggtaagtaac ctctctgaac ctcagtgtcc
     5581 ttacaacatt ctgatagcac tttgcaattg gacacacctt tcacacatca taatagtctc
     5641 ccgctatgag ggaagcaggg cagagatgat gattccattt ttgcacaagg ggcttagagg
     5701 atagtggctt gcctaaaatc acacagcatg tcagtagaag ggtcaggact taaagtgcta
     5761 actctaattt tccactgctt gtctacaaag aatctctaat tttttttttt tttttttttt
     5821 ttttttgaga cagagtctcg ctctgtcgct caggctagag tgcagtggca cgatctcggc
     5881 tcactgcaac ctccatctcc tgggctcaag cagttctcct gcctcagcct ctcaagtagc
     5941 tgggattaca ggcatgtgcc accatgccca gctaattttt gtatttttag tagagacagg
     6001 gtttcaccat gttggccagg ctggtctaga actcctgacc tcaggtaatc ggcccacctc
     6061 agcctcccaa agtgccaggg ttacaggcgt gagccacggc gcccggccaa gaatctctaa
     6121 attttatatt caagaacgga tcttggaatc ctctacagtt gtacataaaa agttaaacat
     6181 cactttggga ggcaaaggca ggaggattgc ttgaggccag aagttcaaga ccagccctga
     6241 ccacatacca agaccctgtc tctaaaaaaa taaataaata aaaaataaaa cttttcatta
     6301 gccaggcatg ctggtacttg cctgtagtcc cagctactgt tgaggctgag gcaaagtgat
     6361 cacttgagcc caggagttca aggctacagt gagccatgat agtgcgactg ctactctggc
     6421 ctaggcatca gagtaagacc tcatctcttt aaaaaaaaaa aaaaaagaaa ggttaaacat
     6481 gtattttcct ggaaagggaa tctgtattca tcagattctc agtgggacct attgatcaaa
     6541 aaattttaag aatcaccatt tacgtcatcc tatttgggga gaagaatctg tccattcttt
     6601 ttatcaatcc gtatttttat ctaaaagaaa cctccagagg atgaaataca atcactagac
     6661 tttcttgcct tgaatatctc tgcatttagt attttgtcct tgtctcaaat aatctgcttt
     6721 ggaaggtgac acttaacccc aactggccac acagctcctc actgttgcat tttgaaagtt
     6781 tggtctgaaa gaaaatatta ataaaagaga catgatctcc a
//
