LOCUS       NM_178128               2174 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens fatty acid desaturase 6 (FADS6), mRNA.
ACCESSION   NM_178128 XM_006721820
VERSION     NM_178128.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2174)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC117230.1, AC087651.19 and AY203929.1.
            
            On May 17, 2019 this sequence version replaced NM_178128.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY203929.1, SRR3476690.711820.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000612771.5/ ENSP00000481684.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1243              BC117230.1         8-1250
            1244-1978           AC087651.19        24487-25221         c
            1979-2174           AY203929.1         1965-2160
FEATURES             Location/Qualifiers
     source          1..2174
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..2174
                     /gene="FADS6"
                     /gene_synonym="FP18279"
                     /note="fatty acid desaturase 6"
                     /db_xref="GeneID:283985"
                     /db_xref="HGNC:HGNC:30459"
                     /db_xref="MIM:620577"
     exon            1..282
                     /gene="FADS6"
                     /gene_synonym="FP18279"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1145
                     /gene="FADS6"
                     /gene_synonym="FP18279"
                     /EC_number="1.14.19.-"
                     /note="fatty acid desaturase domain family, member 6"
                     /codon_start=1
                     /product="fatty acid desaturase 6"
                     /protein_id="NP_835229.3"
                     /db_xref="CCDS:CCDS54163.2"
                     /db_xref="GeneID:283985"
                     /db_xref="HGNC:HGNC:30459"
                     /db_xref="MIM:620577"
                     /translation="MEPTEPMEPTEPMEPTEPMEPTEPMEPTEPMEPARSAHRGGEAL
                     LRELEVLVQDVVRTSSWWERHGVDCAILALSLFALPAGFLCLRWENALVFASGITILG
                     VCHYTLTVKGSHLATHGALTESKRWSKIWLLFFVEVCTAFTAEHATHGHVKMHHAYTN
                     VVGLGDSSTWRLPCLNRYVYMFLAPFLLPIATPLVAVERLRKVELGTALRTLALISLG
                     LYSHYWLLLNVSGFKNPSSALGCMFLTRSLLAHPYLHVNIFQHIGLPMFSRDNKPRRI
                     HMMSLGVLNLARLPVLDWAFGHSIISCHVEHHLFPRLSDNMCLKVKPVVSQFLREKQL
                     PYNEDSYLARFQLFLRRYEEFMVQAPPITELVGL"
     exon            283..449
                     /gene="FADS6"
                     /gene_synonym="FP18279"
                     /inference="alignment:Splign:2.1.0"
     exon            450..630
                     /gene="FADS6"
                     /gene_synonym="FP18279"
                     /inference="alignment:Splign:2.1.0"
     exon            631..818
                     /gene="FADS6"
                     /gene_synonym="FP18279"
                     /inference="alignment:Splign:2.1.0"
     exon            819..998
                     /gene="FADS6"
                     /gene_synonym="FP18279"
                     /inference="alignment:Splign:2.1.0"
     exon            999..2174
                     /gene="FADS6"
                     /gene_synonym="FP18279"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcctccgt gcgcgtcggg cccgagccca cagagtccat ggaacccacg gagccgatgg
       61 aacctacgga gcccatggaa cctacggagc ccatggaacc tacggagccc atggaaccta
      121 cggagcccat ggaaccggcg cggagcgcgc accgtggggg cgaggcgctg ctgcgggagc
      181 tggaggtgct ggtgcaggac gtggtgagga cgagctcctg gtgggagcgc cacggcgtgg
      241 actgcgccat cctcgcgctc agcctcttcg ccttgccggc aggcttcctg tgcctgcgct
      301 gggagaatgc cctggtcttt gcatccggca tcaccatctt gggtgtgtgc cactacacac
      361 tcactgtcaa gggcagccac ctggccactc atggggccct caccgagtcc aaacgctgga
      421 gcaagatctg gctgcttttc tttgtggagg tgtgcacagc cttcactgca gagcacgcca
      481 cgcatgggca cgtcaagatg caccatgcct acaccaacgt ggtgggcctg ggggactcca
      541 gcacgtggag gctgccttgc ctcaaccgct atgtctacat gttccttgct cctttcctcc
      601 tccccatcgc cactccactg gtggctgtcg agcggctgag gaaggtggag ctcgggacag
      661 ccctgcggac gctggccctg atttctctgg gcctttattc tcactactgg ctgctcctga
      721 acgtgtcagg cttcaagaac cccagctcag ccctgggctg catgttcctc accagatccc
      781 tgttggccca cccctacctc cacgtcaaca tcttccagca catcggactg cccatgttct
      841 cccgggacaa caagccccgt cggattcaca tgatgagcct gggggtgctt aacctggccc
      901 ggctgcccgt gctggactgg gcgttcggcc actcgatcat cagctgccat gtggaacacc
      961 atctattccc caggctctct gataacatgt gcctgaaggt gaagcccgtg gtgtcccagt
     1021 tcctacgtga gaagcagcta ccgtacaacg aggactcata cctggctcgc ttccagctgt
     1081 ttctccgtcg ctatgaggaa ttcatggtgc aggccccacc catcactgag cttgtggggc
     1141 tgtaatgagg ccgggccggt gcagccaccc tgcccctccc tggcctggcc ctggccctcc
     1201 tgctgctgct ggtccagggg gtgtggctca gtggctggtg gtggacctgg agagtggagg
     1261 caccggccag gcaggggggc aggggagctc aggcctgggg tctgggggcc acctgccttg
     1321 cgtgcttttc tgggttttga ggggtgtctg ggtgaagcgg taatggtggc tgtgcattct
     1381 ggtcagtctg gacctcagca acttcatctc aggactaaag agctgggtcc ttccccctgc
     1441 tccatctgag ccttggtagg gttaaaggga ggtgacaggg tgaagaggga tcctgtgcag
     1501 gggccacctg ggagatagca gggggcacag agagaacagg gtcagctccc tcggctggga
     1561 cctccctggc attgggagag ccccacacgg ccttggctat tgcttccttc aggctctgcc
     1621 caccaaggtg ccctctcccc ggggacctta gggtgagctt gcttttggca ggccttcctc
     1681 gatcctcagc caaaggaacc tgtgcaagac actggctcag cagttcccca ggccacagta
     1741 tcagcaagat aaaagtgagt gtgttttgtc gggagggaac tccaggggaa gtgaggggag
     1801 aaggttcccc agggacagag ttagggaaag agtataaata gccagccagg ggcggtggct
     1861 catgcctgta atcccagcac tttgggaggc caaggcgggt ggatcgcgag atcaggagct
     1921 cgagaccacc ctggccaaca tggtgaaacc ccgtctctac taaaaataca aaaaattagc
     1981 tggatgtggt ggcatacact tgtagtccca gctacttggc aggctgaggc agaagaatca
     2041 cctgaacccg ggaggtggag gttgcagtga gccaagattg caccattgca ttccagcctg
     2101 ggtgacagag cgagactcca tctcaaaaaa ataaaaaaat aaaaaataag actcccgttc
     2161 aaaaaaaaaa aaaa
//
