LOCUS       NM_001445                496 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens fatty acid binding protein 6 (FABP6), transcript
            variant 2, mRNA.
ACCESSION   NM_001445
VERSION     NM_001445.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Luo,J., Yu,H., Yuan,Z., Tang,W. and Wang,C.
  TITLE     REST Promotes Autophagy in Gastric Cancer by Transcriptionally
            Activating FABP6 to Inhibit the Akt/mTOR Signaling Pathway
  JOURNAL   Front Biosci (Landmark Ed) 29 (6), 212 (2024)
   PUBMED   38940038
  REMARK    GeneRIF: REST Promotes Autophagy in Gastric Cancer by
            Transcriptionally Activating FABP6 to Inhibit the Akt/mTOR
            Signaling Pathway.
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Horvath,G., Balterer,B., Micsonai,A., Kardos,J. and Toke,O.
  TITLE     Multiple Timescale Dynamic Analysis of Functionally-Impairing
            Mutations in Human Ileal Bile Acid-Binding Protein
  JOURNAL   Int J Mol Sci 23 (19), 11346 (2022)
   PUBMED   36232642
  REMARK    GeneRIF: Multiple Timescale Dynamic Analysis of
            Functionally-Impairing Mutations in Human Ileal Bile Acid-Binding
            Protein.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 496)
  AUTHORS   Lin,C.H., Chang,H.H., Lai,C.R., Wang,H.H., Tsai,W.C., Tsai,Y.L.,
            Changchien,C.Y., Cheng,Y.C., Wu,S.T. and Chen,Y.
  TITLE     Fatty Acid Binding Protein 6 Inhibition Decreases Cell Cycle
            Progression, Migration and Autophagy in Bladder Cancers
  JOURNAL   Int J Mol Sci 23 (4), 2154 (2022)
   PUBMED   35216267
  REMARK    GeneRIF: Fatty Acid Binding Protein 6 Inhibition Decreases Cell
            Cycle Progression, Migration and Autophagy in Bladder Cancers.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 496)
  AUTHORS   Pai,F.C., Huang,H.W., Tsai,Y.L., Tsai,W.C., Cheng,Y.C., Chang,H.H.
            and Chen,Y.
  TITLE     Inhibition of FABP6 Reduces Tumor Cell Invasion and Angiogenesis
            through the Decrease in MMP-2 and VEGF in Human Glioblastoma Cells
  JOURNAL   Cells 10 (10), 2782 (2021)
   PUBMED   34685761
  REMARK    GeneRIF: Inhibition of FABP6 Reduces Tumor Cell Invasion and
            Angiogenesis through the Decrease in MMP-2 and VEGF in Human
            Glioblastoma Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 496)
  AUTHORS   Wu,G., Zhang,Z., Tang,Q., Liu,L., Liu,W., Li,Q. and Wang,Q.
  TITLE     Study of FABP's interactome and detecting new molecular targets in
            clear cell renal cell carcinoma
  JOURNAL   J Cell Physiol 235 (4), 3776-3789 (2020)
   PUBMED   31602654
  REMARK    GeneRIF: Study of FABP's interactome and detecting new molecular
            targets in clear cell renal cell carcinoma.
REFERENCE   6  (bases 1 to 496)
  AUTHORS   Lucke,C., Zhang,F., Ruterjans,H., Hamilton,J.A. and
            Sacchettini,J.C.
  TITLE     Flexibility is a likely determinant of binding specificity in the
            case of ileal lipid binding protein
  JOURNAL   Structure 4 (7), 785-800 (1996)
   PUBMED   8805562
REFERENCE   7  (bases 1 to 496)
  AUTHORS   Fujita,M., Fujii,H., Kanda,T., Sato,E., Hatakeyama,K. and Ono,T.
  TITLE     Molecular cloning, expression, and characterization of a human
            intestinal 15-kDa protein
  JOURNAL   Eur J Biochem 233 (2), 406-413 (1995)
   PUBMED   7588781
REFERENCE   8  (bases 1 to 496)
  AUTHORS   Watanabe,K., Hoshi,N., Tsuura,Y., Kanda,T., Fujita,M., Fujii,H.,
            Ono,T. and Suzuki,T.
  TITLE     Immunohistochemical distribution of intestinal 15 kDa protein in
            human tissues
  JOURNAL   Arch Histol Cytol 58 (3), 303-306 (1995)
   PUBMED   8527237
REFERENCE   9  (bases 1 to 496)
  AUTHORS   Oelkers,P. and Dawson,P.A.
  TITLE     Cloning and chromosomal localization of the human ileal
            lipid-binding protein
  JOURNAL   Biochim Biophys Acta 1257 (2), 199-202 (1995)
   PUBMED   7619861
REFERENCE   10 (bases 1 to 496)
  AUTHORS   Birkenmeier,E.H., Rowe,L.B., Crossman,M.W. and Gordon,J.I.
  TITLE     Ileal lipid-binding protein (Illbp) gene maps to mouse chromosome
            11
  JOURNAL   Mamm Genome 5 (12), 805-806 (1994)
   PUBMED   7894165
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X90908.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001445.2.
            
            Summary: This gene encodes the ileal fatty acid binding protein.
            Fatty acid binding proteins are a family of small, highly
            conserved, cytoplasmic proteins that bind long-chain fatty acids
            and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty
            acid binding protein) are also able to bind bile acids. It is
            thought that FABPs roles include fatty acid uptake, transport, and
            metabolism. Transcript variants generated by alternate
            transcription promoters and/or alternate splicing have been found
            for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks two 5' exons and has an
            alternate 5' sequence, and the translation initiation starts from a
            downstream AUG codon, as compared to variant 1. The encoded protein
            (isoform 2) is dominant and shorter at the N-terminus, as compared
            to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X90908.1, BX108052.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000402432.4/ ENSP00000385433.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-496               X90908.1           77-572
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     gene            1..496
                     /gene="FABP6"
                     /gene_synonym="I-15P; I-BABP; I-BALB; I-BAP; ILBP; ILBP3;
                     ILLBP"
                     /note="fatty acid binding protein 6"
                     /db_xref="GeneID:2172"
                     /db_xref="HGNC:HGNC:3561"
                     /db_xref="MIM:600422"
     exon            1..119
                     /gene="FABP6"
                     /gene_synonym="I-15P; I-BABP; I-BALB; I-BAP; ILBP; ILBP3;
                     ILLBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..439
                     /gene="FABP6"
                     /gene_synonym="I-15P; I-BABP; I-BALB; I-BAP; ILBP; ILBP3;
                     ILLBP"
                     /note="isoform 2 is encoded by transcript variant 2;
                     gastrotropin; ileal bile acid binding protein; illeal
                     lipid-binding protein; GT; intestinal 15 kDa protein;
                     ileal lipid-binding protein; fatty acid binding protein 6,
                     ileal"
                     /codon_start=1
                     /product="gastrotropin isoform 2"
                     /protein_id="NP_001436.1"
                     /db_xref="CCDS:CCDS4349.1"
                     /db_xref="GeneID:2172"
                     /db_xref="HGNC:HGNC:3561"
                     /db_xref="MIM:600422"
                     /translation="MAFTGKFEMESEKNYDEFMKLLGISSDVIEKARNFKIVTEVQQD
                     GQDFTWSQHYSGGHTMTNKFTVGKESNIQTMGGKTFKATVQMEGGKLVVNFPNYHQTS
                     EIVGDKLVEVSTIGGVTYERVSKRLA"
     exon            120..295
                     /gene="FABP6"
                     /gene_synonym="I-15P; I-BABP; I-BALB; I-BAP; ILBP; ILBP3;
                     ILLBP"
                     /inference="alignment:Splign:2.1.0"
     exon            296..385
                     /gene="FABP6"
                     /gene_synonym="I-15P; I-BABP; I-BALB; I-BAP; ILBP; ILBP3;
                     ILLBP"
                     /inference="alignment:Splign:2.1.0"
     exon            386..496
                     /gene="FABP6"
                     /gene_synonym="I-15P; I-BABP; I-BALB; I-BAP; ILBP; ILBP3;
                     ILLBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      476..481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FABP6"
                     /gene_synonym="I-15P; I-BABP; I-BALB; I-BAP; ILBP; ILBP3;
                     ILLBP"
                     /note="hexamer: AATAAA"
     polyA_site      496
                     /gene="FABP6"
                     /gene_synonym="I-15P; I-BABP; I-BALB; I-BAP; ILBP; ILBP3;
                     ILLBP"
                     /note="major polyA site"
ORIGIN      
        1 accacccatt ctcctcatcc ctctgctctc tggcctccag cctcccagca gcatggcttt
       61 caccggcaag ttcgagatgg agagtgagaa gaattatgat gagttcatga agctccttgg
      121 gatctccagc gatgtaatcg aaaaggcccg caacttcaag atcgtcacgg aggtgcagca
      181 ggatgggcag gacttcactt ggtcccagca ctactccggg ggccacacca tgaccaacaa
      241 gttcactgtt ggcaaggaaa gcaacataca gacaatgggg ggcaagacgt tcaaggccac
      301 tgtgcagatg gagggcggga agctggtggt gaatttcccc aactatcacc agacctcaga
      361 gatcgtgggt gacaagctgg tggaggtctc caccatcgga ggcgtgacct atgagcgcgt
      421 gagcaagaga ctggcctaag cagccaggcc cggcccaggg agctacaaac ccaccaataa
      481 aactgatata aggaca
//
