LOCUS       NM_001446                785 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens fatty acid binding protein 7 (FABP7), transcript
            variant 1, mRNA.
ACCESSION   NM_001446
VERSION     NM_001446.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 785)
  AUTHORS   Hamilton,H.L., Kinscherf,N.A., Balmer,G., Bresque,M., Salamat,S.M.,
            Vargas,M.R. and Pehar,M.
  TITLE     FABP7 drives an inflammatory response in human astrocytes and is
            upregulated in Alzheimer's disease
  JOURNAL   Geroscience 46 (2), 1607-1625 (2024)
   PUBMED   37688656
  REMARK    GeneRIF: FABP7 drives an inflammatory response in human astrocytes
            and is upregulated in Alzheimer's disease.
REFERENCE   2  (bases 1 to 785)
  AUTHORS   Liu,R.Z., Choi,W.S., Jain,S., Xu,X., Elsherbiny,M.E.,
            Glubrecht,D.D., Tessier,A.G., Easaw,J.C., Fallone,B.G. and
            Godbout,R.
  TITLE     Stationary-to-migratory transition in glioblastoma stem-like cells
            driven by a fatty acid-binding protein 7-RXRalpha neurogenic
            pathway
  JOURNAL   Neuro Oncol 25 (12), 2177-2190 (2023)
   PUBMED   37499046
  REMARK    GeneRIF: Stationary-to-migratory transition in glioblastoma
            stem-like cells driven by a fatty acid-binding protein 7-RXRalpha
            neurogenic pathway.
REFERENCE   3  (bases 1 to 785)
  AUTHORS   Holst,C.B., Brochner,C.B., Vitting-Seerup,K. and Mollgard,K.
  TITLE     The HOPX and BLBP landscape and gliogenic regions in developing
            human brain
  JOURNAL   J Anat 243 (1), 23-38 (2023)
   PUBMED   36794762
  REMARK    GeneRIF: The HOPX and BLBP landscape and gliogenic regions in
            developing human brain.
REFERENCE   4  (bases 1 to 785)
  AUTHORS   Umaru,B.A., Kagawa,Y., Ohsaki,Y., Pan,Y., Chen,C.T., Chen,D.K.,
            Abe,T., Shil,S.K., Miyazaki,H., Kobayashi,S., Maekawa,M.,
            Yamamoto,Y., Wannakul,T., Yang,S., Bazinet,R.P. and Owada,Y.
  TITLE     Oleic acid-bound FABP7 drives glioma cell proliferation through
            regulation of nuclear lipid droplet formation
  JOURNAL   FEBS J 290 (7), 1798-1821 (2023)
   PUBMED   36325660
  REMARK    GeneRIF: Oleic acid-bound FABP7 drives glioma cell proliferation
            through regulation of nuclear lipid droplet formation.
REFERENCE   5  (bases 1 to 785)
  AUTHORS   Lock,F.E., Rebollo,R., Miceli-Royer,K., Gagnier,L., Kuah,S.,
            Babaian,A., Sistiaga-Poveda,M., Lai,C.B., Nemirovsky,O.,
            Serrano,I., Steidl,C., Karimi,M.M. and Mager,D.L.
  TITLE     Distinct isoform of FABP7 revealed by screening for
            retroelement-activated genes in diffuse large B-cell lymphoma
  JOURNAL   Proc Natl Acad Sci U S A 111 (34), E3534-E3543 (2014)
   PUBMED   25114248
  REMARK    GeneRIF: identified 98 transposable element-FABP7 gene chimeric
            transcripts that were exclusively expressed in primary diffuse
            large B-cell lymphoma (DLBCL) cases and confirmed several in
            DLBCL-derived cell lines
            Erratum:[Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):E4630. doi:
            10.1073/pnas.1512789112.. PMID: 26159417]
REFERENCE   6  (bases 1 to 785)
  AUTHORS   Shimizu,F., Watanabe,T.K., Shinomiya,H., Nakamura,Y. and
            Fujiwara,T.
  TITLE     Isolation and expression of a cDNA for human brain fatty
            acid-binding protein (B-FABP)
  JOURNAL   Biochim Biophys Acta 1354 (1), 24-28 (1997)
   PUBMED   9375786
REFERENCE   7  (bases 1 to 785)
  AUTHORS   Shi,Y.E., Ni,J., Xiao,G., Liu,Y.E., Fuchs,A., Yu,G., Su,J.,
            Cosgrove,J.M., Xing,L., Zhang,M., Li,J., Aggarwal,B.B., Meager,A.
            and Gentz,R.
  TITLE     Antitumor activity of the novel human breast cancer growth
            inhibitor, mammary-derived growth inhibitor-related gene, MRG
  JOURNAL   Cancer Res 57 (15), 3084-3091 (1997)
   PUBMED   9242429
REFERENCE   8  (bases 1 to 785)
  AUTHORS   Borchers,T., Hohoff,C., Buhlmann,C. and Spener,F.
  TITLE     Heart-type fatty acid binding protein - involvement in growth
            inhibition and differentiation
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 57 (1), 77-84 (1997)
   PUBMED   9250612
  REMARK    Review article
REFERENCE   9  (bases 1 to 785)
  AUTHORS   Xu,L.Z., Sanchez,R., Sali,A. and Heintz,N.
  TITLE     Ligand specificity of brain lipid-binding protein
  JOURNAL   J Biol Chem 271 (40), 24711-24719 (1996)
   PUBMED   8798739
REFERENCE   10 (bases 1 to 785)
  AUTHORS   Young,J.K., Baker,J.H. and Muller,T.
  TITLE     Immunoreactivity for brain-fatty acid binding protein in
            gomori-positive astrocytes
  JOURNAL   Glia 16 (3), 218-226 (1996)
   PUBMED   8833192
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC012299.1 and AW156936.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001446.4.
            
            Summary: The gene encodes a small, highly conserved cytoplasmic
            protein that bind long-chain fatty acids and other hydrophobic
            ligands. The encoded protein is important in the establishment of
            the radial glial fiber in the developing brain. Alternative
            splicing and promoter usage results in multiple transcript variants
            encoding different isoforms. Pseudogenes of this gene are found on
            multiple chromosomes. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012299.1, SRR5189652.18412.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368444.8/ ENSP00000357429.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-692               BC012299.1         108-799
            693-785             AW156936.1         6-98                c
FEATURES             Location/Qualifiers
     source          1..785
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.31"
     gene            1..785
                     /gene="FABP7"
                     /gene_synonym="B-FABP; BLBP; FABPB; MRG"
                     /note="fatty acid binding protein 7"
                     /db_xref="GeneID:2173"
                     /db_xref="HGNC:HGNC:3562"
                     /db_xref="MIM:602965"
     exon            1..152
                     /gene="FABP7"
                     /gene_synonym="B-FABP; BLBP; FABPB; MRG"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..478
                     /gene="FABP7"
                     /gene_synonym="B-FABP; BLBP; FABPB; MRG"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mammary-derived growth inhibitor-related; brain
                     lipid-binding protein; brain-type fatty acid-binding
                     protein; hypothetical protein DKFZp547J2313"
                     /codon_start=1
                     /product="fatty acid-binding protein, brain isoform 1"
                     /protein_id="NP_001437.1"
                     /db_xref="CCDS:CCDS5127.1"
                     /db_xref="GeneID:2173"
                     /db_xref="HGNC:HGNC:3562"
                     /db_xref="MIM:602965"
                     /translation="MVEAFCATWKLTNSQNFDEYMKALGVGFATRQVGNVTKPTVIIS
                     QEGDKVVIRTLSTFKNTEISFQLGEEFDETTADDRNCKSVVSLDGDKLVHIQKWDGKE
                     TNFVREIKDGKMVMTLTFGDVVAVRHYEKA"
     exon            153..325
                     /gene="FABP7"
                     /gene_synonym="B-FABP; BLBP; FABPB; MRG"
                     /inference="alignment:Splign:2.1.0"
     exon            326..427
                     /gene="FABP7"
                     /gene_synonym="B-FABP; BLBP; FABPB; MRG"
                     /inference="alignment:Splign:2.1.0"
     exon            428..785
                     /gene="FABP7"
                     /gene_synonym="B-FABP; BLBP; FABPB; MRG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      764..769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FABP7"
                     /gene_synonym="B-FABP; BLBP; FABPB; MRG"
                     /note="hexamer: AATAAA"
     polyA_site      785
                     /gene="FABP7"
                     /gene_synonym="B-FABP; BLBP; FABPB; MRG"
                     /note="major polyA site"
ORIGIN      
        1 gtaaagggtc ttctgagctg cagtggcaat tagaccagaa gatccccgct cctgtctcta
       61 aagaggggaa agggcaagga tggtggaggc tttctgtgct acctggaagc tgaccaacag
      121 tcagaacttt gatgagtaca tgaaggctct aggcgtgggc tttgccacta ggcaggtggg
      181 aaatgtgacc aaaccaacgg taattatcag tcaagaagga gacaaagtgg tcatcaggac
      241 tctcagcaca ttcaagaaca cggagattag tttccagctg ggagaagagt ttgatgaaac
      301 cactgcagat gatagaaact gtaagtctgt tgttagcctg gatggagaca aacttgttca
      361 catacagaaa tgggatggca aagaaacaaa ttttgtaaga gaaattaagg atggcaaaat
      421 ggttatgacc cttacttttg gtgatgtggt tgctgttcgc cactatgaga aggcataaaa
      481 atgttcctgg tcggggcttg gaagagctct tcagtttttc tgtttcctca agtctcagtg
      541 ctatcctatt acaacatggc tgatcattaa ttagaaggtt atccttggtg tggaggtgga
      601 aaatggtgat ttaaaaactt gttactccaa gcaacttgcc caattttaat ctgaaaattt
      661 atcatgtttt ataatttgaa ttaaagtttt gtcccccccc cccttttttt tataaacaag
      721 tgaatacatt ttataatttc ttttggaatg taaatcaaat ttgaataaaa atcttacacg
      781 tgaaa
//
