LOCUS       NM_001444                676 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens fatty acid binding protein 5 (FABP5), mRNA.
ACCESSION   NM_001444
VERSION     NM_001444.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 676)
  AUTHORS   Saizonou,I., Lascombe,I., Monnien,F., Bedgedjian,I.,
            Kleinclauss,F., Algros,M.P. and Fauconnet,S.
  TITLE     Concomitant decrease of E- and A-FABP expression predicts worse
            survival in urothelial bladder cancer patients
  JOURNAL   Sci Rep 14 (1), 15390 (2024)
   PUBMED   38965292
  REMARK    GeneRIF: Concomitant decrease of E- and A-FABP expression predicts
            worse survival in urothelial bladder cancer patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 676)
  AUTHORS   Soto-Avellaneda,A., Oxford,A.E., Halla,F., Vasquez,P., Oe,E.,
            Pugel,A.D., Schoenfeld,A.M., Tillman,M.C., Cuevas,A., Ortlund,E.A.
            and Morrison,B.E.
  TITLE     FABP5-binding lipids regulate autophagy in differentiated SH-SY5Y
            cells
  JOURNAL   PLoS One 19 (6), e0300168 (2024)
   PUBMED   38900831
  REMARK    GeneRIF: FABP5-binding lipids regulate autophagy in differentiated
            SH-SY5Y cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 676)
  AUTHORS   Matas-Nadal,C., Gatius,S., Ribes-Santolaria,M., Guasch-Valles,M.,
            Gomez Arbones,X., Casanova,J.M., Aguayo-Ortiz,R.S. and Gari,E.
  TITLE     FABP5 in keratinocyte carcinomas: expression, secretion, and its
            impact on tumor aggressiveness
  JOURNAL   Arch Dermatol Res 316 (7), 342 (2024)
   PUBMED   38847933
  REMARK    GeneRIF: FABP5 in keratinocyte carcinomas: expression, secretion,
            and its impact on tumor aggressiveness.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 676)
  AUTHORS   Michler,S., Schoffmann,F.A., Robaa,D., Volmer,J. and
            Hinderberger,D.
  TITLE     Fatty acid binding to the human transport proteins FABP3, FABP4,
            and FABP5 from a Ligand's perspective
  JOURNAL   J Biol Chem 300 (6), 107396 (2024)
   PUBMED   38777142
  REMARK    GeneRIF: Fatty acid binding to the human transport proteins FABP3,
            FABP4, and FABP5 from a Ligand's perspective.
REFERENCE   5  (bases 1 to 676)
  AUTHORS   Li,X., He,W., Chen,X., Zhang,Y., Zhang,J., Liu,F., Li,J., Zhao,D.,
            Xia,P., Ma,W., Wu,T., Wang,H. and Yuan,Y.
  TITLE     TRIM45 facilitates NASH-progressed HCC by promoting fatty acid
            synthesis via catalyzing FABP5 ubiquitylation
  JOURNAL   Oncogene 43 (27), 2063-2077 (2024)
   PUBMED   38755308
  REMARK    GeneRIF: TRIM45 facilitates NASH-progressed HCC by promoting fatty
            acid synthesis via catalyzing FABP5 ubiquitylation.
REFERENCE   6  (bases 1 to 676)
  AUTHORS   Masouye,I., Saurat,J.H. and Siegenthaler,G.
  TITLE     Epidermal fatty-acid-binding protein in psoriasis, basal and
            squamous cell carcinomas: an immunohistological study
  JOURNAL   Dermatology 192 (3), 208-213 (1996)
   PUBMED   8726632
REFERENCE   7  (bases 1 to 676)
  AUTHORS   Siegenthaler,G., Hotz,R., Chatellard-Gruaz,D., Didierjean,L.,
            Hellman,U. and Saurat,J.H.
  TITLE     Purification and characterization of the human epidermal fatty
            acid-binding protein: localization during epidermal cell
            differentiation in vivo and in vitro
  JOURNAL   Biochem J 302 (Pt 2) (Pt 2), 363-371 (1994)
   PUBMED   8092987
REFERENCE   8  (bases 1 to 676)
  AUTHORS   Siegenthaler,G., Hotz,R., Chatellard-Gruaz,D., Jaconi,S. and
            Saurat,J.H.
  TITLE     Characterization and expression of a novel human fatty acid-binding
            protein: the epidermal type (E-FABP)
  JOURNAL   Biochem Biophys Res Commun 190 (2), 482-487 (1993)
   PUBMED   8427590
REFERENCE   9  (bases 1 to 676)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   10 (bases 1 to 676)
  AUTHORS   Madsen,P., Rasmussen,H.H., Leffers,H., Honore,B. and Celis,J.E.
  TITLE     Molecular cloning and expression of a novel keratinocyte protein
            (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is
            highly up-regulated in psoriatic skin and that shares similarity to
            fatty acid-binding proteins
  JOURNAL   J Invest Dermatol 99 (3), 299-305 (1992)
   PUBMED   1512466
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK226036.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001444.2.
            
            Summary: This gene encodes the fatty acid binding protein found in
            epidermal cells, and was first identified as being upregulated in
            psoriasis tissue. Fatty acid binding proteins are a family of
            small, highly conserved, cytoplasmic proteins that bind long-chain
            fatty acids and other hydrophobic ligands. FABPs may play roles in
            fatty acid uptake, transport, and metabolism. Polymorphisms in this
            gene are associated with type 2 diabetes. The human genome contains
            many pseudogenes similar to this locus.[provided by RefSeq, Feb
            2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.178998.1,
                                           SRR5189652.209560.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297258.11/ ENSP00000297258.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-676               AK226036.1         3-678
FEATURES             Location/Qualifiers
     source          1..676
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.13"
     gene            1..676
                     /gene="FABP5"
                     /gene_synonym="E-FABP; EFABP; KFABP; PA-FABP; PAFABP"
                     /note="fatty acid binding protein 5"
                     /db_xref="GeneID:2171"
                     /db_xref="HGNC:HGNC:3560"
                     /db_xref="MIM:605168"
     exon            1..139
                     /gene="FABP5"
                     /gene_synonym="E-FABP; EFABP; KFABP; PA-FABP; PAFABP"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..468
                     /gene="FABP5"
                     /gene_synonym="E-FABP; EFABP; KFABP; PA-FABP; PAFABP"
                     /note="epidermal-type fatty acid-binding protein;
                     psoriasis-associated fatty acid-binding protein homolog;
                     fatty acid binding protein 5 (psoriasis-associated)"
                     /codon_start=1
                     /product="fatty acid-binding protein 5"
                     /protein_id="NP_001435.1"
                     /db_xref="CCDS:CCDS6228.1"
                     /db_xref="GeneID:2171"
                     /db_xref="HGNC:HGNC:3560"
                     /db_xref="MIM:605168"
                     /translation="MATVQQLEGRWRLVDSKGFDEYMKELGVGIALRKMGAMAKPDCI
                     ITCDGKNLTIKTESTLKTTQFSCTLGEKFEETTADGRKTQTVCNFTDGALVQHQEWDG
                     KESTITRKLKDGKLVVECVMNNVTCTRIYEKVE"
     exon            140..312
                     /gene="FABP5"
                     /gene_synonym="E-FABP; EFABP; KFABP; PA-FABP; PAFABP"
                     /inference="alignment:Splign:2.1.0"
     exon            313..414
                     /gene="FABP5"
                     /gene_synonym="E-FABP; EFABP; KFABP; PA-FABP; PAFABP"
                     /inference="alignment:Splign:2.1.0"
     exon            415..676
                     /gene="FABP5"
                     /gene_synonym="E-FABP; EFABP; KFABP; PA-FABP; PAFABP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      657..662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FABP5"
                     /gene_synonym="E-FABP; EFABP; KFABP; PA-FABP; PAFABP"
                     /note="hexamer: AATAAA"
     polyA_site      676
                     /gene="FABP5"
                     /gene_synonym="E-FABP; EFABP; KFABP; PA-FABP; PAFABP"
                     /note="major polyA site"
ORIGIN      
        1 acagcacgct gccacgccga cgcagacccc tctctgcacg ccagcccgcc cgcacccacc
       61 atggccacag ttcagcagct ggaaggaaga tggcgcctgg tggacagcaa aggctttgat
      121 gaatacatga aggagctagg agtgggaata gctttgcgaa aaatgggcgc aatggccaag
      181 ccagattgta tcatcacttg tgatggtaaa aacctcacca taaaaactga gagcactttg
      241 aaaacaacac agttttcttg taccctggga gagaagtttg aagaaaccac agctgatggc
      301 agaaaaactc agactgtctg caactttaca gatggtgcat tggttcagca tcaggagtgg
      361 gatgggaagg aaagcacaat aacaagaaaa ttgaaagatg ggaaattagt ggtggagtgt
      421 gtcatgaaca atgtcacctg tactcggatc tatgaaaaag tagaataaaa attccatcat
      481 cactttggac aggagttaat taagagaatg accaagctca gttcaatgag caaatctcca
      541 tactgtttct ttcttttttt tttcattact gtgttcaatt atctttatca taaacatttt
      601 acatgcagct atttcaaagt gtgttggatt aattaggatc atccctttgg ttaataaata
      661 aatgtgtttg tgctaa
//
